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Full Length Research Paper

Detailed profiling of anti-desmoglein autoantibodies identifies anti-Dsg1 reactivity as a key driver of disease activity and clinical expression in pemphigus vulgaris

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Pages 231-241 | Received 10 Jun 2014, Accepted 05 Oct 2014, Published online: 11 Nov 2014

References

  • Amagai, M., V. Klaus-Kovtun, and J. R. Stanley. 1991. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 67: 869–877
  • Kalantari-Dehaghi, M., G. J. Anhalt, M. J. Camilleri, et al. 2013. Pemphigus vulgaris autoantibody profiling by proteomic technique. PloS. One. 8: e57587
  • Calkins, C. C., S. V. Setzer, J. M. Jennings, et al. 2006. Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies. J. Biol. Chem. 281: 7623–7634
  • Amagai, M., A. R. Ahmed, Y. Kitajima, et al. 2006. Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just “witnesses of disease”? Exp. Dermatol. 15: 815–831
  • Kurzen, H., and S. Brenner. 2006. Significance of autoimmunity to non-desmoglein targets in pemphigus. Autoimmunity. 39: 549–556
  • Nguyen, V. T., A. Ndoye, L. D. Shultz, et al. 2000. Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J. Clin. Investig. 106: 1467–1479
  • Amagai, M., K. Tsunoda, D. Zillikens, et al. 1999. The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J. Am. Acad. Dermatol. 40: 167–170
  • Mahoney, M. G., Z. Wang, K. Rothenberger, et al. 1999. Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J. Clin. Investig. 103: 461–468
  • Harman, K. E., P. T. Seed, M. J. Gratian, et al. 2001. The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. Br. J. Dermatol. 144: 775–780
  • Jamora, M. J., D. Jiao, and J. C. Bystryn. 2003. Antibodies to desmoglein 1 and 3, and the clinical phenotype of pemphigus vulgaris. J. Am. Acad. Dermatol. 48: 976–977
  • Ding, X., V. Aoki, J. M. Mascaro, Jret al. 1997. Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles. J. Investig. Dermatol. 109: 592–596
  • Yoshida, K., Y. Takae, H. Saito, et al. 2005. Cutaneous type pemphigus vulgaris: a rare clinical phenotype of pemphigus. J. Am. Acad. Dermatol. 52: 839–845
  • Harman, K. E., M. J. Gratian, B. S. Bhogal, et al. 2000. A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype. Br. J. Dermatol. 143: 343–348
  • Cheng, S. W., M. Kobayashi, K. Kinoshita-Kuroda, et al. 2002. Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3. Br. J. Dermatol. 147: 261–265
  • Sharma, V. K., H. R. Prasad, S. Khandpur, and A. Kumar. 2006. Evaluation of desmoglein enzyme-linked immunosorbent assay (ELISA) in Indian patients with pemphigus vulgaris. Int. J. Dermatol. 45: 518–522
  • Daneshpazhooh, M., C. Chams-Davatchi, A. Khamesipour, et al. 2007. Desmoglein 1 and 3 enzyme-linked immunosorbent assay in Iranian patients with pemphigus vulgaris: correlation with phenotype, severity, and disease activity. J. Eur. Acad. Dermatol. Venereol. JEADV 21: 1319–1324
  • Abasq, C., H. Mouquet, D. Gilbert, et al. 2009. ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus. Arch. Dermatol. 145: 529–535
  • Belloni-Fortina, A., D. Faggion, B. Pigozzi, et al. 2009. Detection of autoantibodies against recombinant desmoglein 1 and 3 molecules in patients with pemphigus vulgaris: correlation with disease extent at the time of diagnosis and during follow-up. Clin. Dev. Immunol. 2009: 187864
  • Herrero-Gonzalez, J. E., P. Iranzo, D. Benitez, et al. 2010. Correlation of immunological profile with phenotype and disease outcome in pemphigus. Acta Dermato-venereolog. 90: 401–405
  • Schmidt, E., C. Dahnrich, A. Rosemann, et al. 2010. Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients. Exp. Dermatol. 19: 458–463
  • Anand, V., S. Khandpur, V. K. Sharma, and A. Sharma. 2012. Utility of desmoglein ELISA in the clinical correlation and disease monitoring of pemphigus vulgaris. J. Eur. Acad. Dermatol. Venereol. JEADV 26: 1377–1383
  • Luftl, M., A. Stauber, A. Mainka, et al. 2003. Successful removal of pathogenic autoantibodies in pemphigus by immunoadsorption with a tryptophan-linked polyvinylalcohol adsorber. Br. J. Dermatol. 149: 598–605
  • Sardana, K., V. K. Garg, and P. Agarwal. 2013. Is there an emergent need to modify the desmoglein compensation theory in pemphigus on the basis of Dsg ELISA data and alternative pathogenic mechanisms? Br. J. Dermatol. 168: 669–674
  • Murrell, D. F., S. Dick, A. R. Ahmed, et al. 2008. Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. J. Am. Acad. Dermatol. 58: 1043–1046
  • Sinha, A. A. 2012. Constructing immunoprofiles to deconstruct disease complexity in pemphigus. Autoimmunity 45: 36–43
  • Daneshpazhooh, M., K. Kamyab, M. S. Kalantari, et al. 2014. Comparison of desmoglein 1 and 3 enzyme-linked immunosorbent assay and direct immunofluorescence for evaluation of immunological remission in pemphigus vulgaris. Clin. Exp. Dermatol. 39: 41–47
  • Reguiai, Z., T. Tabary, M. Maizieres, and P. Bernard. 2012. Rituximab treatment of severe pemphigus: long-term results including immunologic follow-up. J. Am. Acad. Dermatol. 67: 623–629
  • Colliou, N., D. Picard, F. Caillot, et al. 2013. Long-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response. Sci. Transl. Med. 5: 175ra130
  • Herbst, A., and J. C. Bystryn. 2000. Patterns of remission in pemphigus vulgaris. J. Am. Acad. Dermatol. 42: 422–427
  • Saha, M., B. Bhogal, M. M. Black, et al. 2014. Prognostic factors in pemphigus vulgaris and pemphigus foliaceus. Br. J. Dermatol. 170: 116–122

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