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Original Article

Insulin-Dependent Diabetes in the Nod Mouse Model I. Detection and Characterization of Autoantibody Bound to the Surface of Pancreatic Beta Cells Prior to Development of the insulitis Lesion in Prediabetic Nod Mice

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Pages 123-135 | Published online: 07 Jul 2009

References

  • Gepts W, Lecompte PM. The pancreatic islets in diabetes. Am J Med 1981; 70: 105–115
  • Foulis AK, Stewart JA. The pancreas in recent-onset Type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 1984; 26: 456–461
  • Eisenbarth GS. Type I diabetes mellitus, a chronic autoimmune disease. N Engl J Med 1986; 314: 1360–1368
  • Kanazawa Y, Komeda K, Sato S, Mori S, Akanuma K, Takaku F. Non-obese diabetic mice: immune mechanisms of pancreatic β-cell destruction. Diabelologia 1984; 27: 113–115
  • Miyazaki A, Hanafusa T, Yamada K, Miyagawa J, Fujino-Kurihara H, Nakajima H, Nonaka K, Tauri S. Predominance of T lymphocytes in pancreatic islets and spleen of prediabetic non-obese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol 1985; 60: 622–630
  • Leiter EH, Prochazka M, Coleman DL. Animal model of human disease, the non-obese diabetic (NOD) mouse. Amer J Pathol 1987; 128: 380–383
  • Todd JA, Mijovic C, Fletcher J, Jenkins D, Bradwell AR, Barnett AH. Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Science, 338: 587–589
  • Hattori M, Buse JB, Jackson RA, Glimcher L, Dort ME, Minami M, Makino S, Moriwaki K, Kuzuya H, Imura H, Strauss WM, Seidman JG, Eisenbarth GS. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 1986; 231: 733–735
  • Prochazka M, Leiter EH, Serreze DV, Coleman DL. Three recessive loci required for insulin-dependent Diabetes in nonobese diabetic mice. Science 1987; 237: 286–289
  • Wicker LS, Miller BJ, Coker LZ, McNally SE, Scott S, Mullen Y, Appel M. Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med 1987; 165: 1639–1654
  • Prochazka M, Serreze DV, Worthen SM, Leiter EH. Genetic control of diabetogenesis in NOD/Lt mice: development and analysis of congenic stocks. Diabetesc 1989; 38: 1446–1455
  • Serreze DV, Leiter EH, Worthen SM, Shulyz LD. NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice. Diabetes 1988; 37: 252–255
  • LaFace DM, Peck AB. Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsuscep-tible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 1989; 38: 894–901
  • Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 1986; 355: 855–860
  • Miller BJ, Appel MC, O'Neil JJ, Wicker LS. Both the Lyt-2 + and L3T4+ T ell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 1988; 140: 52–58
  • O'Neil JJ, Wicker L, Miller B, Appel M. Anti-L3T4 antibody therapy prevents Diabetes in the NOD mouse. Diabetes 1988; 37: 205A
  • Bendelac A, Carnaud C, Boitard C, Bach JF. Syngeneic transfer of autoimmune Diabetes from diabetic NOD mice to healthy neonates. J Exp Med 1987; 166: 823–832
  • Boitard C, Bendelac A, Carnaud C, Bach JF. In vivo prevention of diabetes in NOD mice: induction of suppressor T lymphocytes. Diab Res Clin Prac 1988; 5: S52
  • Bendelac A, Boitard C, Bedossa P, Bazin H, Bach JF, Carnaud C. Adoptive transfer of autoimmune nonobese diabetic mouse Diabetes does not require recruitment of host B lymphocytes. J Immunol 1988; 141: 2625–2628
  • Hanafusa T, Sugihara S, Fujino-Kurihara H, Miyagawa JI, Miyazaki A, Yoshioka T, Yamada K, Nakajima N, Asakawa H, Kono N, Fujiwara H, Hamaoka T, Tauri S. Induction of insulitis by adoptive transfer with L3T4+ Lyt2-T-lymphocytes in T-Iymphocyte-depleted NOD mice. Diabetes 1988; 37: 204–208
  • Wang Y, Hao L, Gill RG, Lafferty KJ. Autoimmune Diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 1987; 36: 535–538
  • Shizuru JA, Taylor-Edwards C, Banks BA, Gregory AK, Fathman CG. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 1988; 240: 659–662
  • Formby B, Miller N, Garret R, Peterson CM. Effects of low-dose cyclosporin prophylaxis in nonobese diabetic mice. J Pharm Exp Therapeutics 1987; 241: 1106–1111
  • Rossini AA, Mordes JP, Handler ES. Speculations on the etiology of Diabetes mellitus: the tumbler hypothesis. Diabetes 1988; 37: 257–261
  • Nerup J, Mandrup-Poulson T, Molvig J, Helqvist S, Wogensen L, Egeberg J. Mechanisms of pancreatic β-cell destruction in type I diabetes. Diabetes Care 1989; 11: 16–23
  • Harrison LC, Campbell IL, Allison J, Miller JAFP. MHC molecules and β-cell destruction: immune and nonimmune mechanisms. Diabetes 1989; 38: 815–818
  • Cahill GF, McDevitt HO. Insulin-dependent Diabetes mellitus: the initial lesion. N Engl J Med 1981; 304: 1454–1465
