Intervention Therapies for Insulin-Dependent Diabetes

References

• Ford ES, Destefano F. Risk factors for mortality from all causes and from coronary heart disease among persons with diabetes. Findings from the National Health and Nutrition Examination Survey I epidemiologic follow-up study. Am J Epidemiol 1991; 133: 1220–1230
   PubMed Web of Science ®Google Scholar
• Diabetes Epidemiology Research International Mortality Study Group. Major cross-country differences in risk of dying for people with IDDM. Diabetes Care 1991; 14: 49–54
   Google Scholar
• Viberti G. Etiology and prognostic significance of albuminuria in diabetes. Diabetes Care 1988; 11: 840–845
   PubMedGoogle Scholar
• Brownlee M, Vlassara H, Cerami A. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Arm Intern Med 1984; 101: 527–537
   Google Scholar
• Muir A, Schatz DA, Maclaren NK. The pathogenesis, prediction, and prevention of insulin-dependent diabetes mellitus. Endocrinology and Metabolism Clinics of North America21st Ed, JH. Karam. W.B. Saunders Co., Philadelphia 1992; 199–219
   Google Scholar
• Canadian-European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention: association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 1988; 37: 1574–1582
   Google Scholar
• Bougnères PF, Carel JC, Castano L, Boitard C, Gardin JP, Landais P. Factors associated with early remission of type 1 diabetes in children treated with cyclosporine. N Engl J Med 1988; 318: 663–670
   PubMed Web of Science ®Google Scholar
• Silverstein J, Maclaren N, Riley W, Spillar R, Radjenovic D, Johnson S. Immunosuppression with Azathioprine and Prednisone in recent-onset insulin-dependent diabetes mellitus. N Engl J Med 1988; 319(10)599–604
   PubMed Web of Science ®Google Scholar
• Martin S, Schernthaner G, Nerup J, Gries FA, Koivisto VA, Dupré J. Follow-up of Cyclosporin A Treatment in Type 1 Insulin Dependent Diabetes Mellitus: Lack of Long-Term Effects. Diabetologia 1991; 34: 429–434
   PubMed Web of Science ®Google Scholar
• Maclaren NK. Perspectives in diabetes:How, when, and why to predict IDDM. Diabetes 1988; 37(12)1591–1994
   Google Scholar
• Todd JA. Genetic control of autoimmunity type I diabetes. Immunol Today 1990; 11: 122–129
   PubMedGoogle Scholar
• Rossetti L, Giaccari A, DeFronzo RA. Glucose toxicity. Diabetes Care 1990; 13: 610–630
   PubMed Web of Science ®Google Scholar
• Leahy JL, Bonner-Weir S, Weir GC. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced secretion. Diabetes Care 1992; 15: 442–455
   PubMed Web of Science ®Google Scholar
• Aaen K, Rygaard J, Josefsen K, Petersen H, Brogren CH, Horn T. Dependence of antigen expression on functional state of beta-cells. Diabetes 1990; 39: 697–701
   PubMed Web of Science ®Google Scholar
• Shah S, Malone J, Simpson NE. A randomized trial of intersine insulin therapy in newly diagnosed insulin dependent diabetes mellitus. N Engl J Med 1989; 320: 540–544
   Web of Science ®Google Scholar
• Hramiak I, Mahon J, Finegood D, Dupre J. Effect of short course of high dose insulin treatment in insulin dependent diabetes mellitus. Clin Invest Med 1991; 14: A28
   PubMed Web of Science ®Google Scholar
• Fahey JL, Sarna G, Gale RP, Seeger R. Immune interventions in disease [published erratum appears in Ann Intern Med 1987 May;106(5):783]. Ann Intern Med 1987; 106: 257–274
   PubMed Web of Science ®Google Scholar
• Hoyt EG, Hagberg RC, Billingham ME, Baldwin JC, Jamieson SW. Analysis of the immunosuppressive and nephrotoxic effects of cyclosporin. J Heart Transplant 1988; 7: 707–709
   Google Scholar
• Hanto DW, Gajl-Peczalska KJ, Frizzera G, Arthur DC, Balfour HH, McClain K. Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy. Ann Surg 1983; 198: 356–369
   PubMed Web of Science ®Google Scholar
• Wakugami T, Islam MR, Higa S, Murakami K, Mimura G. Effect of FK506 on the development of diabetes in BB rats in comparison with cyclosporine. Diab Res Clin Prac 1991; 14: S52
