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Original Article

Antibodies in the Serum of Patients with Autoimmune Thyroid Disorders React with a Recombinant 98 Amino Acid Fragment of a Full Length 64 KDA Eye Muscle Membrane Protein which is also Expressed in the Thyroid

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Pages 151-157 | Received 04 Feb 1992, Published online: 07 Jul 2009

References

  • Wall J R. Autoimmunity and Graves' ophthalmopathy. The Eye and Orbit in Thyroid Disease, C Gorman, R Waller, J Dyer. Raven Press, NY 1984; 103–114
  • Wall J R, Salvi M, Bernard N. Eye disease and autoimmune thyroid disorders: mechanisms for the association. Pathogenesis and Management of Graves' Ophthalmopathy. Contemporary issues in Endocrinol. and Metab, J R Wall, J How. Blackwell Scientific Pubs. Inc. 1989; 1: 63–77
  • Weetman A P, Cohen S, Gatter K, Fells P, Shine B. Immuno-histochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy. Clin Exp Immunol 1989; 75: 222–227
  • Ahmann A, Baker J R, Weetman A P, Wartofski L, Nauman T B, Burman K D. Antibodies to porcine eye muscle in patients with Graves' ophthalmopathy. Identification of serum immunoglobulins directed against unique determinants by immunoblotting and enzyme-linked immunosorbent assay. J Clin Endocrinol Metab 1987; 64: 454–460
  • Faryna M, Nauman T, Gardas A. Measurement of autoantibodies against human eye muscle plasma membranes in Graves' ophthalmopathy. Br Med J 1985; 290: 454–460
  • Bahn R S, Gorman C A, Woloschak G E, David C S, Johnson P M, Johnson C M. Human fibroblasts in vitro: A model for the study of Graves' ophthalmopathy. J Clin Endocrinol Metab 1987; 65: 665–670
  • Jacobson D H, Gorman C A. Endocrine ophthalmopathy: current ideas concerning etiology, pathogenesis and treatment. Endocr Rev 1984; 5: 200–220
  • Kodama K, Sikorska H, Bandy-Dafoe P, Bayly R, Wall J R. Demonstration of circulating autoantibody against a soluble eye muscle antigen in Graves' ophthalmopathy. Lancet 1982; 2: 1353–1356
  • Kendall-Taylor P, Atkinson S, Halcombe M. A specific IgG in Graves' ophthalmopathy and its relation to retro-orbital and thyroid autoimmumity. Brit Med J 1989; 288: 1183–1186
  • Salvi Miller M. A, Wall J R. Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in serum of patients with thyroid-associated ophthalmopathy. FEBS Lett 1989; 232: 135–139
  • Mengistu M, Laryea E A, Miller A, Wall J R. Clinical significance of a new autoantibody against a human eye muscle soluble antigen detected by immunofluorescence. Clin Exp Immunol 1986; 65: 19–27
  • Wang P W, Hiromatsu Y, Laryea E A, How J R. Immunologically mediated cytotoxicity against human eye muscle cells in Graves' ophthalmopathy. J Clin Endocrinol Metαb 1986; 63: 316–320
  • Hiromatsu Y, Fukazawa H, How J, Wall J R. Antibody-dependent cell-mediated cytotoxicity against human eye muscle cells and orbital fibroblasts in Graves' ophthalmopathy—roles of Class II MHC antigen expression and interferon-γ action on effector and target cells. Clin Exp Immunol 1987; 70: 593–603
  • Hiromatsu Y, How J, Fukazawa H, Guinard Salvi F. M, How J, Wall J R. A thyroid cytotoxic antibody that cross-reacts with an eye muscle cell surface antigen may be the cause of thyroid-associated ophthalmopathy. J Clin Endocrinol Metαb 1988; 67: 565–570
  • Hiromastu Y, Cadarso L, Salvi M, Wall J R. Significance of cytotoxic eye muscle antibodies in patients with thyroid-associated ophthalmopathy. Autoimmunity 1990; 5: 205–213
  • Hiromatsu Y, Wang P W, Wosu L, How J, Wall J R. Mechanisms of immune damage in Graves' ophthalmopathy. Hor Res 1987; 26: 198–207
  • Salvi M, Bernard N, Miller A, Zhang Z-G, Gardini A, Wall J R. Prevalence of antibodies reactive with a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Thyroid 1991; 1: 207–213
  • Elisei R, Dong Q, Weightman D, Ludgate M. Cloning and sequencing of candidate eye muscle antigens in Graves' ophthalmopathy. Proc. 10th International Thyroid Congress, The HagueNetherlands, Feb., 1991, 166, [Abstract]
  • Dong Q, Ludgate M, Vassart G. Novel 64 kDa autoantigen recognized by patients with autoimmune thyroid disease. J Clin Endocrinol Metab 1991; 72: 1375–1381
  • Laemmli U K. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970; 227: 680–684
  • Miller A, Arthurs B, Boucher A, Liberman A, Bernard N, Salvi M, Wall J R. Significance of antibodies reactive with a 64 kDa eye muscle membrane antigen in patients with thyroid-associated ophthalmopathy. Thyroid, (in press)
  • McLean J M, Norton E WD. Unilateral lid retraction without exophthalmos. Arch Ophthalmol 1959; 61: 681–686
  • Feldon S E, Levin L. Graves' ophthalmopathy: V. Aetiology of upper eyelid retraction in Graves' ophthalmopathy. Brit J Ophthal 1990; 74: 484–485
  • Zhang Z-G, Salvi M, Miller A, Bernard N, Arthurs B, Wall J R. Restricted tissue reactivity of autoantibodies to a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Clin Immunol Immunopath, (in press)
  • Boucher A, Zhang Z-G, Bernard N, Salvi M, Wall J R. Immuno-precipitation of eye muscle cell membrane antigens and two dimension gel electrophoresis confirm the importance of a 64 kDa eye muscle antigen in Thyroid-Associated Ophthalmopathy. Proc 10th International Thyroid Congress, The HagueNetherlands, Feb, 1991, 17, [Abstract]
  • Wall J R, Salvi M, Bernard N F, Boucher A, Haegert D. Thyroid-associated ophthalmopathy—a model for the association of organ-specific autoimmune disorders. Immunology Today 1991; 12: 150–153

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