  • Baekkeskov S, Nielson JH, Mamer B, Bilde T, Ludvigsson J, Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 1982; 298: 167–169
  • Takei I, Maruyama T, Taniyama M, Kataoka K. Humoral immunity in the NOD mouse. Insulitis and Type I Diabetes, S Tarui, Y Tochino, K. Nonaka. Academic Press, Tokyo 1986; 101–110
  • Pontesilli O, Carotenuto P, Gazda LS, Pratt PF, Prowse SJ. Circulating lymphocyte populations and autoantibodies in nonobese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol 1987; 70: 84–93
  • Reddy S, Bibby NJ, Elliot RB. Ontogeny of islet cell antibodies, insulin autoantibodies and insulitis in the non-obese diabetic mouse. Diabetologia 1988; 31: 322–328
  • Atkinson MA, Maclaren NK. Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen. Diabetes 1988; 37: 1587–1590
  • Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P. Identification of the 64K autoantigen in insulin-dependent Diabetes as the GABA-synthesizing enzyme glutamine acid decarboxylase. Nature 1990; 347: 151–156
  • Elias D, Markovits D, Reshef T, van der Zee R., Cohen IR. Induction of therapy of autoimmune Diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 1990; 87: 1576–1580
  • Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Akerblom HK, Dosch HM. A bovine albumin peptide as a possible trigger of insulin-dependent Diabetes mellitus. N Eng J Med 1992; 327: 302
  • Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune Diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 1986; 35: 855–860
  • Wang Y, Hao L, Gill RG, Lafferty KJ. Autoimmune Diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 1987; 36: 535–538
  • Bendelac A, Carnaud C, Boitard C, Bach JF. Syngeneic transfer of autoimmune Diabetes from diabetic NOD mice to healthy neonates. J Exp Med 1987; 166: 823–832
  • Miller BJ, Appel MC, O'Neil JJ, Wicker IS. Both the, Lyt-2 + and L3T4+ T ell subsets are required for the transfer of Diabetes in nonobese diabetic mice. J Immunol 1988; 140: 52–58
  • Hanafusa T, Sugihara Fujino-Kurihara H, Miyagawa Jl, Miyazaki A, Yoshioka T, Yamada K, Nakajima N, Asakawa H, Kowko H, Fujiwara H, Hamaoka T, Tauri S. Induction of insulitis by adoptive transfer with L3T4+ Lyt2-T-lymphocytes in T-lymphocyte-depleted NOD mice. Diabetes 1988; 37: 204–208
  • Serreze DV, Leiter EH. Defective activation of T suppressor cell function in nonobese diabetic mice. J Immunol 1988; 140: 3801–3807
  • Signore A, Pozzilli P, Gale EAM, Andreani D, Beverly PCL. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 1989; 32: 282–289
  • Gepts W. Pathological anatomy of the pancreas in juvenile Diabetes mellitus. Diabetes 1986; 14: 619–633
  • Foulis AK, Liddie CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the the pancreas in Type 1 (insulin-dependent) Diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267–274
  • Shimizu J, Ikehara S, Toki J, Ohtsuki H, Yasumizu R, Hamashima Y. Immunohistochemical and ultrastructural studies on beta cell destruction in NOD mouse, an animal model for Type I Diabetes mellitus. Acta Histochem Cytochem 1987; 20: 9–19
  • Fujita T, Yui R. Histological changes in the pancreatic islets on NOD mice. Insulitis and Type I Diabetes, S Tarui, Y Tochino, K. Nonaka. Academic Press, Tokyo 1986; 35–50
  • Beppu H, Winter WE, Atkinson MA, Maclaren NK, Fujita K, Takahashi H. Bovine albumin antibodies in NOD mice. Diabetes Res 1987; 6: 67–69
  • Seffeze DV, Leiter EH, Kuff EL, Jardieu P, Ishizaka K. Molecular mimicry between insulin and retroviral antigen p73. Diabetes 1988; 37: 351–358
  • Jarpe AJ, Winter WE, Peck AB. The changing profile of monoclonal cell populations infiltrating the islets of Langerhan during the progressive insulitis phase in prediabetic NOD mice. Allergy & Immunol (Life Sci Adv) 1991; 9: 283–292
  • Jarpe AJ, Hickman Anderson JT, Winter WE, Peck AB. Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhan in prediabetic NOD mice: Development of a model of autoimmune insulitis for type I diabetes. Regional Immunol 1991; 3: 305–317
  • Bottazzo GF, Florin-Christensen A, Doniach D. Islet cell antibodies in Diabetes mellitus with autoimmune polyen-docrine deficiencies. Lancet 1974; 2: 1279–1284
  • Bottazzo GF, Dean BM, McNally JM. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985; 313: 353–360
  • Fujita H, Fujino H, Nonaka K, Tarui S, Tochino Y. Retrovirus-like particles in pancreatic β cells of NOD (non-obese diabetic) mice. Biomed Res 1984; 5: 67–70
  • Serreze DV, Leiter EH, Kuer EL, Jardieu P, Ishizaka K. Molecular mimicry between insulin and retroviral antigen p73. Diabetes 1988; 37: 351–358

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