Onset and Regulation of Anti-Lamin b Autoantibody Production is Independent of the Level of Polyclonal Activation

References

• Gerace L, Blobel G. Nuclear lamina and the structural organization of the nuclear envelope. Cold Spring Harbor Svmp Quant Biol 1982; 46: 967–978
   PubMedGoogle Scholar
• Aebi U, Cohn J, Buhle L, Gerace L. The nuclear lamina is a meshwork of intermediate-type filaments. Nature (Land) 1986; 323: 560–564
   PubMed Web of Science ®Google Scholar
• McKeon F D, Kirschner M W, Caput D. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature (Londl 1986; 319: 463–468
   PubMed Web of Science ®Google Scholar
• Fisher D Z, Chaudhary N, Blobel G. cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci USA 1986; 83: 6450–6454
   PubMed Web of Science ®Google Scholar
• Hoger T H, Krohne G, Franke W W. Amino acid sequence and molecular characterization of murine lamin B as deduced from cDNA clones. Eur J Cell Biol 1988; 47: 283–290
   PubMed Web of Science ®Google Scholar
• McKeon F D, Tuffanelli D L, Fukuyama K, Kirschner M W. Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma. Proc Natl Acad Sci USA 1983; 80: 4374–4378
   PubMedGoogle Scholar
• Reeves W H, Chaudhary N, Salerno A, Blobel G. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987; 165: 750–762
   PubMedGoogle Scholar
• Guilly M N, Danon F, Brouet J C, Bornens M, Courvalin J C. Autoantibodies to nuclear lamin B in a patient with thrombocytopenia. Eur J Cell Biol 1987; 43: 266–272
   PubMedGoogle Scholar
• Wesierska-Gadek J, Pcnner E., Hitchman E, Sauerann G. Antibodies to nuclear lamins in autoimmune liver disease. Clin Immunol Immunopathol 1988; 49: 107–115
   PubMedGoogle Scholar
• Lassoued K, Guilly M N, Danon F, et al. Antinuclear antibodies specific for lamins: characterization and clinical significance. Ann Intern Med 1988; 108: 829–833
   PubMedGoogle Scholar
• Tan E M, Cohen A S, Fries J F, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271–1277
   PubMed Web of Science ®Google Scholar
• Beam A G, Kunkel H G., Slater R J. The problem of chronic-liver disease in young women. Am J Med 1956; 21: 3–15
   PubMedGoogle Scholar
• Mackay I R, Taft L I, Cowling D C. Lupoid hepatitis. Lancet 1956; 2: 1323–1326
   Google Scholar
• Tan E M. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes of cell biology. Adv Immunol 1989; 44: 93–151
   PubMed Web of Science ®Google Scholar
• Estes D, Christian C L. The natural history of systemic lupus erythematosus by prospective analysis. Medicine 1971; 50: 85–95
   PubMed Web of Science ®Google Scholar
• Dziarski R. Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysacch-aride: In vitro studies. J Immunol 1982; 128: 1018–1025
   PubMedGoogle Scholar
• Smith H R, Steinberg A D. Autoimmunity: a perspective. Annu Rev Immunol 1983; 1: 175–210
   PubMed Web of Science ®Google Scholar
• Theofilopoulos A N, Dixon F J. Murine models of systemic lupus erythematosus. Adv Immunol 1985; 37: 269–390
   PubMed Web of Science ®Google Scholar
• Klinman D M, Steinberg A D. Systemic autoimmune disease arises from polyconal B cell activation. J Exp Med 1987; 165: 1755–1760
   PubMed Web of Science ®Google Scholar
• Sakane T, Suzuki N, Takada S, et al. B cell hyperactivity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 1988; 31: 80–87
   PubMed Web of Science ®Google Scholar
• Wallace R B, Johnson M J, Hirose T, Miyake T, Kawashima E H, Itakura K. The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucl Acids Res 1981; 9: 879–894
   PubMed Web of Science ®Google Scholar
• Pearson W R, Lipman D J. Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 1988; 85: 2444–2448
   PubMed Web of Science ®Google Scholar
• Maniatis T, Fritsch E F, Sambrook J. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1982
   Google Scholar
• Sanger F. Determination of nucleotide sequences in DNA. Science (Wash DC) 1981; 214: 1205–1210
   PubMed Web of Science ®Google Scholar
• Tabor S, Richardson C C. DNA sequence analysis with a modified T7 DNA polymerase. Proc Natl Acad Sci USA 1987; 84: 4767–4771
   PubMed Web of Science ®Google Scholar
• Dieckmann C L, TzagolofF A. Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b. J Biol Chem 1985; 260: 1513–1520
   PubMedGoogle Scholar
• Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350–4354
   PubMed Web of Science ®Google Scholar
• Reeves W H, Ali S A. Preferential use of lambda light chain in lamin B autoantibodies. J Immunol 1989; 143: 3614–3618
