Cellular Immune Mechanisms in Chronic Autoimmune Thrombocytopenic Purpura (ATP)

References

• Glimcher L H, Schroer J A, Chan C, Shevach E. Fine specificity of cloned insulin-specific T cell hybridomas: Evidence supporting a role for tertiary conformation. J Immunol 1983; 131: 2868
   PubMed Web of Science ®Google Scholar
• Herber-Katz E, Hansburg D, Schwartz R S. The la molecule of the antigen presenting cell plays a critical role in immune response gene regulation of T cell activation. J Mol cell Immunol 1983; 1: 3
   PubMedGoogle Scholar
• Miller A, Halfer D A, Weiner H L. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis; implications for immunofherapy of human autoimmune diseases. Faseb J 1991; 5: 2560
   PubMed Web of Science ®Google Scholar
• Kappler J W, Staerz U, White J, Marrack P C. Self-tolerance eliminates T cells specific for MLS-modified products of the major histocompatibility complex. Nature 1988; 332: 35
   PubMed Web of Science ®Google Scholar
• Mueller D L, Jenkins M K, Schwartz R H. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Ann Rev Immunol 1989; 7: 445
   PubMed Web of Science ®Google Scholar
• Sinha A A, Lopez T, McDevitt H O. Autoimmune Diseases: The failure of self tolerance. Science 1990; 248: 1380
   PubMed Web of Science ®Google Scholar
• Karpatkin S, Garg S K, Siskind G W. Autoimmune thrombo-cytopenic purpura and the compensated thrombocytolytic state. Am J Med 1971; 51: 1
   PubMed Web of Science ®Google Scholar
• Nel J D, Stevens K, Mouton A, Pretorius F J. Platelet-bound IgM in autoimmune thrombocytopenia. Blood 1983; 61: 1–19
   PubMed Web of Science ®Google Scholar
• Karpatkin S. Immunological platelet disorders. Immunological Diseases, M Santer, DW Talmage, et al. Little, Brown and Co, Boston 1988; 1631
   Google Scholar
• Waters A H. Autoimmune thrombocytopenia: Clinical Aspects. Sem Hematol 1992; 29: 18
   PubMed Web of Science ®Google Scholar
• Jensen P HP, Reiner W O, de Vaan G, Reekers P, Vingerhoets D M, Gabreels F JM. Effect of thymectomy on myasthenia gravis and autoimmune thrombocytopenic purpura in a 13-year-old girl. Eur J Pediatrics 1987; 146: 587
   PubMed Web of Science ®Google Scholar
• Stuart M J. Chronic idiopathic thrombocytopenic purpura: a familial immunodeficiency syndrome. JAMA 1978; 239: 939
   PubMed Web of Science ®Google Scholar
• Saleh M N, Moore D L, Lee J Y, Lo Buglio A F. Monocyte-plate-let interaction in immune and nonimmune thrombocytopenia. Blood 1989; 74: 1328
   PubMed Web of Science ®Google Scholar
• Doan C A, Bouroncle B A, Wiseman B. Idiopathic and secondary thrombocytopenic purpura: clinical study and evaluation of 381 cases over a period of 28 years. Ann Intern Med 1960; 53: 861
   Web of Science ®Google Scholar
• Rabinowitz Y, Dameschek W. Systemic lupus erythromatosus after “idiopathic” thrombocytopenic purpura: a review. A study of systemic lupus erythromatosus occurring after 78 splen-ectomies for “idiopathic” thrombocytopenic purpura, with review of the pertinent literature. Ann Intern Med 1960; 52: 1
   PubMed Web of Science ®Google Scholar
• McClure P D. Idiopathic thrombocytopenic purpura in children. Diagnosis and management. Pediatrics 1975; 55: 68
   PubMed Web of Science ®Google Scholar
• Miescher P A, Tucci A, Beris P, Favre H. Autoimmune hemo-lytic anemia and/or thrombocytopenia associated with lupus parameters. Sem Hematol 1992; 29: 13
   PubMed Web of Science ®Google Scholar
• Cines D B, Schreiber A D. Immune thrombocytopenia. Use of a Coombs antiglobulin test to detect IgG and C3 on platelets. N Engl J Med 1979; 300: 106
   PubMed Web of Science ®Google Scholar
• Kunicki T J, Koenig M B, Kristopeit S M, Aster R H. Direct quantitation of platelet-associated IgG by electroimmunoassay. Blood 1982; 60: 54
