6
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Lack of 64,000-MR Islet Autoantigen Overexpression and Antibody Development Following Coxsackievirus B4 Infection in Diabetes-Resistant Mice

&
Pages 197-203 | Received 21 Jun 1992, Accepted 25 Sep 1992, Published online: 07 Jul 2009

References

  • Bottazzo G F, Todd I, Mirakian R, Belfiore A, Pujol-Borrell R. Organ-specific autoimmunity: a 1986 overview. Immunol Rev 1986; 94: 137–169
  • Maclaren N, Schatz D, Drash A, Grave G. Initial pathogenic events in IDDM. Diabetes 1989; 38: 534–538
  • Ziegler A G, Eisenbarth G S. Immunology of IDDM (Type I diabetes). The Diabetes Annual, K GMM Alberti, L P Krall. Elsevier, New York 1990; Vol 5: 22–50
  • Baekkeskov S, Landin M, Kristensen J K, et al. Antibodies to a 64.000 M, human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987; 79: 926–934
  • Baekkeskov S, Aanstoot H-J, Christgau S, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151–156
  • Baekkeskov S, Dyrberg T, Lemmark Å. Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science 1984; 224: 1348–1350
  • Atkinson M A, Maclaren N K. Autoantibodies in nonobese diabetic mice immuno-precipitate 64,000-Mr, islet antigen. Diabetes 1988; 37: 1587–1590
  • Yoon J W, Austin M, Onodera T, Notkins A L. Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 1979; 300: 1173–1179
  • Jenson A B, Rosenberg H S, Notkins A L. Pancreatic islet cell damage in children with fatal viral infection. Lancet 1980; 11: 354–358
  • Banatvala J E, Bryant J, Schernthaner G, et al. Coxsackie B. mumps, rubella and cytomegalovirus specific IgM responses in patient with juvenile-onset insulin-dependent diabetes mellitus in Britain. Austria and Australia. Lancer 1985; 1: 1409–1412
  • Chatterjee N K, Haley T M, Nejman C. Functional alterations in pancreatic beta cells as a factor in virus-induced hyperglycemia in mice. J Biol Chem 1985; 260: 12786–12791
  • Gerling I, Nejman C, Chatterjee N K. Effect of coxsackievirus B4 infection in mice on expression of 64.000-M, autoantigen and glucose sensitivity of islets before development of hyperglycemia. Diabetes 1988; 37: 1419–1425
  • Gerling I, Chatterjee N K, Nejman C. Coxsackievirus B4-induced development of antibodies to 64.000-M, autoantigen and hyperglycemia in mice. Autoimmunity 1991; 10: 49–56
  • Chatterjee N K, Nejman C. Insulin mRNA content in pancreatic beta cells of coxsackievirus B4-induced diabetic mice. Mol Cell Endocrinol 1988; 55: 193–202
  • Hartig P C, Madge G E, Webb S R. Diversity within a human isolate of coxsackie B4: relationship to viral-induced diabetes. J Med Virol 1983; 11: 23–30
  • Chatterjee N K, Hou J, Dockstader P, Charbonneau T. Coxsackievirus B4 infection alters thymic. splenic, and peripheral blood lymphocyte repertoire preceding onset of hyperglycemia in mice. J Med Virol 1992; 38: 124–131

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.