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Original Article

Human Monoclonal Thyroglobulin Autoantibodies of High Affinity. II. Interaction Between Thyroglobulin and Thyroglobulin Autoantibodies of Different IgG Subclasses

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Pages 97-105 | Received 10 Sep 1991, Published online: 07 Jul 2009

References

  • Roitt I M, Campbell P N, Doniach D. The nature of the thyroid auto‐antibodies present in patients with Hashimoto's thyroiditis (lymphadenoid goitre). Biochem J, 69: 248–256
  • Shulman S, Witebsky E. Studies on organ specificity. IX. Biophysical and immunochemical studies on human thyroid autoantibody. J Immunol, 85: 559–567
  • Nye L, Pontes De Carvalho I, Roitt I M. Restrictions in the response to autologous thyroglobulin in the human. Clin Exp Immunol 1980; 41: 252–263
  • Parkes A B, McLachlan S M, Bird P, Rees Smith B. The distribution of microsomal and thyroglobulin antibody activity among the IgG subclasses. Clin Exp Immunol 1984; 57: 239–243
  • McLachlan S M, Feldt‐Rasmussen U, Young E T, Middleton S L, Blichcrt‐Toft M, Siersboek Nielsen K, Date J, Carr D, Clark F, Rees Smith B. IgG subclass of thyroid autoantibodies: a “fingerprint” of an individual's response to thyroglobulin and thyroid microsomal antigen. Clin Endocrinol 1987; 26: 335–346
  • Fukuma N, McLachlan S M, Petersen V B, Kau P, Bradbury J, Devey M, Bleasdale K, Grabowski P, Smith Rees. Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin. Immunology 1989; 67: 129–131
  • Fukuma N F, Petersen V B, Pegg C AS, McLachlan S M, Rees Smith B. Monoclonal human thyroglobulin autoantibodies of high affinity. I. Production, characterisation and interaction with a panel of murine monoclonal thyroglobulin antibodies. Autoimmunity 1991, In press
  • Petersen V B, Fukuma N, McLachlan S M, Bradbury J, Beever K, Devey M E, Bleasdale‐Barr K M, Phillips D IM, Baylis P, Ryley H, Rees Smith B. A human‐mouse hybridoma which secretes monoclonal thyroglobulin autoantibody with proper‐tics similar to those of the donor patient's serum autoantibodies. Autoimmunity 1989; 4: 89–102
  • Devey M E, Bleadale‐Barr K M, McLachlan S M, Bradbury J, Clark F, Young E T. Serial studies on the affinity and heterogeneity of human antibodies to thyroglobulin. Clin Exp Immunol 1989; 77: 191–195
  • McLachlan S M, Clark S, Stimson W H, Clark F, Rees Smith B. Studies of thyroglobulin autoantibody synthesis using a micro‐ELISA assay. Immunol Letters 1982; 4: 27–33
  • Beever K, Bradbury J, Phillips D, McLachlan S M, Pegg C, Goral G, Overbeck W, Feitel G, Rees Smith B. Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase. Clin Cliem 1989; 35: 1949–1954
  • Davies D R, Padlan E A. Antibody‐antigen complexes. Ann Rev Biochem 1990; 59: 439–473
  • Fukuma N, Sarsero D, Furmaniak J, Pegg C AS, McLachlan S M, Rees Smith B. B, and T cell epitopes on thyroid peroxidase. Thyroperoxidase and Thyroid Autoimmunity, P Carayon. John Libbey Eurotext Ltd. 1990; 207195–201, and Ruf J. Colloque INSERM
  • Hammarstrom L, Smith C IL. IgG subclasses in bacterial infections. Monogr Allergy 1986; 19: 122–133
  • Morahan G, Berek C, Miller J FA. P. An idiotype determinant formed by both immunoglobulin constant and variable regions. Nature 1983; 301: 720–722
  • Chan C TJ, Byfield P GH, Himsworth R L, Shepherd P. Human autoantibodies to thyroglobulin are directed towards a restricted number of human specific epitopes. Clin Exp Immunol, 70: 516–523
  • Male D K, Champion B R, Pryce G, Matthews H, Shepherd P. Antigenic determinants of human thyroglobulin differentiated using antigen fragments. Immunology 1985; 54: 419–427
  • Jackson D C, Poumboros P, White D O. Simultaneous binding of two monoclonal antibodies to epitopes separated in sequence by only three amino acid residues. Mol Immunol 1988; 25: 465–471
  • Laver W G, Air G, Webster R G, Smith‐Gill S J. Epitopes on protein antigens: misconceptions and realities. Cell 1990; 61: 553–556

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