FUNDAMENTAL AND CLINICAL ASPECTS OF ANTI NEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA)

References

• Donald K J, Edwards R L, McEvoy J DS. An ultrastructural study of the pathogenesis of tissue injury in limited Wegener's granulomatosis. Pathology 1976; 8: 161
   PubMed Web of Science ®Google Scholar
• Dale D C, Fauci A S, Wolff S M. The effect of cyclophosphamide on leucocyte kinetics and susceptibility to infection in patients with Wegener's granulomatosis. Arthritis Rheum 1973; 16: 657
   PubMedGoogle Scholar
• Davies D J, Moran J E, Niall J F, Ryan G B. Segmental necrotizing glomerulonephritis with antineutrophil antibodies: possible arbovirus aetiology?. Br Med J 1982; 285: 606
   PubMed Web of Science ®Google Scholar
• Hall J B, Waldham B M, Wood C J, Ashton V, Adam W R. Vasculitis and glomerulonephritis: a subgroup with an antineutrophil cytoplasmic antibody. Aust NZ J Med 1884; 14: 177
   Google Scholar
• Van der Woude F J, Rasmussen N, Lobatto S, et al. Autoantibodies to neutrophils and monocytes: a new tool for diagnosis and a marker for disease activity in Wegener's granulomatosis. Lancet 1985; i: 425–429
   Google Scholar
• Wilk A, Van der Woude F J. The new ACPA/ANCA nomenclature. Neth J Med 1990; 36: 107–108
   PubMed Web of Science ®Google Scholar
• Faber V, Elling P, Norup G, Mansa B, Nissen N J. An antinu‐clear factor specific for leucocytes. Lancet 1964; ii: 344–345
   Google Scholar
• Wiik A, Jensen E, Friis J. Granulocyte specific antinuclear factors in synovial fluids and sera from patients with rheumatoid arthritis. Ann Rheum Dis 1974; 33: 515
   PubMed Web of Science ®Google Scholar
• Falk R J, Jennette J C. Anti‐neutrophil cytoplasmic antibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651–1657
   PubMed Web of Science ®Google Scholar
• Jayne D RW, Jones S J, Severn A, Shaunak S, Murphy J, Lock‐wood C M. Severe pulmonary hemorrhage and systemic vasculitis in association with circulating anti‐neutrophil cytoplasmic antibodies of IgM class only. Clin Nephrol 1989; 32: 101–106
   PubMed Web of Science ®Google Scholar
• Van den Wall Bake A WL, Lobatto S, Jonges L, Daha M R, Van Es L A. IgA antibodies directed against cytoplasmic antigens of polymorphonuclear leucocytes in patients with Henoch‐Schonlein purpura. Recent Advances in Mucosal Immunity:, J Mestecky, et al. Plenum, London 1987; 1593, Part B
   Google Scholar
• Nässberger L, Geborek P. IgM.‐ANCA in a patient with systemic vasculitis without pulmonary involvement. Clin Nephrol 1990; 34: 6
   Web of Science ®Google Scholar
• Daha M R, Falk R J. Ig‐class specificity of ANCA. Neth J Med 1990; 36: 126–127
   PubMed Web of Science ®Google Scholar
• Brouwer E, Cohen Tervaert J WC, Horst G, Huitema M G, Van der Giessen M, Limburg P C, Kallenberg C GM. Predominance of IgGl and IiG4 subclasses of anti‐neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders. Clin Exp Immunol 1991; 83: 379–386
   PubMed Web of Science ®Google Scholar
• Jayne D RW, Lockwood C M. The isotype distribution of ANCA in systemic vasculitis. APMIS 1990; 98(suppl 19)45
   Google Scholar
• Rossi F, Jayne D RW, Lockwood C M, Kazatchkine M D. Antiidiotypes against anti‐neutrophil cytoplasmic antigen autoantibodies in normal human polyspecific IgG for therapeutic use and in remission sera of patients with systemic vasculitis. Clin Exp Immunol 1991; 83: 298–303
   PubMed Web of Science ®Google Scholar
