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Renal Failure Volume 36, 2014 - Issue 7
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Brief Report

More on the “Triple Whammy”: antihypertensive drugs, non-steroidal anti-inflammatory agents and acute kidney injury – a case/non-case study in the French pharmacovigilance database

Jean-Pascal FournierFaculté de Médecine, Laboratoire de Pharmacologie Médicale et Clinique, Université Paul Sabatier ToulouseFrance;UMR 1027 Inserm, ToulouseFrance;Faculté de Médecine, Département Universitaire de Médecine Générale, Université Paul Sabatier ToulouseFranceCorrespondence[email protected]
,
Agnès SommetFaculté de Médecine, Laboratoire de Pharmacologie Médicale et Clinique, Université Paul Sabatier ToulouseFrance;UMR 1027 Inserm, ToulouseFrance;Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Centre Hospitalier Universitaire de Toulouse ToulouseFrance
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Geneviève DurrieuFaculté de Médecine, Laboratoire de Pharmacologie Médicale et Clinique, Université Paul Sabatier ToulouseFrance;UMR 1027 Inserm, ToulouseFrance;Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Centre Hospitalier Universitaire de Toulouse ToulouseFrance
,
Jean-Christophe PoutrainFaculté de Médecine, Département Universitaire de Médecine Générale, Université Paul Sabatier ToulouseFrance
,
Maryse Lapeyre-MestreFaculté de Médecine, Laboratoire de Pharmacologie Médicale et Clinique, Université Paul Sabatier ToulouseFrance;UMR 1027 Inserm, ToulouseFrance;Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Centre Hospitalier Universitaire de Toulouse ToulouseFrance
,
Jean-Louis MontastrucFaculté de Médecine, Laboratoire de Pharmacologie Médicale et Clinique, Université Paul Sabatier ToulouseFrance;UMR 1027 Inserm, ToulouseFrance;Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Centre Hospitalier Universitaire de Toulouse ToulouseFrance
& the French Network of Regional Pharmacovigilance Centres show all
Pages 1166-1168 | Received 24 Jan 2014, Accepted 21 Apr 2014, Published online: 15 May 2014

References

  • Thomas MC. Diuretics, ACE inhibitors and NSAIDs – the triple whammy. Med J Aust. 2000;172(4):184–185
  • Boyd IW, Mathew TH, Thomas MC. COX-2 inhibitors and renal failure: the triple whammy revisited. Med J Aust. 2000;173(5):274
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  • Lapi F, Azoulay L, Yin H, Nessim SJ, Suissa S. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. Br Med J. 2013;346:e8525
  • Fournier J-P, Sommet A, Durrieu G, Poutrain J-C, Lapeyre-Mestre M, Montastruc J-L. Drug interactions between antihypertensive drugs and non-steroidal anti-inflammatory agents: a descriptive study using the French Pharmacovigilance database. Fundam Clin Pharmacol. 2014;28(2):230–235
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  • Imbriano LJ, Maesaka JK, Drakakis J, Mattana J. Reversible anuric acute kidney injury secondary to acute renal autoregulatory dysfunction. Ren Fail. 2014;36(1):111–113
  • Fournier J-P, Lapeyre-Mestre M, Sommet A, Dupouy J, Poutrain J-C, Montastruc J-L. Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study. PLoS One. 2012;7(3):e34187
  • Onuigbo MA. The nephrotoxic “triple whammy” of combining diuretics, ACE inhibitors, and NSAIDs [corrected]. Br Med J. 2013;346:f678
  • Huerta C, Castellsague J, Varas-Lorenzo C, García Rodríguez LA. Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population. Am J Kidney Dis. 2005;45(3):531–539

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