Common immunogenetic profile in children with multiple autoimmune diseases: the signature of HLA-DQ pleiotropic genes

References

• Sattar N, Lazare F, Kacer M, . Celiac disease in children, adolescents, and young adults with autoimmune thyroid disease. J Pediatr. 2011; 158:272–275.
   PubMed Web of Science ®Google Scholar
• Kakleas K, Karayianni C, Critselis E, . The prevalence and risk factors for coeliac disease among children and adolescents with type 1 diabetes mellitus. Diabetes Res Clin Pract. 2010; 90:202–208.
   PubMed Web of Science ®Google Scholar
• Karavanaki K, Kakleas K, Paschali E, . Screening for associated autoimmunity in children and adolescents with type 1 diabetes mellitus (T1DM). Horm Res. 2009; 71:201–206.
   PubMed Web of Science ®Google Scholar
• Sumnik Z, Cinek O, Bratanic N, . Thyroid autoimmunity in children with coexisting type 1 diabetes mellitus and celiac disease: a multicenter study. J Pediatr Endocrinol Metab. 2006; 19:517–522.
   PubMed Web of Science ®Google Scholar
• Jaeger C, Hatziagelaki E, Petzoldt R, . Comparative analysis of organ-specific autoantibodies and celiac disease–associated antibodies in type 1 diabetic patients, their first-degree relatives, and healthy control subjects. Diabetes Care.. 2001; 24:27–32.
   PubMed Web of Science ®Google Scholar
• Vandiedonck C, Beaurain G, Giraud M, . Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia. Proc Natl Acad Sci USA. 2004 26; 101:15464–15469.
   PubMed Web of Science ®Google Scholar
• Mazzilli MC, Ferrante P, Mariani P, . A study of Italian pediatric celiac disease patients confirms that the primary HLA association is to the DQ(alpha 1*0501, beta 1*0201) heterodimer. Hum Immunol. 1992; 33:133–139.
   PubMed Web of Science ®Google Scholar
• De Block CE, De Leeuw H, Vertommen JJ, . Beta-cell, thyroid, gastric, adrenal and celiac autoimmunity and HLA-DQ types in type 1 diabetes. Belgian Diabetes Registry. Clin Exp Immunol. 2001; 126:236–241.
   PubMed Web of Science ®Google Scholar
• Wang H, He R. HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus. Chin Med Sci J. 1993; 8:231–234.
   PubMedGoogle Scholar
• Margaritte-Jeannin P, Babron MC, Bourgey M, . HLA-DQ relative risks for celiac disease in European populations: A study of the European Genetics Cluster on Celiac Disease. Tissue Antigens. 2004; 63:562–567.
   PubMed Web of Science ®Google Scholar
• Reichstetter S, Kwok WW, Nepom GT. Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer. Tissue Antigens. 1999; 53:101–105.
   PubMedGoogle Scholar
• Bratanic N, Smigoc Schweiger D, Mendez A, . An influence of HLA-A, B, DR, DQ, and MICA on the occurrence of Celiac disease in patients with type 1 diabetes. Tissue Antigens. 2010; 76:208–215.
   PubMed Web of Science ®Google Scholar
• Simell S, Hoppu S, Simell T, . Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth. Diabetes Care. 2010; 33:774–779.
   PubMed Web of Science ®Google Scholar
• Catino M, Tumini S, Mezzetti A, . Celiac disease and diabetes mellitus in children: a non casual association. Diab Nutr Metab. 1998; 11:296–302.
   Google Scholar
• Mackay IR. Clustering and commonalities among autoimmune diseases. J Autoimmun. 2009; 33:170–177.
   PubMed Web of Science ®Google Scholar
• Smyth DJ, Plagnol V, Walker NM, . Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med. 2008; 359:2767–2777.
   PubMed Web of Science ®Google Scholar
• Acerini CL, Ahmed ML, Ross KM, . Celiac disease in children and adolescents with IDDM: clinical characteristics and response to gluten-free diet. Diabet Med. 1998; 15:38–44.
   PubMed Web of Science ®Google Scholar
• Ventura A, Magazzù G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune disorders in celiac disease. Gastroenterology. 1999; 117:297–303.
   PubMed Web of Science ®Google Scholar
• Jankosky C, Deussing E, Gibson RL, . Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. Virus Res. 2012; 163:424–430.
   PubMed Web of Science ®Google Scholar
• Costenbader KH, Gay S, Riquelme ME, et al. Genes, epigenetic regulation and environmental factors: Which is the most relevant in developing autoimmune diseases?, Autoimmun Rev 2011 Oct 25. [Epub ahead of print].
   Google Scholar
• Rewers M, Eisenbarth GS. Autoimmunity: Celiac disease in T1DM-the need to look long term. Nat Rev Endocrinol. 2011; 8:5–8.
   Web of Science ®Google Scholar
• Ergür AT, Oçal G, Berberoğlu M, Adıyaman P, . Celiac disease and autoimmune thyroid disease in children with type 1 diabetes mellitus: clinical and HLA-genotyping results. J Clin Res Pediatr Endocrinol. 2010; 2:151–154.
   PubMedGoogle Scholar
• Picarelli A, Di Tola M, D'Amico T, et al. Type 1 diabetes mellitus and celiac disease: endothelial dysfunction, Acta Diabetol. 2011 Sep 16. [Epub ahead of print].
   Google Scholar
• Kim EY, Shin CH, Yang SW. Polymorphisms of HLA class II predispose children and adolescents with type 1 diabetes mellitus to autoimmune thyroid disease. Autoimmunity. 2003; 36:177–181.
   PubMed Web of Science ®Google Scholar
• Spadaccino AC, Basso D, Chiarelli S, Albergoni MP, D'Odorico A, Plebani M, Pedini B, Lazzarotto F, Betterle C. Celiac disease in North Italian patients with autoimmune thyroid diseases. Autoimmunity. 2008; 41:116–121.
   PubMed Web of Science ®Google Scholar
• Eyre S, Hinks A, Bowes J, . Yorkshire Early Arthritis Consortium; Biologics in RA Control Consortium, Thomson W, Worthington J, Barton A. Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and celiac disease. Arthritis Res Ther. 2010; 12 5: R175.
   PubMed Web of Science ®Google Scholar