The defective bone marrow-derived mesenchymal stem cells in patients with chronic immune thrombocytopenia

References

• Lai, R. C., T. S. Chen, and S. K. Lim. 2011. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen. Med. 6: 481–492
   PubMed Web of Science ®Google Scholar
• Owen, M. 1988. Marrow stromal stem cells. J. Cell Sci. Suppl. 10: 63–76
   PubMedGoogle Scholar
• Almeida-Porada, G., C. D. Porada, N. Tran, and E. D. Zanjani. 2000. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 95: 3620–3627
   PubMed Web of Science ®Google Scholar
• Nasef, A., A. Chapel, C. Mazurier, et al. 2007. Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells. Gene Expr. 13: 217–226
   PubMed Web of Science ®Google Scholar
• Di Nicola, M., C. Carlo-Stella, M. Magni, et al. 2002. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99: 3838–3843
   PubMed Web of Science ®Google Scholar
• Klyushnenkova, E., J. D. Mosca, V. Zernetkina, et al. 2005. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression. J. Biomed. Sci. 12: 47–57
   PubMed Web of Science ®Google Scholar
• Uccelli, A., L. Moretta, and V. Pistoia. 2006. Immunoregulatory function of mesenchymal stem cells. Eur. J. Immunol. 36: 2566–2573
   PubMed Web of Science ®Google Scholar
• Duffy, M. M., T. Ritter, R. Ceredig, and M. D. Griffin. 2011. Mesenchymal stem cell effects on T-cell effector pathways. Stem Cell Res. Ther. 2: 34
   PubMed Web of Science ®Google Scholar
• Aggarwal, S., and M. F. Pittenger. 2005. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105: 1815–1822
   PubMed Web of Science ®Google Scholar
• English, K., J. M. Ryan, L. Tobin, et al. 2009. Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells. Clin. Exp. Immunol. 156: 149–160
   PubMed Web of Science ®Google Scholar
• Tasso, R., C. Ilengo, R. Quarto, et al. 2012. Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Investig. Ophthalmol. Vis. Sci. 53: 786–793
   PubMed Web of Science ®Google Scholar
• Stasi, R. 2012. Immune thrombocytopenia: pathophysiologic and clinical update. Semin. Thromb. Hemost. 38: 454–462
   PubMed Web of Science ®Google Scholar
• Semple, J. W., D. Provan, M. B. Garvey, and J. Freedman. 2010. Recent progress in understanding the pathogenesis of immune thrombocytopenia. Curr. Opin. Hematol. 17: 590–595
   PubMed Web of Science ®Google Scholar
• Mouzaki, A., M. Theodoropoulou, I. Gianakopoulos, et al. 2002. Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis. Blood 100: 1774–1779
   PubMed Web of Science ®Google Scholar
• Liu, B., H. Zhao, M. C. Poon, et al. 2007. Abnormality of CD4+CD25+ regulatory T cells in idiopathic thrombocytopenic purpura. Eur. J. Haematol. 78: 139–143
   PubMed Web of Science ®Google Scholar
• Nishimoto, T., and M. Kuwana. 2013. CD4+CD25+Foxp3+ regulatory T cells in the pathophysiology of immune thrombocytopenia. Semin. Hematol. 50: S43–S49
   PubMedGoogle Scholar
• Perez-Simon, J. A., S. Tabera, M. E. Sarasquete, et al. 2009. Mesenchymal stem cells are functionally abnormal in patients with immune thrombocytopenic purpura. Cytotherapy 11: 698–705
   PubMed Web of Science ®Google Scholar
• Provan, D., R. Stasi, A. C. Newland, et al. 2010. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 115: 168–186
   PubMed Web of Science ®Google Scholar
• Sun, L. Y., H. Y. Zhang, X. B. Feng, et al. 2007. Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 16: 121–128
   PubMed Web of Science ®Google Scholar
• Nie, Y., C. Lau, A. Lie, et al. 2010. Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 19: 850–859
   PubMed Web of Science ®Google Scholar
• Larghero, J., D. Farge, A. Braccini, et al. 2008. Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis. Ann. Rheum. Dis. 67: 443–449
   PubMed Web of Science ®Google Scholar
• Glennie, S., I. Soeiro, P. J. Dyson, et al. 2005. Bone marrow mesenchymal stem cells induce division arrest energy of activated T cells. Blood 105: 2821–2827
   PubMed Web of Science ®Google Scholar
• Mohanty, S. T., L. Kottam, A. Gambardella, et al. 2010. Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis. Arthritis Res. Ther. 12: R149
   PubMed Web of Science ®Google Scholar
• Uccelli, A., G. Mancardi, and S. Chiesa. 2008. Is there a role for mesenchymal stem cells in autoimmune diseases? Autoimmunity 41: 592–595
   PubMed Web of Science ®Google Scholar
• Chen, X. T., S. T. Chan, H. Hosseini, et al. 2011. Transplantation of retrovirally transduced bone marrow prevents autoimmune disease in aged mice by peripheral tolerance mechanisms. Autoimmunity 44: 384–393
   PubMed Web of Science ®Google Scholar
• Volarevic, V., A. Al-Qahtani, N. Arsenijevic, et al. 2010. Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis. Autoimmunity 43: 255–263
   PubMed Web of Science ®Google Scholar
• Ma, J., Y. N. Ning, M. Xu, et al. 2013. Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia. Blood 122: 2074–2082
   PubMed Web of Science ®Google Scholar
• Solchaga, L. A., K. Penick, J. D. Porter, et al. 2005. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J. Cell. Physiol. 203: 398–409
