21
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Fk 506 and Autoimmune Disease: Perspective and Prospects

&
Pages 303-313 | Received 16 Oct 1991, Accepted 14 Feb 1992, Published online: 07 Jul 2009

References

  • Kino T., Hatanaka H., Hashimoto M., Nishiyama M., Goto T., Okuhara M., Kohsaka M., Aoki H., Imanaka H. FK 506, a novel immunosuppressant isolated from Streptomyces. I. Fermentation, isolation and physicochemical and biological characteristics. J Antibiot 1987; 40: 1249–1255
  • Kino T., Hatanaka H., Miyata S., Inamura N., Nishiyama M., Yajima T., Goto T., Okuhara M., Kohsaka M., Aoki H., Ochiai T. FK 506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK 506 in vitro. J Antibiot, 40: 1256–1265
  • Thomson A. W. FK 506. How much potential. Immunol Today 1989; 10: 6–9
  • Starzl T. E., Fung J., Venkataramanan R., Todo S., Demetris A. J., Jain A. FK 506 for liver, kidney and pancreas transplantation. Lancet 1989; ii: 1000–1004
  • Kahan B. D., Chang J. Y., Seghal S. N. Preclinical evaluation of a new potent immunosuppressive agent rapamycin. Transplantation 1991; 52: 185–191
  • Fung J. J., Alessiani M., Abu-Elmagd K., Todo S., Shapiro R., Tzakis A., Van Thiel D., Armitage J., Jain A., McCauley J., Selby R., Starzl T. E. Adverse effects associated with the use of FK 506. Transplant Proc 1991; 23: 3105–3108
  • Todo S., Fung J. J., Demetris A. J., Jain A., Venkataramanan R., Starzl T. E. Early trials with FK 506 as primary treatment in liver transplantation. Transplantation Proc 1990; 22: 13–16
  • Shapiro R., Jordan M., Fung J., McCauley J., Johnston J., Iwaki Y., Tzakis A., Hakala T., Todo S., Starzl T. E. Kidney transplantation under FK 506 immunosuppression. Transplant Proc 1991; 23: 920–923
  • Armitage J. M., Kormos R. L., Fung J., Lavee J., Fricker F. J., Griffith B. P. Preliminary experience with FK 506 in thoracic transplantation. Transplantation 1991; 52: 164–167
  • Starzl T. E., Thomson A. W., Todo S., Fung J. J. Proceedings of the first international congress on FK 506. Transplant Proc 1991; 23: 2709–3380
  • Starzl T. E., Makowka L., Todo S. FK 506: a potential breakthrough in immunosuppression. Transplant Proc 1987; 19: 3–103
  • Starzl T. E., Todo S., Fung J. J., Groth C. FK 506. A potential breakthrough in immunosuppression-clinical implications. Transplant Proc 1990; 22: 5–113
  • Thomson A. W. FK 506: Profile of an important new immunosuppressant. Transplant Rev 1990; 4: 1–13
  • Macleod A. M., Thomson A. W. FK 506: an immunosuppressant for the 1990′s. Lancet 1991; 337: 25–27
  • Goto T., Kino T., Hatanaka H., Nishiyama M., Okuhara M., Kohsaka M., Aoki H., Imamaka H. Discovery of FK 506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant Proc 1987; 19(Suppl 6)4–8
  • Harding M. W., Galat A., Uehling D. E., Schreiber S. L. A receptor for the immunosuppressant FK 506 is a cis-trans peptidyl-prolyl isomerase. Nature 1989; 341: 758–760
  • Siekierka J. J., Hung S. H. Y., Poe M., Lin S. C., Sigal N. H. A cytosolic binding protein for the immunosuppressant FK 506 has peptid-yl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341: 755–757
  • Tocci M. J., Matkovich D. A., Collier K. A., Kwok P., Dumont F., Lin S., Degudicibus S., Siekierka J. J., Chin J., Hutchinson N. I. The immunosuppressant FK 506 selectively inhibits expression of early T cell activation genes. J Immunol 1989; 143: 718–726
  • Zeevi A., Duquesnoy R., Eiras G., Rabinowich H., Todo S., Makowka L., Starzl T. E. Immunosuppressive effect of FK 506 on in vitro lymphocyte alloactivation: synergism with cyclosporin A. Transplant Proc 1987; 19(Suppl. 6)40–44
  • Sawada S., Suzuki G., Kawase Y., Takaku F. Novel immunosuppressive agent, FK 506. In vitro effects on the cloned T cell activation. J Immunol 1987; 139: 1797–1803
  • Woo J., Propper D. J., Thomson A. W. Antigen presentation and HLA-DR expression by FK 506-treated human monocytes. Immunology 1990; 71: 551–555
  • DePaulis A., Cirillo R., Ciccarelli A., Condorelli M., Marone G. FK 506, a potent novel inhibitor of the release of proinflammatory mediators from human FcRI+ cells. J Immunol 1991; 146: 2374–2381
