Transgenic Models of Tolerance and Autoimmunity

References

• The Autoimmune Diseases, N R Rose, I R Mackay. Academic Press, London 1985
   Google Scholar
• Burnet F M. The Clonal Selection Theory of Acquired Immunity. Cambridge Univ. Press. 1959
   Google Scholar
• Billingham R E, Brent L, Medawar P B. “Actively acquired tolerance” of foreign cells. Nature 1953; 172: 603–606
   PubMed Web of Science ®Google Scholar
• Nossal G JV. Cellular mechanisms of immunologic tolerance. Ann Rev Immunol 1983; 1: 33–62
   PubMed Web of Science ®Google Scholar
• Miller J FAP. Immunological function of the thymus. Lancet 1961; 2: 748–749
   PubMed Web of Science ®Google Scholar
• Sprent J, Webb S R. Function and specificity of T cell subsets in the mouse. Adv Immunol 1987; 41: 39–133
   PubMed Web of Science ®Google Scholar
• Bjorkman P J, Saper M A, Samraoui B, Bennett W S, Strominger J L, Wiley D C. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987; 329: 512–518
   PubMed Web of Science ®Google Scholar
• Kappler J W, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273–280
   PubMed Web of Science ®Google Scholar
• Kappler J W, Staerz U, White J, Marrack P C. Self tolerance eliminates T cells specific for the Mis modified products of the major histocompatibility complex. Nature 1988; 332: 35–40
   PubMed Web of Science ®Google Scholar
• MacDonald H R, Sneider R, Lees R K, Howe R C, Acha-Orbea H, Fetenstein H, Zinkernagel R M, Hengartner H. T cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 1988; 332: 40–45
   PubMed Web of Science ®Google Scholar
• Miller J FAP, Watson J D. Intracellular recognition events eliminate self-reactive T cells. Scand J Immunol 1988; 28: 389–395
   PubMed Web of Science ®Google Scholar
• Lorenz R G, Allen P M. Direct evidence for functional self-protein/Ia-molecule complexes in vivo. Proc Nat Acad Sci USA 1988; 85: 5220–5223
   PubMed Web of Science ®Google Scholar
• Boguniewicz M, Sunshine G H, Borel Y. Role of the thymus in natural tolerance to an autologous protein antigen. J Exp Med 1989; 169: 285–290
   PubMed Web of Science ®Google Scholar
• Nievwenhuis P, Stet R JM, Wagenaar J PA, Wubbena A S, Kampinga J, Karrenbeld A. The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier. Immunol Today 1988; 9: 372–376
   PubMedGoogle Scholar
• Braciale T J, Morrison L A, Sweetser M T, Sambrook J, Gething M-J, Braciale V L. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol Rev 1987; 98: 95–114
   PubMed Web of Science ®Google Scholar
• Lafferty K. J, Andrus L, Prowse S J. Role of lymphokine and antigen in the control of specific T cell responses. Immunol Rev 1980; 51: 279–314
   PubMed Web of Science ®Google Scholar
• Brinster R L, Palmiter R D. Introduction of genes into the germ line of animals. Harvey Lect 1986; 80: 1–38
   Web of Science ®Google Scholar
• Palmiter R D, Brinster R L. Germ line transformation of mice. Ann Rev Genet 1986; 20: 465–499
   PubMed Web of Science ®Google Scholar
• Hanahan D. Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 1985; 315: 115–122
   PubMed Web of Science ®Google Scholar
• Adams T E, Alpert S, Hanahan D. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 1987; 325: 223–228
   PubMed Web of Science ®Google Scholar
• Lo D, Burkly L C, Widera G, Cowing C, Flavell R A, Palmiter R D, Brinster R L. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 1988; 53: 159–168
   PubMed Web of Science ®Google Scholar
• Jerne N K. Towards a network theory of the immune system. Ann Immunol Inst Pasteur 1974; 125C: 373–389
   PubMedGoogle Scholar
