13
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Time Clustering of High Titre Insulin Autoantibodies (IAA) in the Cord Blood of Infants Born to Non-Diabetic Mothers

, , , &
Pages 17-26 | Received 22 Dec 1998, Published online: 07 Jul 2009

References

  • Gorsuch A. N, Spencer K. M., Lister J. The natural history of type I diabetes mellitus: evidence for a long prediabetic period. Lancet 1981; 2: 1363–1365
  • Todd J. A. From genome to aetiology in a multifactorial disease, type 1 diabetes. Bioassays 1999; 21: 164–174
  • Pilcher C. C, Dickens K., Elliott R. B. ICA only develop in early childhood. Diabetes Res. Clin. Pratt. 1991; 14(Suppl. 1)582
  • Lendrum A., Walker G. J, Cudworth A. G., Bottazzo G F. Islet cell antibodies in diabetes mellitus. Lancet 1976; 2: 1275–1276
  • Baekkeskov S., Aanstoot H. J., Christgau S., Reetz A., Solimena M., Cascalho M., Folli F., Richter-Oleson H., De Camilli P. Identification of the 64 K autoantigen in insulin-dependent diabetes as the GABA synthesising enzyme glutamic acid decarboxylase. Nature 1990; 347: 151–156
  • Rabin D. U, Pleasic S. M, Shapiro J. A, Yoo-Warren H., Oles J., Hicks J. M, Goldstein D. E., Rae D. M.M. Islet cell antigen 512 is a diabetes-specific autoantigen related to protein tyrosine phosphatase. J. Immunol. 1994; 152: 3183–3188
  • Palmer J. P, Asplin C M., Clemons P., Lycn K., Tatpati O., Raghu P. K., Paquette T. L. Insulin antibodies in insulin dependent diabetics before treatment. Science 1983; 222: 1337–1339
  • Vardi P., Ziegler A. G., Matthews J. H, Dib S., Keller R. J, Ricker A. T, Wolsdorf J. H, Herskowitz R. D, Rabizadeh A., Eisenbarth G. S. The concentration of insulin autoantibodies at onset of type 1 diabetes: inverse log-linear correlation with age. Diab. Care 1988; 11: 736–739
  • Karjalainen J., Salmela P., Ilonen J. A comparison of childhood and adult type 1 diabetes. N. Engl. J. Med. 1989; 320: 881–883
  • Ziegler A. G, Hillebrand B., Robl W., Mayrhofer M., Hummel M., Molienhauer V., Vardemann J., Lenz A., Standi E. On the appearance of islet associated autoimmunity in the offspring of diabetic mothers: a prospective study from birth. Diabetologia 1993; 36: 402–405
  • Dotta F., Gillio C, Fanilla C, Moretti A., Bosco N., Sulli P., Colarizi C, Tibcrti E., Anastasi G., Di Mario U. Autoimmunity to pancreatic β cells in congenital diabetes mellitus. Diabetologia 1996; 39(Suppl. 1)A97
  • Petersen J. S, Hejnaes K. R, Moody A., Karllsen A. E, Marshall M. O, Hoier-Madsen M., Boel E., Michelsen B. K., Dyrberg T. Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radio ligand assay. Diabetes 1994; 43: 459–467
  • Wellik S. R, de Veciana M., Mark A., Morgan M. A, Berkowitz K. M., Arquilla E. R. Naturally occurring insulin autoantibodies in neonates of normal pregnancies, and their relationship to insulinaemia and birthweight. Am. J. Obstet. Gynaecol. 1995; 173: 1878–1884
  • Fineberg S. E, Biegel A. A, Durr K. L., et al. Presence of insulin autoantibodies as a regular feature of non-diabetic repertoire of immunity. Diabetes 1991; 40: 1187–1193
  • Pugliese A., Bugawan T., Moromisato R., Awdet Z. L, Alper C. A, Jackson R. A, Erlich H. A., Eisenbarth G. S. Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of IAA in first degree relatives at risk for IDDM. J. Clin. Invest. 1994; 93: 2447–2452
  • Rewers M., Eisenbarth G. S, Norris J., Erlich H., Beatty B., Klingensmith G., Elliott R. B. Population and familial risk of β cell autoimmunity in the first two years of life: diabetes autoimmune study in the young. Diabetologia 1996; 39(Suppl. 1)A15
  • Levy-Marchal C, Dubois F., Noel M., Tichet J., Czernechow P. Immunogenetic determinants and prediction of IDDM in French school children. Diabetes 1995; 44: 1029–1032
  • Ivarsson S. A, Ackefors M., Carlsson A., Ekberg G., Falorni A., Kockum I., et al. Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes IDDM in the mother but not necessarily the offspring. Auioimmunitv 1997; 26: 261–269
  • Dahlquist G., Frisk G., Ivarsson S. A, Svanberg L., Forsgren M., Diderholm H. Indications that maternal Coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM. Diahetohgia 1995; 38: 1371–1373
  • Desbuquois B., Aurbach G. D. Use of polyethylene glycol to separate free and antibody bound peptide hormones in radioimmuno assays. J. Clin. Endocrinol. Metah. 1971; 33: 732–739
  • Ooi G. T., Herrington A. C. The biological and structural characterisation of specific serum binding proteins for the insulin-like growth factors. J. Endocrinol. 1988; 118: 7–18
  • Froeseh E. R, Bargi H., Ramseier E. P, Bally P., Labhart A. Antibody-suppressible and insulin-like activities in human serum, and their physiological significance. An insulin assay with adipose tissue of increased precision and specificity. J. Clin. Invest. 1963; 42: 1816–1834
  • Blundell T. L, Bcdarkar S., Rinderknecht E., Humbel R. E. Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding. Proc. Nat. Acad. Sci. USA 1978; 75: 180–184
  • Diaz J. L., Wilkin T. J. Differences in epitope restriction of autoantibodies to native human insulin (IAA) and antibodies to heterologous insulin (IA). Diabetes 1987; 36: 66–72
  • Bilbao J. R, Calvo B., Urrutia I., Linaves A., Castano L. Anti-insulin activity in normal newborn cord blood serum. Diabetes 1997; 46: 713–716
  • Hummel M., Ziegler A. G. Vaccines and the appearance of islet cell antibodies in the offspring of diabetic patients. Results from the BABYDIAB. Diab. Care 1996; 19: 1456–1457

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.