  • Wang S. C., Zeevi A., Tweardy D. J., Jordan M. L., Simmons R. L. FK 506, rapamycin and cyclosporine A: effects on IL-4 and IL-10 mRNA levels in a T helper cell line. Transplant Proc 1991; 23: 2920–2922
  • Schreiber S. L. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 1991; 251: 283–287
  • Liu J., Farmer J. D., Lane W. S., Friedman J., Weissman I., Schreiber S. L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK 506 complexes. Cell 1991; 66: 807–815
  • Flanagan W. M., Corthesy B., Bram R. J., Crabtree G. R. Nuclear association of a T-cell transcription factor blocked by FK 506 and cyclosporin A. Nature 1991; 352: 803–807
  • Tamura K., Kobayashi M., Hashimoto K., Kojima K., Nagase K., Iwasaki K., Kaizu T., Tanaka H., Niwa M. A highly sensitive method to assay FK 506 in plasma. Transplant Proc 1987; 19(Suppl 6)23–29
  • Cadoff E. M., Venkataramanan R., Krajack A., Jain A. S., Fung J. J., Todo S., Starzl T. E. Assay of FK 506 in plasma. Transplant Proc 1990; 22: 50–51
  • Venkataramanan R., Jain A., Cadoff E., Warty V., Iwasaki K., Nagase K., Krajack A., Imventarza O., Todo S., Fung J. J., Starzl T. E. Pharmacokinetics of FK 506: Preclinical and clinical studies. Transplant Proc 1990; 22: 52–56
  • Venkataramanan R., Jain A., Warty V., Abu-Elmagd K., Furukawa H., Imventarza O., Fung J. J., Todo S., Starzl T. E. Pharmacokinetics of FK 506 following oral administration. A comparison of FK 506 and cyclosporine. Transplant Proc 1991; 23: 931–933
  • O'Hara K., Billington R., James R. W., Dean G. A., Nishiyama M., Noguchi H. Toxicologic evaluation of FK 506. Transplant Proc 1990; 22: 83–86
  • Reyes J., Tzakis A., Green M., Nour B., Nalesnik M., Van Thiel D., Martin M., Breinig M. K., Fung J. J., Cooper M., Starzl T. E. Post-transplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression. Transplant Proc 1991; 23: 3044–3046
  • Sigal N. H., Dumont F., Durette P., Siekierka J. J., Peterson L., Rich D. H., Dunlap B. E., Slaruch M. J., Melino M. R., Koprak S. L., Williams D., Witzel B., Pisano J. M. Is cyclophilin involved in the nephrotoxic mechanism of action of cyclosporin A. J exp Med 1991; 173: 619–628
  • Woo J., Ross C. S., Milton J. I., Thomson A. W. Immunosuppressive activity of FK 506 in rats: flow cytometric analysis of lymphocyte populations in blood, spleen and thymus during treatment and following drug withdrawal. Clin Exp Immunol 1990; 79: 115–122
  • Pugh-Humphreys R. G. P., Ross C. S. K., Thomson A. W. The influence of FK 506 on the thymus: an immunophenotypic and structural analysis. Immunoloy 1990; 70: 398–404
  • Woo J., Ildstad S. T., Hronakes M. L., Thomson A. W. Kinetics of early T cell repopulation in the mouse following syngeneic bone marrow transplantation: FK 506 causes a maturational defect of CD4* CD8 T cells. Transplant Proc 1991; 23: 2323–2924
  • Kawashima H., Mochizuki M. Effects of a new immunosuppressive agent FK 506, on the efferent limb of the immune responses. Exp Eye Res 1990; 51: 565–572
  • Kawashima H., Fujino Y., Mochizuki M. Effects of a new immunosuppressive agent, FK 506, on experimental autoimmune uveoretinitis in rats. Invest Ophthalmol Vis Sci 1988; 29: 1265–1271
  • Mochizuki M., Kawashima H. Effects of FK 506, 15-deoxy-spergualin and cyclosporine on experimental autoimmune uveoretinitis in the rat. Autoimmunity 1990; 8: 37–41
  • Kawashima H., Fujino Y., Mochizuki M. Antigen-specific suppressor cells induced by FK 506 in experimental autoimmune uveoretinitis in the rat. Invest Ophthalmol Vis Sci 1990; 31: 31–38
  • Ni M., Chan C. -C., Nussenblatt R. B., Mochizuki M. FR900506 (FK 506) and 15-deoxyspergualine (15-DSG) modulate the kinetics of infiltrating cells in eyes with experimental autoimmune uveoretinitis. Autoimmunity 1990; 8: 43–51
  • Liversidge J., Thomson A. W., Forrester J. V. FK 506 modulates accessory cell adhesion molecule expression and inhibits CD4′ lymphocyte adhesion to retinal pigment epithelial cells in vitro; implications for therapy of uveoretinitis. Transplant Proc 1991; 23: 3339–3342
  • Fujino Y., Mochizuki M., Raber J., Kotake S., Gery I., Nussenblatt R. B. FK 506 treatment of S-antigen induced uveitis in primates. Invest Ophthalmol Vis Sci 1990; 31: 61
