Idiotypic Analysis of Human Anti-Topoisomerase I Autoantibodies

References

• Jerne N K. Towards a network theory of the immune system. Ann Immunol (Inst. Pasteur). 1984; 125C: 373–389
   Google Scholar
• Horsfall A C, Isenberg D A. Idiotypes and autoimmunity: a review of their role in human disease. J Autoimmun. 1988; 1: 7–30
   PubMedGoogle Scholar
• Capra J D. Immunoglobulin VH genes in systemic lupus eryhematosus. Current Opinion in Rheumatology. 1989; 1: 343–346
   Google Scholar
• Chen P P, Liu M F, Sinha S, Carson D. A 16/6 idiotype‐positive anti‐DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arth Rheum. 1988; 31: 1429–1431
   PubMed Web of Science ®Google Scholar
• Cairns E, Kwong P C, Misener V, Ip P, Bell D A, Siminovitch K A. Analysis of variable region genes encoding a human anti‐DNA antibody of normal origin: Implications for the molecular basis of human autoimmune responses. J. Immunol. 1989; 143: 685–69
   PubMedGoogle Scholar
• Siminovitch A K, Misener V, Kwong P C, Song Q L, Chen P J. A natural autoantibody is encoded by germline heavy and lamda light chain variable region genes without somatic mutation. J Clin Invest. 1989; 84: 1675–1678
   PubMed Web of Science ®Google Scholar
• Chen P P, Liu M L, Glass C A, Sinha S, Kipps T J, Carson D. Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors. Arth Rheum. 1989; 32: 72–76
   PubMedGoogle Scholar
• Kipps T J, Tomhave E, Chen P P, Fox R I. Molecular characterization of a major autoantibody‐associated cross‐reactive idiotype in Sjögren's syndrome. J Immunol. 1989; 142: 4261–4268
   PubMed Web of Science ®Google Scholar
• Sanz I, Dang H, Takei M, Talal N, Capra J D. VH‐sequence of a human anti‐Sm autoantibody: Evidence that autoantibodies can be unmutated copies of germline genes. J Immunol. 1989; 142: 883–887
   PubMed Web of Science ®Google Scholar
• Davidson A, Preud'homme J L, Solomon A, Chang M Y, Beede S, Diamond B. Idiotypic analysis of myeloma proteins: anti‐DNA activity of monoclonal immunoglobulins bearing an SLE idiotypes is more common in IgG than IgM antibodies. J Immunol. 1987; 138: 1515–1519
   PubMed Web of Science ®Google Scholar
• Davidson A, Smith A, Katz J, Preud'homme J L, Solomon A, Diamond B. A cross‐reactive idiotype on anti‐DNA antibodies defines a H chain determinant present almost exclusively on IgG antibodies. J Immunol., 143: 174–180
   Google Scholar
• Hildebrandt S, Weiner E S, Earnshaw W C, Zanetti M, Rothfield N F. Idiotypic analysis of human anticentromere autoantibodies: further evidence for an autoantigen driven immune response. Autoimmunity.
   Google Scholar
• Zanetti M. Self‐immunity and the autoimmune network. A molecular perspective to ontogeny and regulation of the immune system. Ann Immunol (Inst. Pasteur). 1988; 139: 619–631
   PubMedGoogle Scholar
• Bona C A. Regulatory Idiotypes. John Wiley & Sons, New York 1987; 232
   Google Scholar
• French D L, Laskov R, Scharff M D. The role of somatic hyper‐mutation in the generation of antibody diversity. Science 1989; 244: 1152–1157
   PubMed Web of Science ®Google Scholar
• Behar S M, Scharff M. Somatic diversification of the S107 (TIS) VHII germ‐line gene that encodes the heavy‐chain variable region of antibodies to double‐stranded DNA in (NZB× NZW)FI mice. Proc, Natl Acad Sci USA. 1988; 85: 3970–3974
   PubMed Web of Science ®Google Scholar
• Shlomchik M J, Marshak‐Rothstein A, Wolfowicz C B, Rothstein T L, Weigert M G. The role of clonal selection and somatic mutation in autoimmunity. Nature 1987; 328: 805–811
   PubMed Web of Science ®Google Scholar
• Shlomchik M, Mascelli M, Shan H, Radic M Z, Pisetsky D, Marshak‐Rothstein A, Weigert M. Anti‐DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med. 1990; 171: 265–292
   PubMed Web of Science ®Google Scholar
• Marion T N, Bothwell A L M, Briles D E, Janeway C A, Jr. IgG anti‐DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J Immunol. 1989; 142: 4269–4274
   PubMed Web of Science ®Google Scholar
• Berek C. Molecular dissection of an antigen‐specific immune response. J Autoimmun. 1989; 2: 195–201, (Suppl)
   Google Scholar
• Douvas A S, Achten M, Tan E M. Identification of a nuclear protein (Scl‐70) as a target of human antinuclear antibodies in scleroderma. J Biol Chem. 1979; 254: 10514–10522
   PubMed Web of Science ®Google Scholar
• Moroi Y, Peebles C, Fritzler M J, Steigerwald J, Tan E M. Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl Acad Sci USA. 1980; 77: 1627–1631
   PubMed Web of Science ®Google Scholar
