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Original Article

The Functional State of the Beta Cells in the Pathogenesis of Insulin-Dependent Diabetes Mellitus

Pages 65-69 | Received 14 Dec 1990, Accepted 05 Mar 1991, Published online: 07 Jul 2009

References

  • Bottazzo G F, Bosi E, Bonifacio E, Mirakian R, Todd I, Pujol‐Borrell R. Pathogenesis of type 1 (insulin‐dependent) diabetes: possible mechanisms of autoimmune damage. Br Med Bull. 1989; 45: 37–57
  • Assan R, Feutren G, Debray‐Sachs M, Quiniou‐Debrie M C, Laborie C, Thomas G, Chatenoud L, Bach J F. Metabolic and immunological effects of cyclosporin in recently diagnosed type 1 diabetes mellitus. Lancet. 1985; i: 67–71
  • Mordes J P, Desemone J, Rossini A A. The BB rat. Diabetes Metab Rev. 1987; 3: 725–750
  • Leiter E H, Prochazka M, Coleman D L. Animal model of human disease. The non‐obese diabetic (NOD) mouse. Am J Pathol. 1987; 128: 380–383
  • Appels B, Burkart V, Kantwerk‐Funke G, Funda J, Kolb‐Bachofen V, Kolb H. Spontaneous cytotoxicity of macrophages against pancreatic islet cells. J Immunol. 1989; 142: 3803–3808
  • Rothe H, Fehsel K, Kolb H. Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats. Diabetologia. 1990; 33: 573–575
  • Buschard K. The thymus‐dependent immune system in the pathogenesis of type 1 (insulin‐dependent) diabetes mellitus. Animal model and human studies. Dan Med Bull. 1985; 32: 139–151
  • West D B, Seino Y, Woods S C, Porte D, Jr. Ventromedial hypothalamic lesions increase pancreatic sensitivity to streptozotocin in rats. Diabetes. 1980; 29: 948–951
  • D'Andrea B J, Wilson G L, Craighead J E. Effect of genetic obesity in mice on the induction of diabetes by encephalomy‐ocarditis virus. Diabetes. 1981; 30: 451–454
  • Carter W R, Herrman J, Stokes K, Cox D J. Promotion of diabetes onset by stress in the BB rat. Diabetologia. 1987; 30: 674–675
  • Williams A, Lampeter E F, Signore A, Beales P E, Mansfield K, Gale E A M, Ward T, Pozzilli P. Increase in environmental temperature reduces diabetes incidence in the Non‐obese‐diabetic mouse. Diabetologia. 1989; 32: 557A
  • Buschard K, Buch I, Mølsted‐Pedersen L, Hougaard P, Kühl C. Increased incidence of true type 1 diabetes during pregnancy. Brit Med J. 1987; 294: 275–279
  • Rewers M, LaPorte R E, King H, Tuomilehto J. Trends in the prevalence and incidence of diabetes: insulin‐dependent diabetes mellitus in childhood. World Health Stat Q. 1988; 41: 179–189
  • Rewers M, Akerblom H K, Ballard D G, et al. (Diabetes Epider‐miology Research International Group). Geographic patterns of childhood insulin‐dependent diabetes mellitus. Diabetes. 1988; 37: 1113–1119
  • Green A, the EURODIAB Subarea A Study Group. Geographical distribution of childhood Type 1 (insulin‐dependent) diabetes in Europe: the EURODIAB Subarea A Study. Diabetologia. 1990; 33: A17
  • Eizirik D L, Migliorini R H. Reduced diabetogenic effect of streptozotocin in rats previously adapted to a high‐protein, carbohydrate‐free diet. Diabetes. 1984; 33: 383–388
  • Schliack V. Mangelernährung und Diabetesmorbiditat. Untersuchungen an 11,294 Diabetikern. Z klin Med. 1954; 151: 382–396
  • Hau J, Buschard K. Effect of the diabetogenic EMC‐virus on murine fetal and placental growth monitored by quantification of maternal plasma levels of pregnancy‐associated murine pro‐tein‐2 and alfa‐feto‐protein. Acta Path Microbiol Scand, Sect B. 1986; 94: 339–342
  • Szopa T M, Gamble D R, Taylor K W. Biochemical changes induced by Coxsackie B4 virus in short‐term culture of mouse pancreatic islets. Bioscience Reports. 1985; 5: 63–69
  • Hollander P H, Asplin C M, Kniaz D, Hansen J A, Palmer J P. Beta‐cell dysfunction in nondiabetic HLA identical siblings of insulin‐dependent diabetics. Diabetes. 1982; 31: 149–153
  • Schober E, Schernthaner G, Frisch H, Bieber J, Mayr W. Beta cell function in siblings of diabetic children and HLA type. Archives of Disease in Childhood 1983; 58: 923–925
  • Gamble D R. The epidemiology of insulin dependent diabetes. Proceedings of the 10th Congress of the International Diabetes Federation, W K Waldhäusel. 1980; 389–394, Excerpta Medica
  • Cudworth A G, Gamble D R, White G B B, Lendrum R, Woodrow J C, Bloom A. Etiology of juvenile‐onset diabetes. A prospective study. Lancet. 1977; i: 385–388
  • Ryan N T, Blackburn G L, Clowers G HA, Jr. Differential tissue sensitivity to elevated endogenous insulin levels during experimental peritonitis in rats. Metabolism. 1974; 23: 1081–1089
  • Keenan R A, Moldawer L L, Sakamoto A, Blackburn G L, Bistrian B R. Effect of leukocyte endogenous mediator(s) on insulin and substrate profiles in the fasted rat. J Surg Res. 1982; 33: 151–157
