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Original Article

Inherited Susceptibility to Insulin-Dependent Diabetes is Associated with HLA-DR1, while DR5 is Protective

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Pages 197-205 | Received 23 Sep 1987, Published online: 07 Jul 2009

References

  • Singal D P, Blajchman M A. Histocompatibility antigens (HLA), lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 1973; 22: 429–32
  • Nerup J, Platz P, Ortred-Anderson M, Christy M, Lyngsoe J, Powlsen J, Ryder L, Staub-Nielson L, Thomsen M, Svejgaard A. HLA antigens and diabetes mellitus. Lancet 1974; ii: 864–6
  • Cudworth A G, Woodrow J C. HLA system and diabetes mellitus. Diabetes 1975; 24: 345–9
  • Seignalet J, Mirouze H, Sattiol J, Selam J, Lapinski H. HLA in Grave's disease and in diabetes mellitus. Tissue Antigens 1975; 6: 272–4
  • Platz P, Thomsen M, Christy M, Kromann H, Benn J, Nerup J, Green A, Hauge M. HLA-D and DR antigens in genetic analysis of insulin dependent diabetes mellitus. Diabetologia 1981; 21: 108–15
  • Wolf E, Spencer K, Cudworth A. The genetic susceptibility to type I (insulin dependent) diabetes; analysis of the HLA-DR association. Diabetologia 1983; 24: 224–30
  • Sheey M J, Quintieri P B, Yang S Y, Alosco S M, Matsui Y, Yunis B J, Gabbay K H. HLA antigens of insulin dependent diabetes. Tissue Antigens 1984; 23: 290–300
  • Maclaren N K, Riley W J. Inherited susceptibility to autoimmune Addison's disease is linked to HLA-DR3 and/or DR4, except when associated with type I autoimmune polyglandular syndrome. J Clin Endocrinol Metab 1986; 62: 455–9
  • Raum D, Awdeh Z, Yunis E J, Alper C A, Gabbay K H. Extended major histocompatibility complex haplotypes in type I diabetes mellitus. J Clin Invest 1984; 74: 449–54
  • Kelly M, McCann V J, Kay P M, Dawkins R L. Susceptibility to IDDM is worked by MHC supratypes rather than individual alleles. Immunogenetics 1985; 22: 643–51
  • Baxevanis C N, Nagy Z A, Klein O J. A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complex. Proc Natl Acad Sci 1981; 78: 3809–13
  • Thomson G. HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet 1984; 36: 1309–17
  • National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979; 28: 1039–57
  • Amos B. Cytotoxicity testing. NIADD Manual of Tissue Typing Techniques, 78: 545, 25–6, DHBW Pub. NIH 1976-7
  • Van Rood J, Van Leeumen A, Phoem J. A method to detect simultaneously two cell populations by two color fluorescence. Nature 1976; 262: 795–7
  • Woolf B. On estimating the relation between blood group and disease. Ann of Hum Gen 1955; 19: 251–3
  • Svejgaard A, Jersild C, Staub-Nielsen L, Bodmer W. HLA antigens and disease: statistical and genetical considerations. Tissue Antigens 1974; 4: 95–9
  • Miettinen O S. Estimability and estimation in case-referent studies. Am J Epidemiol 1976; 103: 226–35
  • Greene A. The epidemiological approach to studies of association between HLA and disease. II. Estimation of absolute risks, etiological and preventative fractions. Tiss Antigens 1982; 19: 259–68
  • Schober E, Schernthaner G, Mayr W R. HLA-DR antigens in insulin-dependent diabetes. Arch Dis Child 1981; 56: 227–9
  • McKenna R, Albert E D, McCarthy C F. HLA-DR antigens and insulin-dependent diabetes mellitus in the west of Ireland. Ir J Med Sci 1984; 153(7)238
  • Owerbach D, Hagglof B, Lernmark A, Holmgren G. Susceptibility to insulin-dependent diabetes defined by restriction enzyme polymorphism of HLA-D region genomic DNA. Diabetes 1984; 33: 958–65
