A Non-Cytotoxic Suppressor Of Immunoglobulin Synthesis And Secretion By B Cells Of Normal Humans And Patients With Rheumatoid Arthritis And Systemic Lupus Erythematosus

References

• Talor E, Richter M. Cells involved in the immune response. XXXV. The antigen‐specific antibody response in the rabbit is suppressed by thymocytes of allogeneic immunized rabbits (ITSC) and by the non‐toxic suppressor factor (ITSF) secreted by these thymocytes. Clin Immunol Immunopath 1988; 48: 150–160
   PubMedGoogle Scholar
• Richter M, Talor E. Cells involved in the immune response. XXXIV. Suppressor cells in the thymus of the immunized rabbit capable of secreting a factor which can suppress the secretion of antibodies from antibody‐forming cells in vitro. Clin Immunol Immunopalhol 1986; 41: 461–478
   PubMedGoogle Scholar
• Talor E, Jodouin C A, Richter M. Cells involved in the immune response. XXXVI. The thymic antigen‐specific suppressor cell in the immunized rabbit is a T cell with receptors for FcG and the antigen and it acts, via a secreted suppressor factor, directly on the immune splenic AFC B cell to inhibit antibody secretion. Immunol 1988; 64: 253–259
   PubMedGoogle Scholar
• Richter M, Jodouin C A. Cells and mediators which participate in immunoglobulin synthesis by human mononuclear cells. I. The obligatory requirement of Null lymphocytes in the synthesis of immunoglobulins in vitro. Cell Immunol 1985; 94: 614–618
   Google Scholar
• Richter M, Taylor S, MacPhail S, Jodouin C A. Cells and mediators which participate in immunological synthesis by human mononuclear cells. II. The mechanism of Null cell participation in immunoglobulin synthesis and secretion by B cells. Clin Exp Immunol 1990; 80: 122–129
   Google Scholar
• Richter M, Ettin G, Sklar S, Richter M A, Hamdy H, Jodouin C A, Kazaniwsky N. Surface receptors and immune activity of purified human circulating mononuclear cells. IV. The demonstration of seven subclasses of T cells in the circulation of the normal individual. The cytotoxic activities of these cells. Cell Immunol 1983; 82: 352–369
   Google Scholar
• Sklar S, Richter M A, Ettin G, Richter M. Surface receptors and immune activity of purified human circulating mononuclear cells. I. The effects of lysis of the SRBC in the T cell rosettes on the receptors and cytotoxic activities of the T cells. T cells with receptors for complement. Immunopharm 1980; 2: 349–359
   Google Scholar
• Richter M. Clinical Immunology, A Physician's Guide. Williams and Wilkins, Publisher. 1982
   Google Scholar
• Moretta U, Webb S R, Grossi C E, Lydyard P M, Cooper M D. Functional analysis of two human T‐cell subpopulations: Help and suppression of B‐cell response by T cells bearing receptors for IgM or IgG. J Exp Med 1977; 146: 184–200
   PubMed Web of Science ®Google Scholar
• Moretta L, Mingari M C, Moretta A, Cooper M D. Human T lymphocyte subpopulations: Studies of the mechanism by which T cells bearing Fc receptors for IgG suppress T‐depen‐dent B cell differentiation induced by pokeweed mitogen. J Immunol 1979; 122: 984–990
   Google Scholar
• Siegel F P, Siegel M. Enhancement by irradiated T cells of human plasma cell production: Dissection of helper and suppressor functions in vitro. J Immunol 1977; 118: 642–647
   Google Scholar
• Keightley R G, Cooper M D, Lawton A R. The T cell depednence of B cell differentiation induced by pokeweed mitogen. J Immunol 1976; 117: 1538–1544
   PubMed Web of Science ®Google Scholar
• Saxon E, Stevens R H, Ashman R F. Regulation of immunoglobulin production in human peripheral blood leukocytes: Cellular interaction. J Immunol 1977; 118: 1872–1879
   Google Scholar
• Misiti J, Waldman T A. In vitro generation of antigen‐specific hemolytic plaque‐forming cells from human peripheral blood mononuclear cells. J Exp Med 1981; 154: 1069–1084
   PubMed Web of Science ®Google Scholar
• Chiorazzi N, Fu S M, Kunkel H G. Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors. J Exp Med 1979; 149: 1543–1548
   PubMedGoogle Scholar
• Insel R A, Merler E. The necessity for T cell help for human tonsil B cell responses to pokeweed mitogen: Induction of DNA synthesis, immunoglobulin, and specific antibody production with a T cell helper factor produced with pokeweed mitogen. J Immunol 1977; 118: 2009–2014