  • Møller N, Beckwith R, Butler P C, Christensen N J, Osrskov H, Alberti K G M M. Metabolic and hormonal responses to exogenous hyperthermia in man. Clin Endocrinol. 1989; 30: 651–660
  • Gotfredsen C F, Buschard K, Frandsen E K. Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes‐prone animals. Diabetologia. 1985; 28: 933–935
  • Like A A. Insulin injections prevent diabetes (DB) in Bio‐Breeding/Worcester (BB/Wor) rats. Diabetes. 1986; 35(suppl. 1)74A
  • Atkinson M A, MacLaren N K, Luchetta R. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes. 1990; 39: 933–937
  • Hunt U, Eardley D D. Suppressive effects of insulin and insulin like growth factor 1 (IGF‐I) on immune responses. J Immunol. 1986; 136: 3994–3999
  • Argoud G M, Schade D S, Eaton R P. Insulin suppresses its own secretion in vivo. Diabetes. 1987; 36: 959–962
  • Tivolet C H, Goillot E, Bedossa P. Insulin treatment prevents T cell transfer in the autoimmune NOD mouse. Diabetologia. 1990; 33: A61
  • Vlahos W D, Yale J ‐F. Prevention of Type 1 diabetes in the BB rat by Diazoxide. Clin Invest Med. 1987; 10: B65
  • Shah S C, Malone J I, Simpson N E. A randomized trial of intensive insulin therapy in newly diagnosed insulin‐dependent diabetes mellitus. N Engl J Med. 1989; 320: 550–554
  • Ludvigsson J, Heding L G, Larsson Y, Leander E. C‐peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetes control. Acta Paediatr Scand. 1977; 66: 177–184
  • Buschard K, Brogren C ‐H, Ropke C, Rygaard J. Antigen expression of the pancreatic beta‐cells is dependent on their functional state, as shown by a specific, BB rat monoclonal autoantibody IC2. APMIS. 1988; 96: 342–346
  • Brogren C ‐H, Hirsch F, Wood P, Druet P, Poussier P. Production and characterization of a monoclonal islet cell surface autoantibody from the BB rat. Diabetologia. 1986; 29: 330–333
  • Aaen K, Buschard K, Josefsen K, Petersen H, Horn T, Rygaard J. Antigen expression in beta‐cells, as detected by monoclonal antibodies, is dependent on the functional stale of the cells. Diabetes. 1989; 38(suppl. 2)71A
  • Aaen K, Rygaard J, Josefsen K, Petersen H, Brogren C ‐H, Horn T, Buschard K. Dependence of antigen expression on functional state of beta‐cells. Diabetes. 1990; 39: 697–701
  • Eisenbarth G S, Shimizu K, Bowring M A, Wells S. Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells. Proc Natl Acad Sci USA. 1982; 79: 5066–5070
  • Appel M C, Dotta F, O'Neil J J, Eisenbarth G S. B‐cell activity regulates the expression of islet antigenic determinants. Diahetologia. 1989; 32: 461A
  • Dotta F, Ziegler R, O'Neill J J, Hayak R C, Eisenbarth G S, Appel M C. Islet autoimmunity: Identification and initial characterization of a metabolically regulable pancreatic ganglioside. Diabetologia. 1989; 32: 483A
  • Kämpe O, Andersson A, Björk E, Hallberg A, Karlsson F A. High‐glucose stimulation of 64,000‐M, islet cell autoantigen expression. Diabetes. 1989; 38: 1326–1328
  • Roep B O, Arden S D, de Vries R R P, Hutton J C. T‐cell clones from a type‐I diabetes patient respond to insulin secretory granule proteins. Nature 1990; 345: 632–634
  • Buschard K, Jørgensen M, Aaen K, Bock T, Josefsen K. Prevention of diabetes mellitus in BB rats by neonatal stimulation of beta‐cells. Lancet. 1990; 335: 134–135
  • Bock T, Kjaer T W, Jørgensen M, Josefsen K E, Buschard K. Prevention of diabetes in NOD mice by neonatal glucose treatment. Diabetologia. 1990; 33: A61
  • Warram J H, Krolewski A S, Gottlieb M S, Kahn C R. Differences in risk of insulin‐dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med. 1984; 311: 149–152
  • Buschard K, Kühl C, Mølsted‐Pedersen L, Lund E, Palmer J, Bottazzo G F. Investigation in children who were in utero at onset of insulin‐dependent diabetes in their mothers. Lancet. 1989; i: 811–814
  • Buschard K, Jørgensen M, Kjaer T, Bock T, Aaen K, Josefsen K. Reduction of diabetes incidence in BB rats by neonatal injections of beta‐cell stimulating drugs. Diabetologia. 1990; 33: A189
  • Adam T E, Alpert S, Hanahan D. Non‐tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 1987; 325: 223–228
  • Spinas G A, Palmer J P, Mandrup‐Poulsen T, Andersen H, Nielsen J H, Nerup J. The bimodal effect of interleukin 1 on rat pancreatic beta‐cells‐stimulation followed by inhibition‐depends upon dose, duration of exposure, and ambient glucose concentration. Acta Endocrinol. 1988; 119: 307–311
  • Palmer J P, Helqvist S, Spinas G A, Mølvig J, Mandrup‐Poulsen T, Andersen H U, Nerup J. Interaction of beta‐cell activity and IL‐1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes. 1989; 38: 1211–1216
  • Eizirik D L, Strandell E, Sandler S. Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin. Diaberologia. 1988; 31: 168–174

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