Foxp3-transduced polyclonal regulatory T cells suppress NK cell functions in a TGF-β dependent manner

References

• Sakaguchi S, Setoguchi R, Yagi H, Nomura T. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. Curr Top Microbiol Immunol. 2006; 305:51–66.
   PubMed Web of Science ®Google Scholar
• Piccirillo CA, Shevach EM. Naturally-occurring CD4+CD25+ immunoregulatory T cells: Central players in the arena of peripheral tolerance. Semin Immunol. 2004; 16:81–88.
   PubMed Web of Science ®Google Scholar
• Rudd CE. CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets. Eur J Immunol. 2009; 39:687–690.
   Google Scholar
• Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003; 4:330–336.
   PubMed Web of Science ®Google Scholar
• Hori S, Takahashi T, Sakaguchi S. Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv Immunol. 2003; 81:331–371.
   PubMed Web of Science ®Google Scholar
• Wing K, Suri-Payer E, Rudin A. CD4+CD25+-regulatory T cells from mouse to man. Scand J Immunol. 2005; 62:1–15.
   Google Scholar
• Mills KH. Regulatory T cells: Friend or foe in immunity to infection?. Nat Rev Immunol. 2004; 4:841–855.
   PubMed Web of Science ®Google Scholar
• Lim HW, Hillsamer P, Banham AH, Kim CH. Cutting edge: Direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol. 2005; 175:4180–4183.
   PubMed Web of Science ®Google Scholar
• Vlad G, Cortesini R, Suciu-Foca N. License to heal: Bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC. J Immunol. 2005; 174:5907–5914.
   PubMed Web of Science ®Google Scholar
• Taams LS, van Amelsfort JM, Tiemessen MM, Jacobs KM, de Jong EC, Akbar AN, Bijlsma JW, Lafeber FP.. Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells. Hum Immunol. 2005; 66:222–230.
   PubMed Web of Science ®Google Scholar
• Smyth MJ, Teng MW, Swann J, Kyparissoudis K, Godfrey DI, Hayakawa Y. CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer. J Immunol. 2006; 176:1582–1587.
   PubMed Web of Science ®Google Scholar
• Ghiringhelli F, Menard C, Terme M, Flament C, Taieb J, Chaput N, Puig PE, Novault S, Escudier B, Vivier E, Lecesne A, Robert C, Blay JY, Bernard J, Caillat-Zucman S, Freitas A, Tursz T, Wagner-Ballon O, Capron C, Vainchencker W, Martin F, Zitvogel L. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med. 2005; 202:1075–1085.
   PubMed Web of Science ®Google Scholar
• Ralainirina N, Poli A, Michel T, Poos L, Andres E, Hentges F, Zimmer J. Control of NK cell functions by CD4+CD25+ regulatory T cells. J Leukoc Biol. 2007; 81:144–153.
   PubMed Web of Science ®Google Scholar
• Kopcow HD, Karumanchi SA. Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia. J Reprod Immunol. 2007; 76:23–29.
   PubMed Web of Science ®Google Scholar
• Jie HB, Sarvetnick N. The role of NK cells and NK cell receptors in autoimmune disease. Autoimmunity. 2004; 37:147–153.
   PubMed Web of Science ®Google Scholar
• Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L., Regulatory T. cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008; 180:4679–4686.
   PubMed Web of Science ®Google Scholar
• Barao I, Hanash AM, Hallett W, Welniak LA, Sun K, Redelman D, Blazar BR, Levy RB, Murphy WJ. Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells. Proc Natl Acad Sci USA. 2006; 103:5460–5465.
   PubMed Web of Science ®Google Scholar
• Zimmer J, Andres E, Hentges F. NK cells and Treg cells: A fascinating dance cheek to cheek. Eur J Immunol. 2008; 38:2942–2945.
   Google Scholar
• Trzonkowski P, Szmit E, Mysliwska J, Dobyszuk A, Mysliwski A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction. Clin Immunol. 2004; 112:258–267.
   PubMed Web of Science ®Google Scholar
• Trzonkowski P, Szarynska M, Mysliwska J, Mysliwski A. Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy. Cytometry A. 2009; 75:175–188.