   PubMed Web of Science ®Google Scholar
• van Leuven E F, van der Ven JTHM, Engelfriet C P, von dem Borne AEG Kr. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 1982; 59: 23
   PubMed Web of Science ®Google Scholar
• Woods V L, Kurata Y, Montgomery R R, Tani P, Mason D, Oh E H, McMillian R. Autoantibodies against platelet glycoprotein Ib in patients with chronic immune thrombocytopenic purpura. Blood 1984; 64: 156
   PubMed Web of Science ®Google Scholar
• Woods V L, Oh E H, Mason D, McMillan R. Autoantibodies against the platelet glycoprotein Ilb/IIIa complex in patients with chronic ITP. Blood 1984; 63: 368
   PubMed Web of Science ®Google Scholar
• Nugent D J, Kunicki T J, Berglund C, Berstein I D. A human monoclonal autoantibody recognizes a neoantigen on glycoprotein IIIa expressed on stored and activated platelets. Blood 1987; 70: 16
   PubMed Web of Science ®Google Scholar
• Beardsley D S. Platelet autoantigens. Platelet Immunobiology, Molecular and Clinical Aspects, TJ Kunicki, JN George. Lippencott, Philadelphia 1989; 121
   Google Scholar
• Fitzgerald L A. Platelet Membrane Glycoproteins. Hemostasis and Thrombosis, R Colman, J Hirsh, V Marder, E. Salzman. Lippencott, Philadelphia 1989; 572
   Google Scholar
• Fujisawa K, O'Toole T E, Tani P, Plow E F, Ginsberg M H, McMillan R. Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura. Blood 1991; 77: 2207
   PubMed Web of Science ®Google Scholar
• Fujisawa K, Tani P, O'Toole T E, Ginsberg M H, McMillan R. Different specificities of platelet-associated and plasma autoantibodies to platelet GP IIb-IIIa in patients with chronic immune thrombocytopenic purpura. Blood 1992; 79: 1441
   PubMed Web of Science ®Google Scholar
• Kekomaki R, Dawson B, McFarland J, Kunicki T J. Localization of human platelet autoantigen to the cysteine-rich region of glycoprotein IIIa. J Clin Invest 1991; 88: 847
   PubMed Web of Science ®Google Scholar
• Schreuder G MT, Tilanus M GJ, Bontrop R E, Bruining G J, Giphart M J, van Rood J J. HLA-DQ polymorphism associated with resistance to type 1 diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism. J Exp Med 1986; 164: 938
   PubMed Web of Science ®Google Scholar
• Todd J A, Bell J I, McDevitt H O. HLA-DQ8 gene contributes to susceptibility and resistance to insulin-resistant diabetes mel-litus. Nature 1987; 329: 599
   PubMed Web of Science ®Google Scholar
• Morel P A, Dorman J S, Todd J A, McDevitt H O. Aspartic acid at position 57 of the HLA-DQ β chain protects against type I diabetes: A Family study. Proc Natl Acad Sci USA 1988; 85: 8111
   PubMed Web of Science ®Google Scholar
• Castano L, Eisenbarth G S. Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat. Ann Rev Immunol 1990; 8: 647
   PubMed Web of Science ®Google Scholar
• Karpatkin S. Association of HLA-DRw2 with autoimmune thrombocytopenic purpura. J Clin Invest 1979; 63: 1085
   PubMed Web of Science ®Google Scholar
• El-Khateeb M S, Awidi A S, Tarawneh M S, Abu-Khalaf M. HLA antigens, blood groups and immunoglobulin levels in idiopathic thrombocytopenic purpura. Acta Haematol 1986; 76: 110
   PubMed Web of Science ®Google Scholar
• Goebel K M, Hahn E, Havemann K. HLA matching in autoimmune thrombocytopenic purpura. Br J Haematol 1977; 35: 341
   PubMed Web of Science ®Google Scholar
• Porges A, Bussel J, Kimberly R, Schulman I, Pollack M, Pandey Jlgartner M. Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes. Tissue Antigens 1985; 64: 1179
   Google Scholar
• Gratama J W, D'Amaro J, de Koning J, den Ottolander G J. The HLA-system in immune thrombocytopenic purpura: Its relation to the outcome of therapy. Br J Haematol 1984; 56: 287
