Epigenetics and the IRFs: A complex interplay in the control of immunity and autoimmunity

References

• Eisenberg, R. 2003. Mechanisms of autoimmunity. Immunol. Res. 27: 203–218
   PubMed Web of Science ®Google Scholar
• Kong, P., J. Odegard, F. Bouzahzah, et al. 2003. Intrinsic T cell defects in systemic autoimmunity. Ann. N Y Acad. Sci. 987: 60–67
   PubMed Web of Science ®Google Scholar
• Shlomchik, M. J., J. E. Craft, and M. J. Mamula. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol. 1: 147–153
   PubMed Web of Science ®Google Scholar
• Tsokos, G. C. 2011. Systemic lupus erythematosus. N. Engl. J. Med. 365: 2110–2121
   PubMed Web of Science ®Google Scholar
• Hsu, H. C., P. Yang, J. Wang, et al. 2008. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 9: 166–175
   PubMed Web of Science ®Google Scholar
• Odegard, J. M., B. R. Marks, L. D. Di Placido, et al. 2008. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J. Exp. Med. 205: 2873–2886
   PubMed Web of Science ®Google Scholar
• Vinuesa, C. G., M. C. Cook, C. Angelucci, et al. 2005. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435: 452–458
   PubMed Web of Science ®Google Scholar
• Pisitkun, P., H. L. Ha, H. Wang, et al. 2012. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity 37: 1104–1115
   PubMed Web of Science ®Google Scholar
• Pernis, A. B. 2009. Th17 cells in rheumatoid arthritis and systemic lupus erythematosus. J. Intern. Med. 265: 644–652
   PubMed Web of Science ®Google Scholar
• Crispin, J. C., V. C. Kyttaris, C. Terhorst, et al. 2010. T cells as therapeutic targets in SLE. Nat. Rev. Rheumatol. 6: 317–325
   PubMed Web of Science ®Google Scholar
• Theofilopoulos, A. N., S. Koundouris, D. H. Kono, et al. 2001. The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res. 3: 136–141
   PubMedGoogle Scholar
• Theofilopoulos, A. N. 2012. TLRs and IFNs: critical pieces of the autoimmunity puzzle. J. Clin. Invest. 122: 3464–3466
   PubMed Web of Science ®Google Scholar
• Niewold, T. B. 2011. Interferon alpha as a primary pathogenic factor in human lupus. J. Interferon Cytokine Res. 31: 887–892
   PubMed Web of Science ®Google Scholar
• Crow, M. K. 2010. Type I interferon in organ-targeted autoimmune and inflammatory diseases. Arthritis Res. Ther. 12: S5
   PubMedGoogle Scholar
• Elkon, K. B., and A. Wiedeman. 2012. Type I IFN system in the development and manifestations of SLE. Curr. Opin. Rheumatol. 24: 499–505
   PubMed Web of Science ®Google Scholar
• Davidson, A. 2010. Targeting BAFF in autoimmunity. Curr. Opin. Immunol. 22: 732–739
   PubMed Web of Science ®Google Scholar
• Scapini, P., Y. Hu, C. L. Chu, et al. 2010. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med. 207: 1757–1773
   PubMed Web of Science ®Google Scholar
• Schiffer, L., R. Bethunaickan, M. Ramanujam, et al. 2008. Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis. J. Immunol. 180: 1938–1947
   PubMed Web of Science ®Google Scholar
• Lohoff, M., and T. W. Mak. 2005. Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat. Rev. Immunol. 5: 125–135
   PubMed Web of Science ®Google Scholar
• Salloum, R., and T. B. Niewold. 2011. Interferon regulatory factors in human lupus pathogenesis. Transl. Res. 157: 326–331
   PubMed Web of Science ®Google Scholar
• Santana-de Anda, K., D. Gomez-Martin, M. Diaz-Zamudio, et al. 2011. Interferon regulatory factors: beyond the antiviral response and their link to the development of autoimmune pathology. Autoimmun. Rev. 11: 98–103
   PubMed Web of Science ®Google Scholar
• Tamura, T., H. Yanai, D. Savitsky, et al. 2008. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 26: 535–584
   PubMed Web of Science ®Google Scholar
• Chen, W., S. S. Lam, H. Srinath, et al. 2008. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat. Struct. Mol. Biol. 15: 1213–1220
   PubMed Web of Science ®Google Scholar
• Qin, B. Y., C. Liu, S. S. Lam, et al. 2003. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat. Struct. Biol. 10: 913–921
   PubMedGoogle Scholar
• Takahasi, K., N. N. Suzuki, M. Horiuchi, et al. 2003. X-ray crystal structure of IRF-3 and its functional implications. Nat. Struct. Biol. 10: 922–927
   PubMedGoogle Scholar
• Huntzinger, E., and E. Izaurralde. 2011. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat. Rev. Genet. 12: 99–110
   PubMed Web of Science ®Google Scholar
• Lee, J. T. 2012. Epigenetic regulation by long noncoding RNAs. Science 338: 1435–1439
   PubMed Web of Science ®Google Scholar
• Arrowsmith, C. H., C. Bountra, P. V. Fish, et al. 2012. Epigenetic protein families: a new frontier for drug discovery. Nat. Rev. Drug Discov. 11: 384–400