   Google Scholar
• Hirano T, Kuritana T, Kishimoto T, Yamamura Y. In vitro immune response of human peripheral lymphocytes. I. The mechanism(s) involved in T cell helper functions in the pokeweed mitogen‐induced differentiation and proliferation of B cells. J Immunol 1977; 119: 1235–1241
   Google Scholar
• Heijnen C J, Uytdehaag F, Pot K H, Ballieux R E. Antigen‐specific human T cell factors. I. T cell helper factor: Biological properties. J Immunol 1981; 126: 497–502
   Google Scholar
• Uytdehaag F, Heijnen C J, Pot K H, Ballieux R E. Antigen‐specific human T cell factors. II. T cell suppressor factor;Biological properties. J Immunol 1981; 126: 503–507
   Google Scholar
• Tada T, Okamura K O. The role of antigen‐specific T cell factors in the immune response. Adv Immunol 1979; 28: 1–87
   PubMedGoogle Scholar
• Hay ward A R, Lay ward L, Lydyard P M, Moretta L, Dagg M, Lawton A R. Fc‐receptor heterogeneity of human suppressor T cells. J Immunol 1978; 121: 1–5
   Google Scholar
• Jones M. B cell activation by pokeweed mitogen in cultures of normal peripheral blood monocytes depleted of T regulator subsets by treatment with OKT4 and OKT8 monoclonal antibodies. Clin Exp Immunol 1983; 51: 461–469
   PubMedGoogle Scholar
• Thomas Y, Rogozinski L, Irogoyen D H, Friedman S M, Kung P C, Goldstein G, Chess L. Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population. J Exp Med 1981; 154: 459–467
   PubMed Web of Science ®Google Scholar
• Damle N K, Gupta S. Heterogeneity of concanavalin‐A induced suppressor T cells in a man defined with monoclonal antibodies. Clin Exp Immunol 1982; 48: 581–588
   Google Scholar
• Yachie A, Miyawaki T, Nagaoki T, Yokoi T, Mukai M, Vwadana N, Taniguchi N. Regulation of B cell differentiation by T cell subsets defined with monoclonal OKT4 and OKT8 antibodies in human cord blood. J Immunol 1981; 127: 1314–1317
   PubMed Web of Science ®Google Scholar
• Gershon R K, Kondo K. Infectious immunological tolerance. Immunol 1971; 21: 903–914
   PubMed Web of Science ®Google Scholar
• Talor E, Richter M. Suppressor cells in the regulation of humoral immunity in humans. Clin Immunol Newsletter 1987; 8: 161–164
   Google Scholar
• Talor E, Richter M. Suppressor factors of non‐T‐cell origin in the regulation of the humoral immune response in humans. Clin Immunol Newsletter 1988; 9: 6–9
   Google Scholar
• Talor E, Richter M. T‐cell derived suppressor factors in the regulation of humoral immunity. Clin Immunol Newsletter 1988; 9: 60–64
   Google Scholar
• Talor E, Richter M. Suppressor cells and suppressor factors in the regulation of humoral immunity. Contemporary Clinical Immunology, M R Escabar. Plenum Press, in press
   Google Scholar
• Aune T M. Role and function of antigen non‐specific suppressor factors. CRC Critical Review in Immunol 1987; 7: 93–130
   Google Scholar
• Paraskevas F. Pathways of T cell suppression. CRC Critical Reviews in Immunol 1984; 5: 95–148
   Google Scholar
• Keller R H, Calvanico N J. Suppressor macromolecules. CRC Critical Reviews in Immunol 1984; 5: 149–199
   Google Scholar
• Dorf M E, Benacerraf B. Suppressor cells and immunoregu‐lation. Annu Rev Immunol 1984; 2: 127–158
   PubMed Web of Science ®Google Scholar
• Warrington R J, Sauder P J, Olivier S L, Rutherford W J, Wiokins J A. A human T cell‐derived soluble factor able to suppress pokeweed mitogen‐induced immunoglobulin production. J Immunol 1983; 130: 237–241
   Google Scholar
• Fleisher T A, Greene W C, Blaese R M, Waldman T A. Soluble suppressor supernatants elaborated by concanavalin‐A‐acti‐vated human mononuclear cells. II. Characterization of a soluble suppressor of B cell immunoglobulin production. J Immunol 1981; 126: 1192–1197
   PubMed Web of Science ®Google Scholar
• Lau C Y, Wong E Y, Budz‐Tymkewycz S, Visconti V, Ishaque A. Mechanism of action of a suppressor‐activating factor (SAF) produced by a human T cell line. J Immunol 1985; 134: 3155–3162
   PubMed Web of Science ®Google Scholar
• Mortari F, Singhal S K. Production of human bone marrow‐derived suppressor factor. Effect on antibody synthesis and lectin‐activated cell proliferation. J Immunol 1988; 141: 3037–3042
   Google Scholar