• Rasmussen N, Petersen J, Ralfkiaer E, Wilk A. Spontaneous and induced immunoglobulin synthesis and anti‐neutrophil cytoplasmic antibodies in Wegener's granulomatosis: relation to leucocyte subpopulation in blood and active lesions. Rheumatol Int 1988; 8: 153–158
   PubMed Web of Science ®Google Scholar
• Baltaro R J, Hoffman G S, Sechler J MG, Suffredini A F, Shel‐hamer J H, Fauci A S, Fleisher T A. Immunoglobulin G antineutrophil cytoplasmic antibodies are produced in the respiratory tract of patients with Wegener's granulomatosis. Am Rev RespirDis 1991; 143: 275–278
   PubMedGoogle Scholar
• Lockwood C M, Bakes D, Jones S, Whitaker K B, Moss D W, Savage C OS. Association of alkaline phosphatase with an autoantigen recognized by circulating anti‐neutrophil antibodies in systemic vasculitis. Lancet 1987; i: 716
   Google Scholar
• Rasmussen N, Borregaard N, Wilk A. Anti‐neutrophil‐cyto‐plasmic antibodies in Wegener's Granulomatosis are not directed against alkaline phosphatase. Lancet 1987; i: 1488
   Google Scholar
• Borregaard N, Heipe J M, Simons E R, Clark R A. Subcellular localization of the b‐cytochrome during activation. J Cell Biol 1983; 97: 52
   PubMed Web of Science ®Google Scholar
• Borregaard N, Rasmussen N. Constitutents of the human neutrophil cytoplasm: methods for examination and methodological problems with special reference to the binding site of the anti‐neutrophil cytoplasmic antibodies. APMIS 1989; 97(suppl.6)10
   Google Scholar
• Proceedings of the First International Workshop on ANCA, 1988. APMIS, 1989; 97, (supplement no. 6)
   Google Scholar
• Goldschmeding R, van der Schoot C E, ten Bokkel Huinink D, et al. Wegener's granulomatosis autoantibodies identify a novel isopropylfluorophosphate‐binding protein in the lysosomes of normal human neutrophils. J Clin Invest 1989; 84: 1577–1587
   PubMed Web of Science ®Google Scholar
• Niles J L, McClusky R T, Ahmed M F, et al. Wegener's granulomatosis autoantigen is a novel neutrophil serine protease. Blood 1989; 74: 1888–1893
   PubMed Web of Science ®Google Scholar
• Lüdemann J, Utecht B, Gross W L. Detection and quantification of anti‐neutrophil cytoplasmic antibodies in Wegener's granulomatosis by ELISA using affinity‐purified antigen. J lmm Meth 1988; 114: 167–174
   PubMed Web of Science ®Google Scholar
• Liidemann J, Utrecht B, Gross W L. Anti‐neutrophil cytoplasmic antibodies in Wegener's granulomatosis recognize an elas‐tinolytic enzyme. J Exp Med 1990; 171: 357–362
   PubMed Web of Science ®Google Scholar
• Kao R C, Wehner N G, Skubitz K M, et al. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J Clin Invest 1988; 82: 1963–1973
   PubMed Web of Science ®Google Scholar
• Jenne D E, Tschopp J, Lüdemann J, et al. Wegener's autoantigen decoded. Nature 1990; 346: 520
   PubMed Web of Science ®Google Scholar
• Wilde C G, Snable J L, Griffith J E, Scott R W. Characterization of two azurophil granule proteases with active‐site homology to neutrophil elastase. J Biol. Chem 1990; 265: 2038–2041
   PubMed Web of Science ®Google Scholar
• Bories D, Raynal M C, Solomon D H, et al. Down‐regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell 1989; 59: 959–968
   PubMed Web of Science ®Google Scholar
• Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay J. Cloning of cDNA for proteinase‐3: a serine protease, antibiotic, and autoantigen from human neutrophils. J Exp Med 1990; 172: 1709–1715
