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Original Article

Do Immune Complexes Formed with Autoantibodies Have a Role in the Maintenance of Immune Homeostasis Through Interaction with FC Receptors

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Pages 153-160 | Received 06 Sep 1999, Accepted 13 Mar 2000, Published online: 07 Jul 2009

References

  • Logtenberg T, Melissen P BM, Kroon A, Gmelig-Meyling F HJ, Ballieux R. E. Autoreactive B cells in normal humans. Autoantibody production upon lymphocyte stimulation with autoantigen-xenoantigen conjiugates. J Immunol 1988; 140: 446–50
  • Cohen I R, Young D. B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today 1991; 12: 105–10
  • Avrameas S. Natural autoantibodies: from “horror autotoxicus” to “gnothi seauton”. Immunol Today 1991; 12: 154–9
  • Shoenfeld Y, Isemberg D. A. Natural autoimmunity. The Mosaic of autoimmunity, Y Shoen-Feld, D A Isemberg. Elsevier, Amsterdam, New York, Oxford 1989; 53–80
  • Riboldi P, Kasain M T, Mantovani L, Tkematzu H, Casali P. Natural antibodies. The Molecular pathology of autoimmune diseases, C A Bona, K Siminovitch, M Zanetti, A N Theofilopoulus. Harwood Academic Publisher, ChutSwitzerland 1993; 45–65
  • Lydyard P M, Quartey-Papafio R, Broker B, Mackenzie L, Jouquan J., Blaschek M A, Steele J, Petrou M, Collins P, Isen-Berg D., Youinou P. The antibody repertoire of early human B cells. I. High frequency of autoreactivity and polyreactivity. Scand. J Immunol 1990; 31: 33–43
  • Tomer Y, Shoenfeld Y. The idiotypic network in autoimmunity. Giorn. It. Allergol. Immunol. Clin 1991; 1: 3–15
  • Valesini G, Shoenfeld Y. A new player in the antiphospholipid syndrome: the p2 glycoprotein I cofactor. Autoimmunity 1992; 14: 105–10
  • Dighiero G, Rose N. R. Critical self-epitopes are key to the understanding of self tolerance and autoimmunity. Immunol. Today 1999; 20: 423–28
  • Cantor H, Gershon R. K. Immunological circuits: Cellular composition. Fed Proc 1979; 38: 2058–64
  • Roitt I. M. Essential Immunology, eight edition. Blackwell Scientific Publications. 1994
  • Klinman D M, Steinberg A. D. Systemic autoimmune disease arises from policlonal B cell activation. J Exp Med 1987; 165: 1755–60
  • Nemazee D. A. Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice. J Exp Med 1985; 161: 242–56
  • Sinclair N RSTC, Panoskaltsis A. The immunoregulatory apparatus and autoimmunity. Immunol Today 1988; 71: 260–5
  • Heyman B. The immune complex: possible ways of regulating the antibody response. Immunol Today 1990; 11: 310–3
  • Theofilopoulos A. N. Immune complexes in autoimmunity. The Molecular pathology of autoimmune diseases, C A Bona, K Siminovitch, M Zanetti, A N Theofilopoulus. Harwood Academic Publisher, ChutSwitzerland 1993; 229–243
  • Ravetch J V, Kinet J. P. Fc receptors. Annu Rev Immunol 1991; 9: 457–92
  • Gergely J, Sarmay G, Rajnavolgyi E. Regulation of antibody production mediated by Fey receptors, IgG binding factors, and IgG Fc-binding autoantibodies. CRC Crit Rev Biochem Mol Biol 1992; 27: 191–225
  • Gergely J, Rozsnyay Z, Sarmay G. New aspects of Feγ RII-mediated B-cell inhibition. Switch of Fcγ RIIb isoforms depends on B-cell activation. The Immunologist 1994; 2: 77
  • Fridman W H, Sautès C. Immunoglobulin-binding factors. Fc Receptor and The Action of Antibodies Am Soc Microbiol, H Metzger. Teilford Press, Caldwell, NJ 1990; 335–355
  • Neauport-Sautes C, Robourdin-Combe C, Fridman W. H. T cell hybrids bear Fcγ receptors and secrete suppressor immunoglobulin binding factor. Nature 1979; 277: 656–9
