39
Views
18
CrossRef citations to date
0
Altmetric
Original Article

The Length of the CTLA-4 Microsatellite (AT)N-Repeat Affects the Risk for Type 1 Diabetes: For the Swedish Childhood Diabetes Study Group

, , , , , , , , & show all
Pages 173-180 | Received 04 Jan 2000, Accepted 11 Apr 2000, Published online: 07 Jul 2009

References

  • Davies J L, Kawaguchi Y, Bennett S T, Copeman J B, Cordell H J, Pritchard L E, Reed P W, Gough S CL, Jenkins S C, Palmer S. M. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130–136
  • Buzzetti R, Quattrocchi C C, Nistico L. Dissecting the genetics of type 1 diabetes: relevance for familial clustering and differences in incidence. Diabetes Metab. Rev. 1998; 14: 111–128
  • Concannon P, Gogolin E KJ, Hinds D A, Wapelhorsl B, Morrison V A, Stirling B, Mitra M, Farmer J, Williams S R, Cox N. J. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nature Genetics 1998; 19: 292–6
  • Schranz D, Lernmark Å. Immunology in Diabetes: An Update. Diab. Metab. Rev. 1998; 14: 3–29
  • Nistico L, Buzzetti R, Pritchard L E, Van der Auwera B, Gio-Vaninni C., Bosi E, Larrad M T, Rios M S, Chow C C, Cockram C. S. The CTLA-4 gene region on chromosome 2q33 is linked to, and associated with type 1 diabetes. Belgian-Diabetes Registry. Human Molecular Genetics 1996; 5: 1075–1080
  • Awata T, Kurihara S, Litaka M, Takei S, Inoue I, Lshii C., Negishi K, Izumida T., Yoshida Y, Hagura R. Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. Diabetes 1998; 47: 128–9
  • Krokowski M, Bodalski J, Bratek A, Machejko P, Caillat-Zucman S. CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland. 1998; 24
  • Marron M P, Raffel L J, Garchon J H, Jacob C O, Serrano-Rios M, Martinez-Larrad M T, Teng W P, Park Y, Zhang Z X, Goldstein D. R. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum. Mol. Genet 1997; 6: 12751282
  • Todd J A, Farrall M. Panning for gold: Genome-wide scanning for linkage in type 1 diabetes. Human Molecular Genetics 1996; 5: 1443–1448
  • Tivol E A, Bordello F, Schweitzer A N, Lynch W P, Bluestone J, Sharpe A. H. Loss of CTLA-4 leads to massive lymphopro-liferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3: 541–547
  • Buzzetti R, Nistico L, Pozilli P, Serrano-Rios M, Larraz M, Tosi R, Giovannini C. The CTLA-4 microsatellite identifies a new region on chromosome 2 linked to IDDM. Diabetelogia 1995; 38: 105
  • Yanagawa T, Taniyama M, Enomoto S, Gomi Z., Maruyama H, Ban Y, Saruta T. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid 1997; 7: 843–846
  • Donner H, Seidl C, Braun J, Siegmund T, Herwig J, Seifried E, Usadel K H, Badenhoop K. CTLA4 gene haplotypes cannot protect from IDDM in the presence of high- risk HLA DQ8 or DA2 alleles in German families. Diabetes 1998; 47: 1158–1160
  • Deichmann K, Heinzmann A, Bruggenolte E, Forster J, Kuehr J. An Mse I RFLP in the human CTLA4 promotor. Biochem. Biophys. Res. Commun 1996; 225: 817–8
  • Djilali-Saiah I, Larger E, Harfouch-Hammoud E, Timsit J, Clerc J, Bertin E, Assan R, Boitard C, Bach J F, Caillat-Zuc-Man S. No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM. Diabetes 1998; 47: 125–127
  • Dahlquist G, Blom L, Holmgren G, Hägglöf B, Larsson Y, Sterky G, Wall S. The epidemiology of diabetes in Swedish children 0-14 years old a six-year prospective study. Diabet-ologia 1985; 28: 802–808
  • Östman J, Amqvist H, Blohmé G, Lithner F, Littorin B, Nyström L, Sandström A, Scherstén B, Wall S, Wibell L. Epidemiology of diabetes mellitus in Sweden. Results of the first year of a prospective study in the population age group 15-34 years. Acta Med Scand 1986; 220: 437–445
  • Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark Å, Sundkvist G. Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched controls. Diabetologia 1989; 32: 387–395
  • Landin-Olsson M, Karlsson F A, Lernmark Å, Sundkvist G. Islet cell and thyrogastric antibodies in 633 consecutive 15-34 years old patients in the Diabetes Incidence Study in Sweden (DISS). Diabetes 1992; 41: 1022–1027
  • Agresti A. Categorical Data Analysis. Inc. JWS, ed., New York 1990; 48–54
  • Donner H, Rau H, Walfish P G, Braun J, Siegmund T, Finke R, Herwig J, Usadel K H, Badenhoop K. CTLA4 alanine-17 confers genetic susceptibility to Graves' diease and to type 1 diabtes mellitus. J. Clin. Endocrinol. Metab 1997; 82: 143–146
  • Badenhoop K, Donner H, Braun J, Siegmund T, Rau H, Usadel K. H. Genetic markers in diagnosis and prediction of relapse in Graves' disease. Exp. Clin. Endocrinol. Diabetes 1996; 104: 98–100
  • Barbesino G, Tomer Y CE., Davies T F, Greenberg D. A. Linkage analysis of candidate genes in autoimmune thryoid disease: 1. Selected immunoregulatory genes. International Consortium for the Genetics of Autoimmune Thyroid Disease. J. Clin. Endocrinol. Metab 1998; 83: 1580–1584
  • Braun J, Donner H, Siegmund T, Walfish P G, Usadel K H, Badenhoop K. CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis. Tissue Antigens 1998; 51: 562–566
  • Huang D, Liu L, Noren K, Xia S W, Trifunovic J, Pirskanen R, Lefvert S. K. Genetic association of CTLA-4 to myasthenia gravis with thymoma. J. Neuroimmunol 1998; 88: 192–198
  • Seidl C, Donner H, Fischer B, Usadel K H, Seifried E, Kalt-Wasser J. P., Badenhoop K. CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis. Tissue Antigens 1998; 51: 62–66
  • Waterman E A, Watson P F, Lazarus J H, Parkes A B, Darke C, Weetman A. P. A study of the association between a polymorphism in the CTLA-4 gene and postpartum thyroiditis. Clin. Endorcinol 1998; 49: 251–255
  • Yanagawa T, Hidaka Y, Guimaraes V, Soliman M, De Groot L. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. J. Clin. Endocrinol. Metab 1995; 80: 41–45
  • Drell D W, Notkins A. L. Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 132–143
  • Field L L, Tobias R. Unraveling complex trait: the genetics of insulin-dependent diabetes mellitus. Clin Invest Med 1997; 20: 41–47

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.