   Google Scholar
• Charlton B, Mandel TE. Recurrence of insulitis in the NOD mouse after early prolonged anti-CD4 monoclonal antibody treatment. Autoimmunity 1989; 4: 1–7
   Web of Science ®Google Scholar
• Skyler J, Byers V, Einhorn D, Eisenbarth G, Lorenz T, Palmer J. Effects of CD-5 immunocojugate (H65-RTA) on pancreatic islet beta cell function in type 1 diabetes mellitus (IDDM). Diab Res Clin Prac 1991; 14: S54
   Google Scholar
• Boitard C, Beridelac A, Richard MF, Carnaud C, Bach JF. Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclon il antibodies: transfer of protection by splenic T cells. Proc Vail Acad Sci USA 1988; 85: 9719–9723
   PubMedGoogle Scholar
• Boitard C, Michie S, Serrurier P, Butcher WG, Larkins AP, McDevitt HO. In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products. Natl Acad Sci USA 1985; 82: 6627–6631
   PubMed Web of Science ®Google Scholar
• Tarn AC, Deun BM, Schwarz G, Thomas JM, Ingram D, Botazzo GF. Predicting insulin-dependent diabetes. Lancet 1988; 1: 845–850
   PubMed Web of Science ®Google Scholar
• Vardi P, Crisa L, Jackson RA. Predictive value of intravenous glucose tolerance test insulin secretion less or greater than the first percentile in islet antibody positive relatives of type 1 (insulin-dependent) diabetic patients. Diabetologia 1991; 34: 93–102
   PubMed Web of Science ®Google Scholar
• Yamada K, Nonaka K, Hanafusa T, Miyazaki A, Toyoshima H, Tarui S. Preventive and therapeutic effects of large dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice. Diabetes 1982; 31: 749–753
   PubMed Web of Science ®Google Scholar
• Drash AL, Rudert WA, Borquaye S, Wang R, Lieberman I. Effect of probucol on development of diabetes mellitus in BB rats. Amer J Cardiol 1988; 62: 27B–30B
   Web of Science ®Google Scholar
• LeDoux SP, Hall CR, Forbes N, Patton NJ, Wilson GL. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity. Diabetes 1988; 37: 1015–1019
   Google Scholar
• Sandler S, Andersson A. Stimulation of cell replication in transplanted pancreatic islets by nicotinamide treatment. Transplantation 1988; 46: 30–31
   Google Scholar
• Terazono K, Tamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y. A novel gene activated in regenerating islets. J Biol Chem 1988; 263: 2111–2114
   PubMed Web of Science ®Google Scholar
• Chase HP, Butler-Simon N, Garg S, McDuffie M, Hoops SL, O'Brien D. A trial of nicotinamide in newly diagnosed patients with type I (insulin-dependent) diabetes mellitus. Diabetologia 1990; 33: 444–446
   PubMed Web of Science ®Google Scholar
• Mendola G, Casamitjana R, Gomis R. Effect of nicotinamide therapy upon B-cell function in newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 1989; 32: 160–162
   PubMed Web of Science ®Google Scholar
• Pozzilli P, Visalli N, Ghirlanda G, Manna R, Andreani D. Nicotinamide increases C-peptide secretion in patients with recent onset type 1 diabetes. Diabetic Medicine 1989; 6: 568–572
   Google Scholar
• Vague P, Picq R, Bernal M, Lassmann-Vague V, Vialettes B. Effect of nicotinamide treatment on the residual insulin secretion in type 1 (insulin-dependent) diabetic patients. Diabetologia 1989; 32: 316–321
   PubMed Web of Science ®Google Scholar
• Elliott R, Chase H. Prevention or delay of type 1 (insulin dependent) diabetes mellitus in children using nicotinamide. Diabetologia 1991; 34: 362–365
   PubMed Web of Science ®Google Scholar
• Elliott RB, Pilcher CC. Prevention of diabetes in normal school children. Diabetes Res Clin Pract 1991; 14: S85
   Google Scholar
• Michels JE, Bauer GE, Dixit PK. On the origin of induced pancreatic islet tumors: a radiographic study. Diab Res Clin Prac 1987; 184: 218–224
   Google Scholar
• Atkinson MA, Maclaren NK, Scharp D, Lacy P, Riley WJ. 64,000 Mr autoantibodies as predictors of insulin-dependent diabetes. Lancet 1990; 335: 1357–1360
