Polyclonal B Cell Activation and Antigen-Driven Antibody Response as Mechanisms of Autoantibody Production Insle

References

• Casali P, Notkins A L. Probing the human B cell repertoire with EBV: polyreactive antibodies and CDS+B lymphocytes. Ann Rev Immunol 1989; 7: 513
   PubMed Web of Science ®Google Scholar
• Terninck T, Avrameas S. Murine natural monoclonal auto-antibodies: a study of their polyspecificity and their affinities. Immunol Rev 1986; 94: 99
   PubMed Web of Science ®Google Scholar
• Nakamura M, Burastero S E, Ueki Y, Larrick J W, Notkins A L, Casali P. Probing the normal and autoimmune B cell repertoire with EBV. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and SLE. J. Immunol 1988; 141: 4165
   PubMed Web of Science ®Google Scholar
• Nakamura M, Burastero S E, Notkins A L, Casali P. Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive. J Immunol 1988; 140: 4180
   PubMed Web of Science ®Google Scholar
• Casali P, Burastero S E, Nakamura M, Inghirami G, Notkins A L. Human lymphocytes capable of making rheumatoid factor and antibodies to ssDNA belong to the Leu-1+ cell subset. Science 1987; 236: 77
   PubMed Web of Science ®Google Scholar
• Hardy R R, Hayakawa K, Shimuzu M, Yamasaki K, Kishimoto T. Rheumatoid factor secretion from human Leu-1+ B cells. Science 1987; 236: 81
   PubMed Web of Science ®Google Scholar
• Antin J H, Emerson S G, Martin P, Gadol N, Ault K A. Leu-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: phenotypic and functional studies. J Immunol 1986; 136: 505
   PubMed Web of Science ®Google Scholar
• Hardy R R, Hayakawa K. Normal, autoimmune, and malignant CDS+ B cells: the Ly-l+ B cells. Ann Rev Immunol 1988; 6: 197
   PubMed Web of Science ®Google Scholar
• Izui S, McConhey, Dixon F J. Increased spontaneous polyclonal activation of B lymphocytes in mice with spontaneous autoimmune disease. J Immunol 1978; 121: 2213
   PubMed Web of Science ®Google Scholar
• Hang L, Slack J H, Amudson C, Izui S, Theofilipoulos A N, Dixon F J. Induction of murine autoimmune disease by chronic polyclonal B cell activation. J Exp Med 1983; 157: 874
   PubMed Web of Science ®Google Scholar
• Theofilopolous A N, Dixon F J. Murine models of systemic lupus erythematosus. Adv Immunol 1985; 37: 269
   PubMed Web of Science ®Google Scholar
• Klinman D M, Steinberg A D. Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med 1987; 165: 1755
   PubMed Web of Science ®Google Scholar
• Theofilopoulos A N, Prud'homme G J, Fieser T M, Dixon F J. B cell hyperactivity in lupus. I. Im-munological abnormalities in lupus-prone strains and the activation of normal B cells. Imunol Today 1983; 4: 287
   PubMedGoogle Scholar
• Sakane T, Suzuki N, Takada S, Ueda Y, Murakawa Y, Tsuchida T, Yamauchi Y, Kishimoti T. B cell hyperactivity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus. Arthritis Rhuem 1988; 31: 80
   PubMed Web of Science ®Google Scholar
• Sakane T, Takada S, Suzuki N, Tsuchida Y, Murakawa Y, Ueda Y. Deficiencies in suppressor T cell activity seen in patients with active systemic lupus erythematosus are due to the dilution of normally functioning suppressor T cells by nonsuppressor T cells. J Immunol 1986; 137: 3809
   PubMed Web of Science ®Google Scholar
• Morimoto C, Steinberg A D, Letvin N L, Hagan M, Takeuki T, Daley J, Levine H, Schlossman S F. A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. J Clin Invest 1987; 79: 762
   PubMed Web of Science ®Google Scholar
• Stollar B D. Antibodies to DNA. CRC Crit Rev Biochem 1986; 20: 1
   PubMed Web of Science ®Google Scholar
• Zouali M, Stollar B D, Schwartz R S. Origin and diversification of anti-DNA antibodies. Immunol Rev 1989; 105: 137
   Web of Science ®Google Scholar
• Kofler R, Noonan D J, Levy D E, Wilson M C, Moller N PH, Dixon F J, Theofilopoulos A N. Genetic elements used for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens. J Exp Med 1985; 161: 805
   PubMed Web of Science ®Google Scholar
• Trepicchio W, Jr, Maruya A, Barrett K J. The heavy chain genes of a lupus anti-DNA antibody are encoded in the germ-line of a non-autoimmune strain of mouse and conserved in strains of mice polymorphic in this locus. J Immunol 1987; 139: 3139
   PubMed Web of Science ®Google Scholar
• Der Simonian H, Schwartz R S, Barret K J, Stollar B D. Relationship of human variable region heavy chain (Vh) germline genes to genes encoding anti-DNA autoantibodies. J Immunol 1987; 139: 2496
   PubMed Web of Science ®Google Scholar
• Sanz I, Dang H, Takei M, Talal N, Capra J D. VH sequence of a human anti-Sm autoantibody: evidence that autoantibodies can be unmutated copies of germlines genes. J Immunol 1989; 142: 883
   PubMed Web of Science ®Google Scholar
• Hall G M, Highton J, Kalmakoff J, Palmer D G. Changes in anti-DNA antibody affinity during exacerbation of systemic lupus erythematosus. Scand J Rheumatology 1986; 15: 243
   PubMed Web of Science ®Google Scholar
• Casali P, Burastero S E, Balow J E, Notkins A L. High affinity antibodies to ssDNA are produced by CD5–B lymphocytes in SLE patients. J Immunol 1989, Submitted
   Google Scholar
• Dziarski R. Autoimmunity: polyclonal activation or antigen induction. Immunol Today 1988; 9: 340
   PubMedGoogle Scholar
• Klinman D M, Ishigatsubo Y, Steinberg A D. Acquisition and maturation of expressed B cell repertoires in normal and autoimmune mice. J Immunol 1988; 141: 801
   PubMed Web of Science ®Google Scholar
• Carol P, Stafford D, Schwartz R S, Stollar B D. Murine monoclonal antibodies to DNA bind to endogenous bacteria. J Immunol 1985; 135: 1086
   PubMed Web of Science ®Google Scholar
• Burastero S E, Casali P, Wilder R L, Notkins A L. Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by DC5+B cells in patients with rheumatoid arthritis. J Exp Med 1988; 168: 1989
   Web of Science ®Google Scholar
• Burastero S E, Casali P. Characterization of the human CD5 (Leu-], OKTI)+B lymphocytes and the antibodies they produce. Contr Microb Immunol 1989; 11, in press
   PubMedGoogle Scholar
• Schlomchik M J, Aucoin A H, Pisetsky D S, Weigert M G. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Nail Acad Sci USA 1987; 84: 9150
   PubMed Web of Science ®Google Scholar
• Shlomchik M J, Marshak-Rothstein A, Wolfowicz, Rothstein T L, Weigert M G. The role of clonal selection and somatic point mutation in autoimmunity. Nature 1987; 328: 805
   PubMed Web of Science ®Google Scholar
• Buoanani M, Piechaczyk M, Pau B, Bastide M. Significance of the recognition of certain antigenic regions on the human thyroglobulin molecule by natural autoantibodies from healthy subjects. J Immunol 1989, In press
   Web of Science ®Google Scholar