   PubMed Web of Science ®Google Scholar
• Bogart L, Wittels E G. Idiopathic thrombocytopenic purpura in two elderly siblings. Arch Int Med 1985; 145: 2259
   PubMed Web of Science ®Google Scholar
• Conley C L. Idiopathic thrombocytopenic purpura. Arch Int Med 1986; 146: 1244
   PubMedGoogle Scholar
• Burastero S E, Casali P, Wilder R L, Notkins A L. Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. J Exp Med 1988; 168: 1979
   PubMed Web of Science ®Google Scholar
• Hardy R R, Hayakawa K, Shimizu M, Yamasaki K, Kishimoto T. Rheumatoid factor secretion from human Leu-1+ B cells. Science 1987; 236: 81
   PubMed Web of Science ®Google Scholar
• Shirai T, Okada T, Hirose S. Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia. Annals New York Acad Aci 1992; 651: 509
   PubMed Web of Science ®Google Scholar
• Mizutani H, Furubayashi T, Kashiwagi H, Honda S, Take H, Kurata Y, Yonezawa T, Tarui S. B cells expressing CDS antigen are markedly increased in peripheral blood and spleen lymphocytes from patients with immune thrombocytopenic purpura. Br J Hematol 1991; 78: 474
   PubMed Web of Science ®Google Scholar
• Semple J W, Freedman J. Increased anti-platelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenic purpura. Blood 1991; 78: 2619
   PubMed Web of Science ®Google Scholar
• van der Harst D, de Jong D, Limpens J, Kluin Ph.M., Rozier Y, van Ommen G JB, Brand A. Clonal B-cell populations in patients with idiopathic thrombocytopenic purpura. Blood 1990; 76: 2321
   PubMed Web of Science ®Google Scholar
• Trent R J, Clancy R L, Danis V, Basten A. Disordered immune homeostasis in chronic idiopathic thrombocytopenic purpura. Clin Exp Immunol 1981; 41: 9
   Google Scholar
• Semple J W, Ellis J, Freedman J. Regulation of B lymphocyte immunoglobulin production by T helper cells from patients with primary chronic autoimmune thrombocytopenic purpura. Blood 1991; 78((suppl.1))473a
   Google Scholar
• Lauria F, Mantovani V, Catosky D, Gaurini A, Gugliotta L, Mirone E, Tura S. T gammacelldeficiency in idiopathic thrombocytopenia purpura (ITP). Scand J Haematol 1981; 26: 156
   PubMedGoogle Scholar
• Trent R, Adams E, Erhardt C, Basten A. Alterations in T-gamma cells in patients with chronic idiopathic thrombocytopenic purpura. J Immunol 1981; 127: 621
   PubMed Web of Science ®Google Scholar
• Mylvaganam R, Ahn Y S, Harrington W J, Kim C I, Gratzner H G. Differences in Tcellsubsets between men and women with idiopathic thrombocytopenic purpura. Blood 1985; 66: 967
   PubMed Web of Science ®Google Scholar
• Peller S, Kaufman S, Shaked U. Immuno-regulatory defect in patients with autoimmune thrombocytopenic purpura (ATP). Thymus 1986; 8: 361
   PubMedGoogle Scholar
• Lauria F, Raspadori D, Gobbi M, Guarini A, Gugliotta L, Aieta M, Tura S. T-cell subsets defined by monoclonal antibodies in autoimmune thrombocytopenic purpura (ATP). Haemalologia 1983; 68: 600
   PubMed Web of Science ®Google Scholar
• Scott C S, Wheeler R, Ford P, Bynoe A G, Roberts B E. T lymphocyte subpopulations in idiopathic thrombocytopenic purpura (ITP). Scand J Haematol 1983; 40: 401
   Google Scholar
• Mizutani H, Katagri S, Uejimma K, Ohnishi M, Tamaki T, Kanayama Y, Tsubakio T, Kurata Y, Yonezawa T, Tarui S. T-cellabnormalities in patients with idiopathic thrombocytopenic purpura: The presence of OKT4+8+ cells. Scand J Haemalol 1985; 35: 233
   PubMedGoogle Scholar
• Mizutani H, Tsubakio T, Tomiyama Y, Katagiri S, Tamaki T, Kurata Y, Yonezawa T, Tarui S. Increased circulating Ia-positive T cells in patients with idiopathic thrombocytopenic purpura. Clin Exp Immunol 1987; 67: 191
   PubMed Web of Science ®Google Scholar
