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Original Article

Eye Muscle Membrane Reactive Antibodies are not Detected in the Serum or Immunoglobulin Fraction of Patients with Thyroid-Associated Ophthalmopathy Using an Elisa and Crude Membranes

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Pages 33-40 | Received 10 Jun 1989, Published online: 07 Jul 2009

References

  • Wall J R, How J, Salvi M, Hiromatsu Y. Can endocrine exophthalmos now be viewed as separate from thyroid autoimmunity. Bailliere's Clin Immunol All 1987; 1: 141–163
  • Kodama K, Sikorska H, Bandy-Dafoe P, Bayly R, Wall J R. Demonstration of a circulating autoanti-body against a soluble eye muscle antigen in Graves' ophthalmopathy. Lancet 1982; ii: 1353–1356
  • Kendall-Taylor P, Atkinson S, Holcombe M. A specific IgG in Graves' ophthalmopathy and its relation to retro-orbital and thyroid autoimmunity. Br Med J 1984; 288: 1183–1186
  • Faryna M, Nauman J, Gardas A. Measurement of autoantibodies against human eye muscle plasma membranes in Graves' ophthalmopathy. Br Med J 1985; 290: 191–192
  • Mengistu M, Laryea E, Miller A, Wall J R. Clinical significance of a new autoantibody against a human eye muscle soluble antigen detected by immunofluorescence. Clin Exp Immunol 1986; 65: 19–27
  • Miller A, Sikorska H, Salvi M, Wall J R. Evaluation of an enzyme-linked immunosorbent assay for the measurement of autoantibodies against eye muscle membrane antigens in Graves' ophthal-mopathy. Acta Endocrinol (Kbh) 1986; 113: 514–522
  • Werner S C. Modification of the classification of the eye changes in Graves' disease: recommendations of an Ad Hoc Committee of the American Thyroid Association. J Clin Endocrinol Metab 1977; 44: 203–204
  • Laemmli U K. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970; 227: 680–684
  • Salvi M, Fukazawa H, Bernard H, Hiromatsu Y, How J, Wall J R. Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders. Endocrine Rev 1988; 9: 450–466
  • Hiromatsu Y, Fukazawa H, How J, Wall J R. Antibody-dependent cell-mediated cytotoxicity against human eye muscle cells and orbital fibroblasts in Graves' ophthalmopathy-roles of Class II MHC antigen expression and γ-interferon action on effector and target cells. Clin Exp Immunol 1987; 70: 597–603
  • Banovac K, Levis S, Frazier-Byrne S. A study of the binding of Graves' immunoglobulins to orbital antigens. J Endocrinol Invest 1988; 11: 483
  • Salvi M, Miller A, Wall J R. Human orbital tissue and thyroid membranes express a 64kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy. FEBS Lett 1988; 232: 135–139
  • Kadlubowski M, Irvine W J, Rowland A C. The lack of specificity of ophthalmic immunoglobulins in Graves' disease. J Clin Endocrinol Metab 1986; 63: 990–995
  • Ahmann A, Baker J R, Jr, Weetman A P, Wartofsky L, Nutman T B, Burman K D. Antibodies to porcine eye muscle in patients with Graves' ophthalmopathy: Identification of serum immuno globulins directed against unique determinants by immunoblotting and enzyme-linked immunosorbent assay. J Clin Endocrinol Metab 1987; 64: 454–460
  • Salvi M., Bingoye F., Chung F, Wall J R. Afinity purification of orbital membrane antigens for the study of the pathogenesis of Graves' ophthalmopathy. J Clin Endocrinol Metab, 66: 939–945

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