   PubMed Web of Science ®Google Scholar
• Daha M R, Leusen J, Kramps J A, et al. Isolation from purulent sputum of an antigen reactive with antibodies in serum of patients with Wegener's granulomatosis. Neth J Med 1990; 36: 117–120
   PubMed Web of Science ®Google Scholar
• Van der Woude F J, Daha M R, Van Es L A. The current status of neutrophil cytoplasmic antibodies. Clin Exp Immunol 1989; 78: 143–148
   PubMed Web of Science ®Google Scholar
• Van der Wiel B, Dolman K M, Goldschmeding R, et al. al‐anti‐tripsin is the major inhibitor of the 29 kD c‐ANCA antigen. Proceedings of 3rd Workshop on ANCA. Washington, DC 1990
   Google Scholar
• Falk R J, Becker M, Terrell R, Jennette J C. Antigen specificity of P.‐ANCA and of C.‐ANCA. Proceedings of 3rd International ANCA Workshop. Washington, DC 1990
   Google Scholar
• Burkholder L, Bainton D F. Auto‐antigens in Wegener's granulomatosis. Blood 1990; 75: 1588
   PubMedGoogle Scholar
• Wiik A. Granulocyte‐specific antinuclear antibodies. Possible significance for the pathogenesis, clinical features and diagnosis of rheumatoid arthritis. Allergy 1980; 35: 263–289
   PubMed Web of Science ®Google Scholar
• Goldschmeding R, Tervaert Cohen JW, Gans R OB, Dolman K M, et al. Different immunological specificities and disease associations of c‐ANCA and p‐ANCA. Neth J Med 1990; 36: 114–116
   PubMed Web of Science ®Google Scholar
• Cohen Tervaert J W, Huitema M G, Dolman K D, Goldschmeding R, The T H, Kallenberg C GM. The clinical significance of autoantibodies to human leukocyte elastase. Antineutrophil Cytoplasmic Antib: a new class of autoantibodies in vasculitis and glomerulonephritis, Cohen JW Tervaert. Thesis, Universi‐teitsdrukkerij Groningen
   Google Scholar
• Savage C OS, Winnearls C G, Jones S, Marshall P D, Lockwood C M. Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet 1987; i: 1389–1393
   Google Scholar
• Savige J A, Yeung S P, Gallicchio M, Davies D J. Two ELISA's to detect anti‐neutrophil cytoplasm antibodies (ANCA) in various vasculitides. Pathology 1989; 21: 282–287
   PubMed Web of Science ®Google Scholar
• Nölle B, Specks U, Liidemann J, Rohrbach M S, DeRemee R A, Gross W L. Anticytoplasmic antibodies: their immunodiagnos‐tic value in Wegener Granulomatosis. Annals of Int Med 1989; 111: 28–40
   PubMed Web of Science ®Google Scholar
• Rasmussen N, Sjolin C, Isaksson B, Bygren P, Wieslander J. An ELISA for the detection of anti‐neutrophil cytoplasm antibodies (ANCA). J lmm Meth 1990; 127: 139–145
   PubMed Web of Science ®Google Scholar
• Halma C, Daha M R, Schrama E, Hermans J, Van Es L A, Van der Woude F J. Value of anti‐neutrophil cytoplasmic antibodies and other laboratory parameters in follow‐up of vasculitis. Scand J Rheumatol
   Google Scholar
• Tervaert Cohen JW, Goldschmeding R, Elema J D, Van der Giessen M, Huitema M G, Van der Hem G K, The T H, Von dem Borne A EGK, Kallenberg C GM. Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis. Kidney Int 1990; 37: 799–806
   PubMed Web of Science ®Google Scholar
• Kallenberg C GM, Rasmussen N. Solid phase assays for ANCA. Neth.I Med 1990; 36: 132–136
   PubMed Web of Science ®Google Scholar
• Van der Woud Daha MR, Van der Wall Bake A WL, Van Es L A. Anticorps diriges contre le cytoplasme des polynucleaires neutrophiles et des monocytes. Actualites Nephrologiques. Flammarion Médicine‐Sciences, Paris, 183
   Google Scholar
