Advanced search
Publication Cover
Autoimmunity Volume 47, 2014 - Issue 8
Submit an article Journal homepage
187
Views
17
CrossRef citations to date
0
Altmetric
Research Articles

In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy – candidiasis – ectodermal dystrophy provides evidence in support of an IL-22 defect

Sini M. LaaksoDepartment of Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki HelsinkiFinland
,
Eliisa KekäläinenDepartment of Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki HelsinkiFinland
,
Nelli HeikkiläDepartment of Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki HelsinkiFinland
,
Helga MannerströmDepartment of Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki HelsinkiFinland
,
Kai KisandMolecular Pathology, Institute of General and Molecular Pathology, University of Tartu TartuEstonia
,
Pärt PetersonMolecular Pathology, Institute of General and Molecular Pathology, University of Tartu TartuEstonia
,
Annamari RankiDepartment of Skin and Allergic Diseases, Skin and Allergy Hospital, Helsinki University Central Hospital HelsinkiFinland
&
T. Petteri ArstilaDepartment of Immunology, Haartman Institute, and Research Programs Unit, Immunobiology, University of Helsinki HelsinkiFinlandCorrespondence[email protected]
 show all
Pages 556-562 | Received 25 Nov 2013, Accepted 25 May 2014, Published online: 24 Jun 2014

References

  • Perheentupa J. 2006. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Clin. Endocrinol. Metab. 91: 2843–2850
  • Heino, M., P. Peterson, J. Kudoh, et al. 1999. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257: 821–825
  • Anderson, M. S., E. S. Venanzi, L. Klein, et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science. 298: 1395–1401
  • Liston, A., S. Lesage, J. Wilson, et al. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4: 350–354
  • Anderson, M. S., E. S. Venanzi, Z. Chen, et al. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity. 23: 227–239
  • Kogawa, K., S. Nagafuchi, H. Katsuta, et al. 2002. Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol. Lett. 80: 195–198
  • Pitkänen J, P. Vahamurto, K. Krohn, and P. Peterson. 2001. Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain. J. Biol. Chem. 276: 19597–19602
  • Meager, A., K. Visvalingam, P. Peterson, et al. 2006. Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med. 3: e289
  • Kisand, K., A. S. Boe Wolff, K. T. Podkrajsek, et al. 2010. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med. 207: 299–308
  • Puel, A., R. Döffinger, A. Natividad, et al. 2010. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. 207: 291–297
  • Ng, W.-F., A. von Delwig, A. J. Carmichael, et al. 2010. Impaired Th17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy – candidiasis – ectodermal dystrophy. J. Allergy Clin. Immunol. 126: 1006–1015
  • Ahlgren, K. M., S. Moretti, B. A. Lundgren, et al. 2011. Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model. Eur. J. Immunol. 41: 235–245
  • Jin, D., L. Zhang, J. Zheng, and Y. Zhao. 2008. The inflammatory Th17 subset in immunity against self and non-self antigens. Autoimmunity. 41:154–162
  • Devoss, J. J., A. K. Shum, K. P. Johannes, et al. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J. Immunol. 181: 4072–4079
  • Vukmanovic-Stejic, M., E. Agius, N. Booth, et al. 2008. The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J. Clin. Invest. 118: 3639–3650
  • Laakso, S. M., T. T. Laurinolli, L. H. Rossi, et al. 2010. Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population. J. Autoimmun. 35: 351–357
  • Kekäläinen, E., H. Tuovinen, J. Joensuu, et al. 2007. A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Immunol. 178: 1208–1215
  • Tuovinen, H., J. T. Salminen, and T. P. Arstila. 2006. Most human thymic and peripheral-blood CD4+ CD25+ regulatory T cells express 2 T-cell receptors. Blood. 108: 4063–4070
  • Yeh, S., C. S. de Paiva, C. S. Hwang, et al. 2009. Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. Br. J. Ophthalmol. 93: 1260–1264
  • Clark, R. A. 2010. Skin-resident T cells: the ups and downs of onsite immunity. J. Invest. Dermatol. 130: 362–370
  • Sonnenberg, G. F., L. A. Fouser, and D. Artis. 2011. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 12: 383–390
  • Chen, Y., C. J. Haines, I. Gutcher, et al. 2011. Foxp3+ regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. Immunity. 34: 409–421
  • Pandiyan, P., H. R. Conti, L. Zheng, et al. 2011. CD4+CD25+Foxp3+ regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 34: 422–434
  • van de Veerdonk, F. L., T. S. Plantinga, A. Hoischen, et al. 2011. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N. Engl. J. Med. 365: 54–61
  • De Luca, A., A. Carvalho, C. Cunha, et al. 2013. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. PLoS Pathog. 9: e1003486

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.