   PubMed Web of Science ®Google Scholar
• Badeaux, A. I., and Y. Shi. 2013. Emerging roles for chromatin as a signal integration and storage platform. Nat. Rev. Mol. Cell Biol. 14: 211–224
   Web of Science ®Google Scholar
• Medzhitov, R., and T. Horng. 2009. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 9: 692–703
   PubMed Web of Science ®Google Scholar
• Natoli, G., S. Ghisletti, and I. Barozzi. 2011. The genomic landscapes of inflammation. Genes Dev. 25: 101–106
   PubMedGoogle Scholar
• Kanno, Y., G. Vahedi, K. Hirahara, et al. 2012. Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30: 707–731
   PubMed Web of Science ®Google Scholar
• Harada, H., T. Fujita, M. Miyamoto, et al. 1989. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58: 729–739
   PubMed Web of Science ®Google Scholar
• Miyamoto, M., T. Fujita, Y. Kimura, et al. 1988. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell 54: 903–913
   PubMed Web of Science ®Google Scholar
• Pine, R., A. Canova, and C. Schindler. 1994. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFNα and IFNγ, and is likely to autoregulate the p91 gene. EMBO J. 13: 158–167
   PubMed Web of Science ®Google Scholar
• Marsili, G., A. L. Remoli, M. Sgarbanti, et al. 2012. HIV-1, interferon and the interferon regulatory factor system: an interplay between induction, antiviral responses and viral evasion. Cytokine Growth Factor Rev. 23: 255–270
   PubMed Web of Science ®Google Scholar
• Yu-Lee, L. Y., J. A. Hrachovy, A. M. Stevens, et al. 1990. Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells. Mol. Cell. Biol. 10: 3087–3094
   PubMed Web of Science ®Google Scholar
• Dogusan, Z., M. L. Book, P. Verdood, et al. 2000. Prolactin activates interferon regulatory factor-1 expression in normal lympho-hemopoietic cells. Eur. Cytokine Netw. 11: 435–442
   PubMed Web of Science ®Google Scholar
• Coccia, E. M., N. Passini, A. Battistini, et al. 1999. Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells. J. Biol. Chem. 274: 6698–6703
   PubMed Web of Science ®Google Scholar
• Gupta, S., M. Jiang, and A. B. Pernis. 1999. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 163: 3834–3841
   Google Scholar
• Gupta, S., D. Xia, M. Jiang, et al. 1998. Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IRF-1 promoter. J. Immunol. 161: 5997–6004
   PubMed Web of Science ®Google Scholar
• Ohmori, Y., R. Screiber, and T. Hamilton. 1997. Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J. Biol. Chem. 272: 14899–14907
   PubMed Web of Science ®Google Scholar
• Pine, R. 1997. Convergence of TNFα and IFNγ signaling pathways through synergistic induction of IRF-1/ISGF2 is mediated by a composite GAS/κB promoter element. Nucleic Acids Res. 25: 4346–4354
   PubMed Web of Science ®Google Scholar
• Klampfer, L., J. Huang, L. A. Swaby, et al. 2004. Requirement of histone deacetylase activity for signaling by STAT1. J. Biol. Chem. 279: 30358–30368
   PubMed Web of Science ®Google Scholar
• Chang, H. M., M. Paulson, M. Holko, et al. 2004. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proc. Natl. Acad. Sci. USA 101: 9578–9583
   PubMed Web of Science ®Google Scholar
• Nusinzon, I., and C. M. Horvath. 2003. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Natl. Acad. Sci. USA 100: 14742–14747
   PubMed Web of Science ®Google Scholar
• Choi, J. C., R. Holtz, and S. P. Murphy. 2009. Histone deacetylases inhibit IFN-gamma-inducible gene expression in mouse trophoblast cells. J. Immunol. 182: 6307–6315
   PubMed Web of Science ®Google Scholar
• Su, R. C., A. Sivro, J. Kimani, et al. 2011. Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals. Blood 117: 2649–2657
   PubMed Web of Science ®Google Scholar
• Buro, L. J., E. Chipumuro, and M. A. Henriksen. 2010. Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1). Epigenetics Chromatin 3: 16
   PubMed Web of Science ®Google Scholar
• Auriemma, L. B., S. Shah, L. M. Linden, et al. 2012. Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene. Epigenetics Chromatin 5: 2
   PubMed Web of Science ®Google Scholar
• Shah, S., and M. A. Henriksen. 2011. A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression. J. Biol. Chem. 286: 41195–41204
   PubMed Web of Science ®Google Scholar
• Zhang, R., K. Chen, L. Peng, et al. 2012. Regulation of T helper cell differentiation by interferon regulatory factor family members. Immunol. Res. 54: 169–176
   PubMed Web of Science ®Google Scholar
• Taki, S., T. Sato, K. Ogasawara, et al. 1997. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6: 673–679
   PubMed Web of Science ®Google Scholar
