307
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Low number of memory B cells in the salivary glands of patients with primary Sjögren's syndrome

, , , &
Pages 547-555 | Received 29 Mar 2012, Accepted 11 Jul 2012, Published online: 05 Sep 2012

References

  • Jonsson R, Bolstad AI, Brokstad KA, Brun JG. Sjogren's syndrome—A plethora of clinical and immunological phenotypes with a complex genetic background. Ann. NY Acad. Sci.. 2007; 1108:433–447.
  • Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjogren syndrome. Arch. Intern. Med.. 2004; 164 12: 1275–1284.
  • Jonsson R, Vogelsang P, Volchenkov R, Espinosa A, Wahren-Herlenius M, Appel S. The complexity of Sjogren's syndrome: novel aspects on pathogenesis. Immunol. Lett.. 2011; 141 1: 1–9.
  • Mavragani CP, Tzioufas AG, Moutsopoulos HM. Sjogren's syndrome: autoantibodies to cellular antigens. Clinical and molecular aspects. Int. Arch. Allergy Immunol.. 2000; 123 1: 46–57.
  • Garberg H, Jonsson R, Brokstad KA. The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjogren's syndrome patients and healthy controls. Scand. J. Rheumatol.. 2005; 34 1: 49–55.
  • Burbelo PD, Leahy HP, Issa AT, Groot S, Baraniuk JN, Nikolov NP, Illei GG, Iadarola MJ. Sensitive and robust luminescent profiling of anti-La and other autoantibodies in Sjogren's syndrome. Autoimmunity. 2009; 42 6: 515–524.
  • Franceschini F, Cavazzana I. Anti-Ro/SSA and La/SSB antibodies. Autoimmunity. 2005; 38 1: 55–63.
  • Gordon TP, Bolstad AL, Rischmueller M, Jonsson R, Waterman SA. Autoantibodies in primary Sjogren's syndrome: new insights into mechanisms of autoantibody diversification and disease pathogenesis. Autoimmunity. 2001; 34 2: 123–132.
  • Hansen A, Lipsky PE, Dorner T. B cells in Sjogren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. Arthritis Res. Ther.. 2007; 9 4: 218.
  • Bohnhorst JO, Thoen JE, Natvig JB, Thompson KM. Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjogren's syndrome. Scand. J. Immunol.. 2001; 54 4: 421–427.
  • Bohnhorst JO, Bjorgan MB, Thoen JE, Jonsson R, Natvig JB, Thompson KM. Abnormal B cell differentiation in primary Sjogren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with Serum IgG concentration. Clin. Immunol.. 2002; 103 1: 79–88.
  • Bohnhorst JO, Bjorgan MB, Thoen JE, Natvig JB, Thompson KM. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjogren's syndrome. J. Immunol.. 2001; 167 7: 3610–3618.
  • Hansen A, Gosemann M, Pruss A, Reiter K, Ruzickova S, Lipsky PE, Dorner T. Abnormalities in peripheral B cell memory of patients with primary Sjogren's syndrome. Arthritis Rheum.. 1897; 50 61908.
  • Agematsu K, Hokibara S, Nagumo H, Komiyama A. CD27: A memory B-cell marker. Immunol. Today. 2000; 21 5: 204–206.
  • Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med.. 1998; 188 9: 1679–1689.
  • Jung J, Choe J, Li L, Choi YS. Regulation of CD27 expression in the course of germinal center B cell differentiation: The pivotal role of IL-10. Eur. J. Immunol.. 2000; 30 8: 2437–2443.
  • Odendahl M, Jacobi A, Hansen A, Feist E, Hiepe F, Burmester GR, Lipsky PE, Radbruch A, Dorner T. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J. Immunol.. 2000; 165 10: 5970–5979.
  • Szyszko EA, Brokstad KA, Oijordsbakken G, Jonsson MV, Jonsson R, Skarstein K. Salivary glands of primary Sjogren's syndrome patients express factors vital for plasma cell survival. Arthritis Res. Ther.. 2011; 13 1: R2.
  • Szyszko EA, Brun JG, Skarstein K, Peck AB, Jonsson R, Brokstad KA. Phenotypic diversity of peripheral blood plasma cells in primary Sjogren's syndrome. Scand. J. Immunol.. 2011; 73 1: 18–28.
  • Szyszko EA, Skarstein K, Jonsson R, Brokstad KA. Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice. Autoimmunity. 2011; 44 5: 415–426.
  • Klein U, Kuppers R, Rajewsky K. Human IgM+IgD+B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur. J. Immunol.. 1993; 23 12: 3272–3277.
  • Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med.. 1994; 180 1: 329–339.
  • Cambridge G, Leandro MJ, Teodorescu M, Manson J, Rahman A, Isenberg DA, Edwards JC. B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles. Arthritis Rheum.. 2006; 54 11: 3612–3622.
  • Vallerskog T, Gunnarsson I, Widhe M, Risselada A, Klareskog L, van Vollenhoven R, Malmstrom V, Trollmo C. Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE. Clin. Immunol.. 2007; 122 1: 62–74.
