Insulin-Dependent Diabetes in the Nod Mouse Model II. β Cell Destruction in Autoimmune Diabetes is a T_H2 and not A T_H1 Mediated Event

References

• Gepts W, Lecompte PM. The pancreatic islets in diabetes. Am J Med 1981; 70: 105–115
   PubMed Web of Science ®Google Scholar
• Foulis AK, Stewart JA. The pancreas in recent-onset Type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 1984; 26: 456–461
   PubMed Web of Science ®Google Scholar
• Eisenbarth GS. Type I diabetes mellitus, a chronic autoimmune disease. N Engl J Med 1986; 314: 1360–1368
   PubMed Web of Science ®Google Scholar
• Kanazawa Y, Komeda K, Sato S, Mori S, Akanuma K, Takaku F. Non-obese diabetic mice: immune mechanisms of pancreatic β-cell destruction. Diabetologia 1984; 27: 113–115
   PubMedGoogle Scholar
• Miyazaki A, Hanafusa T, Yamada K, Miyagawa J, Fujino-Kurihara H, Nakajima H, Nonaka K, Tauri S. Predominance of T lymphocytes in pancreatic islets and spleen of prediabetic non-obese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol 1985; 60: 622–630
   PubMed Web of Science ®Google Scholar
• Leiter EH, Prochazka M, Coleman DL. Animal model of human disease, the non-obese diabetic (NOD) mouse. Amer J Pathol 1987; 128: 380–383
   PubMed Web of Science ®Google Scholar
• Cahill GF, McDevitt HO. Insulin-dependent diabetes mellitus: the initial lesion. N Engl J Med 1981; 304: 1454–1465
   PubMed Web of Science ®Google Scholar
• Baekkeskov S, Nielson JH, Marner B, Bilde T, Ludvigsson J, Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate humna pancreatic islet cell proteins. Nature 1982; 298: 167–169
   PubMed Web of Science ®Google Scholar
• Takei I, Maruyama T, Taniyama M, Kataoka K., Tarui S, Tochino Y, Nonaka K. Humoral immunity in the NOD mouse. Insulitis and Type I Diabetes. Academic Press, Tokyo 1986; 101–110
   Google Scholar
• Pontesilli O, Carotenuto P, Gazda LS, Pratt PF, Prowse SJ. Circulating lymphocyte populations and autoantibodies in nonobese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol 1987; 70: 84–93
   PubMed Web of Science ®Google Scholar
• Reddy S, Bibby NJ, Elliot RB. Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse. Diabetologia 1988; 31: 322–328
   PubMed Web of Science ®Google Scholar
• Atkinson MA, Maclaren NK. Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen. Diabetes 1988; 37: 1587–1590
   PubMedGoogle Scholar
• Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folti F, Richter-Olesen H, De Camilli P. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamine acid decarboxylase. Nature 1990; 347: 151–156
   PubMed Web of Science ®Google Scholar
• Elias D, Markovits D, Reshef T, van der Zee R., Cohen IR. Induction of therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 1990; 87: 1576–1580
   PubMed Web of Science ®Google Scholar
• Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Åkerblom HK, Dosch HM. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Eng J Med 1992; 327: 302
   PubMed Web of Science ®Google Scholar
• Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 1986; 35: 855–860
   PubMed Web of Science ®Google Scholar
• Wang Y, Hao L, Gill RG, Lafferty KJ. Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 1987; 36: 535–538
   PubMed Web of Science ®Google Scholar
• Bendelac A, Carnaud C, Boitard C, Bach JF. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. J Exp Med 1987; 166: 823–832
   PubMed Web of Science ®Google Scholar
• Miller BJ, Appel MC, O'Neil JJ, Wicker LS. Both the Lyt-2 + and L3T4+ T ell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 1988; 140: 52–58
   PubMed Web of Science ®Google Scholar
• Hanafusa T, Sugihara Fujino-Kurihara H, Miyagawa JI, Miyazaki A, Yoshioka T, Yamada K, Nakajima N, Asakawa H, Kowko H, Fujiwara H, Hamaoka T, Tauri S. Induction of insulitis by adoptive transfer with L3T4 + Lyt2-T-lymphocytes in T-Iymphocyte-depIeted NOD mice. Diabetes 1988; 37: 204–208
   PubMed Web of Science ®Google Scholar
• Serreze DV, Leiter EH. Defective activation of T suppressor cell function in nonobese diabetic mice. J Immunol 1988; 140: 3801–3807
   PubMed Web of Science ®Google Scholar
• Signore A, Pozzilli P, Gale EAM, Andreani D, Beverly PCL. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 1989; 32: 282–289
   PubMed Web of Science ®Google Scholar
• Gepts W. Pathological anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1986; 14: 619–633
   Google Scholar
• Foulis AK, Liddte CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the the pancreas in Type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267–274
   PubMed Web of Science ®Google Scholar
• Shimizu J, Ikehara S, Toki J, Ohtsuki H, Yasumizu R, Hamashima Y. Immunohistochemical and ultrastructural studies on beta cell destruction in NOD mouse, an animal model for Type I diabetes mellitus. Acta Histochem Cytochem 1987; 20: 9–19
   Google Scholar
• Fujita T, Yui R. Histological changes in the pancreatic islets on NOD mice. Insulitis and Type I Diabetes, S Tarui, Y Tochino, K. Nonaka. Academic Press, Tokyo 1986; 35–50
   Google Scholar
• Serreze DV, Leiter EH, Worthen SM, Shulyz LD. NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice. Diabetes 1988; 37: 252–255
