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Original Article

Expression of B Cell Receptor-Associated Signaling Molecules in Human Lupus

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Pages 213-224 | Received 14 Mar 2000, Published online: 07 Jul 2009

References

  • Reth M., Wienands J. Initiation and processing of signals from the B cell antigen receptor. Annu Rev Immunol. 1997; 15: 453–79
  • Buhl A., Cambier J. Co-receptor and accessory regulation of B-cell antigen receptor signal transduction. Immunol Rev. 1997; 160: 127–38
  • Engel P., Zhou L. J., Ord D. C., Sato S., Roller B., Tedder T. F. Abnormal B lymphocyte development, activation. and differentiation in mice that lack or overexpress the CD 19 signal transduction molecule. Immunity. 1995; 3: 39–50
  • Rickert R C., Rajewsky K., Roes J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 1995; 376: 352–5
  • Sato S., Ono N., Steeber D., Pisetsky D., Tedder T. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-l lineage cells and autoimmunity. J Immunol. 1996; 157: 4371–8
  • Molina H., Holers V. M., Li B., Fung Y., Mariathasan S., Goellner J., Strauss-Schoenbergcr J., Karr R. W., Chaplin D. D. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci US A. 1996; 93: 3357–61
  • Kishihara K., Penninger J., Wallace V. A., Kundig T. M., Kawai K., Wakeham A., Timms E., Pfeffer K., Ohashi PS., Thomas M. L., Furlonger C., Paige C. J., Mak T. W. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell. 1993; 74: 143–56
  • Tsitsikov E., Gutierrez-Ramos J., Geha R. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci U S A. 1997; 94: 10844–9
  • Cyster J. G., Healy J. I., Kishihara K., Mak T. W., Thomas M. L., Goodnow C. C. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 1996; 381: 325–8
  • Hibbs M. L., Tarlinton D. M., Amies J., Grail D., Hodgson G., Maglitto R., Stacker S. A., Dunn A. R. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell. 1995; 83: 301–11
  • O'Keefe T. L., Williams G. T., Davies S. L., Neuberger M. S. Hyperresponsive B cells in CD22-deficient mice. Science 1996; 274: 798–801
  • Nishizumi H., Taniuchi I., Yamanashi Y., Kitamura D., Ilic D., Mori S., Watanabe T., Yamamoto T. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 1995; 3: 549–60
  • Sato S., Miller A., Lnaoki M., Bock C., Jansen P., Tang M., Tedder T. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity. 1996; 5: 551–62
  • Nitschke L., Carsetti R., Ocker B., Kohler G., Earners M. CD22 is a negative regulator of B-cell receptor signalling. CurrRiol. 1997; 7: 133–43
  • Otipoby K., Andersson K., Draves K., Klaus S., Farr A., Kerner J., Perlmutter R., Law C., Clark E. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 1996; 384: 634–7
  • O'Keefe T, Williams G., Batista F., Neuberger M. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med. 1999; 189: 1307–13
  • Kuntz L., Fonteneau P., Loor F. Common and individual features of the humoral immunity dysregulation of mice homozygous at the viable motheaten (mev) mutation. Immunol Letters. 1990; 24: 97–101
  • Shultz L., Schweitzer P., Rajan T., Yi T., Ihle J., Matthews R., Thomas M., Beier D. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell. 1993; 73: 1445–54
  • Kozlowski M., Mlinaric-Rascan I., Feng G., Shen R., Pawson T., Siminovitch K. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med. 1993; 178: 2157–63
  • Feuerstein N., Chen F., Madaio M., Maldonado M., Eisenberg R. Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor-induced tyrosine-phosphoprotcins. J Immunol. 1999; 163: 5287–97
  • Liossis S. N., Kovacs B., Dennis G J., Kammer G. M., Tsokos G. C. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest. 1996; 98: 2549–2557
  • Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25: 1271–7
  • Bombardier C., Gladman D. D., Urowitz M. B., Caron D., Chang C. H. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 1992; 35: 630–40
  • Zouali M., Madaio M. P., Canoso R. T., Stollar B. D. Restriction fragment length polymorphism analysis of the V kappa locus in human lupus. Eur J Immunol. 1989; 19: 1757–60
  • Suzuki N., Sakane T. Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in culture in human systemic lupus erythematosus. J Clin Invest. 1989; 83: 937–44
  • Cyster J., Goodnow C. Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity. 1997; 6: 509–17
  • Trowbridge I., Thomas M. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Anna Rev Immunol. 1994; 12: 85–116
  • Cyster J., Goodnow C. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity. 1995; 2: 13–24
