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Autoimmunity Volume 16, 1993 - Issue 2
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Original Article

Amplification by Polymerase Chain Reaction of Immunoglobulin Heavy and Light Chain Genes from Orbital Tissue of Patients with Graves' Ophthalmopathy

Sandra M. McLachlan Thyroid Molecular Biology Unit, V.A. Medical Center and the University of California, San Francisco, California, 94121, USA
,
Mark F. Prummel Thyroid Molecular Biology Unit, V.A. Medical Center and the University of California, San Francisco, California, 94121, USA; Department of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands
,
Richard L. Dallow Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
,
Wilmar M. Wiersinga Department of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands
&
Basil Rapoport Thyroid Molecular Biology Unit, V.A. Medical Center and the University of California, San Francisco, California, 94121, USA
Pages 149-152 | Received 20 Jul 1993, Published online: 07 Jul 2009

References

  • Weetman A. P. Thyroid associated ophthalmopathy. Autoimmunity 1992; 12: 215–222
  • Campbell R. J. Immunology of Graves' ophthalmopathy retrobulbar histology and histochemistry. Acta Endocrinol 1989; 121(Suppl.2)9–16
  • Huse W. D., Sastry L., Iverson S. A., Kang A. S., Alting-Mees M., Burton D. R., et al. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 1989; 246: 1275–1281
  • Chazenbalk G. D., Portolano S., Russo D., Hutchison J. S., Rapoport B., McLachlan S. M. Human organ-specific autoimmune disease: molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic dominant region and restricted immunoglobulin gene usage in the target organ. J Clin Invest 1993; 92: 62–74
  • Butch A. W., Chung G. -H., Hoffman J. W., Nahm M. H. Cytokine expression by germinal center cells. J Immunol 1993; 150: 39–47
  • Jasani B., Smith C., Williams E. D. Lambda light chain restriction in the diffuse thyroid lymphoid infiltrate in untreated Graves' disease. J Endocrinol Invest 1986; 9(Suppl.3)101–101
  • Brodeur P. H. Genes encoding the immunoglobulin variable regions. Molecular genetics of immunoglobulin, F. Calabi, M. S. Neuberger. Elsevier Science Publishers B.V. 1987; 81–84
  • Rosen C. E., Raikow R. B., Burde R. M., Kennerdell J. S., Mosseri M., Scalise D. Immunohistochemical evidence for IgAl involvement in Graves' ophthalmopathy. Ophthalmology 1992; 99: 146–152

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