Experimental Autoimmune Pinealitis in the Rat: Ultrastructure and Quantitative Immunocytochemical Characterization of Mononuclear Infiltrate and MHC Class II Expression

References

• Pfister C, Chabre M. Retinal S-antigen identified as the 48K protein regulating light-dependent phosphodiesterase in rods. Science 1985; 228: 891–893
   PubMed Web of Science ®Google Scholar
• Donoso LA, Merryman CF, Shinohara T, Sery TW, Smith A. S-antigen. Experimental autoimmune uveitis following immunization with a small synthetic peptide. Arch Ophthalmol 1987; 105: 838–840
   PubMedGoogle Scholar
• Shinohara ST, Singh VK, Yamaki K, Abe T, Tsuda M, Suzuki S. S-antigenmolecular mimicry may play a role in autoimmune uveitis. Progr Clin Biol Res 1991; 362: 163–190
   PubMedGoogle Scholar
• Donoso LA, Merryman CF, Sery TW, Shinohara T, Dietz-Schold B, Smith A, Kalsow CM. S-antigencharacterization of a pathogenic epitope which mediates experimental autoimmune uveitis and pinealitis in Lewis rats. Curr Eye Res 1987; 6: 1151–1159
   PubMed Web of Science ®Google Scholar
• Dua HS, Sewell HF, Forrester JV. The effect of retinal S-antigen-specific monoclonal antibody therapy on experimental autoimmune uveoretinitis (EAU) and experimental autoimmune pinealitis (EAP). Clin. exp. Immunol 1989; 75: 100–105
   PubMed Web of Science ®Google Scholar
• Mochizuki M, Kuwabara T, McAllister T, Nussenblatt RB, Gery I. Adoptive transfer of experimental autoimmune uveoretinitis in rats. Invest Ophthalmol Vis Sci 1985; 26: 1–14
   PubMed Web of Science ®Google Scholar
• Atalla L, Linker-Israeli M, Steinman L, Rao NA. Inhibition of autoimmune uveitis by anti-CD4 antibody. Invest Ophthalmol Vis Sci 1990; 31: 1264–1270
   PubMed Web of Science ®Google Scholar
• Nussenblatt RB. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest Ophthalmol Vis Sci 1991; 32: 3131–3141
   PubMed Web of Science ®Google Scholar
• Donoso LA, Merryman CF, Edelberg KE, Naids R, Kalsow C. S-antigen in the developing retina and pineal gland: a monoclonal antibody study. Invest Ophthalmol Vis Sci 1985; 26: 561–567
   PubMed Web of Science ®Google Scholar
• Korf H-W, Moller M, Gery I, Zigler JS, Klein DC. Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species. Cell Tissue Res 1985; 239: 81–85
   PubMedGoogle Scholar
• McNulty JA, Fox LM, Silberman S. Immunocytochemical demonstration of nerve growth factor (NGF) receptor in the pineal gland: effect of NGF on pinealocyte neurite formation. Brain Res 1992, in press
   Google Scholar
• Craft CM, Whitmore DH, Donoso LA. Differential expression of messenger RNA and protein encoding retinal and pineal S-antigen during the light/dark cycle. J Neurochem 1990; 55: 1461–1473
   PubMed Web of Science ®Google Scholar
• Kalsow CM, Wacker WB. Pineal gland involvement in retina-induced experimental allergic uveitis. Invest Ophthalmol Visual Sci 1978; 17: 774–783
   PubMed Web of Science ®Google Scholar
• Kalsow CM, Dwyer AE, Smith AW, Nifong TP. Pinealitis coincident with recurrent uveitis: immunohistochemical studies. Curr Eye Res 1992; 11: 147–151
   PubMed Web of Science ®Google Scholar
• Pedersen EB, Fox LM, Castro AJ, McNulty JA. Immunocytochemical and electron microscopic characterization of microglia/macrophagecells and expression of class II major histocompatibility complex in the pineal gland of the rat. Cell Tissue Res 1993; 272: 257–265
   PubMedGoogle Scholar
• Shinohara T, Singh VK, Tsuda M, Yamaki K, Abe T, Suzuki S. S-antigen: from gene to autoimmune uveitis. Exp Eye Res 1990; 50: 751–757
   PubMedGoogle Scholar
• Forrester JV, Borthwick GM, McMenamin PC. Ultrastruc-tural pathology of S-antigen uveoretinitis. Invest Ophthalmol Vis Sci 1985; 26: 1281–1292
   PubMed Web of Science ®Google Scholar
• Chan C-C, Mochizuki M, Palestine AC, BenEzra D, Gery I, Nussenblatt RB. Kinetics of T-lymphocyte subsets in the eyes of Lewis rats with experimental autoimmune uveitis. Cell Immunol 1985; 96: 430–434
   PubMed Web of Science ®Google Scholar
• Chan CC, Mochizuki M, Nussenblatt RB, Palestine AG, McAllister C, Gery I, BenEzra D. T-lymphocyte subsets in experimental autoimmune uveitis. Clinic Immunol Immuno-pathol 1985; 35: 103–110