   PubMed Web of Science ®Google Scholar
• LaFace DM, Peck AB. Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 1989; 38: 894–901
   PubMed Web of Science ®Google Scholar
• Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 1986; 35: 855–860
   PubMed Web of Science ®Google Scholar
• Miller BJ, Appel MC, O'Neil JJ, Wicker LS. Both the Lyt-2 + and L3T4+ T ell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 1988; 140: 52–58
   PubMed Web of Science ®Google Scholar
• O'Neil JJ, Wicker L, Miller B, Appel M. Anti-L3T4 antibody, therapy prevents diabetes in the NOD mouse. Diabetes 1988; 37: 205A
   Google Scholar
• Bendelac A, Carnaud C, Boitard C, Bach JF. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. J Exp Med 1987; 166: 823–832
   PubMed Web of Science ®Google Scholar
• Boitard C, Bendelac A, Carnaud C, Bach JF. In vivo prevention of diabetes in NOD mice: induction of suppressor T lymphocytes. Diab Res Clin Prac 1988; 5: S52
   Google Scholar
• Bendelac A, Boitard C, Bedossa P, Bazin H, Bach JF, Carnaud C. Adoptive transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes. J Immunol 1988; 141: 2625–2628
   PubMed Web of Science ®Google Scholar
• Hanafusa T, Sugihara S, Fujino-Kurihara H, Miyagawa JI, Miyazaki A, Yoshioka T, Yamada K, Nakajima N, Asakawa H, Kono N, Fujiwara H, Hamaoka T, Tauri S. Induction of insulitis by adoptive transfer with L3T4+ Lyt2-T-lymphocytes in T-lymphocyte-depleted NOD mice. Diabetes 1988; 37: 204–208
   PubMed Web of Science ®Google Scholar
• Wang Y, Hao L, Gill RG, Lafferty KJ. Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 1987; 36: 535–538
   PubMed Web of Science ®Google Scholar
• Rossini AA, Mordes JP, Handler ES. Speculations on the etiology of diabetes mellitus: the tumbler hypothesis. Diabetes 1988; 37: 257–261
   PubMed Web of Science ®Google Scholar
• Nerup J, Mandrup-Poulson T, Molvig J, Helqvist S, Wogensen L, Egeberg J. Mechanisms of pancreatic 18-cell destruction in type I diabetes. Diabetes Care 1989; 11: 16–23
   Web of Science ®Google Scholar
• Harrison LC, Campbell IL, Allison J, Miller JAFP. MHC molecules and /3-cell destruction: immune and nonimmune mechanisms. Diabetes 1989; 38: 815–818
   PubMedGoogle Scholar
• Jarpe AJ, Winter WE, Peck AB. The changing profile of monoclonal ceil populations infiltrating the islets of Langerhan during the progressive insulitis phase in prediabetic NOD mice. Allergy & Immunol (Life Sci Adv) 1991; 9: 283–292
   Google Scholar
• Jarpe AJ, Hickman M, Anderson JT, Winter WE, Peck AB. Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhan in prediabetic NOD mice: Development of a model of autoimmune insulitis for type I diabetes. Regional Immunol 1991; 3: 305–317
   Google Scholar
• Shaut DM, Wakeland EY, Mauer PH, Peck AB. Changes in the Ir gene controlled response phenotypes in mice of the Ap and A families of alleles expressing naturally occurring variant molecules. J Immunol 1984; 133: 1410–1416
   Google Scholar
• Shieh D-C, Cornelius JG, Winter WE, Peck AB. Detection and characterization of autoantibody bound to the surface of pancreatic β cells prior to development of the insulitis lesion in prediabetic NOD mice. ACCOMPANYING ARTICLE
   Google Scholar
• Brenner CA, Tarn AW, Nelson PA, Engleman EG, Suzuki N, Fry KE, Larrick JW. Message amplification phenotyping (MAPPing): A technique to simultaneously measure multiple mRNAs from small numbers of cells. Biotechniques 1989; 7: 1096–1103
   PubMed Web of Science ®Google Scholar
• Huang S-W, Luchetta R, Peck AB. Pertussigen treatment retards, but fails to prevent, the development of type I, insulin-dependent diabetes melliyus (IDDM) in NOD mice. Autoimmunity 1991; 9: 311–317
   PubMed Web of Science ®Google Scholar
• Campbell IL, Cutri A, Wilson A, Harrison LC. Evidence for IL-6 production by and effects on the pancreatic beta cell. J Immunol 1989; 143: 1188–1191
   PubMed Web of Science ®Google Scholar
• Bendtzen K, Buschard K, Diamant M, Horn T, Svenson M. Possible role of IL-l, TNF-alpha and IL-6 in insulin-dependent diabetes mellitus and autoimmune thyroid disease. Lymphokine Res 1989; 8: 335–340
   PubMedGoogle Scholar
• Campbell IL, Kay TW, Oxbrow L, Harrison LC. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest 1991; 87: 739–742
   PubMed Web of Science ®Google Scholar
• Acres RB, Conlon PJ, Mochizuki DY, Gallis B. Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen. J Biol Chem 1986; 34: 16210–16214
   Google Scholar
• Weyand CM, Goronzy J, Fathman CG. Modulation of CD4 by antigenic activation. J Immunol 1987; 138: 1351–1354
   PubMedGoogle Scholar
• Serreze DV, Leiter EH. Defective activation of T suppressor cell function in nonobese diabetic mice. J Immunol 1988; 140: 3801–3807
   PubMed Web of Science ®Google Scholar
• Hatamori N, Yokono K, Nagata M, Shii K, Baba S. Impaired mitogen-induced expression of high-affinity interleukin 2 receptors on spleen cells from NOD/Shi/Kbe mice. Diabetes 1990; 39: 1070–1078
   Google Scholar
• Tsumura H, Komada H, Ito Y, Shimura K. In vitro and in vivo interferon production in NOD mice. Lab Animal Science 1989; 39: 575–578
   Google Scholar