• Salkowski, C. A., K. Kopydlowski, J. Blanco, et al. 1999. IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice. J. Immunol. 163: 1529–1536
   PubMed Web of Science ®Google Scholar
• Liu, J., X. Guan, T. Tamura, et al. 2004. Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. J. Biol. Chem. 279: 55609–55617
   PubMed Web of Science ®Google Scholar
• Fantuzzi, G., D. Reed, M. Qi, et al. 2001. Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity. Eur. J. Immunol. 31: 369–375
   PubMed Web of Science ®Google Scholar
• Lohoff, M., D. Ferrick, H. Mittrucker, et al. 1997. Interferon regulatory Factor-1 is required for a T helper 1 immune response in vivo. Immunity 6: 681–689
   PubMed Web of Science ®Google Scholar
• Kano, S., K. Sato, Y. Morishita, et al. 2008. The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells. Nat. Immunol. 9: 34–41
   Google Scholar
• Elser, B., M. Lohoff, S. Kock, et al. 2002. IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity 17: 703–712
   PubMed Web of Science ®Google Scholar
• Duncan, G. S., H. W. Mittrucker, D. Kagi, et al. 1996. The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo. J. Exp. Med. 184: 2043–2048
   PubMed Web of Science ®Google Scholar
• Ogasawara, K., S. Hida, N. Azimi, et al. 1998. Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature 391: 700–703
   PubMed Web of Science ®Google Scholar
• Tada, Y., A. Ho, T. Matsuyama, et al. 1997. Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J. Exp. Med. 185: 231–238
   PubMed Web of Science ®Google Scholar
• Reilly, C. M., S. Olgun, D. Goodwin, et al. 2006. Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice. Eur. J. Immunol. 36: 1296–1308
   PubMed Web of Science ®Google Scholar
• Pollard, K. M., P. Hultman, C. B. Toomey, et al. 2003. Definition of IFN-gamma-related pathways critical for chemically-induced systemic autoimmunity. J. Autoimmun. 39: 323–331
   Google Scholar
• Thanos, D., and T. Maniatis. 1995. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell 83: 1091–1100
   PubMed Web of Science ®Google Scholar
• Ford, E., and D. Thanos. 2010. The transcriptional code of human IFN-beta gene expression. Biochim. Biophys. Acta 1799: 328–336
   PubMed Web of Science ®Google Scholar
• Merika, M., A. J. Williams, G. Chen, et al. 1998. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol. Cell 1: 277–287
   PubMed Web of Science ®Google Scholar
• Masumi, A., I. M. Wang, B. Lefebvre, et al. 1999. The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. Mol. Cell. Biol. 19: 1810–1820
   PubMed Web of Science ®Google Scholar
• Masumi, A., and K. Ozato. 2001. Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. J. Biol. Chem. 276: 20973–20980
   PubMed Web of Science ®Google Scholar
• Masumi, A., H. Fukazawa, T. Shimazu, et al. 2006. Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation. Oncogene 25: 5113–5124
   Google Scholar
• Masumi, A., Y. Yamakawa, H. Fukazawa, et al. 2003. Interferon regulatory factor-2 regulates cell growth through its acetylation. J. Biol. Chem. 278: 25401–25407
   Google Scholar
• Masumi, A. 2011. Histone acetyltransferases as regulators of nonhistone proteins: the role of interferon regulatory factor acetylation on gene transcription. J. Biomed. Biotechnol. 2011: 640610
   PubMedGoogle Scholar
• Zhang, Z., L. Song, K. Maurer, et al. 2010. Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes. Genes Immun. 11: 124–133
   PubMed Web of Science ®Google Scholar
• Kim, E. J., J. S. Park, and S. J. Um. 2008. Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1. Biochem. Biophys. Res. Commun. 377: 952–956
   PubMed Web of Science ®Google Scholar
• Park, J., K. Kim, E. J. Lee, et al. 2007. Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis. Proc. Natl. Acad. Sci. USA 104: 17028–17033
   PubMed Web of Science ®Google Scholar
• Park, S. M., M. Chae, B. K. Kim, et al. 2009. SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2. Biochem. Biophys. Res. Commun. 391: 926–930
   PubMed Web of Science ®Google Scholar
• De Marchis, M. L., M. Ballarino, B. Salvatori, et al. 2009. A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells. Leukemia 23: 856–862
   PubMed Web of Science ®Google Scholar
• Lian, J., H. Tian, L. Liu, et al. 2010. Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. Cell Death Dis. 1: e94
   PubMed Web of Science ®Google Scholar
• Taylor, K. E., and K. L. Mossman. 2012. Recent advances in understanding viral evasion of type I interferon. Immunology 138: 190–197
   Web of Science ®Google Scholar
