Autoimmunity to isomerized histone H2B in systemic lupus erythematosus

References

• Mamula M. J., Gee R. J., Elliot J. I., . Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins. J. Biol. Chem.. 1999; 274:22321–22327.
   PubMed Web of Science ®Google Scholar
• Clarke S.. Protein carboxyl methyltransferases: Two distinct classes of enzymes. Annu. Rev. Biochem.. 1985; 54:479–506.
   PubMed Web of Science ®Google Scholar
• Young A. L., Carter W. G., Doyle H. A., Mamula M. J., Aswad D. W.. Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme. J. Biol. Chem.. 2001; 276:37161–37165.
   PubMed Web of Science ®Google Scholar
• Young G. W., Hoofring S. A., Mamula M. J., . Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B. J. Biol. Chem.. 2005; 280:26094–26098.
   Google Scholar
• Aswad D. W., Paranandi M. V., Schurter B. T.. Isoaspartate in peptides and proteins: formation, significance, and analysis. J. Pharm. Biomed. Anal.. 2000; 21:1129–1136.
   PubMed Web of Science ®Google Scholar
• Rubin R. L., Fritzler M. J.. 2007. Antibodies to histones and nucleosome-related antigens. 7th ed. In: D. J. Wallace, B. H. Hahn. editors. Dubois' Lupus Erythematosus. Philadelphia, PA: Lippincott Williams & Wilkins.
   Google Scholar
• Burlingame R. W., Rubin R. L.. Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin. J. Clin. Invest.. 1991; 88:680–690.
   PubMed Web of Science ®Google Scholar
• Rubin R. L., Burlingame R. W.. Drug-induced autoimmunity: a disorder at the interface between metabolism and immunity. Biochem. Soc. Trans.. 1991; 19:153–159.
   PubMed Web of Science ®Google Scholar
• Fritzler M. J.. 1997. Antibodies to histone and the role of the nucleosome. In: D. J. Wallace, B. H. Hahn. editors. Dubois Lupus Erythematosus. Baltimore, MD: Williams & Williams423–441.
   Google Scholar
• Dieker J. W., Fransen J. H., van Bavel C. C., . Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus. Arthritis Rheum.. 2007; 56:1921–1933.
   PubMed Web of Science ®Google Scholar
• Neeli I., Khan S. N., Radic M.. Histone deimination as a response to inflammatory stimuli in neutrophils. J. Immunol.. 2008; 180:1895–1902.
   PubMed Web of Science ®Google Scholar
• Lowenson J. D., Kim E., Young S. G., Clarke S.. Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice. J. Biol. Chem.. 2001; 276:20695–20702.
   PubMed Web of Science ®Google Scholar
• Roark J. H., Kuntz C. L., Nguyen K. A., Caton A. J., Erikson J.. Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. J. Exp. Med.. 1995; 181:1157–1167.
   PubMed Web of Science ®Google Scholar
• Erikson J., Radic M. Z., Camper S. A., Hardy R. R., Carmack C., Weigert M.. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature. 1991; 349:331–334.
   PubMed Web of Science ®Google Scholar
• Christensen S. R., Kashgarian M., Alexopoulou L., Flavell R. A., Akira S., Shlomchik M. J.. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J. Exp. Med.. 2005; 202:321–331.
   PubMed Web of Science ®Google Scholar
• Doyle H. A., Zhou J., Wolff M. J., . Isoaspartyl posttranslational modification triggers anti-tumor T and B lymphocyte immunity. J. Biol. Chem.. 2006; 281:32676–32683.
   PubMed Web of Science ®Google Scholar
• Lindner H., Helliger W.. Age-dependent deamidation of asparagine residues in proteins. Exper. Gerontol.. 2001; 36:1551–1563.
   PubMed Web of Science ®Google Scholar
• Commerford S. L., Carsten A. L., Cronkite E. P.. Histone turnover within nonproliferating cells. Proc. Natl. Acad. Sci. USA. 1982; 79:1163–1165.
   PubMed Web of Science ®Google Scholar
• Lu L., Kaliyaperumal A., Boumpas D. T., Datta S. K.. Major peptide autoepitopes for nucleosome-specific T cells of human lupus. J. Clin. Invest.. 1999; 104:345–355.
   PubMed Web of Science ®Google Scholar
• Neeli I., Richardson M. M., Khan S. N., Nicolo D., Monestier M., Radic M. Z.. Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs. Mol. Immunol.. 1914; 44:1914–1921.
   Google Scholar
• Yang M. L., Doyle H. A., Gee R. J., . Intracellular protein modification associated with altered T cell functions in autoimmunity. J. Immunol.. 2006; 177:4541–4549.
   PubMed Web of Science ®Google Scholar
• Casciola-Rosen L. A., Anhalt G., Rosen A.. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med.. 1994; 179:1317–1330.
   PubMed Web of Science ®Google Scholar
• Rosen A., Casciola-Rosen L.. Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ.. 1999; 6:6–12.
   PubMed Web of Science ®Google Scholar
• Utz P. J., Hottelet M., Schur P. H., Anderson P.. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J. Exp. Med.. 1997; 185:843–854.
   PubMed Web of Science ®Google Scholar
• White S., Rosen A.. Apoptosis in systemic lupus erythematosus. Curr. Opin. Rheumatol.. 2003; 15:557–562.
   PubMed Web of Science ®Google Scholar
• Radic M., Marion T., Monestier M.. Nucleosomes are exposed at the cell surface in apoptosis. J. Immunol.. 2004; 172:6692–6700.
   PubMed Web of Science ®Google Scholar
• van Bavel C. C., Dieker J., Muller S., . Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodies. Mol. Immunol.. 2009; 47:511–516.
   PubMed Web of Science ®Google Scholar
• van Bavel C. C., Dieker J. W., Kroeze Y., . Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann. Rheum. Dis.. 2011; 70:201–207.
   PubMed Web of Science ®Google Scholar
• Cimmino A., Capasso R., Muller F., . Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation. PLoS ONE. 2008; 3:e3258.
   Web of Science ®Google Scholar
• D'Angelo S., Ingrosso D., Migliardi V., . Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic. Biol. Med.. 2005; 38:908–919.
   PubMed Web of Science ®Google Scholar
• Egner W.. The use of laboratory tests in the diagnosis of SLE. J. Clin. Pathol.. 2000; 53:424–432.
   PubMed Web of Science ®Google Scholar
• Tsai W., Clarke S.. Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair. Biochem. Biophys. Res. Commun.. 1994; 203:491–497.
   PubMed Web of Science ®Google Scholar
• David C. L., Szumlanski C. L., DeVry C. G., . Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability. Arch. Biochem. Biophys.. 1997; 346:277–286.
   PubMed Web of Science ®Google Scholar
• Rubin R. L.. Drug-induced lupus. Toxicology. 2005; 209:135–147.
   PubMed Web of Science ®Google Scholar
• Richardson B.. DNA methylation and autoimmune disease. Clin. Immunol.. 2003; 109:72–79.
   PubMed Web of Science ®Google Scholar
• Deng C., Kaplan M. J., Yang J., . Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum.. 2001; 44:397–407.
   PubMed Web of Science ®Google Scholar
• Cournoyer P., Desrosiers R. R.. Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway. Neuropharmacology. 2009; 56:839–848.
   PubMed Web of Science ®Google Scholar