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Anastoot HJ, Christgaun S, Reetz A, Solim-Ena M, Cascalho M. Identification of the 64K autoan-tigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151–156
   PubMed Web of Science ®Google Scholar
• Riley WJ, Maclaren NK, Krisher J, Spillar R, Silverstein J, Schatz D. A prospective study of I he development of diabetes in relatives of patients with insulin dependent diabetes. N Engl J Med 1990; 323: 1167–1172
   PubMed Web of Science ®Google Scholar
• Ziegler AG, Ziegler R, Vardi P, Jacksoi RA, Soeldner JS, Eisebarth GS. Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with type I diabetes. Diabetes 1989; 38: 1320–1325
   PubMed Web of Science ®Google Scholar
• Schatz DA, Riley WJ, Maclaren NK, Barrett DJ. Defective inducer T-cell function before the onset of insulin-dependent diabetes mellitus. J Autoimmunity 1991; 4: 125–136
   Google Scholar
• Christie MR, Tun RYM, Lo SSS, Cassidy D, Brown TJ, Hollands J. Antibodies to GAD and tryptic fragments of islet 64D antigen as distinct markers for development of IDDM. Diabetes 1992; 41: 782–787
   PubMed Web of Science ®Google Scholar
• Atkinson M, Maclaren N, Luchetta R, Burr I. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 1990; 39(8)933–937
   PubMed Web of Science ®Google Scholar
• Godfredson GF, Buschard K, Frandsen EK. Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabetalogia 1985; 28: 933–935
   PubMed Web of Science ®Google Scholar
• Muir A, Luchetta R, Schatz D. Insulin-specific immunotherapy ameliorates diabetes in non-obese diabetic mice. Diabetes 1992; 41: 39A
   Google Scholar
• Keller RJ, Eisenbarth GS, Jackson RA. Insulin prophylaxis in individuals at high risk of type 1 diabetes. Lancet 1993; 341: 927–928
   PubMed Web of Science ®Google Scholar
• Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Sci 1993; 259: 1321–1324
   PubMed Web of Science ®Google Scholar
• Dong J, Muir A, Schatz D, Luchetta R, Hao W, Atkinson M. Oral administration of insulin prevents diabetes in NOD mice. Diabetes Res Clin Pract 1991; 14: S55
   Google Scholar
• Zhang I, Davidson L, Eisenbarth G, Weiner HL. Suppression of diabetes in non-obese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 1991; 88: 10252–10256
   PubMed Web of Science ®Google Scholar
• Higgins PJ, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin-basic-protein and its fragments. J Immunol 1988; 140: 440–445
   PubMed Web of Science ®Google Scholar
• Wraith DC, Smilek DE, Mitchell DJ, Stemman L, McDevitt HO. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 1989; 59: 247–255
   PubMed Web of Science ®Google Scholar
• Lider O, Reshef T, Beraud E, Ben Nun A., Cohen IR. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Sci 1988; 239: 181–183
   PubMed Web of Science ®Google Scholar
• Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR. Induction and therapy of autoimmune diabetes in the non-obese diabetic mouse by a 64-kDa heat shock protein. Proc Natl Acad Sci 1990; 87: 1576–1580
   PubMed Web of Science ®Google Scholar
• Suzuki T, Tamada T, Fujimura T, Kawamura E, Shimizu M, Yamashita R. Diabetogenic effects of lymphocyte transfusion on the NOD or NOD nude mouse. Immune-deficient animals in biomedical research, J Rygaard, N Brünner, N Graem, M. Spang-Thomsen. Karger, Basel 1987; 112–116
   Google Scholar
• Qin H-Y, Sadelain MWJ, Hitchon C, Lauzon J, Singh B. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in Nonobese diabetic mice. J Immunol 1993; 150: 2072–2080
   PubMed Web of Science ®Google Scholar
• Jacob C, Aiso S, Michie S, McDevitt HO, Acha-Orbea H. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF):similarities between TNF-alpha and interleukin 1. Proc Natl Acad Sci USA 1990; 87: 968–972
   PubMed Web of Science ®Google Scholar
