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Research Article

Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic “fingerprints”

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Pages 188-194 | Received 18 Mar 2010, Accepted 23 Aug 2010, Published online: 01 Oct 2010

References

  • Weetman AP. Determinants of autoimmune thyroid disease. Nat Immunol. 2001; 2:769–770.
  • Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, Braverman LE. Prospective study of the spontaneous course of subclinical hypothyroidism: Prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. J Clin Endocrinol Metab. 2002; 87:3221–3226.
  • Nielsen CH, Brix TH, Leslie RG, Hegedus L. A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase. Clin Immunol. 2009; 133:218–227.
  • Gardas A, Watson PF, Hobby P, Smith A, Weetman AP, Sutton BJ, Banga JP. Human thyroid peroxidase: Mapping of autoantibodies, conformational epitopes to the enzyme surface. Redox Rep. 2000; 5:237–241.
  • McLachlan SM, Rapoport B. Thyroid peroxidase autoantibody epitopes revisited. Clin Endocrinol. 2008; 69:526–527.
  • Jastrzebska-Bohaterewicz E, Gardas A. Proportion of antibodies to the A and B immunodominant regions of thyroid peroxidase in Graves' and Hashimoto's disease. Autoimmunity. 2004; 37:211–216.
  • Nielsen CH, Brix TH, Gardas A, Banga JP, Hegedus L. Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis. Clin Endocrinol. 2008; 69:664–668.
  • Jaume JC, Costante G, Nishikawa T, Phillips DIW, Rapoport B, McLachlan SM. Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women. J Clin Endocrinol Metab. 1995; 80:994–999.
  • Czarnocka B, Szabolcs I, Pastuszko D, Feldkamp J, Dohan O, Podoba J, Wenzel B. In old age the majority of thyroid peroxidase autoantibodies are directed to a single TPO domain irrespective of thyroid function and iodine intake. Clin Endocrinol. 1998; 48:803–808.
  • Brix TH, Kyvik KO, Hegedüs L. A population-based study of chronic autoimmune hypothyroidism in Danish twins. J Clin Endocrinol Metab. 2000; 85:536–539.
  • Brix TH, Hansen PS, Kyvik KO, Hegedüs L. Aggregation of thyroid autoantibodies in first-degree relatives of patients with autoimmune thyroid disease is mainly due to genes: A twin study. Clin Endocrinol. 2004; 60:329–334.
  • Hansen PS, Brix TH, Iachine IA, Kyvik KO, Hegedüs L. The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity. A study of healthy Danish twins. Eur J Endocrinol. 2006; 154:29–38.
  • Jaume JC, Guo J, Pauls DL, Zakarija M, McKenzie JM, Egeland JA, Burek CL, Rose NR, Hoffman WH, Rapoport B, McLachlan SM. Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic “fingerprints”. J Clin Endocrinol Metab. 1999; 84:1424–1431.
  • Vonk R, van der Schot AC, Kahn RS, Nolen WA, Drexhage HA. Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?. Biol Psychiat. 2007; 62:135–140.
  • Brix TH, Petersen HC, Iachine IA, Hegedüs L. Preliminary evidence of genetic anticipation in Graves' disease. Thyroid. 2003; 13:447–451.
  • Jensen E, Hyltoft PP, Blaabjerg O, Hansen PS, Brix TH, Kyvik KO, Hegedüs L. Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies. Clin Chem Lab Med. 2004; 42:824–832.
  • Gardas A, Sutton BJ, Piotrowska U, Pasieka Z, Barnett PS, Huang G, McGregor AM, Banga JP. Distinct immunological and biochemical properties of thyroid peroxidase purified form human thyroid glands and recombinant protein produced in insect cells. Biochim Biophys Acta. 1999; 1433:229–239.
  • Gardas A, Sohi MK, Sutton BJ, McGregor AM, Banga JP. Purification and crystallisation of the autoantigen thyroid peroxidase from human Graves' thyroid tissue. Biochem Biophys Res Commun. 1997; 234:366–370.
  • Jaume JC, Guo J, Kakinuma A, Rapoport B, McLachlan SM. The epitopic “fingerprint” of thyroid peroxidase-specific Fab isolated from a patient's thyroid gland by the combinatorial library approach resembles that of autoantibodies in the donor's serum. Clin Immunol Immunopathol. 1997; 84:150–157.
  • Guo J, McIntosh RS, Czarnocka B, Weetman AP, Rapoport B, McLachlan SM. Relationship between autoantibody epitopic recognition and immunoglobulin gene usage. Clin Exp Immunol. 1998; 111:408–414.
  • McLachlan SM, Rapoport B. Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: Markers of the human thyroid autoimmune response. Clin Exp Immunol. 1995; 101:200–206.
  • Manheimer-Lory A, Katz JB, Pillinger M, Ghossein C, Smith A, Diamond B. Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype. J Exp Med. 1991; 174:1639–1652.
  • Schrauder A, Gause A, Jung W, Mierau R, Pfreundschuh M. Persistence of a rheumatoid factor (RF)-producing B cell clone with a somatically mutated Ig kappa chain in a patient with rheumatoid arthritis. Clin Exp Immunol. 1994; 97:200–203.
  • Weetman AP, Cohen SB, Oleesky DA, Morgan BP. Terminal complement complexes and C1/C1 inhibitor complexes in autoimmune thyroid disease. Clin Exp Immunol. 1989; 77:25–30.
  • Rebuffat SA, Nguyen B, Robert B, Castex F, Peraldi-Roux S. Antithyroperoxidase antibody-dependent cytotoxicity in autoimmune thyroid disease. J Clin Endocrinol Metab. 2008; 93:929–934.
  • Brix TH, Knudsen GP, Kristiansen M, Kyvik KO, Ørstavik KH, Hegedüs L. High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: A possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab. 2005; 90:5949–5953.
  • Worthington J, Silman AJ. Genetic control of autoimmunity, lessons from twin studies. Clin Exp Immunol. 1995; 101:390–392.
  • Jaume JC, Parkes AB, Lazarus JH, Hall R, Costante G, McLachlan SM, Rapoport B. Thyroid peroxidase autoantibody fingerprints. II. A longitudinal study in postpartum thyroiditis. J Clin Endocrinol Metab. 1995; 80:1000–1005.

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