  • Isaksen K, Jonsson R, Omdal R. Anti-CD20 treatment in primary Sjogren's syndrome. Scand. J. Immunol.. 2008; 68 6: 554–564.
  • Pijpe J, van Imhoff GW, Spijkervet FK, Roodenburg JL, Wolbink GJ, Mansour K, Vissink A, Kallenberg CG, Bootsma H. Rituximab treatment in patients with primary Sjogren's syndrome: an open-label phase II study. Arthritis Rheum.. 2005; 52 9: 2740–2750.
  • Sacchi S, Federico M, Dastoli G, Fiorani C, Vinci G, Clo V, Casolari B. Treatment of B-cell non-Hodgkin's lymphoma with anti CD 20 monoclonal antibody Rituximab. Crit. Rev. Oncol. Hematol.. 2001; 37 1: 13–25.
  • Pijpe J, van Imhoff GW, Vissink A, van der Wal JE, Kluin PM, Spijkervet FK, Kallenberg CG, Bootsma H. Changes in salivary gland immunohistology and function after rituximab monotherapy in a patient with Sjogren's syndrome and associated MALT lymphoma. Ann. Rheum. Dis.. 2005; 64 6: 958–960.
  • Shih WJ, Ghesani N, Hongming Z, Alavi A, Schusper S, Mozley D. F-18 FDG positron emission tomography demonstrates resolution of non-Hodgkin's lymphoma of the parotid gland in a patient with Sjogren's syndrome: before and after anti-CD20 antibody rituximab therapy. Clin. Nucl. Med.. 2002; 27 2: 142–143.
  • Kimby E. Tolerability and safety of rituximab (MabThera). Cancer Treat. Rev.. 2005; 31 6: 456–473.
  • Jonsson R, Kroneld U, Backman K, Magnusson B, Tarkowski A. Progression of sialadenitis in Sjogren's syndrome. Br. J. Rheumatol.. 1993; 32 7: 578–581.
  • Jonsson R, Nginamau E, Szyszko E, Brokstad KA. Role of B cells in Sjogren's syndrome—From benign lymphoproliferation to overt malignancy. Front Biosci.. 2007; 12:2159–2170.
  • Jonsson MV, Skarstein K. Follicular dendritic cells confirm lymphoid organization in the minor salivary glands of primary Sjogren's syndrome. J. Oral Pathol. Med.. 2008; 37 9: 515–521.
  • Vogelsang P, Brun JG, Oijordsbakken G, Skarstein K, Jonsson R, Appel S. Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjogren's syndrome. Ann. Rheum. Dis.. 2010; 69 6: 1235–1258.
  • Salomonsson S, Jonsson MV, Skarstein K, Brokstad KA, Hjelmstrom P, Wahren-Herlenius M, Jonsson R. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome. Arthritis Rheum.. 2003; 48 11: 3187–3201.
  • Tengner P, Halse AK, Haga HJ, Jonsson R, Wahren-Herlenius M. Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjogren's syndrome. Arthritis Rheum.. 1998; 41 12: 2238–2248.
  • Barcellos KS, Nonogaki S, Enokihara MM, Teixeira MS, Andrade LE. Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjogren's syndrome. J. Rheumatol.. 2007; 34 6: 1283–1292.
  • Halse AK, Wahren M, Jonsson R. Peripheral blood in Sjogren's syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro/SS-A 52 kD and La/SS-B 48 kD autoantigens. Autoimmunity. 1996; 23 1: 25–34.
  • MacLennan IC. Germinal centers. Annu. Rev. Immunol.. 1994; 12:117–139.
  • Jonsson MV, Skarstein K, Jonsson R, Brun JG. Serological implications of germinal center-like structures in primary Sjogren's syndrome. J. Rheumatol.. 2007; 34 10: 2044–2049.
  • Hamel KM, Liarski VM, Clark MR. Germinal Center B-cells. Autoimmunity. 2012 (In press).
  • Halse A, Harley JB, Kroneld U, Jonsson R. Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjogren's syndrome. Clin. Exp. Immunol.. 1999; 115 1: 203–207.
  • Hansen A, Odendahl M, Reiter K, Jacobi AM, Feist E, Scholze J, Burmester GR, Lipsky PE, Dorner T. Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjogren's syndrome. Arthritis Rheum.. 2002; 46 8: 2160–2171.
  • Dorner T, Hansen A, Jacobi A, Lipsky PE. Immunglobulin repertoire analysis provides new insights into the immunopathogenesis of Sjogren's syndrome. Autoimmun. Rev.. 2002; 1 3: 119–124.
  • Aqrawi LA, Skarstein K, Bredholt G, Brun JG, Brokstad KA. Autoantigen-specific memory B cells in primary Sjogren's syndrome. Scand. J. Immunol.. 2012; 75 1: 61–68.
  • Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann. Rheum. Dis.. 2002; 61 6: 554–558.
  • Gottenberg JE, Guillevin L, Lambotte O, Combe B, Allanore Y, Cantagrel A, Larroche C, Soubrier M, Bouillet L, Dougados M, Fain O, Farge D, Kyndt X, Lortholary O, Masson C, Moura B, Remy P, Thomas T, Wendling D, Anaya JM, Sibilia J, Mariette X. Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann. Rheum. Dis.. 2005; 64 6: 913–920.
  • Kunkel EJ, Butcher EC. Chemokines and the tissue-specific migration of lymphocytes. Immunity. 2002; 16 1: 1–4.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.