• Campbell IL, Oxbrow L, Harrison LC. Reduction in insulitis following administration of IFN-y and TNF-a in the NOD mouse. J. Autoimmun. 1991; 4: 249–262
   PubMed Web of Science ®Google Scholar
• La Face D., Peck A. Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-susceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 1989; 38: 894–901
   Google Scholar
• Serreze DV, Leiter EH, Schultz LD. Transplantation analysis of B cell destruction in (NOD × CBA)F1 mouse bone marrow chimeras. Diabetologia 1990; 33: 84–92
   PubMed Web of Science ®Google Scholar
• Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988; 54: 263–273
   PubMed Web of Science ®Google Scholar
• Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA. Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol 1991; 29: 33–40
   PubMed Web of Science ®Google Scholar
• Gold DP, Bellgrau D. Identification of a T-cell receptor β chain variable region repertoire associated with diabetes in the BB rat. Proc Natl Acad Sci USA 1991; 88: 9888–9891
   Google Scholar
• Haskins K, Bergman B, Portas M, McDuffie M, Lafferty K, Bradley B. Islet-specific T cell clones from the NOD mouse. Diab Res Clin Prac 1991; 14: S19
   Google Scholar
• Maeda T, Sumida T, Kurasawa K, Tomioka H, Itoh I, Yoshida S. T-lymphocyte-receptor repertoire of infiltrating T lymphocytes into NOD mouse pancreas. Diabetes 1991; 40: 1580–1585
   PubMed Web of Science ®Google Scholar
• Waters SH, O'Neil JJ, Melican DT, Appel MC. Multiple TCR Vp Usage by infiltrates of young NOD mouse Islets of Langerhans. Diabetes 1002; 41: 308–312
   Google Scholar
• Lipes MA, Rosenzweig A, Tan K-N, Tanigawa G, Ladd D, Seidman JG, Eisenbarth GE. Progression to diabetes in nonobese diabetic (NOD) mice with transgenic T cell receptors. Sci 1993; 259: 1165–1169
   PubMed Web of Science ®Google Scholar
• Hutchings P, Rosen H, O'Reilly L, Simpson E, Gordon S, Cooke A. Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages. Nature 1990; 348: 639–642
   PubMed Web of Science ®Google Scholar
• Jenkins MK, Taylor PS, Norton SD, Urdahl KB. CD28 delivers a co-stimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 1991; 147: 2461–2466
   PubMed Web of Science ®Google Scholar
• Damle NK, Linsley PJ, Ledbetter JA. Direct helper T cell-induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7. Eur J Immunol 1991; 21: 1277–1282
   PubMed Web of Science ®Google Scholar
• Mueller DL, Jenkins MK, Schwartz RH. An accessory cell-derived signal acts independently of protein Kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness. J Immunol 1989; 142: 2617–2628
   PubMed Web of Science ®Google Scholar
• Ramsdell F, Fowlkes BJ. Maintenance of in vivo tolerance by persistence of antigen. Sci 1992; 257: 1130–1134
   PubMed Web of Science ®Google Scholar
• Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g. Sci 1992; 257: 789–792
   PubMed Web of Science ®Google Scholar
• Kaufman D, Erlander M, Clare-Salzler M, Atkinson M, Maclaren N, Tobin A. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent mellitus. J Clin Invest 1992; 89: 283–292
   PubMed Web of Science ®Google Scholar
• Martin JM, Trink B, Daneman D, Dosch HM, Robinson B. Milk proteins in the etiology of insulin-dependent diabetes mellitus. Ann Med 1991; 23(4)447–452
   PubMed Web of Science ®Google Scholar
• Miyazaki T, Uno M, Uehira M, Kikutani H, Kishimoto T. Kimoto Direct evidence for the contribution of the unique I-A NOD to the development of insulitis in non obese diabetic mice. Nature 1990; 345: 722–724
   PubMed Web of Science ®Google Scholar
• Slattery R, Kjer-Nielsen L, Allison J, Charlton B, Mandel TE, Miller JF. Prevention of diabetes in non-obese diabetic I-Ak transgenic mice. Nature 1990; 345: 724–726
   PubMed Web of Science ®Google Scholar
• Lund T, O'Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain [see comments]. Nature 1990; 345: 727–729
   PubMed Web of Science ®Google Scholar