Lupus autoimmunity altered by cellular methylation metabolism

References

• Renaudineau Y., Youinou P.. Epigenetics and autoimmunity, with special emphasis on methylation. Keio J. Med.. 2011; 60:10–16.
   PubMedGoogle Scholar
• Sunahori K., Juang,V Y. T., Kyttaris C., Tsokos G. C.. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J. Immunol.. 2011; 186:4508–4517.
   PubMed Web of Science ®Google Scholar
• Mowen K. A., Tang J., Zhu W., . Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001; 104:731–741.
   PubMed Web of Science ®Google Scholar
• Richard S., Morel M., Cleroux P.. Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5). Biochem. J.. 2005; 388:379–386.
   PubMed Web of Science ®Google Scholar
• Blanchet F., Cardona A., Letimier F. A., Hershfield M. S., Acuto O.. CD28 costimulatory signal induces protein arginine methylation in T cells. J. Exp. Med.. 2005; 202:371–377.
   PubMed Web of Science ®Google Scholar
• Brahms H., Raymackers J., Union A., . The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. J. Biol. Chem.. 2000; 275:17122–17129.
   PubMed Web of Science ®Google Scholar
• Doyle H. A., Gee R. J., Mamula M. J.. A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production. J. Immunol.. 2003; 171:2840–2847.
   PubMed Web of Science ®Google Scholar
• Yang M. L., Doyle H. A., Gee R. J., . Intracellular protein modification associated with altered T cell functions in autoimmunity. J. Immunol.. 2006; 177:4541–4549.
   PubMed Web of Science ®Google Scholar
• Pritzker L. B., Joshi S., Gowan J. J., Harauz G., Moscarello M. A.. Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D. Biochemistry. 2000; 39:5374–5381.
   PubMed Web of Science ®Google Scholar
• Della Ragione F., Pegg A. E.. Effect of analogues of 5′-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5′-isobutylthioadenosine. Biochem. J.. 1983; 210:429–435.
   PubMed Web of Science ®Google Scholar
• Ferro A. J., Vandenbark A. A., MacDonald M. R.. Inactivation of S-adenosylhomocysteine hydrolase by 5′-deoxy-5′-methylthioadenosine. Biochem. Biophys. Res. Commun.. 1981; 100:523–531.
   PubMed Web of Science ®Google Scholar
• Fox I. H., Palella R. D., Thompson D., Herring C.. Adenosine metabolism: modification by S-adenosylhomocysteine and 5′-methylthioadenosine. Arch. Biochem. Biophys.. 1982; 215:302–308.
   PubMed Web of Science ®Google Scholar
• Peng S. L., Fatenejad S., Craft J.. Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help. J. Immunol.. 1996; 157:5225–5230.
   PubMed Web of Science ®Google Scholar
• Kracker S., Radbruch A.. Immunoglobulin class switching: in vitro induction and analysis. Meth. Mol. Biol.. 2004; 271:149–159.
   PubMedGoogle Scholar
• Savarese T. M., Crabtree G. W., Parks R. E.Jr. 5′-Methylthioadenosine phosphorylase-L. Substrate activity of 5′-deoxyadenosine with the enzyme from Sarcoma 180 cells. Biochem. Pharmacol.. 1981; 30:189–199.
   PubMed Web of Science ®Google Scholar
• Mamula M. J., Gee R. J., Elliott J. I., . Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins. J. Biol. Chem.. 1999; 274:22321–22327.
   PubMed Web of Science ®Google Scholar
• Clarke S. G.. 2006. Inhibition of mammalian protein methyltransferases by 5′-methylthioadenosine (MTA): A mechanism of action of dietary SAMe?Protein Methyltransferases. The Enzymes.. XXIV. Amsterdam:: Academic Press. 467–493.
   Google Scholar
• Li T. W., Yang H., Peng H., . Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice. Carcinogenesis. 2012; 33:427–435.
   PubMed Web of Science ®Google Scholar
• Lakowski T. M., Frankel A.. Sources of S-adenosyl-L-homocysteine background in measuring protein arginine N-methyltransferase activity using tandem mass spectrometry. Anal. Biochem.. 2010; 396:158–160.
   PubMed Web of Science ®Google Scholar
• Kamatani N., Yu A. L., Carson D. A.. Deficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo. Blood. 1982; 60:1387–1391.
   PubMed Web of Science ®Google Scholar
• Batova A., Cottam H., Yu J., . EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Blood. 2006; 107:898–903.
   PubMed Web of Science ®Google Scholar
• Harasawa H., Yamada Y., Kudoh M., . Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL). Leukemia. 2002; 16:1799–1807.
   PubMed Web of Science ®Google Scholar
• Vertongen F., Mandelbaum I.. Methylthioadenosine phosphorylase and purine nucleoside phosphorylase in B-chronic lymphocytic leukemia. Thymus. 1984; 6:359–364.
   PubMedGoogle Scholar
• German D. C., Bloch C. A., Kredich N. M.. Measurements of S-adenosylmethionine and L-homocysteine metabolism in cultured human lymphoid cells. J. Biol. Chem.. 1983; 258:10997–11003.
   PubMed Web of Science ®Google Scholar
• Wu Q. L., Fu Y. F., Zhou W. L., . Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. J. Pharmacol. Exp. Ther.. 2005; 313:705–711.
   PubMed Web of Science ®Google Scholar
• Fu Y. F., Wang J. X., Zhao Y., . S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses. J Pharmacol. Exp. Ther.. 2006; 316:1229–1237.
   PubMed Web of Science ®Google Scholar
• Wolos J. A., Frondorf K. A., Babcock G. F., Stripp S. A., Bowlin T. L.. Immunomodulation by an inhibitor of S-adenosyl-L-homocysteine hydrolase: inhibition of in vitro and in vivo allogeneic responses. Cell Immunol.. 1993; 149:402–408.
