29
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Quantitative and Functional Analyses of Spleen and in Situ Islet Immune Cells Before and After Diabetes Onset in the Nod Mouse

, , , , , & show all
Pages 95-102 | Received 18 Sep 1991, Accepted 05 Dec 1991, Published online: 07 Jul 2009

References

  • Signore A., Cooke A., Pozzilli P., Butcher G., Simpson E., Beverly P. C. Class-II and IL-2 receptor positive cells in the pancreas of NOD mice. Diabetologia 1987; 30: 902–905
  • Kanazawa Y., Komeda K., Sato S., Mori S., Akanuma K., Takaku F. Nonobese diabetic mice: Immune mechanisms of pancreatic β-cell destruction. Diabetologia 1984; 27: 113–115
  • Signore A., Pozilli P., Gale E., Andreani D., Beverly P. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 1989; 32: 282–289
  • Nagata M., Yokono K., Hayakawa M., Kawase Yatamori N., Ogawa W., Yonezawa K., Shii K. Baba. Destruction of pancreatic islet cells by cytotoxic lymphocytes in non-obese diabetic mice. Diabetologia 1989; 5: 1155–1162
  • Charlton B., Mandel T. Progression from insulitis to β-cell destruction in NOD mice requires L3T4 T lymphocytes. Diabetes 1988; 37: 108–1112
  • Bacelj A., Charlton B., Mandel T. Prevention of cyclophos-phamide-induced diabetes by anti-Vβ8 T lymphocyte receptor monoclonal antibody therapy in NOD/Wehi mice. Diabetes 1989; 38: 1492–1495
  • Hosszufalusi N., Formby B., Chan E., Miller N., Teruya M., Charles M. Structural and functional analysis of in situ islet inflammatory cells in NOD mouse and BB rat. Diabetes 1991; 40: 49A, (abstr)
  • Shivakumar S., Tsokos G., Datta S. T cell receptor α/β expressing double negative and CD4 T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with Lupus Nephritis. J Immunol 1989; 143: 103–112
  • Sainis K., Datta S. CD4 T cell lines with selective patterns of autoreactivity as well as CD4XD8” T helper cell lines augment the production of idiotypes by pathogenic anti-DNA autoantibodies in the NZBxSWR model of Lupus Nephritis. J Immunol 1988; 140: 2215–2221
  • Chandy G., Cahalan M., Grissner S. Autoimmune diseases linked to abnormal K channel expression in double-negative CD4CD8′ T cells. Eur J Immunol 1990; 20: 747–751
  • Charles M. A., Lawecki J., Pictet R., Grodsky G. M. Insulin secretion interrelationships of glucose, cyclic adenosine-3,5-monophosphate and calcium. J Biol Chem 1975; 250: 6134–6140
  • Charles M. A., Suzuki M., Slater L., Waldeck N., Ong K. Immune islet killing mechanisms associated with insulin-dependent diabetes: Three rabbit antibody-mediated islet cytotoxicity models. Diabetologia 1983; 25: 348–353
  • Lautenschlager I., Inkinen K., Taskinen E., Charles M. A., Hayry P. Major histocompatibility complex protein expression on pancreas and pancreatic islet endocrine cell subsets. Am J Pathol 1989; 135: 1129–1137
  • O'Reilly L. A., Hutchings P. R., Crocker P. R., Simpson E., Lund T., Kioussis D., Takei F., Bird J., Cooke A. Characterization of pancreatic islet infiltrates in NOD mice: effect of cell transfer and transgene expression. Eur J Immunol 1991; 21: 1171–1180
  • Kay T., Campell I., Harrison L. Isolation and characterization of pancreatic T lymphocytes from the NOD mouse. J Autoimmu-nol 1990; 3: 73, (abst.)
  • Reiman J., Bellan A., Conradt P. Development of autoreactive L3T41 T cells from double-negative (L3T47Lyt-2-)Thy-l + spleen cells of normal mice. Eur J Immunol 1988; 18: 989–999
  • Morisset J., Trannoy E., De Talance A., Spinella S., Debre P., Goet P., Seman M. Genetics and strain distribution of cancava-lin A-reactive Lyt-2, L3T4 peripheral precursors of autoreactive T cells. Eur J Immunol 1988; 18: 387–394
  • Sakaguchi S., Fukuma K., Kuribayashi K., Masuda T. Organ specific autoimmune diseases induced in mice by elimination of T cell subset. I: Evidence for the active participation of T cells in natural self tolerance: Deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985; 161: 72–86
  • Santoro T. J., Portanova J., Botzin B. L. The contribution of L3T4 T cells to lymphoproliferation and autoantibody production of MRL-lpr/lpr mice. J Exp Med 1988; 167: 1713–1717
  • Shizuru J., Taylor-Edwards C., Banks B. A., Gregory A., Fathman C. G. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 1988; 240: 659–662
  • Acha-Orbea H., Mitchell D. J., Timmermann L., Wraith D., Taisch C., Waldor M., Zamvil S., McDevitt H. O., Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988; 54: 263–281
  • Fukuda M., Horio F., Kubo R., Hattori M. Monoclonal antibody F23.1 against T cells bearing V beta 8 TcR elements can prevent the development of insulitis in NOD mice. Diabetes 1989; 38(suppl. 2)12A, (abstr.)
  • McDuffie M. Diabetes in NOD mice does not require T lymphocytes expressing Vβ8 or Vβ5. Diabetes 1991; 40: 1555–1559
  • Nakano N., Kikutani H., Nishomoto H., Kishimoto T. T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in nonobese diabetic mice. J Exp Med 1991; 173: 1091–1097
  • Held W., McDonnald H., Weismann I. R., Hess M., Mueller C. Genes encoding tumor necrosis factor a and granzyme A are expressed during development of autoimmune diabetes. Proc Natl Acad Sci USA 1990; 87: 2239–2243
  • Thivolet C., Bendelac A., Bedossa P., Bach J. F., Carnaud C. CD81 T cell homing to the pancreas in the nonobese diabetic mouse is CD4 T cell dependent. J Immunol 1991; 146: 85–88
  • De Baradinis P., James R., Wise P., Londei M., Lake S., Feldman M. Do CD4-positive cytotoxic T cells damage islet β cells in type 1 diabetes. Lancet 1988; ii: 823–824
  • Formby B., Miller N. Autologous CD4 T cell responses to ectopic class II major histocompatibility complex antigen presenting single-cell islet cells: An in vitro insight into the pathogenesis of lymphocytic insulitis in nonobese diabetic mice. Proc Natl Acad Sci USA 1990; 87: 2438–2442
  • Hanafusa T., Fujino-Kurihara H., Miyazki A., Yamada K., Naka-jima H., Miyagawa J., Kono N., Tarui S. Expression of class II major histocompatibility complex antigens on pancreatic B cells in the NOD mouse. Diabetologia 1987; 30: 104–109

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.