   Google Scholar
• Chai JG, Xue SA, Coe D, Addey C, Bartok I, Scott D, Simpson E, Stauss HJ, Hori S, Sakaguchi S, Dyson J. Regulatory T cells, derived from naive CD4+CD25− T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance. Transplantation. 2005; 79:1310–1316.
   PubMed Web of Science ®Google Scholar
• Wang YM, Zhang GY, Wang Y, Hu M, Wu H, Watson D, Hori S, Alexander IE, Harris DC, Alexander SI. Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. J Am Soc Nephrol. 2006; 17:697–706.
   Google Scholar
• Pear WS, Miller JP, Xu L, Pui JC, Soffer B, Quackenbush RC, Pendergast AM, Bronson R, Aster JC, Scott ML, Baltimore D. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 1998; 92:3780–3792.
   PubMed Web of Science ®Google Scholar
• Bunnell BA, Muul LM, Donahue RE, Blaese RM, Morgan RA. High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. Proc Natl Acad Sci USA. 1995; 92:7739–7743.
   PubMed Web of Science ®Google Scholar
• Davies AJ. Immunological tolerance and the autoimmune response. Autoimmun Rev. 2008; 7:538–543.
   Google Scholar
• Flodstrom M, Shi FD, Sarvetnick N, Ljunggren HG. The natural killer cell – Friend or foe in autoimmune disease?. Scand J Immunol. 2002; 55:432–441.
   PubMed Web of Science ®Google Scholar
• Perricone R, Perricone C, De Carolis C, Shoenfeld Y. NK cells in autoimmunity: A two-edged weapon of the immune system. Autoimmun Rev. 2008; 7:384–390.
   PubMed Web of Science ®Google Scholar
• Johansson S, Hall H, Berg L, Hoglund P. NK cells in autoimmune disease. Curr Top Microbiol Immunol. 2006; 298:259–277.
   PubMed Web of Science ®Google Scholar
• Johansson S, Berg L, Hall H, Hoglund P. NK cells: Elusive players in autoimmunity. Trends Immunol. 2005; 26:613–618.
   PubMed Web of Science ®Google Scholar
• Colonna M. NK cells: New issues and challenges. Preface. Eur J Immunol. 2008; 38:2927–2929.
   PubMed Web of Science ®Google Scholar
• Chatila TA. Regulatory T cells: Key players in tolerance and autoimmunity. Endocrinol Metab Clin North Am. 2009; 38:265–272 vii.
   Google Scholar
• Shi FD, Ljunggren HG, Sarvetnick N. Innate immunity and autoimmunity: From self-protection to self-destruction. Trends Immunol. 2001; 22:97–101.
   PubMed Web of Science ®Google Scholar
• Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002; 99:3493–3499.
   PubMed Web of Science ®Google Scholar
• Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci USA. 2005; 102:5138–5143.
   PubMed Web of Science ®Google Scholar
• Hori S, Nomura T, Sakaguchi S. Control of regulatory T-cell development by the transcription factor Foxp3. Science. 2003; 299:1057–1061.
   PubMed Web of Science ®Google Scholar
• Ghiringhelli F, Menard C, Martin F, Zitvogel L. The role of regulatory T cells in the control of natural killer cells: Relevance during tumor progression. Immunol Rev. 2006; 214:229–238.
   PubMed Web of Science ®Google Scholar
• Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR. Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category. J Exp Med. 2008; 205:799–810.
   PubMed Web of Science ®Google Scholar
• Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007; 8:345–350.
   PubMed Web of Science ®Google Scholar
• Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008; 453:236–240.
   PubMed Web of Science ®Google Scholar
• Takatori H, Kanno Y, Chen Z, O'Shea JJ. New complexities in helper T-cell fate determination and the implications for autoimmune diseases. Mod Rheumatol. 2008; 18:533–541.
   PubMed Web of Science ®Google Scholar
• Alderuccio F, Chan J, Toh BH. Tweaking the immune system: Gene therapy-assisted autologous haematopoietic stem cell transplantation as a treatment for autoimmune disease. Autoimmunity. 2008; 41:679–685.
   PubMed Web of Science ®Google Scholar