  • Forwell M A, Peel M G, Froebel K S, Belch J JF, MacSween R NM, Sandilands G. P. Transfusion-induced, Fcγ- receptor-blocking antibodies: spectrum of cellular reactivity. J Clin Lab Immunol 1986; 20: 63–7
  • Kimata H, Saxon A. Subset of natural killer cells is induced by immune complexes to display Fc receptors for IgE and IgA and demonstrates isotype regulatory function. J Clin Invest 1988; 82: 160–7
  • Kiyono H, Mosteller-Barnum L M, Pitts A M, Williamson S I, Michalek S M, McGhee J. R. Isotype-specific immunoregulation. IgA-binding factors produced by Fca receptor-positive T cells. Hybridomas regulate IgA responses. J Exp Med 1985; 161: 731–47
  • Popham A M, Dresser D. W. Rheumatoid factors in mice: non specific activators of heterophile rheumatoid factor production. Immunology 1980; 41: 579–85
  • Guarnotta G, Triolo G. Immune complex-mediated inhibition of lymphocyte Fc-γ receptors in the plasma of patients with type 1 (insulin dependent) diabetes mellitus: association with anti-ssDNA antibodies. Clin Immunol Immunopathol 1990; 54: 228–36
  • Keegan A D, Paul W. E. Multichain immune recognition receptors: similarities in structure and signaling pathways. Immunol Today 1992; 13: 63–8
  • Daeron M. Fc receptor biology. Annu. Rev. Immunol 1997; 15: 203–34
  • Burmeister W P, Gastinel L N, Simister N E, Blum M L, Bjork-Man P. J. Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor. Nature 1994; 372: 336–43
  • Story C M, Mikulska J E, Simister N. E. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J Exp Med 1994; 180: 2377–81
  • Sandor M, Galon J, Takacs L, Tatsumi Y, Mueller A L, Sautès C, Lynch R. G. An alternative Fcγ-receptor ligand: potential role in T cell development. Proc Natl Acad Sci USA 1994; 91: 12857–61
  • Frank M M, Hamburger M. I., Lawley T J, Kimberly R P, Plot P. H. Defective reticuloendothelial system Fc receptor function in systemic lupus erythematosus. New Engl J Med 1979; 300: 518–20
  • Lawley T. J. Immune complexes and reticuloendothelial system function in human disease. J Invest Dermatol 1980; 74: 339–43
  • Boros P, Bona A, Unkeless J. K. The role of Fcγ receptors in autoimmunity. The Molecular Pathology of Autoimmune Diseases, C A Bona, K Siminovitch, M Zanetti, A N Theofilopoulus. Harwood Academic Publisher, ChutSwitzerland 1993; 191–208
  • Khayat D, Soubrane C, Andrieu J M, Visonneau S, Erne D, Tourani J M, Beldjiord K, Weil M, Fernandez E, Jasquillat C. Changes of soluble CD 16 levels in serum of HIV-infected patients: correlation with clinical and biological prognostic factors. J Infect Dis 1990; 161: 430–5
  • Mathiot C, Teillaud J D, Elmalek M, Mossed L, Euller-Ziegler L, Daragon A, Grosbois B, Michaux J L, Facon T, Bernard J F, Duclos B, Monconduit M, Fridman W. H. Correlation between serum soluble CD16 (sCD16) levels and disease stage in patients with multiple mieloma. J Clin Immunol 1993; 13: 41–8
  • Lamour A, Soubrane C, Ichen M, Pennec Y L, Khayat D, Youinou P. Fc-gamma receptor III shedding by polymorphonuclear cells in primary Sjogren's syndrome. Eur J Clin Invest 1993; 23: 97–101
  • Klaus G GB, Bijsterbosch M K, O'Garra A, Harnett M H, Rigley K. P. Receptor signalling and crosstalk in B lymphocytes. Immunol Rev 1987; 99: 19–38
  • Bain D C, Prechl J, Tchorbanov A, Molina H D, Erdei A, Sulica A, Capel P JA, Hazenbos W LW. Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors. J. Immunol 1999; 162: 3125–30
