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Clinical Study

Use of Ophiocordyceps sinensis (syn. Cordyceps sinensis) combined with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) versus ACEI/ARB alone in the treatment of diabetic kidney disease: a meta-analysis

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Pages 614-634 | Received 13 Oct 2014, Accepted 04 Jan 2015, Published online: 16 Feb 2015

References

  • Packham DK, Alves TP, Dwyer JP, et al. Relative incidence of ESRD versus cardiovascular mortality in proteinuric type 2 diabetes and nephropathy: Results from the DIAMETRIC (Diabetes Mellitus Treatment for Renal Insufficiency Consortium) database. Am J Kidney Dis. 2012;59(1):75–83
  • Osta V, Natoli V, Dieguez S. Evaluation of two rapid tests for the determination of microalbuminuria and the urinary albumin/creatinine ratio. An Pediatr (Barc). 2003;59(2):131–137
  • Ting RZ, Luk AO, Chan JC. Treatment and landmark clinical trials for renoprotection. Contrib Nephrol. 2011;170:184–195
  • KDOQI. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis. 2007;49(2 Suppl 2):S12–S154
  • Luk A, Chan JC. Diabetic nephropathy – What are the unmet needs? Diabetes Res Clin Pract. 2008;82 (Suppl 1):S15–S20
  • Xiao Y, Liu Y, Yu K, et al. The effect of chinese herbal medicine on albuminuria levels in patients with diabetic nephropathy: A systematic review and meta-analysis. Evid Based Complement Alternat Med. 2013;2013:937549
  • Liu X, Liu L, Chen P, et al. Clinical trials of traditional Chinese medicine in the treatment of diabetic nephropathy – a systematic review based on a subgroup analysis. J Ethnopharmacol. 2014;151(2):810–819
  • Lo HC, Hsieh C, Lin FY, Hsu TH. A systematic review of the mysterious caterpillar fungus in Dong-ChongXiaCao (Dong Chong Xia Cao) and related bioactive ingredients. J Tradit Complement Med. 2013;3(1):16–32
  • Yue K, Ye M, Zhou Z, Sun W, Lin X. The genus Cordyceps: A chemical and pharmacological review. J Pharm Pharmacol. 2013;65(4):474–493
  • Wang Y, Yin H, Lv X, et al. Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis. Fitoterapia. 2010;81(5):397–402
  • Guo P, Kai Q, Gao J, et al. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci. 2010;113:395–403
  • Cho HJ, Cho JY, Rhee MH, et al. Inhibitory effects of cordycepin (3'-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin. J Microbiol Biotechnol. 2007;17(7):1134–1138
  • Kim HG, Shrestha B, Lim SY, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006;545(2–3):192–199
  • Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int J Surg. 2010;8(5):336–341
  • World Health Organization. Definition,diagnosis and classification of diabetes mellitus Report of a WHO consulation, in Geneva World Health Organization. Geneva: World Health Organization; 1999:442–443
  • Mogensen CE, Chachati A, Christensen CK, et al. Microalbuminuria: An early marker of renal involvement in diabetes. Uremia Invest. 1985;9(2):85–95
  • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 1996;17(1):1–12
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273(5):408–412
  • Gao TW, Wei JS. The effect of Jinshuibao Capsule in treatment of 100 patients with diabetic nephropathy. Health Must-Read. 2013;12(3):291
  • Song J, Li YH, Yang XD, Guo L, Hu Z. Effect of combined therapy with bailing capsule and benazepril on urinary albumin excretion rate and c-reaction protein in patients with early diabetic nephropathy. Chin J Integr Med. 2009;29(9):791–793
  • Xiong J. The effects of bailing capsule on protein marker of renal tubular in patients with diabetic nephropathy. Zhejiang Med J. 2011;33(8):1230–1231
