8
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Anti-Histone Reactivity in Systemic Lupus Erythematosus Sera: A Disease Activity Index Linked to the Presence of Dna:Anti-Dna Immune Complexes

, , , , , , & show all
Pages 61-68 | Received 18 Jun 1991, Published online: 07 Jul 2009

References

  • Tan E L, Chan E KL, Sullivan K F, Rubin R L. Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity. Clin Immunol lmmunopathology 1988; 47: 121–141
  • Lambert P H, Dixon F J. Pathogenesis of glomerulonephritis of NZB/W mice. J Exp Med 1968; 127: 507–522
  • Koffler D, Agnello V, Kunkel H G. Polynucleotide immune complexes in serum and gomeruli of patients with systemic lupus erythematosus. Am J Pathol 1974; 74: 109–124
  • Krishnan C S, Kaplan M H. Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J Clin Invest 1967; 46: 569–579
  • Lafer E M, Rauch J, Andrzjewski C, Mudd D, Furie B, Schwartz R S, Stollar B D. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J Exp Med 1981; 153: 897–909
  • Faaber P, Capel P JA, Rijke G PM, Vierwinden G, Van de Putte L BA, Koene R AP. Crossreactivity of anti–DNA antibodies with proteoglycans. Clin Exp Immunol 1984; 55: 502–508
  • Naparstek Y, Duggan D, Schattner A, Madaio M P, Goni F, Frangione B, Stollar B D, Kabat E A, Schwartz R S. Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti–DNA lupus autoantibodies. J Exp Med 1985; 161: 1525–1538
  • Shoenfeld Y, Vilner Y, Coates A RM, Rauch J, Lavie G, Shauf D, Pinkhas J. Monoclonal anti–tuberculosis antibodies react with DNA, and monoclonal anti–DNA autoantibodies react with Mycobacterium tuberculosis. Clin Exp Immunol 1986; 66: 255–261
  • Darwin B S, Grudier J P, Klatt C L, Pisetsky D S. IgG antinuclear antibodies wtih cross–reactive rheumatoid factor activity. J Immunol 1986; 137: 3796–3801
  • André-Schwartz J, Datta S K, Shoenfeld Y, Isenberg D A, Stollar D B, Schwartz R S. Binding of cytoskeletal proteins by monoclonal anti–DNA lupus autoantibodies. Clin Immunol Immunopathol 1984; 31: 261–269
  • Jacob L, Léty M A, Louvard D, Bach J F. Binding of a monoclonal anti–DNA autoantibody to identical protein(s) present at the surface of several human cell types involved in lupus pathogenesis. J Clin Invest 1985; 75: 315–317
  • Jacob L, Kerjaschki D, Viard J P, Sahuquillo-Merino C, Lety M A, Bach J F, Louvard D. Lupus–associated membrane protein (LAMP): possible target of pathogenic autoantibodies in systemic lupus erythematosus (SLE). Arthritis Rheum 1988; 31(4: suppl), S107 (Abstract)
  • Jacob L, Lety M A, Choquette D, Viard J P, Jacob F, Louvard D, Bach J F. Presence of autoantibodies against a cell–surface protein, cross–reactive with DNA, in systemic lupus erythematosus. Proc Natl Acad Sci USA 1987; 84: 2956–2959
  • Jacob L, Viard J P, Allenet B, Anin M F, Slama F BH, Vandekerckhove J, Primo J, Markovits J, Jacob F, Bach J F, Louvard D. A monoclonal anti–double stranded DNA autoantibody binds to a 94 kDa cell–surface protein on various cell types via nucleosomes or a DNA–histone complex. Proc Natl Acad Sci USA 1989; 86: 4669–4673
  • Tan E M, Cohen A S, Fries J F, Masi A T, McShane D J, Rothfield N R, Schaller J G, Talal N, Winchester R J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271–1277
  • Hochberg M C, Boyd R E, Ahearn J M, Arnett F C, Bias W, Provost T, Stevens M B. Systemic lupus erythematosus: a review of clinicolaboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine 1985; 64: 285–295
  • Burnette W N. “Western Blotting”: electrophoretic transfer of proteins from sodium dodecyl sulfate–polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 1981; 112: 195–203
  • Coudrier E, Reggio H, Louvard D. Characterization of an integral glycoprotein associated with the microfilaments of pig intestinal microvilli. EMBO J 1983; 2: 469–475
  • Tambourin P, Casadevall N, Chopin J, Lacombe C, Heard J M, Fichelson S, Wendling F, Hantzins W D, Varet B. Production of erythropoietin–like activity by a murine erythroleukemia cell–line. Proc Natl Acad Sci USA 1983; 80: 6269–6273
  • Jacob L, Tron F. Monoclonal anti–deoxyribonucleic antibodies. I. Isotype and specificity studies. J Immunol 1982; 128: 895–898
  • SAS Base. 1986, User's Guide. SAS Institute, Box 8000, Cary, North Carolina
  • Bruneau C, Benveniste J. Circulating DNA:anti–DNA complexes in systemic lupus erythematosus. Detection and characterization by ultracentrifugation. J Clin Invest 1979; 64: 191–198
  • Tron F, Letarte J, Roque-Antunes M C, Lesavre P. Specific detection of DNA–Anti–DNA complexes in human SLE sera using murine monoclonal antibody. Clin Exp Immunol 1982; 49: 481–4487
  • Izui S, Lambert P H, Miescher P A. Failure to detect circulating DNA:anti–DNA complexes in systemic lupus erythematosus. Clin Exp Immunol 1977; 30: 388–392
  • Izui S, Lambert P H, Miescher P A. In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA: a possible basis for a local formation of DNA–anti–DNA complexes in systemic lupus erythematosus. J Exp Med 1977; 144: 428–443