  • Banga J P, Guarnotta G, Harte A, Price G, Campbell M A, Quartey-Papafio R, Lydyard P M, Roitt I. M. A common epitope identified by a monoclonal antibody MID2 present on all leukocytes and associated with a group of high molecular weight glycopeptides. Scand J Immunol 1984; 19: 11–21
  • Ledbetter J A, Tonks N K, Fisher E. H. CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells. Proc Natl Acad Sci USA 1988; 85: 8628–32
  • Bell C. G. CD45 isoforms on T cells during ontogeny. Annals NY Acad Sci 1991; 636: 363–8
  • De Berardinis P, Londei M, Kahan M, Balsano F, Kontianen S, Gale E AM, Bottazzo G F, Feldman M. The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+. Clin Exp Immunol 1988; 73: 255–9
  • Halstensen T S, Brandtzaeg P. Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ α/β cells in the lamina propia but proliferation (Ki-67) of α/β and γ/δ cells in the epitelium. Eur J Immunol 1993; 23: 505–10
  • De Maria R, Fais S, Silvestri M, Frati L, Pallone F, Santoni A, Testi R. Continous in vivo activation of transient hypore-sponsiveness to TcR/CD3 triggering of human gut lamina propia lymphocytes. Eur J Immunol 1993; 23: 3104–8
  • Burgio V L, Fais S, Boirivant M, Perrone A, Pallone F. Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology 1995; 109: 1029–38
  • Strand V., Lipsky P. E., Cannon G. W., Calabrese C. W., Wiesenhutter C., Cohen S. B., Olsen N. J., Lee M. L., Lorenz T. J., the CD5+ Rheumatoid Arthritis Investigators Group. Effects of administration of an anti-CD5 plus immunocojiugate in rheumathoid arthrites. Arthritis Rheum 1993; 36: 620–30
  • Sun D, Branum K, Sun Q. Prevention of experimental autoimmune encephalomyelitis in Lewis rats by treatment with an anti-rat CD5 antibody (OX19). Cell Immunol 1992; 145: 263–71
  • Plater-Zyberk C, Taylor P C, Blaylock M G, Maini R. N. Anti-CD5 therapy decreases severity of established disease in collagen type II-induced artritis in DBA/1 mice. Clin Exp Immunol 1994; 98: 442–7
  • Cambier J. C. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol 1995; 155: 3381–3285
  • Vassilev T, Gelin C, Kaveri S V, Zilber M T, Boumsell L, Kazatchkine M. D. Antibodies to the CD5 molecule in normal human immunoglobulins for therapeutic use (intravenous immunoglobulins, IVIg). Clin Exp Immunol 1993; 92: 369–72
  • Dwyer J. M. Manipulating the immune system with immune globulin. N Engl J Med 1992; 326: 107–16
  • Jordan S C, Toyoda M. Treatment of autoimmune diseases and systemic vasculitis with pooled human intravenous immune globulin. Clin Exp Immunol 1994; 97: 31–8
  • Waldmann H, Cobbold S. The use of monoclonal antibodies to achieve immunological tolerance. Immunol Today 1993; 14: 247–51
  • Schonrich G, Kalinke U, Momburg F, Malissen M, Schmitt-Verhulst A M, Malissen B, Hammerling G J, Arnold B. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 1991; 65: 293–304
  • Goodnow C. C. Balancing immunity, autoimmunity and self-tolerance. Annals NY Acad. Sci. 1997; 815: 55–66
  • Mamula M J, Lin R H, Janeway C. A., Jr., Hardin. Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c. J Immunol 1992; 149: 789–800
  • Baum H, Butler R., Davies H, Sternberg M JE, Burroughs A. K. Autoimmune disease and molecular mimicry: an hypothesis. Trends in Bioch Sci 1993; 18: 140–4
  • Wolf-Levin R, Azuma T, Aoki K, Yagami Y, Okada H. Specific IgG autoantibodies are potent inhibitors of autoreactive T cell response to phytohemagglutinin-activated T cells. J Immunol 1993; 151: 5864–77