  • DeJongh B M, Termijtelen A, Bruining G J, de Vries R RP, Van Rood J. Relation of insulin-dependent diabetes mellitus (IDD) and the HLA-linked SB system. Tissue Antigens 1984; 23: 88–93
  • Rich S S, Weitkamp L R, Barbosa J. Genetic heterogeneity of insulin-dependent (type I) diabetes mellitus: evidence from a study of extended haplotypes. Am J Hum Genet 1984; 36: 1015–23
  • Rich S, O'Neill G, Dalmasso A R, Nerl C, Barbosa J. Complement and HLA. Further definition of high-risk haplotypes in insulin-dependent diabetes. Diabetes 1985; 34: 505–9
  • Bhatia E, Mehra N K, Taneua V, Vaidya M C, Ahuja M MS. HLA-DR antigen frequencies in a North Indian type I diabetic population. Diabetes 1985; 34: 565–7
  • Lee B W, Chan S H, Tan S H, Wee G B, Yap H K, Wong H B, Tan C L, Tan K W. HLA-system in Chinese children with insulin-dependent diabetes mellitus: a strong association with D3. Metabolism 1984; 33(12)1102
  • Deschamps I, Lestradet H, Bonaiti C, Schmid M, Busson M, Benajam A, Marcelli-Barge A, Hors J. HLA-genotype studies in juvenile insulin-dependent diabetes. Diabetologia 1980; 19: 189–93
  • Mustonen A, Ilonen J, Tiilikainen A, Kataja M, Akerblom H K. An analysis of epidemiological data in HLA-typed diabetic children. Diabetologia 1985; 28: 397–400
  • Sakurami T, Ueno Y, Nagaoka K, Kuno S, Iwaki Y, Park M A, Terasaki P. HLA-DR specifications in Japanese with juvenile-onset insulin-dependent diabetes mellitus. Diabetes 1982; 31: 105–6
  • Murphy C C, Acton R T, Barger B O, Go R CP, Kirk K A, Reitnauer P J, Roseman J M. Population genetic analyses of insulin dependent diabetes mellitus using HLA allele frequencies. Clinical Genetics 1983; 23: 405–14
  • Garovoy M R, Barbosa J, Reddish M, Martin S, Noreen H, Yunis E J, Carpenter C B. HLA-DR antigens and unique serologic reactions in juvenile onset diabetes mellitus. Trans Proc 1978; X(4)967
  • Contu L, Deschamps I, Lestradet H, Hors J, Schmid M, Busson M, Benjamin A, Marcelli-Barge A, Dausset J. HLA haplotype study of 53 juvenile insulin-dependent diabetic (IDD) families. Tissue Antigens 1982; 20: 123–40
  • Bertrams J, Baur M P. Insulin-dependent diabetes mellitus. Histocompatibility Testing, E D Albert, M P Baur, W R Mayr. Springer-Verlag, New York 1984; 348
  • Tiwari J L, Terresaki P I. HLA and Disease Associations. Springer-Verlag, New York 1985; 185
  • Winearls B C, Bodmer J G, Bodmer W J, Bottazzo G F, McNally J, Mann J I, Thorogood M, Smith M A, Baum J D. A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system. Tissue Antigens 1984; 24: 234–46
  • Owerbach D, Lernmark A, Platz P, Ryder L P, Rask L, Peterson P H, Ludvigsson J. HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin dependent diabetic individuals. Nature 1983; 303: 815–7
  • Henson V, Maclaren N, Winter W, Riley W, Rotter J, Wakeland B. The molecular genetics of insulin dependent diabetes mellitus. Mot Biol Med 1986; 3: 129–36
  • Bach F H, Rich S S, Barbosa J, Segall M. Insulin-dependent diabetes - associated HLA-D region encoded determinants. Human Immunology 1985; 12: 59–64
  • Bohme J, Carlsson B, Wallin J, Moller E, Persson B, Peterson P A, Rask L. Only one DQ-β restriction fragment pattern of each DR specificity is associated with insulin-dependent diabetes. J Immunol 1986; 137: 941
  • Cohen N, Brautbar C, Font M-P, Dausset J, Cohen D. HLA-DR2-associated Dw subtypes correlate with RFLP clusters: most DR2IDDM patients belong to one of these clusters. Immunogenetics 1986; 23: 84–9

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