REFERENCES
- Choudhury D. Diabetic nephropathy—a multifaceted target of new therapies. Discov Med. 2010;10:406–415.
- Wagener FA, Dekker D, Berden JH, Scharstuhl A, van der Vlag J. The role of reactive oxygen species in apoptosis of the diabetic kidney. Apoptosis. 2009;14(12):1451–1458.
- Cao Z, Cooper ME. Pathogenesis of diabetic nephropathy. J Diabet Invest. 2011;2:243–247.
- Tobar N, Cáceres M, Santibáñez JF, Smith PC, Rac MJ. 1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism. Cancer Lett. 2008;267:125–132.
- Shen E, Yanwen L, Ying L, . Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes. 2009;58:2386–2395.
- Jin S, Ray RM, Johnson LR. TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species. Am J Physiol Gastrointest Liver Physiol. 2008;294:928–937.
- Peixoto EB, Pessoa BS, Biswas SK. Lopes de Faria JB. Antioxidant SOD mimetic prevents NADPH oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and hypertension. Am J Nephrol. 2009;29(4):309–318.
- Moon JY, Tanimoto M, Gohda T, . Attenuating effect of angiotensin-(1–7) on angiotensin II-mediated NAD(P)H oxidase activation in type 2 diabetic nephropathy of KK-A(y)/Ta mice. Am J Physiol Renal Physiol. 2011;300:F1271–F1282.
- Yoshida S, Nagase M, Shibata S, Kawarazaki W, Takeuchi M, Fujita T. Intrarenal Rac1 activation and renoprotective effect of mineralocorticoid receptor antagonist in obese diabetic nephropathy. NDT Plus. 2009: ii985. Abstracts from the World Congress of Nephrology, Milan, Italy, May 22–26, 2009.
- American Diabetes Association. Standards of medical care in diabetes—2011. Diabetes Care. 2011;34:S11–S61.
- Menini S, Iacobini C, Oddi G, . Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced Diabetes Mellitus: role in the development of diabetic glomerular disease. Diabetologia. 2007;50:2591–2599.
- Paskaloglu K, Sener G, Ayanoglu-Dülger G. Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. Eur J Pharmacol. 2004;499:345–354.
- Guneli E, Tugyan K, Ozturk H, Gumustekin M, Cilaker S, Uysal N. Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. Eur Surg Res. 2008;40:354–360.
- Asaba K, Tojo A, Onozato ML, Goto A, Quinn Fujita T, Wilcox CS. Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int. 2005;6:1890–1898.
- Onozato ML, Tojo A, Goto A, Fujita T, Wilcox CS. Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney Int. 2002;61:186–194.
- Ishii N, Ogawa Z, Suzuki K, Numakami K, Saruta T, Itoh H. Glucose loading induces DNA fragmentation in rat proximal tubular cells. Metabolism. 1996;45:1348–1353.
- Ortiz A, Ziyadeh FN, Neilson EG. Expression of apoptosis-regulatory genes in renal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J Investig Med. 1997;45:50–56.
- Pesce C, Menini S, Pricci F, . Glomerular cell replication and cell loss through apoptosis in experimental Diabetes Mellitus. Nephron. 2002;90:484–488.
- Gumustekin M, Tekmen I, Guneli E, . Short-term melatonin treatment improved diabetic nephropathy but not hemorheological changes in diabetic rats. Pharmazie. 2007;62:693–698.
- Sato Y, Feng GG, Huang L, . Enhanced expression of naofen in kidney of streptozotocin induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells. Clin Exp Nephrol. 2010;14:205–212.
- Shibata S, Nagase M, Yoshida S, . Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med. 2008;14:1370–1376.
- Shibata S, Mu S, Kawarazaki H, . Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest. 2011;121:3233–3243.
- Thamilselvan V, Menon M, Thamilselvan S. Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury. Urol Res. 2012;40:415–423.
- Jonassen AK, Brar BK, Mjos OD, Sack MN, Latchman DS, Yellon DM. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. J Mol Cell Cardiol. 2000;32:757–764.