  • Guarnotta G, Triolo G, Giardina E, Rossi C M, Accardo Palumbo A, Triolo G. Fc-gamma receptor blocking in the plasma of patients with coeliac disease. Response to treatment. 12th European Immunology Meeting, Barcellona, 1994, Abs. W38/24:344
  • Guarnotta G, Giardina E, Casiglia D, Rossi C, Acca-rdo-Palumbo A, Triolo G. Inhibition of Fcγ receptors in the plasma of subjects with Down's syndrome. Clin Immunol Immunopathol 1993; 69: 92–6
  • Bernier-Valentine F, Rabilloud R, Roussett B. Evidence for anti-tubulin autoantibodies in the form of immune complexes in human sera. Clin Exp Immunol 1988; 71: 261–8
  • Yellen-Shaw A, Monroe J. G. Differential responsiveness of immature- and mature-stage murine B cells to anti-IgM reflects both FcR-dependent and - independent mechanisms. Cell Immunol 1992; 145: 339–350
  • Salojin K V, Zhang J, Madrenas J, Delovitch T. L. T-cell anergy and altered T-cell receptor signalling: effects on autoimmune disease. Immunol. Today 1998; 19: 468–73
  • Parkhouse R ME. Three B-cell surface molecules associating with membrane immunoglobulin. Immunology 1990; 69: 298–302
  • Voisin G. A. Role of antibody classes in the regulatory facilitation reaction. Immunol Rev 1980; 49: 3–59
  • Ravetch J. V. Fc receptors: rubor redux. Cell 1994; 78: 553–60
  • Sandilands G. P., Galbrait I., Reid F. M., McSween R NM. Immune-complex inhiibition of lymphocyte Fcγ-receptors in primary biliary cirrhosis a possible immunomodulatory mechanism. Lancet 1980; 2: 9–13
  • Manca F, Fenoglio D, Li Pira G, Kunkl A, Celada F. Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies. J Exp Med 1991; 173: 37–48
  • Murphy M K, Heimberger A B, Dennis Y. L. Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRlo thymocytes in vivo. Science 1990; 250: 1720–2
  • Lenardo M. J. Interleukin-2 programs mouse T lymphocytes for apoptosis. Nature 1991; 353: 858–61
  • Ramsdell F, Fowlkes B. J. Maintenance of in vivo tolerance by persistence of antigen. Science 1992; 257: 1130–3
  • Rocha B, Tanchot C, von Boehmer H. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J Exp Med 1993; 177: 1517–21
  • Liu Y L, Joshua D E, Williams G T, Smith C A, Gordan J, MacLennan C. M. Mechanism of antigen driven selection in germinal centers. Nature 1989; 342: 929–34
  • Shan H, Shlomchik M J, Marshack-Rothstein A, Pisetsky D S, Litwin S, Weighert M. G. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. J Immunol 1994; 153: 5104–20
  • Yeatman N, Sachs J, Bottazzo G. F. Autoimmunity-towards the year 2001. Immunol Today 1992; 13: 239–40
  • Ohashi P. S. Ignorance is bliss. lmmunologist 1994; 2: 87–92
  • Ikematsu H, Kasaian M T, Schettino E W, Casali P. Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. J Immunol 1993; 151: 3604–16
  • Ichiyoshi Y, Zhou M, Casali P. A human anti-insulin IgG autoantibody apparently arises throug clonal selection from an insulin-specific “germ-line” natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis. J Immunol 1995; 154: 226–38
  • Pulendran B, Kannourakis G, Nouri S, Smith K GC, Nossal G JV. Soluble antigen can cause enhanced apoplosis of germinal-centre B cells. Nature 1995; 375: 331–34
  • Shokat K M, Goodnow C. C. Antigen-induced B cell death and elimination during germinal-centre immune responses. Nature 1995; 375: 334–8
  • Maclennan I CM. Avoiding autoreactivity. Nature 1995; 375: 281
  • Nagata S, Suda T. Fas and Fas ligand: lpr and gld mutations. Immunol Today 1995; 16: 39–43
  • Rieux-Laucat F, Le Deist F, Hivroz C, Roberts A, Debatin K, Fisher A, De Villartay J. Mutations in Fas associated with human lymphoprolipherative syndrome and autoimmunity. Science 1995; 268: 1347–9