  • Zeng SX, Zhang LM. Clinical observation of Irbesartan combined with Jinshuibao Capsule in treatment of type 2 diabetic nephropathy. Chin J Postgrad Med. 2010;33(24):35–37
  • Zhang YK. The effections of Irbesartan combined with Jinshuibao capsule on old patients with type 2 diabetic nephropathy. Jilin Med J. 2011;32(12):2342
  • Li XL. Clinical effects of losartan combined with bailing capsule in treatment of patients with early diabetic nephropathy. J Tradit Chin Med Inform 2010;2(30):184–185
  • Lou PH, Long XS, Li LB. Clinical observation of valsartan combined with bailing capsule in treatment of early diabetic nephropathy. J Pract Med. 2010;26(20):3780–3782
  • Cui Y, Li JH, Chen J, et al. The nephroprotection of Angiotensin Converting Enzyme Inhibitors (ACEI) combined with Jinshuibao capsule to diabetic nephropathy patients in clinical research. J Qiqihar Med Coll. 2010;31(14):2256–2257
  • Huang T, Sun H, Wu TY. Effect of combined therapy with jinshuiba capsule and perindopril on renal function in old patients with early diabetic nephropathy. Herald Med. 2010;29(7):890–892
  • Li H, Nv JN. The nephroprotection of Irbesartan combined with Bailing capsule to Diabetic nephropathy with hypertension patients. China Mod Med. 2011;18(16):56–57
  • Li X. Clinical observation of bailing capsule combined with valsartanl in treatment of diabetic nephropathy. China Foreign Med Treat. 2012;28:112–114
  • Lin J. The nephroprotection of Valsartan combined with Jinshuibao capsule to diabetic nephropathy. Tianjin Pharm. 2009;21(6):37–39
  • Liu YH, Zhao LJ, Wang LH, Gao AM. The influence of Irbesartan combined with Bailing capsule to diabetic nephropathy patients in microalbuminuria. J Chin Physician. 2011;13(2):261–263
  • Qian GF, Qin JH. The clinical observation of jinshuibao capsule combined with enalapril in the treatment of diabetic nephropathy. China J Mod Drug Appl. 2012;6(10):96–97
  • Shen YL, Chen K. The clinical observation of bailing capsule combined with valsartanl in treatment of diabetic nephropathy. Chin J Pract Med. 2011;38(2):124–125
  • Sun QH, Wang J, Liu XL, Zhang WJ, Wang Q. Clinical effect of enalapril combined with Bailing capsule in treatment of old patients with early diabetic kidney disease. Strait Pharm J. 2012;24(10):115–117
  • Wang YZ, Zhen LQ. Clinical observation of Benazepril combined with Bailing capsule in treatment of early diabetic nephropathy. J Emerg Tradit Chin Med. 2010;19(5):754–756
  • Wei SJ. The clinical effects of Jinshuibao capsule combined with Benazepril in treatment of early type 2 diabetic nephropathy. Heilongjiang Med Pharm. 2010;33(1):50
  • Yang JQ, Yang J. Clinical observation of Jinshuibao capsule combined with Benazepril in treatment of early diabetic nephropathy. J Chifeng Univ. 2011;3(2):100–101
  • Ye JB, Liu ZM, Li JJ, Lin HZ, Lu J. Clinical observation of Bailing capsule combined with Candesartan cilexetil in treatment of early diabetic nephropathy. Intern Med China. 2012;7(6):612–613
  • Yi JZ, Ding GH, Zhu L, Gao Z. The effections of Irbesartan and Jinshuibao on patients with type 2 diabetic kidney disease. J Clin Intern Med. 2009;26(11):741–743
  • Yu HT, Shi HT, Xiao LL, Dong CL. The effections of Jinshuibao capsule combined with Olmesartan in treatment of early type 2 diabetic nephropathy. Contemp Med. 2013;19(23):64–65
  • Hong YQ. The effections of Irbesartan combined with Bailing capsule on old patients with type 2 diabetic nephropathy. Chin J Misdiagn. 2010;10(24):5857–5858
  • Li QY. Clinical observation of Irbesartan combined with Cordyceps sinensis in treatment of type 2 diabetic nephropathy. Contemp Med. 2012;18(22):82–83