   PubMedGoogle Scholar
• Staufenbiel M, Deppert W. Different structural systems of the nucleus are targets for SV40 large T antigen. Cell 1983; 33: 173–181
   PubMed Web of Science ®Google Scholar
• Reeves W H, Sthoeger Z M, Lahita R G. Role of antigen-selectivity in autoimmune responses to the Ku (p70/p80) antigen. J Clin Invest 1989; 84: 562–567
   PubMedGoogle Scholar
• Giallongo A, Kochoumian L, King T P. Enzyme and radioimmunoassays for specific murine IgE and IgG with different solid phase immunosorbants. J Immunol Melh 1982; 52: 379–393
   PubMed Web of Science ®Google Scholar
• Seaman W E, Plotz P H. Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers. Arthritis Rheum 1976; 19: 155–160
   PubMed Web of Science ®Google Scholar
• Koffler D, Agnello V, Carr R I, Kunkel H G. Anti-DNA antibodies and the renal lesions of patients with systemic lupus erythematosus. Transplant Proc 1969; 1: 933–938
   PubMedGoogle Scholar
• Swaak A JG, Aarden L A, Statius van Eps L W, Feltkamp T EW. Anti-dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus. Arthritis Rheum 1979; 22: 226–235
   PubMed Web of Science ®Google Scholar
• Burke B, Tooze J, Warren G. A monoclonal antibody which recognises each of the nuclear lamin polypeptides in mammalian cells. EMBO J 1983; 3: 361–367
   Google Scholar
• Tan E M. Autoantibodies to nuclear antigens (ANA): their biology and medicine. Adv Immunol 1982; 33: 167–240
   PubMed Web of Science ®Google Scholar
• Earnshaw W C, Machlin P S, Bordwell B J, Rothfield N F, Cleveland D W. Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci USA 1987; 84: 4979–4983
   PubMedGoogle Scholar
• Habets W J, Sillekens P TG, Hoet M H, McAllister G, Lerner M R, van Vcnrooij W J. Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B-cell epitopes. Proc Natl Acad Sci USA 1989; 86: 4674–4678
   PubMedGoogle Scholar
• Chou C H, Reeves W H. Lamin B autoantibodies react with exposed and hidden epitopes. Clin Res 1990; 38: 316A
   Google Scholar
• Gerace L, Blobel G. The nuclear envelope is reversibly depoly-merized during mitosis. Cell 1980; 19: 277–287
   PubMed Web of Science ®Google Scholar
• Chelsky D, Olson J F, Koshland D E. Cell cycle-dependent methyl esterification of lamin B. J Biol Chem 1987; 262: 4303–4309
   PubMedGoogle Scholar
• Beck L A, Hosick T J, Sinensky M. Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei. J Cell Biol 1988; 107: 1307–1316
   PubMed Web of Science ®Google Scholar
• Farnsworth C C, Wolda S L, Gelb M H, Glomset J A. Human lamin B contain as farnesylated cystein residue. J Biol Chem 1989; 264: 20422–20429
   PubMed Web of Science ®Google Scholar
• Mattioli M, Reichlin M. Physical association of two nuclear antigens and mutual occurrence of their antibodies: the relationship of the Sm and RNA protein (Mo) systems in SLE sera. J Immunol 1973; 110: 1318–1324
   PubMed Web of Science ®Google Scholar
• Conner G E, Nelson D, Wisniewolski R, Lahita R G, Blobel G, Kunkel H G. Protein antigens of the RNA-protein complexes detected by anti-Sm and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders. J Exp Med 1982; 156: 1475–1485
   PubMedGoogle Scholar
• McCarty G A, Rice J R, Bembe M L, Pisetsky D S. Indpendent expression of autoantibodies in systemic lupus erythematosus. J Rheumatol 1982; 9: 691–695
   PubMed Web of Science ®Google Scholar
• Fisher D E, Reeves W H, Wisniewolski R, Lahita R G., Chiorazzi N. Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus. Arthritis Rheum 1985; 28: 1348–1355
   PubMed Web of Science ®Google Scholar
• Van Rappard-Van der Veen F M, Kiesel U, Poels L, et al. Further evidence against random polyclonal antibody formation in mice with lupus-like graft-vs-host disease. J Immunol 1984; 132: 1814–1820
   PubMed Web of Science ®Google Scholar
• Schlomchik M J, Marshak-Rothstein A, Wolfowicz C B, Rothstein T L, Weigert M G. The role of clonal selection and somatic mutation in autoimmunity. Nature (Lond) 1987; 328: 805–811
   PubMedGoogle Scholar
• Gharavi A E, Chu J L, Elkon K B. Autoantibodies to intracellular porteins in human systemic lupus erythematosus are not due to random polyclonal B cell activation. Arthritis Rheum 1988; 31: 1337–1345
   PubMedGoogle Scholar
• Eisenberg R A, Craven S Y, Warren R W, Cohen P L. Stochastic control of anti-Sm autoantibodies in MRL/Mp-lpr/ lpr mice. J Clin Invest 1987; 80: 691–697
   PubMed Web of Science ®Google Scholar