89
Views
2
CrossRef citations to date
0
Altmetric
Research Article

The combined effect of BCL-2 over-expression and E2F2 deficiency induces an autoimmune syndrome in non-susceptible mouse strain C57BL/6

, , &
Pages 111-120 | Received 08 Apr 2009, Accepted 28 Jul 2009, Published online: 26 Feb 2010

References

  • Strasser A, Whittingam S, Vaux DL, Bath ML, Adams JM, Cory S, Harris A. Enforced bcl-2 expression in B-cells prolongs antibody response and elicit autoimmune disease. Proc Nat Acad Sci USA. 1991; 88:8661–8665.
  • Watanabe-Fukunaga R, Brannan CL, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferatives disorder in mice explained by defect in Fas antigen that mediates apoptosis. Nature. 1992; 356:314–317.
  • Garcia I, Murga M, Vicario A, Field SJ, Zubiaga A. A role for E2F1 in the induction of apoptosis during thymic negative selection. Cell Growth Differ. 2000; 11:91–98.
  • Santiago-Raber MI, Lawson BR, Dummer W, Barnhouse M, Koundouris S, . Role of cyclin kinase inhibitor p21 in autoimmunity. J Inmmunol. 2001; 167:4067–4074.
  • Müller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini VE, Helin K. E2Fs regulate the expression of genes involved in differentiation, development, proliferation and apoptosis. Genes Dev. 2001; 15:267–285.
  • Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarrays analysis. Mol Cell Biol. 2001; 21:4684–4699.
  • Polager S, Kalma Y, Berkovich E, Ginsberg D. E2F up-regulates expression of genes involved in DNA replication, DNA repair and mitosis. Oncogene. 2002; 17:437–446.
  • Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Fields SJ, Real FX, Zubiaga AM. Diabetes and a exocrine pancreatic insufficiency in E2F1/E2F2 double mutant mice. J Clin Invest. 2004; 113:1398–1407.
  • Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints. Genes Dev. 2002; 15:245–265.
  • Attwooll C, Denchi EL, Helin K. The E2F family: Specific functions and overlapping interest. EMBO J. 2004; 23:4709–4723.
  • Johnson D, Schwartz JK, Cress WD, Nevins JR. Expression of transcription factor E2F1 induces quiescent cells to enter S-phase. Nature. 1993; 365:349–352.
  • Lukas J, Petersen BO, Holm K, Bartek J, Helin K. Deregulated expression of E2F members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol. 1996; 16:1047–1057.
  • Murga M, Fernandez-Capetillo O, Field SJ, Moreno B, Borlado L, Fujiwara Y, Balomenos D, Carrera A, Orkin S, Zubiaga A. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the develpment of autoimmunity. Immunity. 2001; 15:959–970.
  • Infante A, Laresgoiti U, Fernandez Rueda J, Fullaondo A, Galán J, Díaz Uriarte R, Malumbres R, Field SJ, Zubiaga AM. E2F2 represses cell cycle regulators to maintain quiescence. Cell Cycle. 2008; 7:3915–3927.
  • Vairo G, Innes KM, Adams JM. Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival. Oncogene. 1996; 13:1511–1519.
  • Nuñez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer TJ. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol. 1990; 144:3602–3610.
  • Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol. 1994; 124:1–6.
  • McDonnell TJ, Deane N, Platt FM, Nuñez G, Jaeger U, McKearn JP, Korsmeyer SJ. Bcl-2 inmunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 1989; 57:79–88.
  • Strasser A, Harris AW, Cory S. The role of Bcl-2 in lymphoid differentiation and neoplastic transformation. Curr Top Microbiol Immunol. 1992; 182:299–302.
  • Hartley SB, Cooke MP, Fulcher DA, Harris AW, Cory S, Basten A, Goodnow CC. Elimination of self reactive B lymphocytes proceeds in two stages: Arrested development and cell death. Cell. 1993; 72:325–335.