  • Liu Y. Clinical observation of Telmisartan combined with Jinshuibao capsule in treatment of diabetic kidney disease. China Hosp Pharm J. 2010;30(18):1573–1575
  • Shan GH. The clinical observation of Bailing capsule in treatment of early diabetic nephropathy. Chin J Clin Rational Drug Use. 2012;5(11A):81–82
  • Tao SC, Zhou QT. The effections of Jinshuibao capsule in treatment of early diabetic nephropathy. J Clin Res. 2009;26(7):1271–1272
  • Cao LM. Clinical effects of bailing capsule combined with valsartan in treatment of patients with diabetic nephropathy. Chin J Med Guide. 2012;14(9):1571–1572
  • Chen F, Chen BP, Shi J. Clinical observation of Valsartan combined with Bailing capsule in treatment of early diabetic nephropathy. China Pharmacist. 2010;13(4):551–552
  • Hong RT. Observation on the treatment of diabetic nephropathy with irbesartan jointed by zhiling capsule. China Modern Doctor. 2008;46(36):96–97
  • Liu CP, Li MJ. Effect of combined therapy with irbesartan and bailing capsule on urinary albumin excretion rate and C-reaction protein in patients with early diabetic nephropathy. Hebei Med J. 2011;33(13):1990–1991
  • Liu XD. The clinical research of Cordyceps sinensis combined with benazepril in treatment of patients with early diabetic nephropathy. Asia Pacif Tradit Med. 2011;7(12):135–136
  • Luo F, Cao S, Sun XY. Clinical research on early diabetic nephropathy treated by bailing capsule combined with Irbesartan. J Chin Med. 2011;25(4):466–467
  • Lv ZM. Clinical research of zhiling capsule combined with losartan in treatment of patients with early diabetic nephropathy. Strait Pharm J. 2012;24(2):160–161
  • Ma LY, Chen F, Chen BP. Effect of combined therapy with bailing capsule and irbesartan on il-8 in patients with early diabetic nephropathy. China Pharmacist. 2011;14(7):1027–1028
  • Qiao AM. The effect of Telmisartan combined with Bailing capsule in treatment of 62 patients with early diabetic nephropathy. China Pract Med. 2013;8(28):177–178
  • Shen SM. The clinical observation of valsartan combined with bailing capsule in treatment of 86 patients with early diabetic nephropathy. Chin J Prim Med Pharm. 2012;19(1):127–128
  • Wang SY, Wu CF, Zhang H, Shi J, Chen BP. Clinical effects of bailing capsule combined with benazepril in treatment of patients with early diabetic nephropathy. China Pharmacist. 2009;12(4):501–502
  • Wang YH, Yuan GF. The clinical observation of bailing capsule combined with telmisartan in treatment of patients with early diabetic nephropathy. J Clin Res. 2008;25(5):927–928
  • Yan Y, Wang ZQ. Clinical observation of Bailing Capsule in treatment of patients with early diabetic nephropathy. Chin J Integr Tradit West Nephrol. 2005;6(1):46–47
  • Yang XM, Yang KN, Gao W, Cao XJ. Clinical observation of Enalapril combined with Jinshuibao capsule in treatment of diabetic nephropathy. Hebei Med J. 2012;34(6):938–939
  • Yu J. Clinical effects and nursing of Cordyceps sinensis combined with losartan in treatment of patients with early diabetic nephropathy. Strait Pharm J. 2012;24(7):184–185
  • Zhang Y, Shi HT, Dai HS. The observation on effect of urine protein and lipid metabolism to diabetic nephropathy with Jinshuibao capsules. China Modern Doctor. 2012;50(36):64–65
  • Zhen JX. Clinical observation of Irbesartan combined with Bailing capsule in treatment of type 2 diabetic nephropathy. China Mod Med. 2011;18(24):66–67
  • Cao XX, Zhang RP, Yang JK. Clinical observation on treatment of diabetic nephropathy with Jinshuibao capsules and valsartan. Chin J New Drugs. 2007;16(16):1303–1306
  • Lei SH, Li J, Lai XY, et al. Clinical observation of Irbesartan combined with Jinshuibao capsule in treatment of diabetic nephropathy. Shandong Med J. 2009;49(1):98–99