• Mohammed J R, Mohammed B S, Pawluk L J, Bucci D M, Baker N R, Davis W B. Purification and cytotoxic potential of myeloperoxidase in cystic fibrosis sputum. J Lab Clin Med 1988; 112: 711–20
   PubMed Web of Science ®Google Scholar
• Daha M R, Rasmussen N. Presentation of solid phase asays from several laboratories. Neth J Med 1990; 36: 137–142
   PubMed Web of Science ®Google Scholar
• Godman G C, Churg J. Wegener's granulomatosis. Pathology and review of the literature. Arch Pathol 1954; 58: 533–553
   PubMedGoogle Scholar
• Fauci A S, Haynes B F, Katz, Wolff S M. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 1983; 98: 76–85
   PubMed Web of Science ®Google Scholar
• Tervaert Cohen JW, Van der Woude F J, Fauci A S, et al. Association between active Wegener's granulomatosis and anticytoplasmic antibodies. Arch Int Med 1989; 149: 2461–2465
   PubMed Web of Science ®Google Scholar
• Harrison D J, Simpson R, Kharbanda R, Abernethy V E, Nimmo G. Antibodies to neutrophil cytoplasmic antigens in Wegener's granulomatosis and other conditions. Thorax 1989; 44: 373–377
   PubMed Web of Science ®Google Scholar
• Jennette J C, Wilkman A S, Falk R J. Anti‐neutrophil cytoplasmic antibody‐associated glomerulonephritis and vasculitis. Am J Pathol 1989; 135: 921–30
   PubMed Web of Science ®Google Scholar
• Tervaert Cohen JW, Huitema M G, Hene R J, et al. Relapses of Wegener's granulomatosis: prevention by treatment based on antineutrophil cytoplasmic antibody levels. Lancet 1990; 336: 709–711
   PubMed Web of Science ®Google Scholar
• Jennette J C, Falk R J. Antineutrophil cytoplasmic antibodies and associated diseases: a review. Am J Kidney Diseases 1990; 15: 517–529
   PubMed Web of Science ®Google Scholar
• Nässberger L, Johansson A C, Björck S, Sloholm A G. Antibodies to neutrophil granulocyte myeloperoxidase and elastase: autoimmune responses in gromerulonephritis due to hydralazine treatment. J. Int Med 1991; 229: 261–265
   PubMed Web of Science ®Google Scholar
• Finnegan M J, Hinchcliffe J, Russel‐Jones D, Neill S, Sheffield E, Jayne D, Wise A, Hodson M E. Vasculitis complicating cystic fibrosis. Q. J. Med 1989; 72: 609–621
   PubMedGoogle Scholar
• Efthimion J, Spicket G, Lane D. Antineutrophil cytoplasmic antibodies, cystic fibrosis and infection. Lancet 1991; 337: 1037–1038
   Web of Science ®Google Scholar
• Shanahan F, Duerr R, Landers C, et al. Evidence for ANCA as a marker of genetic susceptibility in ulcerative colitis. Proceedings of 3rd International ANCA.‐Workshop. Washington, DC 1990
   Google Scholar
• Cambridge G, Rampton D, Leaker B. Anti‐neutrophil antibodies in sera from patients with inflammatory bowel disease. Proceedings of 3rd International ANCA.‐Workshop. Washington, DC 1990
   Google Scholar
• Rump J A, Scholmerich J, Roth M, et al. A new type of p‐ANCA in active ulcerative colitis. Proceedings of 3rd International ANCA.‐Workshop. Washington, DC 1990; 33a
   Google Scholar
• Saxon A, Shanahan F, Landers C, Ganz T, Targar S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy in Clin Immunol 1990; 86: 202–210
   PubMed Web of Science ®Google Scholar
• Fauci A S. The spectrum of vasculitis. Ann Intern Med 1978; 89: 660–676
   PubMed Web of Science ®Google Scholar
• Ronco P, Verroust P, Mignon F, Morel Maroger L. Immuno‐pathological studies of polyarteritis and Wegener's granulomatosis: a report of 34 patients with 51 biopsies. Q J Med 1983; 206: 212
   Google Scholar