• Tang, X., J. S. Gao, Y. J. Guan, et al. 2007. Acetylation-dependent signal transduction for type I interferon receptor. Cell 131: 93–105
   PubMed Web of Science ®Google Scholar
• Yoshikawa, T., A. Takata, M. Otsuka, et al. 2012. Silencing of microRNA-122 enhances interferon-alpha signaling in the liver through regulating SOCS3 promoter methylation. Sci. Rep. 2: 637
   PubMed Web of Science ®Google Scholar
• Liang, D., Y. Gao, X. Lin, et al. 2011. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKepsilon. Cell Res. 21: 793–806
   PubMed Web of Science ®Google Scholar
• Jaspers, I., K. M. Horvath, W. Zhang, et al. 2010. Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza. Am. J. Respir. Cell. Mol. Biol. 43: 368–375
   PubMed Web of Science ®Google Scholar
• Li, Q., and M. A. Tainsky. 2011. Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic viruses. PLoS ONE 6: e28683
   Google Scholar
• Lu, R., W. C. Au, W. S. Yeow, et al. 2000. Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation. J. Biol. Chem. 275: 31805–31812
   PubMed Web of Science ®Google Scholar
• Salvi, V., D. Bosisio, S. Mitola, et al. 2010. Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells. Immunobiology 215: 756–761
   PubMed Web of Science ®Google Scholar
• Xu, W. D., Y. J. Zhang, K. Xu, et al. 2012. IRF7, a functional factor associates with systemic lupus erythematosus. Cytokine 58: 317–320
   PubMed Web of Science ®Google Scholar
• Akahoshi, M., H. Nakashima, A. Sadanaga, et al. 2008. Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus. Lupus 17: 568–574
   PubMed Web of Science ®Google Scholar
• Sanchez, E., M. A. Gonzalez-Gay, J. L. Callejas-Rubio, et al. 2009. No evidence for genetic association of interferon regulatory factor 3 in systemic lupus erythematosus. Lupus 18: 230–234
   PubMed Web of Science ®Google Scholar
• Smith, S., J. N. Gabhann, R. Higgs, et al. 2012. Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus. Arthritis Rheum. 64: 1601–1609
   PubMed Web of Science ®Google Scholar
• Salloum, R., B. S. Franek, S. N. Kariuki, et al. 2010. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. Arthritis Rheum. 62: 553–561
   PubMed Web of Science ®Google Scholar
• Kawasaki, A., H. Furukawa, Y. Kondo, et al. 2012. Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population. Lupus 21: 890–895
   PubMed Web of Science ®Google Scholar
• Fu, Q., J. Zhao, X. Qian, et al. 2011. Association of a functional IRF7 variant with systemic lupus erythematosus. Arthritis Rheum. 63: 749–754
   PubMed Web of Science ®Google Scholar
• Sweeney, S. E. 2011. Hematopoietic stem cell transplant for systemic lupus erythematosus: interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease. Lupus 20: 975–980
   PubMed Web of Science ®Google Scholar
• Thibault, D. L., A. D. Chu, K. L. Graham, et al. 2008. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J. Clin. Invest. 118: 1417–1426
   PubMedGoogle Scholar
• Wathelet, M. G., C. H. Lin, B. S. Parekh, et al. 1998. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol. Cell 1: 507–518
   PubMed Web of Science ®Google Scholar
• Parekh, B. S., and T. Maniatis. 1999. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Mol. Cell 3: 125–129
   PubMed Web of Science ®Google Scholar
• Yoneyama, M., W. Suhara, Y. Fukuhara, et al. 1998. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 17: 1087–1095
   PubMed Web of Science ®Google Scholar
• Kumar, K. P., K. M. McBride, B. K. Weaver, et al. 2000. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol. Cell. Biol. 20: 4159–4168
   PubMed Web of Science ®Google Scholar
• Yang, H., C. H. Lin, G. Ma, et al. 2003. Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. J. Biol. Chem. 278: 15495–15504
   PubMed Web of Science ®Google Scholar
• Caillaud, A., A. Prakash, E. Smith, et al. 2002. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J. Biol. Chem. 277: 49417–49421
   PubMed Web of Science ®Google Scholar
• Flammer, J. R., J. Dobrovolna, M. A. Kennedy, et al. 2010. The type I interferon signaling pathway is a target for glucocorticoid inhibition. Mol. Cell. Biol. 30: 4564–4574
   PubMed Web of Science ®Google Scholar
• Reily, M. M., C. Pantoja, X. Hu, et al. 2006. The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J. 25: 108–117
   PubMed Web of Science ®Google Scholar
• Nusinzon, I., and C. M. Horvath. 2006. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol. Cell. Biol. 26: 3106–3113
   PubMed Web of Science ®Google Scholar
• Zhu, J., C. B. Coyne, and S. N. Sarkar. 2011. PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and beta-catenin. EMBO J. 30: 4838–4849
   PubMed Web of Science ®Google Scholar