  • Rademacher T W, Williams P, Dwek R. A. Agalactosyl glyco-forms of IgG autoantibodies are pathogenic. Proc Natl Acad Sri USA 1994; 91: 6123–7
  • Bodman K B, Roitt I. M. The pathophysiology of reumatoid arthritis. Fund and Clin Immunol 1994; 2: 73–81
  • Iwai K, Tsubata T, Katsura Y, Kumagai S, Imura H. Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice. Clin exp Immunol 1991; 86: 106–11
  • Feltkamp T EW, Arden A, Cees J L, Verweij C L, deVries R RP. Genetic risk factors for autoimmune diseases. Immunol. Today 1999; 20: 10–12
  • Bottazzo G F, Pujol-Borrel R, Hanafusa T, Feldman M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983; 2: 1115–8
  • Jones A L, Chin L T, Longo D L, KruisbeeK A. M. Peripheral clonal elimination of functional T cells. Science 1990; 250: 1726–9
  • Lanzavecchia A. How can cryptic epitopes trigger autoimmunity?. J Exp Med 1995; 181: 1945–8
  • Guarnotta G, Quartey-Papafio R, Templeman J, de Carvalho L C, Roitt I. M. Monoclonal thyroglobulin autoantibodies as a tool to study autoimmunity. Protides of the Biological Fluids, 29th, H. Peeters. Pergamon Press, Oxford 1981; 861–4
  • Hang I M, Aguado M J, Dixon F J, Theofilopoulos A. N. Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators. J Exp Med 1985; 161: 423–34
  • Chang J T, Segal B M, Shavach E. M. Role of costlmulation in the induction of the IL-12/IL-12 receptors pathway and development of autoimmunity. J. Immunol 2000; 164: 100–106
  • Wucherpfennig K W, Strominger J. L. Selective binding of self peptides to disease-associated Major Histocompatibility Complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med 1995; 181: 1597–601
  • Heath V., Mason D., Ramirez F., Seddon B. Homeo-static mechanisms in the control of autoimmunity. Semin. Immunol 1997; 9: 375–380
  • Ravetch J V, Margulies D. H. New tricks for old molecules. Nature 1994; 372: 323–4
  • Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumara K, Ono M, Ravetch J V, Takai T. Detection of Fey receptors IIB renders H-2b mice susceptible to collagen induced arthritis. J. Exp. Med. 1999; 189: 187–194
  • Rodewald H R, Moingeon P, Lucich J L, Dosiou C, Lopez P, Reinhertz E. L. A population of early fetal thymocytes expressing FcyRII/III contains precursors of T lymphocytes and natural killer cells. Cell 1992; 69: 139–50
  • Eichman K. Lymphocyte subpopulations. S. Margherita Lig-ure 26-27 October, 1992
  • Ismaili J, Brait M, Leo O, Urbain J. Assessment of a functional role of auto-anti-idiotypes in idiotype dominance. Eur J Immunol 1995; 25: 830–7
  • Weiner H L, Mackin G A, Matsui M, Orav E J, Khoury S J, Dawson D. M., Hafler D. A. Double-blind trial of oral toleriza-tion with myelin antigens in multiple sclerosis. Science 1993; 259: 1321–4
  • Trentham D E, Dynesius-Trentham R A, Orav E J, Combitchi D, Lorenzo C, Sewell K L, Hafler D A, Weiner H. L. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 1993; 261: 1727–30
  • Clarkson S B, Bussel J B, Kimberly R P, Valinsky J E, Nach-Man R. L., Unkeless J. C. Treatment of refractory immune thrombocytopenic purpura with an anti-Fey gamma-receptor antibody. New Engl J Med 1986; 314: 1236–9
  • Lanzavecchia A. Identifying strategies for immune intervention. Science 1993; 260: 937–44
  • Deo Y. M., Graziano R. F., Repp R, van de Winkel J. G.J. Clinical significance and FcγR-directed immunotherapies. Immunol Today 1997; 18,3: 127–135

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