• Morimoto C, Distaso J, Borel Y. Schlossman SF, Reinherz EL. Communicative interactions between subpopulations of human T lymphocytes required for generation of suppressor inducer effector function in primary antibody responses. J Immunol 1982; 128: 1645
   PubMed Web of Science ®Google Scholar
• Morimoto C, Letvin N L, Distaso J A, Aldirch W R, Schlossman S F. The isolation and characterization of the human suppressor inducer Tcellsubset. J Immunol 1985; 134: 1508
   PubMed Web of Science ®Google Scholar
• Raziuddin S, Nur M A, Alwabel A A. Selective loss of the CD4+ inducers of suppressor Tcellsubsets (2H4+) in active systemic lupus erythematosus. J Rheumatol 1990; 16: 1315
   Web of Science ®Google Scholar
• Morimoto C, Halfer D A, Weiner H L. Selective loss of the sup-pressor-inducer Tcellsubset in progressive multiple sclerosis: Analysis with the anti-2H4 monoclonal antibody. N Eng J Med 1987; 316: 67
   PubMed Web of Science ®Google Scholar
• Pitzalis C, Kingsley G, Murphy J. Abnormal distribution of the helper-inducer and suppressor inducer subset in the rheumatoid joints. Clin Immunol lmmunopathol 1987; 45: 252
   PubMedGoogle Scholar
• Mylvaganam R, Ahn Y S, Sprinz P G, Garcia R O, Harrington W J. Sex difference in the CD4+CD45R+ T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura. Clin Immunol lmmunopathol 1989; 52: 473
   PubMedGoogle Scholar
• Singer P A, McEvilly R J, Noonan G J. Clonal diversity and Tcellreceptor beta-chain variable gene expression in enlarged lymph nodes of MLR-lpr/lpr lupus mice. Proc Natl Acad Sci USA 1986; 83: 7018
   PubMed Web of Science ®Google Scholar
• , Deleted in proof
   Google Scholar
• Mtllward B A, Welsh K I, Leslie R DG, Pyke D A, Demaine A G. Tcellreceptor beta chain polymorphisms arc associated with insulin-dependent diabetes. Clin Exp Immunol 1987; 70: 152
   PubMed Web of Science ®Google Scholar
• Reme T, Portier M, Frayssinoux F, Combe B, Miossec P, Favier F, Sany J. Tcellreceptor expression and activation of synovial lymphocyte subsets in patients with rheumatoid arthritis. Ann Rheum 1990; 33: 485
   Google Scholar
• Uematsu Y, Wege H, Straus A, Ott M, Bannwarth W, Lanch-Bury J, Panayi G, Steinmetz M. The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc Natl Acad Sci USA 1991; 88: 8534
   PubMed Web of Science ®Google Scholar
• Posnett D N, Gottlieb A, Bussel J B, Friedman S, Chiorazzi N, LiY Szabo P, Farid N R, Robinson M A. Tcellantigen receptors and auloimmunity. J Immunol 1988; 141: 1963
   PubMedGoogle Scholar
• Piessens W F, Wybran J, Manaster J, Strijckmans P A. Leukocyte transformation induced by autologous platelets in a case of thrombocytopenic purpura. Blood 1970; 36: 421
   PubMed Web of Science ®Google Scholar
• McMillan R, Mason D, Tani P. Suppressor cells in immune thrombocytopenic purpura. Blood 1979; 54: 113
   Google Scholar
• Clancy R. Cellular immunity to autologous platelets and serum blocking factors in idiopathic thrombocytopenic purpura. Lancet 1972; i: 6
   Google Scholar
• Morimoto C, Marmot C, Abe T, Hara M, Homma M. Cell-mediated immune response in idiopathic thrombocytopenic purpura. Clin Immunol lmmunopathol 1977; 88: 181
   Google Scholar
• Unanue E R, Banaceraf B. Textbook of Immunology. Williams and Wilkins, Baltimore 1984; 154
   Google Scholar
• Rocklin R E, Remold H G, David J R. Characterization of human migration inhibitory factor (MIF) from antigen-stimulated lymphocytes. Cell Immunol 1972; 5: 436
   PubMed Web of Science ®Google Scholar
• Younger J, Salvin S B. Production and properties of migration inhibitory factor and interf'eron in the circulation of mice with delayed hypersensitivity. J Immunol 1973; 111: 1914
   PubMed Web of Science ®Google Scholar
• Roberts W K, Vasil A. Evidence for the identity of murine gamma interferon and macrophage activating factor. J Inter-feron Res 1982; 2: 519
