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Original Article

Spectrotypes of Anti-Dna Antibodies Show that Anti-Dna-Secreting B-Cell Clones of Sle Patients are Restricted in Number, Stable and Long Lived

Pages 249-258 | Received 11 Dec 1991, Accepted 23 Jan 1992, Published online: 07 Jul 2009

References

  • Dziarski R. Autoimmunity-polyclonal activation or antigen induction. Immunol Today 1988; 9: 340–341
  • Casali P. Polyclonal B-cell activation and antigen-driven antibody response as mechanisms of autoantibody production in SLE. Autoimmunity 1990; 5: 147–150
  • Van Rooijen N. Are bacterial endotoxins involved in autoimmunity by CD5+ (Ly-1+) B-cells. Immunol Today 1989; 10: 334–336
  • Davidson A., Halpern R., Diamond B. Speculation on the role of somatic mutation in the generation of anti-DNA antibodies. Annals NY Acad Sci 1986; 475: 174–180
  • Isenberg D. A., Staines N. A. DNA antibody idiotypes. An analysis of their role in health and disease. J Autoimmunity 1990; 3: 339–356
  • Shoenfeld Y. Idiotypes and autoimmunity. Current Opinion in Immunol 1990; 2: 593–597
  • Shoenfeld Y., Mozes E. Pathogenic idiotypes of autoantibodies in autoimnunity: lessons from new experimental models of SLE. FASEB Journal 1990; 4: 2646–2651
  • Stott D. I., McLearie J., Neilson L. Analysis of the clonal origins of autoantibodies against thyroglobulin and DNA in autoimmune thyroiditis and systemic lupus erythematosus. Clin Exp Immunol 1986; 65: 520–533
  • Stott D. I., Merino J., Schurmans S., Lambert P. -H. Expression of anti-DNA clonotypes and the role of helper T-lymphocytes during the autoimmune response in mice tolerant to alloantigens. Autoimmunity 1988; 1: 253–266
  • Stott D. I., Brighouse G., Gyotoku Y., Lambert P. -H. Analysis of the autoimmune response in lupus mice: the behaviour and lifespan of anti-DNA-secreting B-cell clones. Autoimmunity 1990; 8: 159–168
  • Williamson A. R., Salaman M. R., Kreth H. W. Microheterogeneity and allomorphism of proteins. Annals NY Acad Sci 1973; 209: 210–224
  • Sinclair D., Kumararatne D. S., Forrester J. B., Lamont A., Stott D. I. The application of isoelectric focusing to routine screening for paraproteinaemia. J Immunol Methods 1983; 64: 147–156
  • Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning, A Laboratory Manual2nd edn. Cold Spring Harbor Laboratory Press. 1989
  • Fraker P. J., Speck J. C. Protein and cell membrane iodinations with a sparingly soluble chloroamide, l,3,4,6-Tetrachloro-3,6-diphenylglycoluril. Biochem Biophys Res Commun 1978; 80: 849–857
  • Stott D. I., McLearie J. Isoelectric focusing and reverse immuno-blotting of autoantibodies against high molecular weight antigens. Immunol Invest 1986; 15: 113–122
  • Yoshida H., Yoshida M., Izui S., Lambert P. -H. Distinct clonotypes of anti-DNA antibodies in mice with lupus nephritis. J Clin Invest 1985; 76: 685–694
  • Ebling F., Hahn B. H. Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus. Comparison of antibodies in serum and renal eluates. Arth Rheum 1980; 23: 392–403
  • Shlomchik M., Mascelli M., Shan H., Radic M. Z., Pisetsky D., Marshak-Rothstein A., Weigert M. Anti-DNA antibodies from autoimmune mice arise by clonal expression and somatic mutation. J Exptl Med 1990; 171: 265–298
  • Merino J., Schurmans S., Luzuy S., Izui S., Vassalli P., Lambert P. -H. Autoimmune syndrome after induction of neonatal tolerance to alloantigens: Effects of in vivo treatment with anti-T cell subset monoclonal antibodies. J Immunol 1987; 139: 1426–1431
  • Conger J. D., Pike B. L., Nossa G. JV. Clonal analysis of the anti-DNA repertoire of murine B-lymphocytes. Proc Natl Acad Sci USA 1987; 84: 2931–3035
  • Starobinski M., Lacour M., Reininger L., Izui S. Autoantibody repertoire analysis in normal and lupus-prone mice. J Autoimmunity 1989; 2: 657–674
  • Tarkowski A., Kjellson B., Carlsten H., Holmdahl R., Josefsson E., Trollmo C. Frequency and phenotypic feature of autoanti-body-producing cell precursors in the preclinical stage of murine lupus. Immunology 1990; 71: 335–340
  • Diamond B., Scharff M. D. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci USA 1984; 81: 5841–5844
  • Williams D. G., Brennan F. M., Stocks M. R., Maini R. N. Individual variation of anti-Sm autoantibodies in the MRL/MP-lpr/lpr mouse: age related increase in diversity. Clin Exp Immunol 1986; 65: 506–512
  • Forrester J. V., Stott D. I., Hercus K. M. Naturally occurring antibodies to bovine and human retinal S antigen: A comparison between uveitis patients and healthy volunteers. Brit J Ophthalmol 1989; 73: 155–159
  • Stott D. I., Hassman R., Neilson L., McGregor A. M. Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis. Clin Exp Immunol 1988; 73: 269–275
  • Forrester J., Stott D. I., Neilson L. Clonal analysis of antibody secretion in uveitis. Modern Trends in Immunology and Immunopathology of the Eye, A. G. Secchi, I. A. Fregona. Masson SpA, Milan 1989; 31–35
  • Miller F. W., Twitty S. A., Biswas T., Plotz P. H. Origin and regulation of a disease-specific autoantibody response. Antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 autoantibodies. J Clin Invest 1990; 85: 468–475
  • Williamson A. R., Askonas B. A. Senescence of an antibody-forming cell clone. Nature (Lond) 1972; 238: 337–339
  • Forster I., Rajewsky K. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc Natl Acad Sci USA 1990; 87: 4781–4784
  • Schittek B., Rajewsky K. Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature (Lond) 1990; 346: 749–751

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