   PubMedGoogle Scholar
• Brown EC, Kasp E, Dumonde DC. Morphometric analysis of T lymphocyte compartmentation in experimental autoimmune uveoretinitis. Clin exp Immunol 1989; 77: 422–427
   PubMed Web of Science ®Google Scholar
• Nepom GT. MHC class-II molecules and autoimmunity. Annu Rev Immunol 1991; 9: 493–525
   PubMed Web of Science ®Google Scholar
• Fujikawa LS, Reay C, Morin ME. Class II antigens on retinal vascular endothelium, pericytes, macrophages, and lymphocytes of the rat. Invest Ophthalmol Vis Sci 1989; 30: 66–73
   PubMed Web of Science ®Google Scholar
• Chan C-C, Hooks JJ, Nussenblatt RB, Detrick B. Expression of la antigen on retinal pigment epithelium in experimental uveoretinitis. Curr Eye Res 1986; 5: 325–330
   PubMed Web of Science ®Google Scholar
• Satoh J, Kim SU, Kastrukoff LF, Takei F. Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murin oligodendrocytes and astrocytes. J Neurosci Res 1991; 29: 1–12
   PubMed Web of Science ®Google Scholar
• Lee SC, Collins M, Vanguri P, Shin ML. Glutamate differentially inhibits the expression of class II MHC antigens on astrocytes and microglia. J Immunol 1992; 148: 3391–3397
   Google Scholar
• Rao NA, Atalla L, Linker-Israeli M, Chen FY, George FW, Martin WJ, Steinman L. Suppression of experimental uveitis in rats by ant-I-A antibodies. Invest Ophthalmol Vis Sci 1989; 30: 2348–2355
   PubMedGoogle Scholar
• Dua HS, Liversidge J, Forrester JV. Immunomodulation of experimental autoimmune uveitis using a rat anti retinal S-antigen specific monoclonal antibody: evidence for a species difference. Eye 1989; 3: 69–78
   PubMed Web of Science ®Google Scholar
• Friedman AH. “Blood circulation to the eye.”. Blood Vessels and Lymphatics in Organ Systems, D. I. Abramson, P. B. Dobrin. Academic Press, New York 1984; 247–258
   Google Scholar
• Dua HS, McKinnon A, McMenamin PG, Forrester JV. Ultra-structural pathology of the “barrier sites” in experimental autoimmune uveitis and experimental autoimmune pinealitis. Brit J Ophthalmol 1991; 75: 391–397
   PubMed Web of Science ®Google Scholar
• McMenamin PG, Forrester JV, Steptoe RJ, Dua HS. Ultra-structural pathology of experimental autoimmune uveitis. Quantitative evidence of activation and possible high endothelial venule-like changes in retinal vascular endothelium. Lab Invest 1992; 67: 42–55
   PubMedGoogle Scholar
• Kraal G, Duijvestijn AM, Hendriks HH. The endothelium of the high endothelial venule: a specialized endothelium with unique properties. Expt Cell Biol 1987; 55: 1–10
   PubMedGoogle Scholar
• Duijvestijn A, Hamann A. Mechanisms and regulation of lymphocyte migration. Immunol Today 1989; 10: 23–28
   PubMedGoogle Scholar
• Mahalak SM, Lin WL, Essner E, Shichi H. Increased immu-noreactivity of collagen type-I, type-Ill and type-V, fibronec-tin and TGF-beta in retinal vessels of rats with experimental autoimmune uveoretinitis. Curr Eye Res 1991; 10: 1059–1063
   PubMed Web of Science ®Google Scholar
• Kovacs EJ. Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today 1991; 12: 17–23
   PubMedGoogle Scholar
• Chiappelli F. Neuroimmunological perspectives on lymphocyte homing and adhesion. Int J Immunopathol Pharm 1991; 4: 115–121
   Google Scholar
• Merryman CF, Solberg S. ELAM-1, ICAM-1, and Beta2 integrin are up-regulated in experimental autoimmune uveitis and experimental autoimmune pinealitis. Invest Ophthalmol Vis Sci 1992; 33: 796, suppl
   Google Scholar
• Fujino Y, Li Q, Chung H, Hikita N, Nussenblatt RB, Gery I, Chan C-C. Immunopathology of experimental autoimmune uveoretinitis in primates. Autoimmunity 1992; 13: 303–309
   PubMed Web of Science ®Google Scholar
• DeBarge LR, Chan CC, Caspi RR, Harming R, Nussenblatt RB, Whitcup SM. Expression of cell adhesion molecules in mice with experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 1992; 33: 796, suppl
   Web of Science ®Google Scholar
• Mochizuki M, Charley J, Kuwabara T, Nussenblatt RB, Gery I. Involvement of the pineal gland in rats with experimental autoimmune uveitis. Invest Ophthal Vis Sci 1983; 24: 1333–1338
   PubMed Web of Science ®Google Scholar