• Alam, S., H. Li, A. Margariti, et al. 2011. Galectin-9 protein expression in endothelial cells is positively regulated by histone deacetylase 3. J. Biol. Chem. 286: 44211–44217
   PubMed Web of Science ®Google Scholar
• Genin, P., R. Lin, J. Hiscott, et al. 2012. Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. PLoS ONE 7: e38336
   Web of Science ®Google Scholar
• Icardi, L., S. Lievens, R. Mori, et al. 2012. Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2. FASEB J. 26: 240–249
   Google Scholar
• Bentz, G. L., J. Shackelford, and J. S. Pagano. 2012. Epstein-Barr virus latent membrane protein 1 regulates the function of interferon regulatory factor 7 by inducing its sumoylation. J. Virol. 86: 12251–12261
   PubMed Web of Science ®Google Scholar
• Kubota, T., M. Matsuoka, T. H. Chang, et al. 2008. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J. Biol. Chem. 283: 25660–25670
   PubMed Web of Science ®Google Scholar
• Liang, Q., H. Deng, X. Li, et al. 2011. Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. J. Immunol. 187: 4754–4763
   PubMed Web of Science ®Google Scholar
• Liu, G., A. Friggeri, Y. Yang, et al. 2009. miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc. Natl. Acad. Sci. USA 106: 15819–15824
   PubMed Web of Science ®Google Scholar
• Gracias, D. T., E. Stelekati, J. L. Hope, et al. 2013. The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat. Immunol. 14: 593–602
   PubMed Web of Science ®Google Scholar
• Biswas, P., G. Bhagat, and A. B. Pernis. 2010. IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol. Rev. 233: 79–96
   PubMed Web of Science ®Google Scholar
• Nutt, S. L., N. Taubenheim, J. Hasbold, et al. 2011. The genetic network controlling plasma cell differentiation. Semin. Immunol. 23: 341–349
   PubMed Web of Science ®Google Scholar
• Shaffer, A. L., N. C. Emre, P. B. Romesser, et al. 2009. IRF4: immunity. Malignancy! Therapy? Clin. Cancer Res. 15: 2954–2961
   PubMed Web of Science ®Google Scholar
• De Silva, N. S., G. Simonetti, N. Heise, et al. 2012. The diverse roles of IRF4 in late germinal center B-cell differentiation. Immunol. Rev. 247: 73–92
   PubMed Web of Science ®Google Scholar
• Grossman, A., H. Mittrucker, J. Nicholl, et al. 1996. Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-25. Genomics 37: 229–233
   PubMed Web of Science ®Google Scholar
• Grumont, R. J., and S. Gerondakis. 2000. Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB. J. Exp. Med. 191: 1281–1292
   PubMed Web of Science ®Google Scholar
• Matsuyama, T., A. Grossman, H. Mittrucker, et al. 1995. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res. 23: 2127–2136
   PubMed Web of Science ®Google Scholar
• Sharma, S., Y. Mamane, N. Grandvaux, et al. 2000. Activation and regulation of interferon regulatory factor 4 in HTLV type I-infected lymphocytes. AIDS Res. Hum. Retroviruses 16: 1613–1622
   PubMed Web of Science ®Google Scholar
• Gupta, S., M. Jiang, A. Anthony, et al. 1999. Lineage-specific modulation of IL-4 signaling by interferon regulatory factor 4. J. Exp. Med. 190: 1837–1848
   PubMed Web of Science ®Google Scholar
• Chung, Y., S. H. Chang, G. J. Martinez, et al. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30: 576–587
   PubMed Web of Science ®Google Scholar
• Saito, M., J. Gao, K. Basso, et al. 2007. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell 12: 280–292
   PubMed Web of Science ®Google Scholar
• Sharma, S., N. Grandvaux, Y. Mamane, et al. 2002. Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. J. Immunol. 169: 3120–3130
   PubMed Web of Science ®Google Scholar
• Lehtonen, A., V. Veckman, T. Nikula, et al. 2005. Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J. Immunol. 175: 6570–6579
   PubMed Web of Science ®Google Scholar
• Zheng, Y., A. Chaudhry, A. Kas, et al. 2009. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458: 351–356
   PubMed Web of Science ®Google Scholar
• Brass, A., E. Kehrli, C. Eisenbeis, et al. 1996. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Develop. 10: 2335–2347
   PubMed Web of Science ®Google Scholar
• Eisenbeis, C., H. Singh, and U. Storb. 1995. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Develop. 9: 1377–1387
   PubMed Web of Science ®Google Scholar
• Satoh, T., O. Takeuchi, A. Vandenbon, et al. 2010. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 11: 936–944
   PubMed Web of Science ®Google Scholar
• Carreras, E., S. Turner, M. B. Frank, et al. 2010. Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4. Blood 115: 238–246
   PubMed Web of Science ®Google Scholar