  • Lu YL. Clinical observation of Telmisartan combined with Bailing capsule in treatment of diabetic nephropathy. Chin J Clin Rational Drug Use. 2010;3(21):43–44
  • Shi HB. Clinical observation of Perindopril combined with Jinshuibao capsule in treatment of type 2 diabetic nephropathy. Chin J Pract Med. 2010;37(7):46–47
  • Wang HP. Clinical observation of Fosinopril combined with Jinshuibao capsule in treatment of type 2 diabetic nephropathy. Tianjin Pharmacy. 2007;19(3):27–28
  • Xue XH. Clinical observation of Irbesartan combined with Bailing capsule in treatment of type 2 diabetic nephropathy. Shanxi Med J. 2009;38(suppl):45–46
  • Yang CH. Clinical observation of Jinshuibao capsule combined with losartan in treatment of early diabetic nephropathy. Mod J Integr Tradit Chin West Med. 2013;22(1):65–66
  • Zhang ZF, Lv J. Clinical observation of bailing capsule in treatment of patients with early diabetic nephropathy. Shanxi Med J. 2009;38(8):730–731
  • Zhou P. Clinical observation of losartan potassium with Jinshuibao capsule in patients with early type 2 diabetic nephropathy. Xinjiang Med J. 2012;42:21–23
  • Chen WJ. Observation of the effect of Zhiling capsule combined with irbesartan treating early diabetic nephropathy. Mod Hospital. 2011;11(8):57–58
  • Guo JZ, Yan HY. Clinical observation of irbesartan combined with Jinshuibao capsule in treatment of patients with early type 2 diabetic nephropathy. Ningxia Med J. 2012;34(9):931–932
  • Liu MW. Clinical effects of losartan combined with bailing capsule in treatment of patients with diabetic nephropathy. Chin J Misdiagn. 2011;11(26):6336
  • Wang L, Su XF. Effect of combined therapy with bailing capsule and losartan on microalbuminuria in patients with early type 2 diabetic nephropathy. Chin J Gerontol. 2007;27:972–973
  • Wu WT. Effect analysis of valsartan and cordyceps preparation in the treatment of type 2 diabetic nephropathy. China Mod Med. 2012;19(27):71–72
  • Fang YY. Clinical observation of Telmisartan combined with Jinshuibao capsule in treatment of early diabetic nephropathy. J Clin Res. 2010;27(10):1907–1908
  • Guan HB, He KP, Huan WM, et al. Effect of Irbesartan with bailing capsules on microalbuminuria-to-creatinine ratio and high-sensitive C-reactive protein in patients with early diabetic nephropathy. Chin Gen Pract. 2010;13(9B):2934–2936
  • Kashihara N, Haruna Y, Kondeti VK, Kanwar YS. Oxidative stress in diabetic nephropathy. Curr Med Chem. 2010;17(34):4256–4269
  • Tang WH, Cheng WT, Kravtsov GM, et al. Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress. Am J Physiol Cell Physiol. 2010;299(3):C643–C653
  • Thallas-Bonke V, Thorpe SR, Coughlan MT, et al. Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway. Diabetes. 2008;57(2):460–469
  • Lim AK, Tesch GH. Inflammation in diabetic nephropathy. Mediators Inflamm. 2012;2012:146154
  • Bohlender JM, Franke S, Stein G, Wolf G. Advanced glycation end products and the kidney. Am J Physiol Renal Physiol. 2005;289(4):F645–F659
  • Navarro-Gonzalez JF, Mora-Fernandez C, Muros de Fuentes M, Garcia-Perez J. Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol. 2011;7(6):327–340
  • Singh DK, Winocour P, Farrington K. Oxidative stress in early diabetic nephropathy: Fueling the fire. Nat Rev Endocrinol. 2011;7(3):176–184
  • Liu ZY, Yao YJ, Liang ZQ, et al. Molecular evidence for the anamorph-teleomorph connection in Cordyceps sinensis. Mycol Res. 2001;105:827–832
  • Wang J, Liu YM, Cao W, et al. Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Metab Brain Dis. 2012;27(2):159–165