   PubMed Web of Science ®Google Scholar
• Tamama, K., V. H. Fan, L. G. Griffith, et al. 2006. Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells 24: 686–695
   PubMed Web of Science ®Google Scholar
• Fang, B., Y. Song, Q. Lin, et al. 2007. Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children. Pediatr. Transplant. 11: 814–817
   PubMed Web of Science ®Google Scholar
• Vishnubalaji, R., M. Al-Nbaheen, B. Kadalmani, et al. 2012. Comparative investigation of the differentiation capability of bone-marrow- and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis. Cell Tissue Res. 347: 419–427
   PubMed Web of Science ®Google Scholar
• Eppley, B. L., J. E. Woodell, and J. Higgins. 2004. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plastic Reconstr. Surg. 114: 1502–1508
   PubMed Web of Science ®Google Scholar
• Alsousou, J., M. Thompson, P. Hulley, et al. 2009. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J. Bone Joint Surg. Br. 91: 987–996
   PubMed Web of Science ®Google Scholar
• Dimitriou, H., E. Linardakis, G. Martimianaki, et al. 2008. Properties and potential of bone marrow mesenchymal stromal cells from children with hematologic diseases. Cytotherapy 10: 125–133
   PubMed Web of Science ®Google Scholar
• Pittenger, M. F., A. M. Mackay, S. C. Beck, et al. 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284: 143–147
   PubMed Web of Science ®Google Scholar
• Prockop, D. J. 1997. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71–74
   PubMed Web of Science ®Google Scholar
• Carvalho, J. F., M. Blank, and Y. Shoenfeld. 2007. Vascular endothelial growth factor (VEGF) in autoimmune diseases. J. Clin. Immunol. 27: 246–256
   PubMed Web of Science ®Google Scholar
• van der Voort, R., T. E. Taher, R. M. Keehnen, et al. 1997. Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. J. Exp. Med. 185: 2121–2131
   PubMed Web of Science ®Google Scholar
• Kurz, S. M., S. S. Diebold, T. Hieronymus, et al. 2002. The impact of c-met/scatter factor receptor on dendritic cell migration. Eur. J. Immunol. 32: 1832–1838
   PubMed Web of Science ®Google Scholar
• Futamatsu, H., J. Suzuki, S. Mizuno, et al. 2005. Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines. Circ. Res. 96: 823–830
   PubMed Web of Science ®Google Scholar
• Okunishi, K., M. Dohi, K. Nakagome, et al. 2005. A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J. Immunol. 175: 4745–4753
   PubMed Web of Science ®Google Scholar
• Benkhoucha, M., M. L. Santiago-Raber, G. Schneiter, et al. 2010. Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 107: 6424–6429
   PubMed Web of Science ®Google Scholar
• Skibinski, G. 2003. The role of hepatocyte growth factor/c-met interactions in the immune system. Arch. Immunol. Ther. Exp. 51: 277–282
   PubMed Web of Science ®Google Scholar
• Krampera, M., A. Pasini, A. Rigo, et al. 2005. HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation. Blood 106: 59–66
   PubMed Web of Science ®Google Scholar
• Kastrinaki, M. C., P. Sidiropoulos, S. Roche, et al. 2008. Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis. Ann. Rheum. Dis. 67: 741–749
   PubMed Web of Science ®Google Scholar
• Bocelli-Tyndall, C., L. Bracci, G. Spagnoli, et al. 2007. Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro. Rheumatology 46: 403–408
   PubMed Web of Science ®Google Scholar
• Semple, J. W., Y. Milev, D. Cosgrave, et al. 1996. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood 87: 4245–4254
   PubMed Web of Science ®Google Scholar
• Ogawara, H., H. Handa, K. Morita, et al. 2003. High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura. Eur. J. Haematol. 71: 283–288
   PubMed Web of Science ®Google Scholar
• Panitsas, F. P., M. Theodoropoulou, A. Kouraklis, et al. 2004. Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood 103: 2645–2647
   PubMed Web of Science ®Google Scholar
• Xu, R., Z. Zheng, Y. Ma, et al. 2014. Elevated NKT cell levels in adults with severe chronic immune thrombocytopenia. Exp. Ther. Med. 7: 149–154
   PubMed Web of Science ®Google Scholar
• Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170: 2081–2095
   PubMed Web of Science ®Google Scholar
• O'Garra, A., and P. Vieira. 2004. Regulatory T cells and mechanisms of immune system control. Nat. Med. 10: 801–805
   PubMed Web of Science ®Google Scholar
• Roncarolo, M. G., S. Gregori, M. Battaglia, et al. 2006. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212: 28–50
   PubMed Web of Science ®Google Scholar
• Di Ianni, M., B. Del Papa, M. De Ioanni, et al. 2008. Mesenchymal cells recruit and regulate T regulatory cells. Exp. Hematol. 36: 309–318
   PubMed Web of Science ®Google Scholar
• Maccario, R., M. Podesta, A. Moretta, et al. 2005. Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 90: 516–525
   PubMed Web of Science ®Google Scholar
• Prevosto, C., M. Zancolli, P. Canevali, et al. 2007. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 92: 881–888
   PubMed Web of Science ®Google Scholar