   PubMed Web of Science ®Google Scholar
• Wolos J. A., Frondorf K. A., Davis G. F., . Selective inhibition of T cell activation by an inhibitor of S-adenosyl-L-homocysteine hydrolase. J. Immunol.. 1993; 150:3264–3273.
   PubMed Web of Science ®Google Scholar
• Lawson B. R., Eleftheriadis T., Tardif V., . Transmethylation in immunity and autoimmunity. Clin. Immunol. 2012; 143:8–21.
   PubMed Web of Science ®Google Scholar
• Saso Y., Conner E. M., Teegarden B. R., Yuan C. S.. S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis. J. Pharmacol. Exp. Ther.. 2001; 296:106–112.
   PubMed Web of Science ®Google Scholar
• Lawson B. R., Manenkova Y., Ahamed J., . Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system. J. Immunol.. 2007; 178:5366–5374.
   PubMed Web of Science ®Google Scholar
• Wolford R. W., Riscoe M. K., Johnson L., Ferro A. J., Fitchen J. H.. Effect of 5′-methylthioadenosine (a naturally occurring nucleoside) on murine hematopoiesis. Exp. Hematol.. 1984; 12:867–871.
   PubMed Web of Science ®Google Scholar
• Moreno B., Hevia H., Santamaria M., . Methylthioadenosine reverses brain autoimmune disease. Ann. Neurol.. 2006; 60:323–334.
   PubMed Web of Science ®Google Scholar
• Moreno B., Fernandez-Diez B., Di Penta A., Villoslada P.. Preclinical studies of methylthioadenosine for the treatment of multiple sclerosis. Mult. Scler.. 2010; 16:1102–1108.
   PubMed Web of Science ®Google Scholar
• Law R. E., Stimmel J. B., Damore M. A., . Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5′-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions. Mol. Cell Biol.. 1992; 12:103–111.
   PubMed Web of Science ®Google Scholar
• Veal N., Hsieh C. L., Xiong S., . Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5′-methylthioadenosine. Am. J. Physiol. Gastrointest. Liver Physiol.. 2004; 287:G352–G362.
   Web of Science ®Google Scholar
• Ara A. I., Xia M., Ramani K., Mato J. M., Lu S. C.. S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology. 2008; 47:1655–1666.
   PubMed Web of Science ®Google Scholar
• Berasain C., Hevia H., Fernandez-Irigoyen J., . Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma. Biochim. Biophys. Acta. 2004; 1690:276–284.
   PubMed Web of Science ®Google Scholar
• 't Hart B. A., Hintzen R. Q., Laman J. D.. Multiple sclerosis—a response-to-damage model. Trends Mol. Med.. 2009; 15:235–244.
   PubMed Web of Science ®Google Scholar
• Stekman I. L., Blasini A. M., Leon-Ponte M., . Enhanced CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus. Arthritis Rheum.. 1991; 34:459–467.
   PubMed Web of Science ®Google Scholar
• Vratsanos G. S., Jung S., Park Y. M., Craft J.. CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus. J. Exp. Med.. 2001; 193:329–337.
   PubMed Web of Science ®Google Scholar
• Kong P. L., Odegard J. M., Bouzahza F., . Intrinsic T cell defects in systemic autoimmunity. Ann. NY Acad. Sci.. 2003; 987:60–67.
   PubMed Web of Science ®Google Scholar
• Gessl A., Waldhausl W.. Increased CD69 and human leukocyte antigen-DR expression on T lymphocytes in insulin-dependent diabetes mellitus of long standing. J. Clin. Endocrinol. Metab.. 1998; 83:2204–2209.
   PubMed Web of Science ®Google Scholar
• Portales-Perez D., Gonzalez-Amaro R., Abud-Mendoza C., Sanchez-Armass S.. Abnormalities in CD69 expression, cytosolic pH and Ca2+ during activation of lymphocytes from patients with systemic lupus erythematosus. Lupus. 1997; 6:48–56.
   PubMed Web of Science ®Google Scholar
• Hernandez-Garcia C., Fernandez-Gutierrez B., Morado I. C., Banares A. A., Jover J. A.. The CD69 activation pathway in rheumatoid arthritis synovial fluid T cells. Arthritis Rheum.. 1996; 39:1277–1286.
   PubMedGoogle Scholar
• Crispin J. C., Kyttaris V. C., Juang Y. T., Tsokos G. C.. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol.. 2008; 29:110–115.
   PubMed Web of Science ®Google Scholar
• Akahoshi M., Nakashima H., Tanaka Y., . Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum.. 1999; 42:1644–1648.
   PubMed Web of Science ®Google Scholar
• Tucci M., Stucci S., Strippoli S., Silvestris F.. Cytokine overproduction, T-cell activation, and defective T-regulatory functions promote nephritis in systemic lupus erythematosus. J. Biomed. Biotechnol.. 2010; 2010:457146.
   PubMedGoogle Scholar
• Liossis S. N., Ding X. Z., Dennis G. J., Tsokos G. C.. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J. Clin. Invest.. 1998; 101:1448–1457.
   PubMed Web of Science ®Google Scholar
• Yi Y., McNerney M., Datta S. K.. Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. J. Immunol.. 2000; 165:6627–6634.
   PubMed Web of Science ®Google Scholar
• Tomasi M. L., Tomasi I., Ramani K., . S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers. Hepatology. 2012; 56:982–993.
   PubMed Web of Science ®Google Scholar
• Yamaji S., Droggiti A., Lu S. C., . Adenosylmethionine regulates connexins sub-types expressed by hepatocytes. Euro. J. Cell Biol.. 2011; 90:312–322.
   PubMed Web of Science ®Google Scholar