  • Dworecka-Kaszak B. Cordyceps fungi as natural killers, new hopes for medicine and biological control factors. Ann Parasitol. 2014;60(3):151–158
  • Yu HM, Wang BS, Huang SC, Duh PD. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. J Agric Food Chem. 2006;54(8):3132–3138
  • Xiao L, Ge Y, Sun L, et al. Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production. Free Radic Res. 2012;46(2):174–183
  • Wang ZJ, Wang SC. Research progress in the mechanism of Cordyceps sinensis in diabetic nephropathy. Chin J Integr Med. 2008;9(1):88–90
  • Yan JK, Li L, Wang ZM, et al. Acidic degradation and enhanced antioxidant activities of exopolysaccharides from Cordyceps sinensis mycelial culture. Food Chem. 2009;117:614–616
  • Choi JW, Ra KS, Kim SY, et al. Enhancement of anti-complementary and radical scavenging activities in the submerged culture of Cordyceps sinensis by addition of citrus peel. Bioresour Technol. 2010;101(15):6028–6034
  • Rathor R, Mishra KP, Pal M, et al. Scientific validation of the Chinese caterpillar medicinal mushroom, Ophiocordyceps sinensis (Ascomycetes) from India: Immunomodulatory and antioxidant activity. Int J Med Mushrooms. 2014;16(6):541–553
  • Dong C, Yao Y. Isolation, characterization of melanin derived from Ophiocordyceps sinensis, an entomogenous fungus endemic to the Tibetan Plateau. J Biosci Bioeng. 2012;113(4):474–479
  • Yang L, Guo J. The influence of bailing capsule on oxidative stress in early diabetic nephropathy. Chin J Gerontol. 2012;16:3518–3520
  • Chung SS, Chung SK. Aldose reductase in diabetic microvascular complications. Curr Drug Targets. 2005;6(4): 475–486
  • Deng YY, Chen YP, He XL, Li L. Study of Cordyceps on mechanism in delaying chronic renal failure. Chin J Integr Tradit West Nephrol. 2001;2(7):381–383
  • Hauser PV, Collino F, Bussolati B, Camussi G. Nephrin and endothelial injury. Curr Opin Nephrol Hypertens. 2009;18(1):3–8
  • Chang QT, Fang JA. Effect of bailing capsule on the expression of nephrin in the kidney of the rats with diabetic nephropathy. Chin J Integr Med. 2010;11(1):10–13
  • Ihn H. Pathogenesis of fibrosis: Role of TGF-beta and CTGF. Curr Opin Rheumatol. 2002;14(6):681–685
  • Gu L, Johno H, Nakajima S, et al. Blockade of Smad signaling by 3'-deoxyadenosine: A mechanism for its anti-fibrotic potential. Lab Invest. 2013;93(4):450–461
  • Li L, He D, Yang J, Wang X. Cordycepin inhibits renal interstitial myofibroblast activation probably by inducing hepatocyte growth factor expression. J Pharmacol Sci. 2011;117(4):286–294
  • Fang JA, Deng GA. Experimental study on the protective effect of bailing capsule on diabetic nephropathy in rats. PhD Thesis. TongJi Medical College, HUST, Wuhan, China; 2005
  • Thomson DM, Winder WW. AMP-activated protein kinase control of fat metabolism in skeletal muscle. Acta Physiol (Oxf). 2009;196(1):147–154
  • Kiho T, Yamane A, Hui J, Usui S, Ukai S. Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol Pharm Bull. 1996;19(2):294–296
  • Yamaguchi Y, Kagota S, Nakamura K, Shinozuka K, Kunitomo M. Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis. Phytother Res. 2000;14(8):647–649
  • Yuan M, Tang R, Zhou Q, et al. Effect of Cordyceps sinensis on expressions of HIF-1alpha and VEGF in the kidney of rats with diabetic nephropathy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38(5):448–457
  • Tu S, Zhou QL, Tang R, et al. Proapoptotic effect of angiotensin II on renal tubular epithelial cells and protective effect of Cordyceps sinensis. J Cent South Univ(Med Sci). 2012;37(1):67–72
  • Shen SJ. Bailing protect against tubular injury in nephrotic syndrome. Zhejiang Med J. 2002;24(8):497–498

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