• Sebastian, C., M. Serra, A. Yeramian, et al. 2008. Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. J. Immunol. 180: 5898–5906
   PubMedGoogle Scholar
• Ortmann, C. A., A. Burchert, K. Holzle, et al. 2005. Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region. Nucleic Acids Res. 33: 6895–6905
   Google Scholar
• Chaudhuri, A. A., A. Y. So, N. Sinha, et al. 2011. MicroRNA-125b potentiates macrophage activation. J. Immunol. 187: 5062–5068
   PubMed Web of Science ®Google Scholar
• Gururajan, M., C. L. Haga, S. Das, et al. 2010. MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int. Immunol. 22: 583–592
   PubMed Web of Science ®Google Scholar
• Malumbres, R., K. A. Sarosiek, E. Cubedo, et al. 2009. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood 113: 3754–3764
   PubMed Web of Science ®Google Scholar
• Brustle, A., S. Heink, M. Huber, et al. 2007. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8: 958–966
   PubMed Web of Science ®Google Scholar
• Chen, Q., W. Yang, S. Gupta, et al. 2008. IRF-4 Binding Protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 299: 899–911
   Google Scholar
• Honma, K., D. Kimura, N. Tominaga, et al. 2008. Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells. Proc. Natl. Acad. Sci. USA 105: 15890–15895
   PubMed Web of Science ®Google Scholar
• Rengarajan, J., K. A. Mowen, K. D. Mcbride, et al. 2002. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J. Exp. Med. 195: 1003–1012
   PubMed Web of Science ®Google Scholar
• Staudt, V., E. Bothur, M. Klein, et al. 2010. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33: 192–202
   PubMed Web of Science ®Google Scholar
• Lohoff, M., H.-W. Mittrucker, S. Prechtl, et al. 2002. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc. Natl. Acad. Sci. USA 99: 11808–11812
   PubMed Web of Science ®Google Scholar
• Bollig, N., A. Brustle, K. Kellner, et al. 2012. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc. Natl. Acad. Sci. USA 109: 8664–8669
   PubMed Web of Science ®Google Scholar
• Kwon, H., D. Thierry-Mieg, J. Thierry-Mieg, et al. 2009. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 31: 941–952
   PubMed Web of Science ®Google Scholar
• Huber, M., A. Brustle, K. Reinhard, et al. 2008. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc. Natl. Acad. Sci. USA 105: 20846–20851
   PubMed Web of Science ®Google Scholar
• Cretney, E., A. Xin, W. Shi, et al. 2011. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat. Immunol. 12: 304–311
   PubMed Web of Science ®Google Scholar
• Klein, U., S. Casola, G. Cattoretti, et al. 2006. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 7: 773–782
   PubMed Web of Science ®Google Scholar
• Sciammas, R., A. L. Shaffer, J. H. Schatz, et al. 2006. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25: 225–236
   PubMed Web of Science ®Google Scholar
• Shaffer, A. L., N. C. Emre, L. Lamy, et al. 2008. IRF4 addiction in multiple myeloma. Nature 454: 226–231
   PubMed Web of Science ®Google Scholar
• Yang, Y., A. L. Shaffer, 3rdN. C. Emre, et al. 2012. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell 21: 723–737
   PubMed Web of Science ®Google Scholar
• Negishi, H., Y. Ohba, H. Yanai, et al. 2005. Negative regulation of toll-like-receptor signaling by IRF-4. Proc. Natl. Acad. Sci. USA 102: 15989–15994
   PubMed Web of Science ®Google Scholar
• Tailor, P., T. Tamura, and K. Ozato. 2006. IRF family proteins and type I interferon induction in dendritic cells. Cell Res. 16: 134–140
   PubMed Web of Science ®Google Scholar
• Yamamoto, M., T. Kato, C. Hotta, et al. 2011. Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. PLoS ONE 6: e25812
   Web of Science ®Google Scholar
• Lech, M., M. Weidenbusch, O. P. Kulkarni, et al. 2011. IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production. J. Am. Soc. Nephrol. 22: 1443–1452
   PubMed Web of Science ®Google Scholar
• Biswas, P., S. Gupta, E. Chang, et al. 2010. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J. Clin. Invest. 120: 3280–3295
   PubMed Web of Science ®Google Scholar
• Fanzo, J. C., W. Yang, S. Y. Jang, et al. 2006. Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J. Clin. Invest. 116: 703–714
   PubMed Web of Science ®Google Scholar
• Gupta, S., A. Lee, C. Hu, et al. 2003. Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. Human Immunol. 64: 389–401
   PubMed Web of Science ®Google Scholar
• Biswas, P. S., S. Gupta, R. A. Stirzaker, et al. 2012. Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity. J. Exp. Med. 209: 581–596
   PubMed Web of Science ®Google Scholar