  • Chan V. W., Meng F., Soriano P., DeFranco A. L., Lowell C. A. Characterization of the B lymphocyte populations in Lyn-defieient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997; 7: 69–81
  • Huck S., Zouali M. Expression of the tyrosine kinase Lyn during B-cell receptor engagement and apoptosis. Ann N YAcadScie. 1997; 815: 122–123
  • Saiki O., Saeki Y., Kishimoto S. Spontaneous immunoglobulin A secretion and lack of mitogen-responsive B cells in systemic lupus erythematosus. J Clin Invest. 1985; 76: 1865–70
  • Ginsburg W., Finkelman F., Lipsky P. Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus. Clin Exp Immunol. 1979; 35: 76–88
  • DeHoratius R., Messner R. Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest. 1975; 55: 1254–8
  • Fauci A., Moutsopoulos H. Polyclonally triggered B cells in the peripheral blood and bone marrow of normal individuals and in patients with systemic lupus erythematosus and primary Sjogren's syndrome. Arthritis Rheum. 1981; 24: 577–83
  • Reininger L., Winkler T. H., Kalberer C. P., Jourdan M., Melchers F., Rolink A. G. Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB × NZW)F1 mice. J Exp Med. 1996; 184: 853–61
  • Kakkanaiah V., Sobel E., MacDonald G., Cheek R., Cohen P., Eisenberg R. B cell genotype determines the fine specificity of autoantibody in Ipr mice. J Immunol. 1997; 159: 1027–35
  • Radic M. Z., Zouali M. Receptor editing, immune diversification and self-tolerance. Immunity. 1996; 5: 505–511
  • Lam K., Kuhn R., Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 1997; 90: 1073–83
  • Delibrias C. C, Floettmann J. E., Rowe M., Fearon D. T. Downregulated Expression Of Shp-1 In Burkitt-Lymphomas and Germinal Center B Lymphocytes. J Exp Med. 1997; 186: 1575–1583
  • Hatta Y., Tsuchiya N., Matsushita M., Shiota M., Hagiwara K., Tokunaga K. Identification of the gene variations in human CD22. Immunogenetics. 1999; 49: 280–286
  • Wang J., Koizumi T., Watanabe T. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in lyn-deficient mice. J Exp Med. 1996; 184: 831–8
  • Chan V., Lowell C., DeFranco A. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998; 8: 545–53
  • Smith K., Tarlinton D., Doody G., Hibbs M., Fearon D. Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med. 1998; 187: 807–11
  • Nishizumi H., Horikawa K., Mlinaric-Rascan I., Yamamoto T. A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med. 1998; 187: 1343–8
  • Tsui H., Simuiovitch K., de Souza L., Tsui F. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet. 1993; 4: 124–9
  • Khaled A., Butfiloski E., Villas B., Sobel E., Schiffenbauer J. Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice. Autoimmunity 1999; 30: 115–28
  • Schmidt K., Hsu C., Griffin C., Goodnow C., Cyster J. Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells. J Exp Med. 1998; 187: 929–37
  • Cornall R. J., Cyster J. G., Hibbs M. L., Dunn A. R., Otipoby K. L., Clark E. A., Goodnow C. C. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity. 1998; 8: 497–508
  • Pani G., Siminovitch K., Paige C. The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med. 1997; 186: 581–8
  • Takeuchi T, Pang M., Amano K., Koike J., Abe T. Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol. 1997; 109: 20–26
  • Takeuchi T., Tsuzaka K., Pang M., Amano K., Koide J., Abe T. TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus. Int Immunol. 1998; 10: 911–921
  • Mimura T., Fernstern P., Jarjour W., Winfield J. Autoantibodies specific for different isoforms of CD45 in systemic lupus erythematosus. J Exp Med. 1990; 172: 653–656
  • Mittler R., Greenfield R., Schacter B., Richard N., Hoffmann M. Antibodies to the common leukocyte antigen (T200) inhibit an early phase in the activation of resting human B cells. J Immunol. 1987; 138: 3159–66
  • Neumeister Kersh E., Shaw A., Allen P. Fidelity of T Cell Activation Through Multistep T Cell Receptor Phosphorylation. Science 1998; 281: 572–575
  • Huck S., Zouali M. DNA methylation: a potential pathway to abnormal autoreative lupus B cells. Clin Immunol Immunopalhol. 1996; 80: 1–8
  • Botto M., Dell'Agnola C., Bygrave A. E., Thompson E. M., Cook H. T., Petry F., Loos M., Pandolfi P. P., Walport M J. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet. 1998; 19: 56–59
  • Huck S., Deveau E., Namane A., Zouali M. Abnormal DNA Methylation and Deoxycytosine-Deoxyguanine content in nucleosomes from lymphocytes undergoing apoptosis. FASEB J. 1999; 13: 1415–1422

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