• Faas S J, Pan S, Pinkert C A, Brinster R L, Knowles B B. Simian virus 40 (SV40) transgenic mice that develop tumors are specifically tolerant to SV40T antigen. J Exp Med 1987; 165: 417–427
   PubMed Web of Science ®Google Scholar
• Frels W I, Bluestone J A, Hodes R J, Capecchi M R, Singer I DS. Expression of a microinjected class I major histocompatibility complex gene in transgenic mice. Science 1985; 228: 577–580
   PubMed Web of Science ®Google Scholar
• Bieberich C, Scangos G, Tanaka K, Jay G. Regulated expression of a murine class I gene in transgenic mice. Mol Cell Biol 1986; 6: 1339–1342
   PubMed Web of Science ®Google Scholar
• Bieberich C, Yoshioka T, Tanaka K, Jay G, Scangos G. Functional expression of a heterologous major histocompatibility complex class I gene in transgenic mice. Mol Cell Biol 1987; 7: 4003–4009
   PubMed Web of Science ®Google Scholar
• Yoshioka T, Bieberich C, Scangos G, Jay G. A transgenic class I antigen is recognized as self and functions as a restriction element. J Immunol 1987; 139: 3861–3867
   PubMed Web of Science ®Google Scholar
• Le Meur M, Gerlinger P, Benoist C, Mathis D. Correcting an immune-response deficiency by creating Eα gene transgenic mice. Nature 1985; 316: 38–42
   PubMed Web of Science ®Google Scholar
• Yamamura K, Kikutani H, Folsom V, Clayton L K, Kimoto M, Akira S, Kashiwamura S, Tonegawa S, Kishimoto T. Functional expression of a microinjected Ed2 gene in C57BL/6 transgenic mice. Nature 1985; 316: 67–69
   PubMed Web of Science ®Google Scholar
• Pinkert C A, Widers G, Cowing C, Heber-Katz E, Palmiter R D, Flavell R A, Brinster R L. Tissue-specific, inducible and functional expression of the Eαd MHC class II gene in transgenic mice. EMBO J 1985; 4: 2225–2230
   PubMed Web of Science ®Google Scholar
• Nishimoto H, Kikutani H, Yamamura K, Kishimoto T. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 1987; 328: 432–434
   PubMed Web of Science ®Google Scholar
• Arnold B, Dill O, Küblbeck G, Jatsch L, Simon M M, Tucker J, Hämmerling G J. Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form. Proc Natn Acad Sci USA 1988; 85: 2269–2273
   PubMed Web of Science ®Google Scholar
• Allison J, Campbell I L, Morahan G, Mandel T E, Harrison L, Miller J FAP. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells. Nature 1988; 333: 529–533
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen D, Peterson P, Rubensten A H, Steiner D F, Lernmark A. Expression of major histocompatibility antigens on pancreatic islet cells. Proc Nat Acad Sci USA 1981; 78: 6456–6460
   PubMed Web of Science ®Google Scholar
• Mandel T E, Allison J, Campbell I C, Koulmanda M, Malcolm L, Miller J FAP. Defective β-cell function in transgenic mice is caused by non-immune damage, Submitted for publication
   Google Scholar
• Sarvetnick N, Liggitt D, Pitts S L, Hansen S E, Stewart T A. Insulin-depedent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 1988; 52: 773–782
   PubMed Web of Science ®Google Scholar
• Harrison L, Campbell I L, Allison J JFAP. Mechanisms of pancreatic β cell destruction—immune and non-immune. Perspectives on the Molecular Biology and Immunology of the Pancreatic β cell. Current Communications in Molecular Biology. Cold Spring Habor Laboratory. 1989; 93–101
   Google Scholar
• Bucchini D, Ripoche M A, Stinnakre M-G, Debois P, Monthioux E, Absil J, Lepesant J-A, Pictet R, Jami J. Pancreatic expression of human insulin gene in transgenic mice. Proc Natl Acad Sci USA 1986; 83: 2511–2515
   PubMed Web of Science ®Google Scholar
• Alpert S, Hanahan D, Tietelman G. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 1988; 53: 295–308
   PubMed Web of Science ®Google Scholar