• Lazorchak, A. S., M. S. Schlissel, and Y. Zhuang. 2006. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol. Cell. Biol. 26: 810–821
   PubMed Web of Science ®Google Scholar
• Ma, S., A. Turetsky, L. Trinh, et al. 2006. IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. J. Immunol. 177: 7898–7904
   PubMed Web of Science ®Google Scholar
• Bevington, S., and J. Boyes. 2012. Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination. EMBO J 32: 1381--1392
   Google Scholar
• Ciofani, M., A. Madar, C. Galan, et al. 2012. A validated regulatory network for Th17 cell specification. Cell 151: 289–303
   PubMed Web of Science ®Google Scholar
• Cao, Y., H. Li, Y. Sun, et al. 2010. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression. Eur. J. Immunol. 40: 3198–3209
   PubMed Web of Science ®Google Scholar
• Cham, C. M., K. Ko, and T. B. Niewold. 2012. Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus. Clin. Dev. Immunol. 2012: 780436
   PubMedGoogle Scholar
• Kozyrev, S. V., and M. E. Alarcon-Riquelme. 2007. The genetics and biology of Irf5-mediated signaling in lupus. Autoimmunity 40: 591–601
   PubMed Web of Science ®Google Scholar
• Shen, H., R. Panchanathan, P. Rajavelu, et al. 2010. Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunity. J. Mol. Cell. Biol. 2: 284–290
   PubMed Web of Science ®Google Scholar
• Barnes, B., B. Lubyova, and P. M. Pitha. 2002. On the role of IRF in host defense. J. Interferon Cytokine Res. 22: 59–71
   PubMed Web of Science ®Google Scholar
• Yamashita, M., M. Toyota, H. Suzuki, et al. 2010. DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae. Cancer Sci. 101: 1708–1716
   PubMed Web of Science ®Google Scholar
• Balasa, A., G. Gathungu, P. Kisfali, et al. 2010. Assessment of DNA methylation at the interferon regulatory factor 5 (IRF5) promoter region in inflammatory bowel diseases. Int. J. Colorectal Dis. 25: 553–556
   PubMed Web of Science ®Google Scholar
• Gestermann, N., M. Koutero, R. Belkhir, et al. 2012. Methylation profile of the promoter region of IRF5 in primary Sjogren’s syndrome. Eur. Cytokine Netw. 23: 166–172
   PubMed Web of Science ®Google Scholar
• Polioudakis, D., A. A. Bhinge, P. J. Killion, et al. 2013. A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. Nucleic Acids Res. 41: 2239–2254
   PubMed Web of Science ®Google Scholar
• Tang, Y., X. Luo, H. Cui, et al. 2009. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 60: 1065–1075
   PubMed Web of Science ®Google Scholar
• Takaoka, A., H. Yanai, S. Kondo, et al. 2005. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434: 243–249
   PubMed Web of Science ®Google Scholar
• Krausgruber, T., K. Blazek, T. Smallie, et al. 2011. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat. Immunol. 12: 231–238
   PubMed Web of Science ®Google Scholar
• Paun, A., R. Bankoti, T. Joshi, et al. 2011. Critical role of IRF-5 in the development of T helper 1 responses to Leishmania donovani infection. PLoS Pathog. 7: e1001246
   PubMed Web of Science ®Google Scholar
• Fang, C. M., S. Roy, E. Nielsen, et al. 2012. Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response. Genes Immun. 13: 421–430
   PubMed Web of Science ®Google Scholar
• Lien, C., C. M. Fang, D. Huso, et al. 2010. Critical role of IRF-5 in regulation of B-cell differentiation. Proc. Natl. Acad. Sci. USA 107: 4664–4668
   PubMed Web of Science ®Google Scholar
• Savitsky, D. A., H. Yanai, T. Tamura, et al. 2010. Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc. Natl. Acad. Sci. USA 107: 10154–10159
   PubMed Web of Science ®Google Scholar
• Purtha, W. E., M. Swiecki, M. Colonna, et al. 2012. Spontaneous mutation of the Dock2 gene in Irf5−/− mice complicates interpretation of type I interferon production and antibody responses. Proc. Natl. Acad. Sci. USA 109: E898–E904
   Web of Science ®Google Scholar
• Feng, D., L. Yang, X. Bi, et al. 2012. Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching. Eur. J. Immunol. 42: 1477–1487
   PubMed Web of Science ®Google Scholar
• Tada, Y., S. Kondo, S. Aoki, et al. 2011. Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice. Arthritis Rheum. 63: 738–748
   PubMedGoogle Scholar
• Xu, Y., P. Y. Lee, Y. Li, et al. 2012. Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus. J. Immunol. 188: 4113–4121
   PubMed Web of Science ®Google Scholar
• Yang, L., D. Feng, X. Bi, et al. 2012. Monocytes from Irf5−/− mice have an intrinsic defect in their response to pristane-induced lupus. J. Immunol. 189: 3741–3750
   PubMed Web of Science ®Google Scholar