  • Bach J F, Jacob L, Feutren G, Tron F. The questionable role of anti–DNA antibodies in the pathogenesis of systemic lupus erythematosus. Autoimmunity: Experimental and Clinical Aspects, R S Schwartz, N R Rose, 1986; 231–240
  • Eilat D. Cross–reactions of anti–DNA antibodies and the central dogma of lupus nephritis. Immunol Today 1985; 6: 123–127
  • Schmiedeke T MJ, Stockl F W, Weber R, Sugisaki Y, Batsford S R, Vogt A. Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J Exp Med 1989; 169: 1879–1894
  • Subiza J L, Caturla A, Pascual-Salcedo D, Chamorro M J, Galapu E, Figueredo M A, De La Concha E G. DNA–anti–DNA complexes account for part of the anti–histone activity in patients with systemic lupus erythematosus. Arthritis Rheum 1989; 32: 406–412
  • Tron F, Bach J F. Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus. Clin Exp Immunol 1977; 289: 426–432
  • Weinstein A, Bordwell B, Stone B, Tibbetts C, Rothfield N R. Antibodies to native DNA and serum complement (C3) levels. Application to diagnosis and classification of systemic lupus erythematosus. Am J Med 1983; 74: 206–216
  • Lightfoot R W, Hughes G RV. Significance of persisting serologic abnormalities in systemic lupus erythematosus. Arthritis Rheum 1976; 19: 837–843
  • Gioud M, Ait-Kaci M, Monier J M. Histone antibodies in systemic lupus erythematosus: a possible diagnostic tool. Arthritis Rheum 1982; 25: 407–413
  • Konstantinov K, Russanova V, Russeva V. Antibodies to histone and disease activity in systemic lupus erythematosus: a comparative study with an enzyme–linked immunosorbent assay and immunoblotting. Arch Dermatol Res 1986; 278: 410–415
  • Rekvig O P, Hannestad K. Certain polyclonal antinuclear antibodies cross–react with the surface membrane of human lymphocytes and granulocytes. Stand J Immunol 1977; 6: 1041–1054
  • Rekvig OP Hannestad K. The specificity of human autoantibodies that react with both cell nuclei and plasma membranes: the nuclear antigen is present on mononucleosomes. J Immunol 1979; 13: 2673–2681
  • Rekvig O P, Hannestad K. Human autoantibodies that react with both cell nuclei and plasma membranes display specificity for the octamer of histones H2A, H2B, H3 and H4. J Exp Med 1980; 152: 1720–1733
  • Bennett R M, Gabor G T, Merritt M M. DNA binding to human leucocytes. Evidence for a receptor–mediated association, internalization and degradation. J Clin Invest 1985; 76: 2182–2190
  • Bennett R M, Peller J S, Merritt M M. Defective DNA receptor function in systemic lupus erythematosus and related disorders: evidence for an autoantibody influencing cell physiology. Lancet 1986; i: 186–188
  • Bennett R M, Kotzin B L, Merritt M M. DNA receptor dysfunction in systemic lupus erythematosus and related disorders. Induction by anti–DNA antibodies, anti–histone antibodies and anti–receptor antibodies. J Exp Med 1987; 166: 850–863
  • Frampton G, Perl S, Bennett A, Cameron J S. Platelet–associated DNA and anti–DNA in systemic lupus erythematosus with nephritis. Clin Exp Immunol 1985; 63: 621–628
  • Holers V M, Kotzin B L. Human peripheral blood monocytes display surface antigens recognized by monoclonal antinuclear antibodies. J Clin Invest 1985; 76: 991–998
  • Okudaira K, Yoshikawa H, Williams R C. Monoclonal Murine anti–DNA antibody interacts with living mononuclear cells. Arthritis Rheum 1987; 30: 669–678
  • Rieber M, Urbina C, Strasberg–Rieder M. DNA on membrane receptors: a target for monoclonal anti–DNA antibody induced by a nucleoprotein shed in systemic lupus erythematosus. Biochem Biophys Res Comm 1989; 159: 1441–1447
  • Yabukov L A, Deeva E A, Zarytova V F, Ovanova E M, Ryte A S, Yurchenko L V, Vlassov V V. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?. Proc Natl Acad Sci USA 1989; 86: 6454–6458
  • Kotzin B L, Laffery J A, Portanova J P, Rubin R L, Tan E M. Monoclonal anti–histone autoantibodies derived from murine models of lupus. J Immunol 1984; 133: 2554–2559
  • Rubin R L, Waga S. Anti–histone antibodies in sytemic lupus erythematosus. J Rheumatol 1987; 14(suppl 13)118–126
  • Totoritis M C, Tan E M, McNally E M, Rubin R C. Association of antibody to histone complexes H2A–H2B with symptomatic procainamide–induced lupus. N Engl J Med 1988; 318: 1431–1436
  • Rumore P M, Steinman C R. Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complex bound to histone. J Clin Invest 1990; 86: 69–74
  • Minota S, Jarjour W N, Roubey R AS, Mimura T, Winfield J B. Reactivity of autoantibodies and DNA/anti–DNA complexes with a novel 110–kilodalton phosphoprotein in systemic lupus erythematosus and other diseases. J Immunol 1990; 144: 1263–1269
  • Termaat R M, Brinkman K, van Gompel F, VandenHeuvel L PWJ, Veerkamp J H, Smeenk R JT, Berden J HM. Cross–reactivity of monoclonal anti–DNA antibodies with heparan sulfate is mediated via bound DNA/histone complexes. J Autoimmunity 1990; 3: 531–545
  • Brinkman K, Termaat R, Berden J HM, Smeenk R JT. Anti–DNA antibodies and lupus nephritis; the complex of cross–reactivity. Immunol Today 1990; 11: 232–234

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.