Can neutrophil–lymphocyte ratio be independent risk factor for predicting acute kidney injury in patients with severe sepsis?

References

• Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365–3370
   PubMed Web of Science ®Google Scholar
• Coca SG, Yusuf B, Shlipak MG, et al. Long-term risk of mortality and other adverse outcomes after acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis. 2009;53:961–973
   PubMed Web of Science ®Google Scholar
• Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the Systemic Inflammatory Response Syndrome (SIRS): A prospective study. JAMA. 1995;273:117–123
   PubMed Web of Science ®Google Scholar
• Bagshaw SM, Lapinsky S, Dial S, et al.; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Acute kidney injury in septic shock: Clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med. 2009;35:871–881
   PubMed Web of Science ®Google Scholar
• Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210–4221
   PubMed Web of Science ®Google Scholar
• Wan L, Bagshaw SM, Langenberg C, Saotome T, May C, Bellomo R. Pathophysiology of septic acute kidney injury: What do we really know? Crit Care Med. 2008;36(Suppl. 4):S198–S203
   PubMedGoogle Scholar
• Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol. 2011;7(4):189–200
   PubMed Web of Science ®Google Scholar
• Slocum JL, Heung M, Pennathur S. Marking renal injury: Can we move beyond serum creatinine? Transl Res. 2012;159(4):277–289
   PubMed Web of Science ®Google Scholar
• Siew ED, Ware LB, Ikizler TA. Biological markers of acute kidney injury. J Am Soc Nephrol. 2011;22(5):810–820
   PubMed Web of Science ®Google Scholar
• Siew ED, Ware LB, Bian A, et al. Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Kidney Int. 2013;84(4):786–794
   PubMedGoogle Scholar
• Kramer AA, Postler G, Salhab KF, Mendez C, Carey LC, Rabb H. Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int. 1999;55:2362–2367
   PubMed Web of Science ®Google Scholar
• Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B. Cloning, molecular characterization, and expression analysis of Copine 8. Biochem Biophys Res Commun. 2003;303:842–847
   PubMedGoogle Scholar
• Lemay S, Rabb H, Postler G, Singh AK. Prominent and sustained up-regulation of gp130-signaling cytokines and the chemokine MIP-2 in murine renal ischemia-reperfusion injury. Transplantation. 2000;69:959–963
   PubMedGoogle Scholar
• Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005;365:1231–1238
   PubMed Web of Science ®Google Scholar
• Rabb H, Daniels F, O’Donnell M, et al. Pathophysiological role of T lymphocytes in renal ischemiareperfusion injury in mice. Am J Physiol Renal Physiol. 2000;279:F525–F531
   PubMed Web of Science ®Google Scholar
• Zhang Y, Woodward VK, Shelton JM, et al. Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro. Am J Physiol Renal Physiol. 2004;286:F1193–F1201
   PubMedGoogle Scholar
• Kitada H, Sugitani A, Yamamoto H, et al. Attenuation of renal ischemiareperfusion injury by FR167653 in dogs. Surgery. 2002;131:654–662
   PubMed Web of Science ®Google Scholar
• Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: A review. Expert Rev Cardiovasc Ther. 2013;11(1):55–59
   PubMedGoogle Scholar
• de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care. 2010;14(5):R192
   PubMed Web of Science ®Google Scholar
• Terradas R, Grau S, Blanch J, et al. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: A retrospective cohort study. PLoS One. 2012;7(8):e42860
   PubMedGoogle Scholar
• Loonen AJ, de Jager CP, Tosserams J, et al. Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit. PLoS One. 2014;9(1):e87315
   PubMed Web of Science ®Google Scholar
• Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707–710
   PubMed Web of Science ®Google Scholar
• Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med. 1985;13:818–829
   PubMed Web of Science ®Google Scholar
• Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250–1256
   PubMed Web of Science ®Google Scholar
• Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network. Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31
   PubMed Web of Science ®Google Scholar
• Akcay A, Nguyen Q, Edelstein CL. Mediators of inflammation in acute kidney injury. Mediators Inflamm. 2009;2009:137072. doi:10.1155/2009/137072
   Google Scholar
• Murugan R, Karajala-Subramanyam V, Lee M, et al. Genetic and Inflammatory Markers of Sepsis (GenIMS) Investigators. Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int. 2010;77(6):527–535
   PubMed Web of Science ®Google Scholar
• Knotek M, Rogachev B, Wang W, et al. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int. 2001;59(6):2243–2249
   PubMed Web of Science ®Google Scholar
• Bhargava R, Altmann CJ, Andres-Hernando A, et al. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies. PLoS One. 2013;8(11):e79037. doi:10.1371/journal.pone.0079037
   PubMedGoogle Scholar
• Chawla LS, Seneff MG, Nelson DR, et al. Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis. Clin J Am Soc Nephrol. 2007;2(1):22–30
   PubMed Web of Science ®Google Scholar
• Nie X, Wu B, He Y, et al. Serum procalcitonin predicts development of acute kidney injury in patients with suspected infection. Clin Chem Lab Med. 2013;51(8):1655–1661
   PubMed Web of Science ®Google Scholar
• Gaini S, Koldkjaer OG, Pedersen C, Pedersen SS. Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: A prospective study. Crit Care. 2006;10(2):R53
   PubMedGoogle Scholar
• Mårtensson J, Bell M, Oldner A, Xu S, Venge P, Martling CR. Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury. Intensive Care Med. 2010;36(8):1333–1340
   PubMedGoogle Scholar
• van den Akker JP, Egal M, Groeneveld JA. Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: A systematic review and meta-analysis. Crit Care. 2013;17(3):R98
   PubMed Web of Science ®Google Scholar
• Iglesias J, Marik PE, Levine JS. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Am J Kidney Dis. 2003;41:62–75
   PubMed Web of Science ®Google Scholar