• Tan E M, Rodnan G P, Garcia I, Moroi Y, Fritzler M J, Peebles C. Diversity of antinuclear antibodies in progressive systemic sclerosis: anticentromere antibody and its relationship to CREST syndrome. Arth Rheum. 1980; 23: 617–625
   PubMed Web of Science ®Google Scholar
• Fritzler M J, Kinsella T D. The CREST syndrome: a distinct serologic entity with anticentromere antibodies. Am J Med. 1980; 69: 520–526
   PubMed Web of Science ®Google Scholar
• Weiner E S, Earnshaw W C, Senecal J L, Bordwell B, Johnson P, Rothfield N F. Clinical associations of anticentromere antibodies and antibodies to topoisomerase 1: a study of 355 patients. Arth Rheum. 1988; 31: 378–385
   PubMed Web of Science ®Google Scholar
• Steen V D, Powell D L, Medsger T A. Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arth Rheum. 1988; 31: 196–203
   PubMed Web of Science ®Google Scholar
• Weiner E S, Hildebrandt S, Senecal J L, Daniels L, Noell G S, Earnshaw W C, Rothfield N F. Prognostic significance of anticentromere antibodies and anti‐topoisomerase I antibodies in Raynaud's disease: a prospective study. Arthr Rheum. 1991; 34: 68–77
   PubMedGoogle Scholar
• Shero J H, Bordwell B, Rothfield N F, Earnshaw A C. High titer of autoantibodies to topoisomerase I (Scl‐70) in sera from scleroderma patients. Science 1986; 231: 737–740
   PubMed Web of Science ®Google Scholar
• Maul G G, French B T, Van Venrooij W J, Jimenez S A. Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase. Proc Natl Acad Sci USA. 1986; 83: 5145–5149
   PubMed Web of Science ®Google Scholar
• Guldner H, Szostecki C, Vosberg H, Lakomek H, Penner E H. Scl‐70 autoantibodies from scleroderma patients recognize a 95 kD protein identified as DNA topoisomerase I. Chromosoma. 1986; 94: 132–138
   PubMed Web of Science ®Google Scholar
• Heck M M S, Hittelman W N, Earnshaw W C. Differential expression of DNA topoisomerase I and II during the eucaryotic cell cycle. Proc Natl Acad Sci USA. 1988; 85: 1086–1090
   PubMed Web of Science ®Google Scholar
• Liu L F, Miller K G. Eukaryotic DNA topoisomerase: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc, Natl Acad Sci USA. 1981; 78: 3487–3491
   PubMed Web of Science ®Google Scholar
• Van Venrooij W J, Stapel S O, Houben H, et al. Scl‐86, a marker antigen for diffuse scleroderma. J Clin Invest. 1985; 75: 1053–2060
   PubMedGoogle Scholar
• Schmitt B, Buhre U, Vosberg H P. Characterization of size variants of type I DNA topoisomerase isolated from calf thymus. Eur Biochem. 1984; 144: 127–134
   PubMedGoogle Scholar
• Juarez C, Vila J L, Gelpi C, Agusti M, Amengual M J, Martinez M A, Rodriguez J L. characterization of the antigen reactive with anti‐Scl‐70 antibodies and its application in an enzyme‐linked immunosorbent assay. Arth Rheum. 1988; 31: 108–115
   PubMedGoogle Scholar
• D'Arpa P, Machlin P S, Ratrie H, III, Rothfield N F, Cleveland D W, Earnshaw W C. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7‐kDa carboxyl‐terminal fragment. Proc Natl Acad Sci USA. 1988; 85: 2543–2547
   PubMed Web of Science ®Google Scholar
• D'Arpa P, Cleveland D W, Rothfield N F, Earnshaw W C. Use of molecular cloning methods to map the epitopes on topoisomerase 1 (Scl‐70) recognized by sera from scleroderma patients, Manuscript submitted for publication
   Google Scholar
• Hildebrandt S, Weiner E, Senecal J L, Noell S, Daniels L, Earnshaw W C, Rothfield N F. The IgG, IgM, and IgA isotypes of anti‐topoisomerase I and anticentromere autoantibodies. Arth Rheum. 1990; 33: 724–727
   Google Scholar
• Hildebrandt S, Weiner E S, Senecal J ‐L, Noell St, Earnshaw W C, Rothfield N F. Autoantibodies to topoisomerase I (Scl‐70): Analysis by gel diffusion, immunoblot and enzyme‐linked immunosorbent assay. Clin. Immunol. Immunopathol. 1990; 57: 399–410
   Google Scholar
• Laemmli U D. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature 1970; 227: 681
   Google Scholar
• Herrera‐Esparza R, Provost Th T, Diaz L A. Molecular characterization of RO (SSA) and La (SSB) proteins. J Rheumatol. 1986; 13: 327–330
   PubMedGoogle Scholar
• Bonagura V R, Hatam L, Wedgwood J F. The major 1gM rheumatoid factor cross‐reactive idiotype (RCRI) is expressed in the serum of adult rheumatoid arthritis (RA) patients on 19s and 7s IgM, IgG and IgA. FASEB J. 1989; 3: A 1123
   Google Scholar
• Earnshaw W C, Machlin P, Bordwell B J, Rothfield N F. Analysis of anticentromere autoantibodies using cloned autoantigen CENP‐B. Proc Natl Acad Sci USA. 1987; 84: 1–5
   PubMedGoogle Scholar
• Eisenberg R A, Earnshaw W C, Bordwell B J, Craven S Y, Rothfield N F. Isotype analysis of the anti‐CENP‐B (anticentromere) autoantibody: evidence for restricted clonality. Arth Rheum. 1989; 32: 1315–1318
   PubMedGoogle Scholar