Circulating irisin levels reflect visceral adiposity in non-diabetic patients undergoing hemodialysis

References

• Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999–2008. JAMA. 2010;303:235–241.
   PubMed Web of Science ®Google Scholar
• Jiang J, Ahn J, Huang WY, Hayes RB. Association of obesity with cardiovascular disease mortality in the PLCO trial. Prev Med. 2013;57:60–64.
   PubMed Web of Science ®Google Scholar
• Romero-Corral A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies. Lancet. 2006;368:666–678.
   PubMed Web of Science ®Google Scholar
• Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis. JAMA. 2013;309:71–82.
   PubMed Web of Science ®Google Scholar
• Beddhu S, Pappas LM, Ramkumar N, Samore M. Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol. 2003;14:2366–2372.
   PubMed Web of Science ®Google Scholar
• Johansen KL, Young B, Kaysen GA, Chertow GM. Association of body size with outcomes among patients beginning dialysis. Am J Clin Nutr. 2004;80:324–332.
   PubMed Web of Science ®Google Scholar
• Kalantar-Zadeh K, Kopple JD, Kilpatrick RD, et al. Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis population. Am J Kidney Dis. 2005;46:489–500.
   PubMed Web of Science ®Google Scholar
• Kalantar-Zadeh K, Abbott KC, Salahudeen AK, Kilpatrick RD, Horwich TB. Survival advantages of obesity in dialysis patients. Am J Clin Nutr. 2005;81:543–554.
   PubMed Web of Science ®Google Scholar
• Port FK, Ashby VB, Dhingra RK, Roys EC, Wolfe RA. Dialysis dose and body mass index are strongly associated with survival in hemodialysis patients. J Am Soc Nephrol. 2002;13:1061–1066.
   PubMed Web of Science ®Google Scholar
• Kakiya R, Shoji T, Tsujimoto Y, et al. Body fat mass and lean mass as predictors of survival in hemodialysis patients. Kidney Int. 2006;70:549–556.
   PubMed Web of Science ®Google Scholar
• Postorino M, Marino C, Tripepi G, Zoccali C; CREDIT (Calabria Registry of Dialysis and Transplantation) Working Group. Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol. 2009;53:1265–1272.
   PubMed Web of Science ®Google Scholar
• Zhang C, Rexrode KM, van Dam RM, Li TY, Hu FB. Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: Sixteen years of follow-up in US women. Circulation. 2008;117:1658–1667.
   PubMed Web of Science ®Google Scholar
• Kalantar-Zadeh K, Streja E, Kovesdy CP, et al. The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clin Proc. 2010;85:991–1001.
   PubMed Web of Science ®Google Scholar
• Jialin W, Yi Z, Weijie Y. Relationship between body mass index and mortality in hemodialysis patients: A meta-analysis. Nephron Clin Pract. 2012;121:c102–c111.
   PubMedGoogle Scholar
• Sarkar SR, Kuhlmann MK, Kotanko P, et al. Metabolic consequences of body size and body composition in hemodialysis patients. Kidney Int. 2006;70:1832–1839.
   PubMed Web of Science ®Google Scholar
• Boström P, Wu J, Jedrychowski MP, et al. A PGC1-alphadependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463–468.
   PubMed Web of Science ®Google Scholar
• Spiegelman BM. Regulation of adipogenesis: Toward new therapeutics for metabolic disease. Diabetes. 2013;62:1774–1782.
   PubMed Web of Science ®Google Scholar
• Hojlund K, Bostrom P. Irisin in obesity and type 2 diabetes. J Diabetes Complications. 2013;27:303–304.
   PubMed Web of Science ®Google Scholar
• Zhang HJ, Zhang XF, Ma ZM, et al. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol. 2013;59:557–562.
   PubMed Web of Science ®Google Scholar
• Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metab: Clin Exp. 2012;61:1725–1738.
   PubMed Web of Science ®Google Scholar
• Crujeiras AB, Pardo M, Arturo RR, et al. Longitudinal variation of circulating irisin after an energy restriction induced weight loss and following weight regain in obese men and women. Am J Human Biol. 2014;26:198–207.
   PubMed Web of Science ®Google Scholar
• Pardo M, Crujeiras AB, Amil M, et al. Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol. 2014;2014:857270.
   PubMed Web of Science ®Google Scholar
• Moreno-Navarrete JM, Ortega F, Serrano M, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013;98:E769–E778.
   Web of Science ®Google Scholar
• Park KH, Zaichenko L, Brinkoetter M, et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab. 2013;98:4899–4907.
   PubMed Web of Science ®Google Scholar
• Daskalopoulou SS, Cooke AB, Gomez YH, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol. 2014;171:343–352.
   PubMed Web of Science ®Google Scholar
• Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – correlation with body mass index. Peptides. 2013;39:125–130.
   PubMed Web of Science ®Google Scholar
• Timmons JA, Baar K, Davidsen PK, Atherton PJ. Is irisin a human exercise gene? Nature. 2012;488:E9–10.
   PubMed Web of Science ®Google Scholar
• Roca-Rivada A, Castelao C, Senin LL, et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoS One. 2013;8:e60563. doi: 10.1371/journal.pone.0060563.
   PubMed Web of Science ®Google Scholar
• Sanchis-Gomar F, Alis R, Pareja-Galeano H, et al. Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients. Endocrine. 2014;46:674–677.
   PubMed Web of Science ®Google Scholar
• Crujeiras AB, Pardo M, Casanueva FF. Irisin: 'Fat' or artefact. Clin Endocrinol (Oxf). 2015;82:467–474.
   PubMed Web of Science ®Google Scholar
• Crujeiras AB, Zulet MA, Lopez-Legarrea P, et al. Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients. Metabolism. 2014;63:520–531.
   PubMed Web of Science ®Google Scholar
• Staiger H, Böhm A, Scheler M, et al. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity. PLoS One. 2013;8:e61903. doi: 10.1371/journal.pone.0061903.
   PubMed Web of Science ®Google Scholar
• Lopez-Legarrea P, de la Iglesia R, Crujeiras AB, et al. Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects. Nutr Diabetes. 2014;4:e110. doi: 10.1038/nutd.2014.7.
   Google Scholar
• Gamas L, Matafome P, Seiça R. Irisin and myonectin regulation in the insulin resistant muscle: Implications to adipose tissue: muscle crosstalk. J Diabetes Res. 2015;2015:359159.
   PubMed Web of Science ®Google Scholar
• Cnop M, Landchild MJ, Vidal J, et al. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: Distinct metabolic effects of two fat compartments. Diabetes. 2002;51:1005–1015.
   PubMed Web of Science ®Google Scholar
• Sanchis-Gomar F, Alis R, Pareja-Galeano H, Romagnoli M, Perez-Quilis C. Inconsistency in circulating irisin levels: What is really happening? Horm Metab Res. 2014;46:591–596.
   PubMed Web of Science ®Google Scholar