  • Inamura N., Hashimoto M., Nakahara K., Aoki H., Yamaguchi 1., Kohsaka M. Immunosuppressive effect of FK 506 on collagen-induced arthritis in rats. Clin Immunol Immunopathol 1988; 46: 82–90
  • Arita C., Hotokebuchi T., Miyahara H., Arai K., Sugioka Y., Takagishi K., Kaibara N. Inhibition by FK 506 of established lesions of collagen-induced arthritis in rats. Clin Exp Immunol 1990; 82: 456–461
  • Takagishi K., Yamamoto M., Nishimura A., Yamasaki G., Kanazawa N., Hotokebuchi T., Kaibara N. Effects of FK 506 on collagen arthritis in mice. Transplant Proc 1989; 21: 1053–1055
  • Murase N., Lieberman I., Nalesnik M., Mintz D., Todo S., Drash A. L., Starzl T. E. FK 506 prevents spontaneous diabetes in the BB rat. Lancet 1990; ii: 373–374
  • Miyagawa J., Yamamoto K., Hanafusa T., Itoh N., Nakagawa C., Otsuka A., Katsura H., Yamagata K., Miyazaki A., Kono N., Tarui S. Preventive effect of a new immunosuppressant FK 506 on insulinitis and diabetes in non-obese diabetic mice. Diahct-ologia 1990; 33: 503–505
  • Takabayashi K., Koike T., Kurasawa K., Matsumura R., Sato T., Tomioka H., Ilo I., Yoshiki T., Yoshida S. Effects of FK 506, a novel immunosuppressive drug on murine systemic lupus erythematosus. Clin Immunol Immunopathol 1989; 51: 110–117
  • Yamamoto K., Mori A., Nakahama T., Ilo M., Okudaira H., Miyamoto T. Experimental treatment of autoimmune MRL-lpr/lpr mice with immunosuppressive compound FK 506. Immunology 1988; 69: 222–227
  • Okuba Y., Tsukada Y., Maezawa A., Ono K., Yano S., Naruse T. FK 506, a novel immunosuppressive agent, induces antigen-specific immunotolerance in active Heymann's nephritis and in the autologous phase of Masugi nephritis. Clin Exp Immunol 1990; 82: 450–455
  • Hara S., Fukatsu A., Suzuki N., Sakamoto N., Matsuo S. The effects of a new immunosuppressive agent, FK 506, on the glomerular injury in rats with accelerated nephrotoxic serum glomerulonephritis. Clin Immunol Immunopathol 1990; 57: 351–362
  • Inamura N., Hashimoto M., Nakahara K., Nakajima Y., Nishio M., Aoki H., Yamaguchi I., Kohsaka M. Immunosuppressive effect of FK 506 on experimental allergic encephalomyelitis in rats. Im J Immunopharmacol 1988; 10: 991–995
  • Bolton C. The ability of myelin basic protein-sensitized leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisone. Transplant Proc 1991; 23: 3363–3364
  • Jegasothy B., Ackerman C. D., Todo S., Fung J., Starzl T. E. FK 506-a new therapeutic agent for severe, recalcitrant psoriasis. Arch Dermatol
  • Abu-Elmagd K., Van Thiel D. H., Jegasothy B. V., Ackerman C. D., Todo S., Fung J. J., Thomson A. W., Starzl T. E. FK 506-a new therapeutic agent for severe, recalcitrant psoriasis. Transplant Proc 1991; 23: 3322–3324
  • Thomson A. W., Nalesnik M., Abu-Elmagd K., Starzl T. E. Influence of FK 506 on T lymphocytes, Langerhans cells, and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study. Transplant Proc 1991; 23: 3330–3331
  • Abu-Elmagd K., Jegasothy B. V., Ackerman C. D., Thomson A. W., Rilo H., Nikolaidis N., Van Thiel D., Fung J. J., Todo S., Starzl T. E. Efficacy of FK 506 in the treatment of pyoderma gangrenosum. Transplant Proc 1991; 23: 3328–3329
  • Mochizuki M., Masuda K., Sakane T., Inaba G., Ito K., Kogure M., Sugino N., Usui M., Mizushima Y., Ohno S., Miyanaga Y., Hayasaka S., Ohizumi K. A multicentre clinical open trial of FK 506 in refractory uveitis, including Behcet's disease. Transplant Proc 1991; 23: 3343–3346
  • McCauley J., Tzakis A. G., Fung J. J., Todo S., Starzl T. E. FK 506 in steroid-resistant focal sclerosing glomerulonephritis of childhood. Lancet 1990; i: 674
  • McCauley J., Shapiro R., Scantlebury V., Gilboa N., Jordan M., Jensen C., Naik A., Tzakis A., Ellis D., Starzl T. E. FK 506 in the management of transplant-related nephrotic syndrome and steroid-resistant nephrotic syndrome. Transplant Proc 1991; 23: 3354–3356
  • Armitage J. M., Fricker F. J., Del Nido P., Cipriani L., Starzl T. E. The clinical trial of FK 506 as primary and rescue immunosuppression in pediatric cardiac transplantation. Transplant Proc 1991; 23: 3058–3060

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.