  • Marquina R, Diez MA, López-Hoyos M, Buelta L, Kuroki S, Villegas J, Pihlgren M, Siegrist C, Arias M. Inhibition of B cell death causes the development of an IgA nephropathy in (New Zeland White(C57BL/6) F(1)-bcl-2 transgenic mice. J Immunol. 2004; 172:7177–7185.
  • López Hoyos M, Carrió R, Merino R, Buelta L, Izui S, Nuñez G, Merino J. Constitutive expression of Bcl-2 in B cells causes lethal form of lupus-like autoimmune disease after induction of neonatal tolerance to H-2b alloantigens. J Exp Med. 1996; 183:2523–2531.
  • Carlucci F, Cortes-Hernandez J, Fossati-Jimark L, Bygrave A, Walport M, Vyse T, Cook HT, Botto M. Genetic dissection of spontaneus autoimmunity driven by 129-derived chromosome 1 loci when expressed on C57BL/6 mice. J Inmmunol. 2007; 178:2352–2360.
  • Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walpot MJ, Botto M. Regulation of B cell-tolerance by 129-derived chromosome 1 loci in C57BL/6. Arthritis Rheum. 2008; 58:1231–1241.
  • Obara T, Tanaka T, Stockert E, Good RA. Autoimmune and lymphoproliferatives diseases in (B6-GIX(129) F1: Relation to naturally occurring antibodies against murine leukaemia virus-related surface antigen. Proc Natl Acad Sci USA. 1979; 76:5289–5293.
  • Santiago-Raber ML, Laporte C, Reininger L, Izui S. Genetic basis of murine lupus. Autoimmun Rev. 2004; 3:33–39.
  • Mitchell DA, Pickering MC, Warrening J, Fossati-Jimark L, Cortes-Hernandez J, . C1q deficiency and autoimmunity: The effects of genetic background on disease expression. J Inmmunol. 2002; 168:2538–2543.
  • Balomenos D, Martin-Caballero J, Garcia MI, Prieto I, Flores JM, Serrano M, Martinez AC. The cell cycle inmhibitor p21 control T proliferation and sex-linked lupus development. Nat Med. 2000; 6:171–176.
  • Morel L. Mouse models of autoimmune disease: Essential tools that require the proper controls. PLOS Biol. 2004; 2 8: e224.
  • Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT, Botto M. A lupus-succeptibility C57BL/6 lucus on chromosome 3 (Sle18) contributes to autoantibodies production in 129 mice. Genes Immune. 2009; 10:47–55.
  • Bouillet P, Purton JF, Godfrey DI, Zhang L-C, Puthalakath H, . BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactives thymocytes. Nature. 2002; 415:922–926.
  • Salvador JM, Hollander C, Thu Nguyen A, Kopp J, Barisoni L, Moore JK, Ashwell J, Fornace AJJr. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity. 2002; 16:499–508.
  • Vairo G, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, Adams JM. Bcl-2 retards cell cycle entry through p27 (Kip1), pRB relative p130, and altered E2F regulation. Mol Cell Biol. 2000; 20:4745–4753.
  • Strasser A, Harris AW, Cory S. E mu-Bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cell, but not T cells. Oncogene. 1993; 8:1–9.
  • Phillips AC, Vousden KH. E2F1 induced apoptosis. Apoptosis. 2001; 6:173–182.
  • Li Q, Dashwood WM, Nakagama H, Zhong X, Dashwood RH. Bcl-2 overexpression in PhIP-induced colon tumors: Cloning the rat Bcl-2 promoter and characterization of a pathway involving β-catenin, c-Myc and E2F1. Oncogene. 2007; 26:6194–7202.
  • Diriam A, Spike BT, Macleod KF. Deregulated E2F2 underlies cell cycle and maturation defects in retinoblastoma null erytroblasts. Mol Cell Biol. 2007; 27:8713–8728.
  • Li FX, Zhu JW, Hogan CJ, DeGregori J. Defective gene expression, S phase progession, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Moll Cell Biol. 2003; 23:3607–3622.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.