• Pinching A J, Rees A J, Pussell B A, et al. Relapses in Wegener's granulomatosis: the role of infections. Br Med J 1980; 281: 836–838
   PubMed Web of Science ®Google Scholar
• Falk R J, Hogan S, Carey T S, Jennette C. Clinical course of anti‐neutrophil cytoplasmic autoantibodies‐associated glomerulonephritis and systemic vasculitis. Ann Int Med 1990; 113: 656–663
   PubMed Web of Science ®Google Scholar
• DeRemee R A. The treatment of Wegener's granulomatosis with trimethoprim/sulfametoxazol: illusion or vision?. Arthritis Rheumatism 1988; 31: 1068–1072
   PubMed Web of Science ®Google Scholar
• DeRemee R A, McDonald T J, Weiland L H. Wegener's granulomatosis: observation on treatment with antimicrobial agents. MayClinProc 1985; 60: 27
   Google Scholar
• Israel H L. Sulfamethoxazole‐trimethoprim therapy for Wegener's granulomatosis. Arch Intern Med 1988; 148: 2293
   PubMedGoogle Scholar
• Roberts D E, Curp J G. Sulfonamides as antiinflammatory agents in the treatment of Wegener's granulomatosis. Arthritis Rheumatism 1990; 33: 1590–1593
   PubMedGoogle Scholar
• Van der Woude F J, Van Es L A, Daha M R. The role of the c‐ANCA antigen in the pathogenesis of Wegener's granulomatosis. A hypothesis based on both humoral and cellular mechanisms. Neth J Med 1990; 36: 169–170
   PubMed Web of Science ®Google Scholar
• Katz P, Ailing D W, Haynes B F, Fauci A S. Association of Wegener's granulomatosis with HLA.‐B8. Clin Immunol Immunopa‐thol 1978; 14: 268
   Google Scholar
• Elkon K B, Sutherland D C, Rees A J. Brief report: HLA antigen frequencies in systemic vasculitis: increase in HLA.‐DR2 in Wegener's granulomatosis. Arthritis Rheumatism 1983; 26: 102
   PubMedGoogle Scholar
• Falk R J, Terrell R S, Charles L A. Anti‐neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci 1990; 87: 4115–4119
   PubMed Web of Science ®Google Scholar
• Caldas M L, Charles L A, Falk R J, Jennette J C. Immunoelectron microscopic documentation of the translation of proteins reactive with ANCA to neutrophil cell surfaces during neutrophil activation. Third Workshop on ANCA. Washington, DC 1990
   Google Scholar
• Ewert B, Falk R, Jennette J C. Anti‐neutrophil cytoplasmic antibody stimulate neutrophils to injure endothelial monolayers in vitro. Third Workshop on ANCA. Washington, DC 1990
   Google Scholar
• Ten Berge I JM, Wilmink L M, Meyer C JLM, et al. Clinical and immunological follow‐up of patients with severe renal disease in Wegener's granulomatosis. Am J Nephrol 1985; 5: 21–29
   PubMed Web of Science ®Google Scholar
• Gephardt G N, Ahmed M, Tubbs R R. Pulmonary vasculitis (Wegener's granulomatosis). Immunohistochemical study of T., and B cell markers. Am J Med 1983; 74: 700–704
   PubMed Web of Science ®Google Scholar
• Rasmussen N, Petersen J, Ralfkaier E, et al. Spontaneously and induced immunoglobulin synthesis and anti‐neutrophil cytoplasmic antibodies in Wegener's granulomatosis: relation to leucocyte subpopulations in blood and active lesions. Rheumatol Int 1988; 8: 153
   PubMed Web of Science ®Google Scholar
• Gephardt G N, Shah L F, Tubbs R R, Ahmed M. Wegener's granulomatosis. Immunomicroscopic and ultrastructural study of four cases. Arch Pathol Lab Med 1990; 114: 961–965
   PubMed Web of Science ®Google Scholar
• Petersen J, Rasmussen N, Szpirt, et al. T‐lymphocyte proliferation to neutrophil cytoplasmic antigen(s) in Wegener's granulomatosis (WG). Third Workshop on ANCA. Washington, DC 1990
   Google Scholar