6
Views
4
CrossRef citations to date
0
Altmetric
Original Article

On the Localization of Effector Cells in Cyclosporin-Induced Autoimmunity

, &
Pages 275-283 | Received 25 Mar 1991, Published online: 07 Jul 2009

References

  • Tutschka P J, Beschorner W E, Allison A C, Burns W H, Santos G W. Use of Cyclosporine A in allogeneic bone marrow transplantation in the rat. Nature 1979; 280: 5718–9
  • Bacigalupo A, Maiolino A, Van Lint M T, Occhini D, Gualandi F, Clavio M, et al. Cyclosporin A and chronic graft versus host disease. Bone Marrow Transplant 1990; 6: 341–4
  • Van Graffenried B, Friend D, Shand N, Schiess W, Timonen P. Cyclosporin A (Sandimmun) in autoimmune disorders. Cyclosporin, Mode of action and clinical applications, AW Thomson. Kluwer Academic, London 1989; 213–50
  • Glazier A, Tutschka P J, Farmer E R, Santos G W. Graft-versus-host disease in Cyclosporin A-treated rats after syngeneic and autologous bone marrow transplantation. J Exp Med 1983; 158: 1–8
  • Sorokin R, Kimura H, Schroder K, Wilson D H, Wilson D B. Cyclosporin-induced autoimmunity. Conditions for expressing disease. Requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-tested rats. J Exp Med 1986; 164: 1615–25
  • Bos G MJ, Majoor G D, van Breda Vriesman P JC. Graft-versus-host disease: the need for a new terminology. Immunol Today 1990; 11: 433–6
  • Fischer A C, Hess A D. Age-related factors in Cyciosporin-induced syngeneic graft-versus-host disease: regulatory role of marrow-derived T lymphocytes. J Exp Med 1990; 172: 85–94
  • Cheney R T, Sprent J. Capacity of Cyclosporin to induce auto-graft-versus-host disease and impair intrathymic T cell differentation. Transplant Proc 1985; 17: 528–30
  • Bryson J S, Jennings C D, Caywood B E, Kaplan A M. Induction of a syngeneic graft-versus-host disease-like syndrome in DBA/2 mice. Transplantation 1989; 48: 1042–7
  • Jones R J, Hess A D, Mann R B, Piantadosi S, Vogelsang G B, Farmer E R, Geller R B, Santos G W. Induction of graft-versus-host disease after autologous bone marrow transplantation. Lancet 1989; 1: 754–7
  • Glazier A, Tutschka P J, Farmer E R. Studies on the immunobiology of syngeneic and autologous graft-versus-host disease in Cyclosporine-treated rats. Transplant Proc 1983; 3035–41
  • Wilson D B. Idiotypic regulation of T cells in graft-versus-host disease and autoimmunity. Immunol Rev 1989; 107: 159–77
  • Majoor G D, Wodzig K WH, van Breda Vriesman P JC. Cyclosporin-induced autoimmunity. Thymus Update, MD Kendall, MA Ritter. Chun Harwood Acad Press. 1991; Vol 4: 179–200
  • Bos G MJ, Majoor G D, Van Breda Vriesman P JC. Cyclosporin A induces a selective, reversible suppression of T-helper lymphocyte regeneration after syngeneic bone marrow transplantation: association with syngeneic graft-versus-host disease in rats. Clin Exp Immunol 1988; 74: 443–8
  • Fischer A C, Laulis M K, Horwitz L, Hess A D. Effect of Cyclosporine on T lymphocyte development. Relationship to syngeneic graft-versus-host disease. Transplantation 1991; 51: 252–9
  • Beschorner W E, Hess A D, Shinn C A, Santos G W. Transfer of Cyclosporine-associated syngeneic graft-versus-host disease by thymocytes. Resemblance to chronic graft-versus-host disease. Transplantation 1988; 45: 209–15
  • Bos G MJ, Majoor G D, Willighagen R GJ, van Breda Vriesman P JC. Chronic Cyclosporine-induced autoimmune disease in the rat: a new experimental model for scleroderma. J Invest Dermatol 1989; 93: 610–5
  • Beschorner W E, Tutschka P J, Santos G W. Chronic graft-versus-host disease in the rat radiation chimera. I. Clinical features, hematology, histology, and immunopathology in long-term chimeras. Transplantation 1982; 33: 393–9
  • Bos G, Majoor G, Slaaf D, Reneman R, van Breda Vriesman P. In vivo demonstration of microvascular pathology by intravital microscopy in experimental chronic graft-versus-host disease: analogy with scleroderma. J Rheumatol 1988; 15: 1339–45
  • Beschorner W E, Olson J L, Hess A D, Di Gennaro K A, Santos G W. Cyclosporin-induced cell-mediated injury of the thymic medullary epithelium. Transplantation 1988; 45: 797–803
  • Beschorner W E, Di Gennaro K A, Hess A D, Santos G W. Cyclosporine and the thymus: Influence of irradiation and age on thymic immunopathology and recovery. Cell Immunol 1987; 110: 350–64
  • Sakaguchi S, Sakaguchi N. Thymus and autoimmunity. Transplantation of the thymus from Cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice. J Exp Med 1988; 167: 1479–85
  • Beschorner W E, Namnoum J D, Hess A D, Shinn C A, Santos G W. Cyclosporin A and the thymus. Immunopathology. Am J Pathol 1987; 126: 487–96
  • Jenkins M K, Schwartz R H, Pardoll D M. Effects of Cyclosporine A on T cell development and clonal deletion. Science 1988; 241: 1655–8
  • Gao E-K, Lo D, Cheney R, Kanagawa O, Sprent J. Abnormal differentiation of thymocytes in mice treated with Cyclosporin A. Nature 1988; 336: 176–9
  • Hess A D, Horwitz L, Beschorner W E, Santos G W. Development of graft-versus-host disease-like syndrome in Cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity. J Exp Med 1985; 161: 718–30

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.