   Google Scholar
• Oki S, Hirose S, Higuchi M, Osawa T. Macrophage migration inhibitory factor (MIF) produced by a human T-cell hybridoma clone. Cytokine Res 1991; 10: 273
   Web of Science ®Google Scholar
• Hirose S, Oki S, Higuchi M, Osawa T. Macrophage migration inhibitory factor (MIF) produced by a human T-cell hybridoma clone. Microbiol Immunol 1991; 35: 235
   PubMed Web of Science ®Google Scholar
• Gauthierrahman S, Elgharbi N, Siddiqui M U, Couderc J, Decreusefond C, Stiffel C. Differential expression of migration inhibitor and migration stimulatory factors in 2 lines of mice genetically selected for high or low responsiveness to phy-tohemaggluiinin. 2. Effects of mitogenic or allogeneic stimulation. Exp Clin Immunogenet 1991; 8: 159
   PubMedGoogle Scholar
• Borkowski W, Karpatkin S. Leukocyte migration inhibition of bully coats from patients with autoimmune thrombocytopenic purpura when exposed to normal platelets: Modulation by transfer factor. Blood 1984; 63: 83
   PubMed Web of Science ®Google Scholar
• Zinberg M, Francus T, Weksler M E, Siskind G W, Karpatkin S. Abnormal autologous mixed lymphocyte reaction in autoimmune thrombocytopenic purpura. Blood 1982; 59: 148
   PubMed Web of Science ®Google Scholar
• Lipsky P E. The control of immunoglobulin production by immunomodularory molecules. Arth Rheum 1989; 32: 1345
   PubMed Web of Science ®Google Scholar
• Kuntz M M, Innes J B, Weksler M E. The cellular bases of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythromatosus. J Clin Invest 1979; 63: 151
   PubMed Web of Science ®Google Scholar
• Hymes K B, Karpatkin S. in vitro suppressor T lymphocyte dysfunction in autoimmune thrombocytopenic purpura associated with a complement fixing antibody. Brit J Haematol 1990; 74: 330
   PubMed Web of Science ®Google Scholar
• Semple J W, Bruce S, Freedman J. Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura. Amer J Hematol 1991; 37: 258
   PubMed Web of Science ®Google Scholar
• Gardiner R A, Smith J G. A study of natural killer cells and interferon-gamma in patients with immune thrombocytopenic purpura. Blood 1990; 76: 206a, (abstract)
   PubMedGoogle Scholar
• Arai S, Yamamoto H, Itoh K, Kumagi K. Suppressive effect of human natural killer cells on pokeweed mitogen-induced B cell differentiation. J Immunol 1983; 131: 651
   PubMed Web of Science ®Google Scholar
• Brieva J A, Targan S, Stevens R H. NK andcellsubsets regulate antibody production by human in vivo antigen-induced lym-phoblastoid B cells. J Immunol 1984; 132: 611
   PubMed Web of Science ®Google Scholar
• Chantry D, Feldmann M. The role of cytokines in autoimmun-ity. Biotechnol Therapeutics 1990; 1: 361
   Google Scholar
• Kroemer G, Martinez-A C. Cytokines and autoimmune disease. Clin Immunol Immunopathol 1991; 61: 275
   PubMedGoogle Scholar
• Proctor S J. Improvement of platelet counts in steroid-unresponsive idiopathic immune thrombocytopenic purpura after short-course therapy with recombinant alfa-2b interferon. Blood 1989; 74: 1894
   PubMed Web of Science ®Google Scholar
• Bellucci S. Interferon alfa-2b therapy in adult chronic thrombocytopenic purpura (ITP). Br J Haematol 1989; 73: 578
   PubMed Web of Science ®Google Scholar
• Hurtaldo R. Recombinant interferon alfa-2b in refractory idiopathic thrombocytopenia. Blood 1990; 75: 1744
   PubMed Web of Science ®Google Scholar
• Ortaldo J R, Herberman R B. Augmentation of natural killer activity. Immunobiology of Natural Killer Cells. CRC Press, Boca Raton 1986; Vol 2: 145
   Google Scholar
• Friedman R M. Interferons. Textbook of Immunophysiology, JJ Oppenheim, EM Shevach. Oxford Press, New York 1988
   Google Scholar