1,056
Views
20
CrossRef citations to date
0
Altmetric
Laboratory Study

Fasudil Ameliorates Rhabdomyolysis-Induced Acute Kidney Injury via Inhibition of Apoptosis

, , , , , , , , & show all
Pages 811-818 | Received 15 Mar 2011, Accepted 15 Jun 2011, Published online: 29 Jul 2011

REFERENCES

  • Zager RA. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int. 1996;49:314–326.
  • Beetham R. Biochemical investigation of suspected rhabdomyolysis. Ann Clin Biochem. 2000;37(Pt. 5):581–587.
  • Abassi ZA, Hoffman A, Better OS. Acute renal failure complicating muscle crush injury. Semin Nephrol. 1998;18:558–565.
  • Homsi E, Janino P, de Faria JB. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Kidney Int. 2006;69:1385–1392.
  • Takuwa Y. Rho-rho kinase pathway. Nippon Rinsho. 2004;62:43–48.
  • Shi J, Wei L. Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz). 2007;55:61–75.
  • Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell. 2000;100:387–390.
  • Chang J, Xie M, Shah VR, . Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci USA. 2006;103:14495–14500.
  • Li Z, Dong X, Wang Z, . Regulation of PTEN by Rho small GTPases. Nat Cell Biol. 2005;7:399–404.
  • Petrache I, Crow MT, Neuss M, Garcia JG. Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Biochem Biophys Res Commun. 2003;306:244–249.
  • Petrache I, Verin AD, Crow MT, Birukova A, Liu F, Garcia JG. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1168–L1178.
  • Uehata M, Ishizaki T, Satoh H, . Calcium sensitization of smooth muscle mediated by a rho-associated protein kinase in hypertension. Nature. 1997;389:990–994.
  • Rikitake Y, Kim HH, Huang Z, . Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005;36:2251–2257.
  • Satoh S, Utsunomiya T, Tsurui K, . Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage. Life Sci. 2001;69:1441–1453.
  • Bao W, Hu E, Tao L, . Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury. Cardiovasc Res. 2004;61:548–558.
  • Teraishi K, Kurata H, Nakajima A, Takaoka M, Matsumura Y. Preventive effect of Y-27632, a selective Rho-kinase inhibitor, on ischemia/reperfusion-induced acute renal failure in rats. Eur J Pharmacol. 2004;505:205–211.
  • Paller MS, Hoidal JR, Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest. 1984;74:1156–1164.
  • Zhu T, Au-Yeung KK, Siow YL, Wang G, O K. Cyclosporine a protects against apoptosis in ischemic/reperfused rat kidneys. Clin Exp Pharmacol Physiol. 2002;29:852–854.
  • Heyne N, Guthoff M, Weisel KC. Rhabdomyolysis and acute kidney injury. N Engl J Med. 2009;361:1412–1413.
  • Ustundag S, Sen S, Yalcin O, Ciftci S, Demirkan B, Ture M. l-Carnitine ameliorates glycerol-induced myoglobinuric acute renal failure in rats. Ren Fail. 2009;31:124–133.
  • Singh D, Chander V, Chopra K. Carvedilol, an antihypertensive drug with antioxidant properties, protects against glycerol-induced acute renal failure. Am J Nephrol. 2003;23:415–421.
  • Homsi E, Janino P, Amano M, Saraiva Camara NO. Endogenous hepatocyte growth factor attenuates inflammatory response in glycerol-induced acute kidney injury. Am J Nephrol. 2009;29:283–291.
  • Nagano T, Mori-Kudo I, Tsuchida A, Kawamura T, Taiji M, Noguchi H. Ameliorative effect of hepatocyte growth factor on glycerol-induced acute renal failure with acute tubular necrosis. Nephron. 2002;91:730–738.
  • Hsu CH, Kurtz TW, Waldinger TP. Cardiac output and renal blood flow in glycerol-induced acute renal failure in the rat. Circ Res. 1977;40:178–182.
  • Paller MS. Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol. 1988;255:F539–F544.
  • Homsi E, Oliveira Dias EP, Garcia WE, Gontijo JA, Figueiredo JF. Effects of nifedipine and platelet activating factor antagonist (BN 52021) in glycerol-induced acute renal failure in rats. Ren Fail. 1996;18:883–892.
  • Papakonstanti EA, Ridley AJ, Vanhaesebroeck B. The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J. 2007;26:3050–3061.
  • Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest. 2005;115:2618–2624.
  • Murphy E. Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. Circ Res. 2004;94:7–16.
  • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005;9:59–71.
  • Sourbier C, Lindner V, Lang H, . The phosphoinositide 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Res. 2006;66:5130–5142.
  • Kuwana H, Terada Y, Kobayashi T, . The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int. 2008;73:430–445.
  • Danial NN, Korsmeyer SJ. Cell death: Critical control points. Cell. 2004;116:205–219.
  • Foo RS, Mani K, Kitsis RN. Death begets failure in the heart. J Clin Invest. 2005;115:565–571.
  • Padanilam BJ. Cell death induced by acute renal injury: A perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol. 2003;284:F608–F627.
  • Datta SR, Dudek H, Tao X, . Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231–241.
  • Peter ME. Programmed cell death: Apoptosis meets necrosis. Nature. 2011;471:310–312.
  • Hetz CA, Hunn M, Rojas P, Torres V, Leyton L, Quest AF. Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: Onset of necrosis is associated with delayed ceramide increase. J Cell Sci. 2002;115:4671–4683.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.