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Autoimmunity Volume 45, 2012 - Issue 3
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Research Article

IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population

Hui YangDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
,
Zhixiao WangDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
,
Kuanfeng XuDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
,
Rong GuDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
,
Heng ChenDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
,
Dan YuDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
,
Chunyan XingDepartment of Endocrinology, Yijishan Hospital of Wannan Medical College, Wuhu, China
,
Yu LiuDepartment of Endocrinology, The Second Hospital of Jilin University, Changchun, China
,
Liping YuBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
,
John HuttonBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
,
George EisenbarthBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
&
Tao YangDepartment of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaCorrespondence[email protected]
 show all
Pages 226-232 | Received 23 Apr 2011, Accepted 14 Oct 2011, Published online: 29 Nov 2011

References

  • Smyth DJ, Cooper JD, Bailey R, . A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet. 2006; 38 6: 617–619.
  • Yoneyama M, Kikuchi M, Matsumoto K, . Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol. 2005; 175 5: 2851–2858.
  • Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature. 2006; 442 7098: 39–44.
  • Kawashima H, Ihara T, Ioi H, . Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan. J Infect. 2004; 49 2: 147–151.
  • Moya-Suri V, Schlosser M, Zimmermann K, . Enterovirus RNA sequences in sera of schoolchildren in the general population and their association with type 1-diabetes-associated autoantibodies. J Med Microbiol. 2005; 54 Pt 9: 879–883.
  • Shibasaki S, Imagawa A, Tauriainen S, . Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes. Endocr J. 2010; 57 3: 211–219.
  • Tanaka S, Nishida Y, Aida K, . Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes. Diabetes. 2009; 58 10: 2285–2291.
  • Downes K, Pekalski M, Angus KL, . Reduced expression of IFIH1 is protective for type 1 diabetes. PLoS One. 2010; 5 9: e12646.
  • Todd JA. Statistical false positive or true disease pathway?. Nat Genet. 2006; 38 7: 731–733.
  • Gröschel S, Piggott KD, Vaglio A, . TLR-mediated induction of negative regulatory ligands on dendritic cells. J Mol Med (Berl). 2008; 86 4: 443–455.
  • Schulte BM, Bakkers J, Lanke KH, . Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. Viral Immunol. 2010; 23 1: 99–104.
  • Shigemoto T, Kageyama M, Hirai R, . Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J BiolChem. 2009; 284 20: 13348–13354.
  • Liu S, Wang H, Jin Y, . IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells. Hum Mol Genet. 2009; 18 2: 358–365.
  • Marinou I, Montgomery DS, Dickson MC, . The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. Arthritis Res Ther. 2007; 9 2: R40.
  • Zouk H, Marchand L, Polychronakos C. Study of transcriptional effects in Cis at the IFIH1 locus. PLoS One. 2010; 5 7: e11564.
  • Kimchi-Sarfaty C, Oh JM, Kim IW, . A “silent” polymorphism in the MDR1 gene changes substrate specificity. Science. 2007; 315 5811: 525–528.
  • Jermendy A, Szatmári I, Laine AP, . The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations. Diabetologia. 2010; 53 1: 98–102.
  • Concannon P, Onengut-Gumuscu S, Todd JA, . A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes. 2008; 57 10: 2858–2861.
  • Qu HQ, Marchand L, Grabs R, . The association between the IFIH1 locus and type 1 diabetes. Diabetologia. 2008; 51 3: 473–475.
  • Aminkeng F, Van Autreve JE, Weets I, . IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population. Hum Immunol. 2009; 70 9: 706–710.
  • Fumagalli M, Cagliani R, Riva S, . Population genetics of IFIH1: ancient population structure, local selection, and implications for susceptibility to type 1 diabetes. MolBiolEvol. 2010; 27 11: 2555–2566.
  • Hermann R, Lipponen K, Kiviniemi M, . Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp Variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia. 2006; 49 6: 1198–1208.
  • Nejentsev S, Walker N, Riches D, . Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009; 324 5925: 387–389.
  • Chistiakov DA, Voronova NV, Savost'Anov KV, . Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients. Hum Immunol. 2010; 71 11: 1128–1134.
  • Li Y, Liao W, Cargill M, . Carriers of rare missense variants in IFIH1 are protected from psoriasis. J Invest Dermatol. 2010; 130 12: 2768–2772.

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