• Richez, C., K. Yasuda, R. G. Bonegio, et al. 2010. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB−/−Yaa and FcgammaRIIB−/− mouse models of systemic lupus erythematosus. J. Immunol. 184: 796–806
   PubMed Web of Science ®Google Scholar
• Feng, D., N. Sangster-Guity, R. Stone, et al. 2010. Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. J. Immunol. 185: 6003–6012
   PubMed Web of Science ®Google Scholar
• Eames, H. L., D. G. Saliba, T. Krausgruber, et al. 2012. KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages. Immunobiology 217: 1315–1324
   PubMed Web of Science ®Google Scholar
• Wang, H., and H. C. Morse3rd. 2009. IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol. Res. 43: 109–117
   PubMed Web of Science ®Google Scholar
• Cattoretti, G., R. Shaknovich, P. M. Smith, et al. 2006. Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. J. Immunol. 177: 6930–6939
   PubMed Web of Science ®Google Scholar
• Banik, D., A. N. Khan, E. Walseng, et al. 2012. Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PLoS ONE 7: e45422
   Web of Science ®Google Scholar
• Lee, K. Y., H. Geng, K. M. Ng, et al. 2008. Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas. Oncogene 27: 5267–5276
   Google Scholar
• McGough, J. M., D. Yang, S. Huang, et al. 2008. DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. Mol. Cancer Res. 6: 1841–1851
   Google Scholar
• Yang, D., M. Thangaraju, K. Greeneltch, et al. 2007. Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer Res. 67: 3301–3309
   PubMed Web of Science ®Google Scholar
• Basso, K., C. Schneider, Q. Shen, et al. 2012. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. J. Exp. Med. 209: 2455–2465
   PubMed Web of Science ®Google Scholar
• Li, H. S., N. Greeley, N. Sugimoto, et al. 2012. miR-22 controls Irf8 mRNA abundance and murine dendritic cell development. PLoS ONE 7: e52341
   Web of Science ®Google Scholar
• Marquis, J. F., O. Kapoustina, D. Langlais, et al. 2011. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. PLoS Genet. 7: e1002097
   Web of Science ®Google Scholar
• Dror, N., M. Alter-Koltunoff, A. Azriel, et al. 2007. Identification of IRF-8 and IRF-1 target genes in activated macrophages. Mol. Immunol. 44: 338–346
   PubMed Web of Science ®Google Scholar
• Satpathy, A. T., K. M. Murphy, and W. Kc. 2011. Transcription factor networks in dendritic cell development. Semin. Immunol. 23: 388–397
   PubMed Web of Science ®Google Scholar
• Tailor, P., T. Tamura, H. J. Kong, et al. 2007. The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity 27: 228–239
   PubMed Web of Science ®Google Scholar
• Kim, Y. M., H. S. Kang, S. G. Paik, et al. 1999. Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression. J. Immunol. 163: 2000–2007
   PubMed Web of Science ®Google Scholar
• Ouyang, X., R. Zhang, J. Yang, et al. 2011. Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nat. Commun. 2: 314
   PubMed Web of Science ®Google Scholar
• Wang, I. M., C. Contursi, A. Masumi, et al. 2000. An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J. Immunol. 165: 271–279
   PubMed Web of Science ®Google Scholar
• Lu, R., K. L. Medina, D. W. Lancki, et al. 2003. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 17: 1703–1708
   PubMed Web of Science ®Google Scholar
• Shin, D. M., C. H. Lee, and H. C. Morse3rd. 2011. IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells. PLoS ONE 6: e27384
   Google Scholar
• Cunninghame Graham, D. S., D. L. Morris, T. R. Bhangale, et al. 2011. Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet. 7: e1002341
   PubMed Web of Science ®Google Scholar
• Lessard, C. J., I. Adrianto, J. A. Ice, et al. 2012. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am. J. Hum. Genet. 90: 648–660
   PubMed Web of Science ®Google Scholar
• Baccala, R., R. Gonzalez-Quintial, A. L. Blasius, et al. 2013. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc. Natl. Acad. Sci. USA 110: 2940–2945
   PubMed Web of Science ®Google Scholar
• Yuan, W., S. Gupta, X. Hu et al. 2013. Rho-kinases modulate the ability of interferon regulatory factor 8 to regulate BAFF production in Murine Macrophages. Submitted
   Google Scholar
• Kuwata, T., C. Gongora, Y. Kanno, et al. 2002. Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element. Mol. Cell. Biol. 22: 7439–7448
   PubMed Web of Science ®Google Scholar
• Huang, W., W. Zhou, G. Saberwal, et al. 2010. Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. Mol. Cell. Biol. 30: 4575–4594
   PubMed Web of Science ®Google Scholar
• Fragale, A., E. Stellacci, R. Ilari, et al. 2011. Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J. Immunol. 186: 1951–1962
   PubMed Web of Science ®Google Scholar