Dysregulation of p56^lck Kinase in Patients with Systemic Lupus Erythematosus

References

• The Molecular Pathology of Autoimmune Diseases, C Bona, K A Siminovitch, M Zanetti, A N Theofilopoulos. Harwood Academic Publishers. 1993
   Google Scholar
• Matache C, Stefanescu M, Onu A, Szegli G, Barel M, Tana-Seanu S., Matei I, Bouillie S, Frade R. Tyrosine Phosphorylation in Peripheral Lymphocytes from Patients with Systemic Lupus Erythematosus. Autoimmunity 1996; 24: 217–228
   PubMed Web of Science ®Google Scholar
• Matache C, Stefanescu M, Onu A, Tanaseanu S, Matei I, Frade R, Szegli G. p56lck Activity and Expression in Peripheral Blood Lymphocytes from Patients with Systemic Lupus Erythematosus. Autoimmunity 1999; 29: 11–120
   PubMed Web of Science ®Google Scholar
• Emlen W, Niebur J, Kandera R. Accelerated In Vitro Apop-tosis of Lymphocytes from Patients with Systemic Lupus Erythematosus. J Immunol 1994; 152: 3685–3691
   PubMed Web of Science ®Google Scholar
• Perniok A, Wedekind F, Hermann M, Specker C, Schneider M. High level of circulating early apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus 1998; 7: 113–118
   PubMed Web of Science ®Google Scholar
• Courtney P A, Crockard A D, Williamson K, McConnel J, Kennedy R J, Bell A L. Lymphocytes apoptosis in systemic lupus erythematosus: relationships with Fas expression, serum soluble Fas and disease activity. Lupus 1999; 8: 508–513
   PubMed Web of Science ®Google Scholar
• Georgescu L, Vakkalanka R K, Elkon K B, Crow M K. Inter-leukin-10 Promotes Activation - induced Cell Death of SLE Lymphocytes Mediated by Fas-Ligand. J Clin Invest 1997; 100: 2622–2633
   PubMed Web of Science ®Google Scholar
• Lorenz H M, Grunke M, Hieronymus T, Hermann M, Kuhnel A, Manger B, Kalden J R. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1997; 40: 306–317
   PubMed Web of Science ®Google Scholar
• Courtney P A, Crockard A D, Williamson K, Irvine A E, Kennedy R J, Bell A L. Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia. Ann Rheum Dis 1999; 58: 309–314
   PubMed Web of Science ®Google Scholar
• Hermann M, Voll R E, Zoller O M, Hagenhofer M, Ponner B B, Kalden J R. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241–1250
   PubMedGoogle Scholar
• Utz P. J., Hottelet M, Schur P. H., Anderson P. Proteins Phos-phorylated during Stress-induced Apoptosis Are Common Targets for Autoantibody Production in Patients with Systemic Lupus Erythematosus. J Exp Med 1997; 185: 843–854
   PubMed Web of Science ®Google Scholar
• Kovacs B, Liossis S N, Dennis G J, Tsokos G C. Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus. Autoimmunity 1997; 25: 213–221
   PubMed Web of Science ®Google Scholar
• Nozawa K, Kayagaki N, Tokano Y, Yagita H, Okumura K, Hasimoto H. Soluble Fas (APO-1, CD95) and soluble Fas ligand in rheumatic diseases. Arthritis Rheum 1997; 40: 1126–1129
   PubMed Web of Science ®Google Scholar
• Suzuki N, Ichino M, Mihara S, Kaneko S, Sakane T. Inhibition of Fas/Fas ligand - mediated apoptotic cell death of lymphocytes in vitro by circulating anti-Fas ligand autoantibodies in patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 344–353
   PubMedGoogle Scholar
• DiSomma M M, Nuti S., Telford J. L., Baldari C. T. p561ck plays a key role in transducing apoptotic signals in T cells. FEBSLett 1995; 363: 101–104
   PubMed Web of Science ®Google Scholar
• Oyaizu N, Than S, McCloskey T W, Pahwa S. Requirement of p561ck in T cell receptor/CD3 - mediated apoptosis and Fas-ligand induction in Jurkat cells. Biochem Biophys Res CommunmS, 213: 994–1001
   PubMed Web of Science ®Google Scholar
• Gonzales-Garcia A R, Borlado R, Leonardo L, Merida E, Martinez A C, Carrera A C. Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. J Immunol 1997; 158: 4104–4112
   PubMed Web of Science ®Google Scholar
• Garcia-Welsh A, Laskin D L, Schuler R L, Laskin J D. Cellular depletion of p561ck during thymocytes apoptosis. J Leukocyte Biology 1994; 56: 528–532
   PubMed Web of Science ®Google Scholar
• Al-Ramadi B K, Zhang H, Bothwell A L. Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes. Proc Natl Acad SciJ/&4 1998; 95: 12498–12503
   PubMed Web of Science ®Google Scholar
• Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium fhiocyanate - phenol - chloroform extraction. Anal Biochem 1987; 162: 156–159
   PubMed Web of Science ®Google Scholar
• Onu A, Pohl T, Krause H, Bulfone-Paus S. Regulation of IL-15 Secretion via the Leader Peptide of Two IL-15 Iso-forms. J Immunol 1997; 158: 255–271
   PubMed Web of Science ®Google Scholar
• Nicoletti I, Migliorati G, Pagliacci M C, Grignani F, Riccardi F. A rapid and simple method for measuring tymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271–279
   PubMed Web of Science ®Google Scholar
• Marth J D, Lewis D B, Wilson C B, Geam M E, Krebs E G, Per-Lmutter R. M. Regulation of pp56 during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J 1987; 6: 2727–2734
   PubMed Web of Science ®Google Scholar
• Vanhee-Brossollet C, Vaquer C. Regulation of p56(lck) messenger turnover upon T cell activation: involvement of 3′ untranslated region in stability as determined in cell-free extracts. Biochem Biophys Research Commun 1997; 233: 419–424
   PubMed Web of Science ®Google Scholar
• Zhu L, Anasetti C. Cell Cycle Control of Apoptosis in Human Leukemic T Cells. J Immunol 1995; 154: 192–200
   PubMed Web of Science ®Google Scholar
• Gmeling-Meyling F, Dawisha S, Steinberg A D. Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus. J Exp Med 1992; 175: 297–300
   PubMed Web of Science ®Google Scholar
• Amasaki Y, Kabayashi S, Takeda T, Ogura N, Jodo S, Nakabayashi T, Tsutsumi A, Fujisaku A, Koike T. Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia. Clin Exp Immunol 1995; 99: 245–250
   PubMed Web of Science ®Google Scholar
• Boehme S A, Leonardo M J. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of cell cycle. Eur J Immunol 1993; 23: 1552–1560
   PubMed Web of Science ®Google Scholar
• Radvanyi L G, Shi Y, Mills G B, Miller R G. Cell cycle progression out of Gl sensitises primary-cultured non transformed T cells to TCR-mediated apoptosis. Cell Immunol 1996; 170: 260–273
   PubMedGoogle Scholar