Repetitive Exposure of Pancreatic Islets to Interleukin-1β. An In Vitro Model of Pre-diabetes?

References

• Eisenbarth G S. Type 1 diabetes mellitus: a chronic autoimmune disease. N Eng J Med 1986; 314: 1360–1368
   PubMed Web of Science ®Google Scholar
• Junker K, Egeberg J, Kromann H, Nerup J. An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathol Microbiol Scand(Sect A) 1977; 85: 699–706
   PubMedGoogle Scholar
• Foulis A K, Farquharson M A, Hardman R. Aberrant expression of class II major histocompatibility complex molecules by β cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type I (insulin-dependent) diabetes mellitus. Diabetalogia 1987; 30: 333–343
   PubMed Web of Science ®Google Scholar
• Nerup J, Mandrup-Poulsen T, Molvig J, Helqvist S, Wogensen L D, Egeberg J. Mechanisms of pancreatic β-cell destruction in Type I diabetes. Diabetes Care 1988; 11: 16–23, (suppl 1)
   PubMed Web of Science ®Google Scholar
• Blom L, Nyström L, Sandström A, Dahlquist G. Infections and vaccinations as risk determinants for diabetes in childhood. Acta Endocrinol (Copenh) 1990; 122: 6, (Abstract)(suppl 3)
   Google Scholar
• Wogensen L, Reimers J, Heding L, Nerup J. Interleukin-1-beta (IL-1) is diabetogenic in normal rats. Diabetes 1990; 39: 19A, 1990,(suppl 1)(Abstract)
   Google Scholar
• The Canadian-European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 1988; 37: 1574–1582
   PubMed Web of Science ®Google Scholar
• Eizirik D L, Strandell E, Bendtzen K, Sandier S. Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1. Diabetes 1988; 38: 16–19
   Web of Science ®Google Scholar
• Brunstedt J, Nielsen J H, Lernmark Å and the Hagedorn Study Group. Isolation of islets from mice and rats. Methods in Diabetes Research, J Larner, SL Pohl. John Wiley & Sons, New York 1984; Vol 1: 254–258, (Laboratory Methods. Part C.)
   Google Scholar
• Palmer J P, Helqvist S, Spinas G A, Molvig J, Mandrup-Poulsen T, Andersen H U, Nerup J. Interaction of β-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes 1989; 38: 1211–1216
   PubMed Web of Science ®Google Scholar
• Dalboge H, Bayne S, Christensen T, Hejnaes K R. Cloning and expression of an interleukin-1β precursor and its conversion to interleukin-1β. FEBS Letters 1989; 246: 89–93
   PubMed Web of Science ®Google Scholar
• Heding L. Determination of total serum insulin (IRI) in insulin-treated diabetic patients. Diabetologia 1972; 8: 260–266
   PubMed Web of Science ®Google Scholar
• Sandier S, Andersson A, Hellerström C. Inhibitory effects of interleukin-1 on insulin secretion, insulin biosynthesis, and oxidalive metabolism of isolated rat pancreatic islets. Endocrinology 1987; 121: 1424–1431
   PubMed Web of Science ®Google Scholar
• Green I C, Taylor K W. Effects of pregnancy in the rat on the si/.e and the insulin secretory response of the islets of Langerhans. J Endocrinol 1972; 54: 317–325
   PubMed Web of Science ®Google Scholar
• Östenson C G. Regulation of glucagon release: effects of insulin on the pancreatic A2-cell of the guinea pig. Diabetologia 1979; 17: 325–330
   PubMed Web of Science ®Google Scholar
• Rabinovitch A, Pukel C, Baquerizo H. Interleukin-1 inhibits glucose-modulated insulin and glucagon secretion in rat islet monolayer cultures. Endocrinology 1988; 122: 2393–2398
   PubMed Web of Science ®Google Scholar
• Hamaguchi K, Leiter E H. Comparison of eytokine effects on mouse pancreatic α-cell and β-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes 1990; 39: 415–425
   PubMed Web of Science ®Google Scholar
• Ling Z, In't Veld P, Pipeleers D. Interleukin-1β is not cytotoxic for rat pancreatic B cells but suppresses their glucose-inducible functions. Diabetes 1991; 40: 149A, (suppl 1)(Abstract)
   Google Scholar
• Pipeleers D, Van De Winkel M. Pancreatic B cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA 1986; 83: 5267–5271
   PubMed Web of Science ®Google Scholar
• Seemayer T A, Tannenbaum G S, Goldman H, Colle E. Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light-microscopic and ultrastructural observations of pancreatic islets of Langerhans. Am J Pathol 1982; 106: 237–249
   PubMed Web of Science ®Google Scholar
• Ganda O P, Srikanta S, Gleason R E, Soeidner J S, Eisenbarth G S. Diminished A-cell secretion in the early phase of Type 1 diabetes mellitus. Metabolism 1986; 35: 1074–1077
   PubMed Web of Science ®Google Scholar
• Eizirik D L, Bendtzen K, Sandler S. Short exposure of rat pancreatic islets to interleukin-1β induces a sustained but reversible impairment in β-cell function. This effect is influenced by protease activation, gene transcription, and protein synthesis. Endocrinology 1991; 128: 1611–1616
   PubMed Web of Science ®Google Scholar
• Johannesen J, Helqvist S, Nerup J. Not all secretagogues sensitize pancreatic islets to recombinant human interleukin-1β. Acta Endocrinol (Copenh) 1990; 123: 445–452
   PubMedGoogle Scholar
• Khatim M S, Bahr G M, Gumaa K A, Behbehani K. Effect of recombinant IL-1 isomers on fetal and adult islet cell function and replication. Diabetes Research 1988; 8: 25–29
   PubMedGoogle Scholar
• Dinarello C A. Interleukin-1. Rev Infect Dis 1984; 6: 51–95
   PubMedGoogle Scholar
• Scharfmann R, Basmaciogulari A, Czernichow P. Effects of growth hormone on islet cell mitosis using 5-bromo-deoxyuridine, a new reagent for detection of DNA replication. Diabetologia 1989; 32: 538, (Abstract)
   Web of Science ®Google Scholar
• Amiel S A, Sherwin R S, Simonson D S, Lauritano A A, Tamborlane W V. Impaired insulin action in puberty. A contributory factor to poor glycemic control in adolescents with diabetes. N Eng J Med 1986; 315: 215–219
   PubMed Web of Science ®Google Scholar
• Eizirik D L, Sandier S, Hallberg A, Bendtzen K, Sener A, Malaisse W J. Differential sensitivity to β-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1β. Endocrinology 1989; 125: 752–759
   PubMed Web of Science ®Google Scholar
• Ganda O P, Srikanta S, Brink S J, Morris M A, Gleason R E, Soeidner J S, Eisenbarth G S. Differential sensitivity to β-cell secretagogues in “early” type 1 diabetes mellitus. Diabetes 1984; 33: 516–521
   PubMed Web of Science ®Google Scholar
• Tominaga M, Komiya I, Johnson J H, Inman L, Alam T, Moltz J, Crider B, Stefan Y, Baetens D, Mc Corkle K, Orci L, Unger R H. Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationship to islet volume and glucose transporter rate. Proc Natl Acad Sci USA 1986; 83: 9749–9753
   PubMed Web of Science ®Google Scholar