• Simonsen M, Skjødt K, Crone M, Sanderson A, Fujita-Yamaguchi Y, Due C, Rønne E, Linnet K, Olsson L. Compound receptors in the cell membrane: ruminations from the borderland of immunology and physiology. Progr Allergy 1985; 36: 151–176
   PubMedGoogle Scholar
• Hochman J H, Edidin M. Associations between class I MHC antigens and viral glycoproteins dettected by fluorescence resoannace energy transfer. Major Histocompatibility Genes and their Role in Immune Function, C. S. David. Academic Press. 1988, in press
   Google Scholar
• Morahan G, Allison J, Miller J FAP. Tolerance of class I histocompatibility antigens expressed extra-thymically. Nature 1989; 339, in press
   PubMed Web of Science ®Google Scholar
• Pilarski L M. A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors. J Exp Med 1977; 145: 709–725
   PubMed Web of Science ®Google Scholar
• Golding H, Singer A. Role of accessory cell processing and presentation of shed H-2 alloantigens in allospecific cytotoxic T lymphocyte responses. J Immunol 1984; 133: 597–605
   PubMed Web of Science ®Google Scholar
• Germain R N. The ins and outs of antigen processing and presentation. Nature 1986; 322: 687–689
   PubMed Web of Science ®Google Scholar
• Markmann J, Lo D, Naji A, Palmiter R D, Brinster R L, Heber-Katz E. Antigen presenting function of class II MHC expressing pancreatic beta cells. Nature 1988; 336: 476–479
   PubMed Web of Science ®Google Scholar
• Foulis A K, Liddle C N, Farquharson M A, Richmond J A, Weir R S. The histopathology of the pancreas in type I (insulin-dependent) diabetes mellitus: a 25 year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267–274
   PubMed Web of Science ®Google Scholar
• Foulis A K, Farquharson M A, Hardman R. Aberrant expression of class I major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type I (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 333–343
   PubMed Web of Science ®Google Scholar
• Morahan G, Brennan F, Bhathal P S, Allison J, Cox K O, Miller J FAP. Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter. Proc Nat Acad Sci USA 1989; 86: 3782–3786
   PubMed Web of Science ®Google Scholar
• Bianchi L, De Groote J, Desmit V J, Gedigk P, Korb G, Popper H, Poulsen H, Scheuer P J, Schmid M, Thaler H, Wepler W. Acute and chronic hepatitis revisited. Lancet 1977; 2: 914–919
   PubMed Web of Science ®Google Scholar
• Sprent J, Schaefer M, Gao E K, Korngold R. Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ T cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I-different hosts. J Exp Med 1988; 167: 556–569
   PubMed Web of Science ®Google Scholar
• Mackay I R. Autoimmune diseases of the liver: chronic active hepatitis and primary biliary cirrhosis. The Autoimmune Diseases, N. R. Rose, I. R. Mackay. Academic Press, London 1985; 291–337
   Google Scholar
• Kisielow P, Blüthmann H, Staerz U D, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 1988; 333: 742–746
   PubMed Web of Science ®Google Scholar
• Sha W C, Nelson C A, Newberry R D, Kranz D M, Russell J H, Loh D. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988; 336: 73–76
   PubMed Web of Science ®Google Scholar
• Goodnow C C, Crosbie J, Adelstein S, Lavoie T B, Smith-Gill S J, Brink R A, Pritchard-Briscoe H, Wotherspoon J S, Loblay R H, Raphael K, Trent R J, Basten A. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988; 334: 676–682
   PubMed Web of Science ®Google Scholar
• Nemazee D A, Bürki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989; 337: 562–566
   PubMed Web of Science ®Google Scholar
• Ehrlich P, Morgenroth J. Collected Studies in Immunity. John Wiley, New York 1910
   Google Scholar