Effect of Syngeneic Islet Antigen Administration on Complement-Dependent Antibody-Mediated Cytotoxicity to Islet Cells and Diabetes Onset in Diabetes-Prone Bb/Ok Rats

References

• Nakhooda A F, Like A A, Chappel C J, Murray F T, Marliss E B. The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. Diabetes 1977; 26: 100–112
   PubMed Web of Science ®Google Scholar
• Logothetopoulos J, Valiquette N, Madura E, Cvet D. The onset and progression of pancreatic insulitis in the overt spontaneously diabetic, young adult BB rat studied by pancreatic biopsy. Diabetes 1984; 33: 33–36
   PubMed Web of Science ®Google Scholar
• Lucke S, Besch W, Ch Kauert, Hahn H J. The endocrine pancreas of BB/OK rats before and at diagnosis of hyperglycaemia. Exp. Clin. Endocrinol 1988; 91(No. 2)161–170
   PubMedGoogle Scholar
• Koevary S T., Rossini A, Stoller W, Chick W, Williams R M. Passive transfer of diabetes in the BB/W rat. Science 1983; 220: 727–728
   PubMed Web of Science ®Google Scholar
• Like A A, Rossini A A, Guberski D L, Appel M C, Williams R M. Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science 1979; 206: 1421–1423
   PubMed Web of Science ®Google Scholar
• Like A A, Kislauskis E, Williams R M, Rossini A A. Neonatal thyrnectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science 1982; 216: 644–646
   PubMed Web of Science ®Google Scholar
• Dryberg T, Poussier P, Nakhooda F, Marliss E B. Lemmark Å. Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat. Diabetologia 1984; 26: 159–165
   PubMed Web of Science ®Google Scholar
• Like A A, Appel M C, Rossini A A. Auto antibodies in the BBW rat. Diabetes 1982; 31: 816–820
   PubMed Web of Science ®Google Scholar
• Dean B M, Bone A J, Varey A M, Walker R, Baird J D, Cooke A. Insulin auto antibodies. islet cell surface antibodies and the development of spontaneous diabetes in the BB/Edinburgh rat. Clin. exp. Immunol 1987; 69: 308–313
   PubMed Web of Science ®Google Scholar
• Diaz J L, Kiesel U, Kolb H, Wilkin T J. The time course of insulin autoantibodies (IAA) in the diabetes prone BB rat. Autoimmunity 1989; 4: 79–88
   PubMed Web of Science ®Google Scholar
• Dyrberg T, Nakhooda A F, Baekkeskov S., Lernmark Å, Poussier P, Marliss E B. Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat. Diabetes 1982; 31: 278–281
   PubMed Web of Science ®Google Scholar
• Martin D R, Logothetopoulos J. Complement-fixing islet cell antibodies in the spontaneously diabetic BB rat. Diabetes 1984; 33: 93–96
   PubMed Web of Science ®Google Scholar
• Laborie C, Sai P, Feutren G., Debray-Sachs M., Qiniou-Debrie M S, Poussier P, Marliss E B, Assan R. Time course of islet cell antibodies in diabetic and nondiabetic BB rats. Diabetes 1985; 34: 904–910
   PubMed Web of Science ®Google Scholar
• Pipeleers D, van de Winkel M, Dyrberg T, Lernmark Å. Spontaneously diabetic BB rats have age-dependent islet β-cell-specific surface antibodies at clinical onset. Diabetes 1987; 36: 1111–1115
   PubMed Web of Science ®Google Scholar
• Schröder D, Hehmke B, Klöting I, Besch W. Effect of serum From diabetes-prone BB/OK rats on neonatal rat pancreatic islets and islet cell suspensions. Exp. Clin. Endocrinol 1989; 3(NO. 2)93, 187–192
   Google Scholar
• Schröder D, Hehmke B., Klöting I, Besch W, Schmidt S. Humoral-mediated anti-islet cyto toxicity in diabetes-prone BB/OK rats—Effect on /β-cell function and autologous islets. Exp. Clin. Endocrinol 1990; 95(No. 1)22–30
   PubMedGoogle Scholar
• Hehmke B, Schröder D, Klöting I. Early appearance of complement-dependent antibody mediated cytotoxicity (C'AMC) to islet cells in serum of diabetes-prone BB/OK rats. Diabetes Res 1990; 13: 183–186
   PubMedGoogle Scholar
• Schröder D, Hehmke B., Klöting I, Schmidt S. Detection and time course of humoral-mediated cytotoxicity to different cell types in diabetes-prone BB/OK rats. Diabetes Res 1991; 17: 81–91
   PubMedGoogle Scholar
• Klöting I, Reiher K. Einige Aspekte zur Haltung und Reproduktion spontandiabetischer BB-Ratten. Z. Versuchstierk 1985; 27: 5–11
   PubMedGoogle Scholar
• Klöting I, Stark O, Hahn H J. Animal model of the insulin-dependent diabetes mellitus in BB rats: Their RT1uhomogeneity and prolonged survival of allogeneic skin grafts. Folia biol 1984; 30: 24–32
   PubMed Web of Science ®Google Scholar
• Hehmke B, Kohnert K D, Odselius R. The use of a new dextran gradient medium for rapid isolation of functionally intact neonatal rat pancreatic islets. Diabetes Res 1986; 3: 13–16
   PubMedGoogle Scholar
• Kohnert K D, Hehmke B. Preparation of suspensions of pancreatic islet cells: a comparison of methods. J. Biochem. Biophys. Meth 1986; 12: 81–88
   PubMedGoogle Scholar
• Hehmke B, Michaelis D, Hildmann W, Richter K V, Kohnert K D. Cytotoxic islet cell auto antibodies in newly diagnosed insulin-dependent diabetes mellitus: lack of correlation to age, residual beta cell function, HLA antigens and Coxsackie B virus antibodies. Diabetes Res 1987; 4: 73–77
   PubMedGoogle Scholar
• Hehmke B, Lucke S, Schröder D, Kloting I, Kohnert K D. Complement-dependent antibody-mediated cyto toxicity in the spontaneously diabetic BB/OK rat: association with β-cell volume density. Eur. J. Immunol 1990; 20: 1091–1096
   PubMed Web of Science ®Google Scholar
• Wilkin T, Nicholson S, Casey C. A micro enzyme-linked immunosorbent assay for insulin antibodies in serum. J. Immunol. Meth 1985; 76: 185–194
   PubMed Web of Science ®Google Scholar
• Besch W, Woltanski K P, Keilacker H, Diaz-Alonso J M, Schulz B, Amend P, Kohnert K D, Ziegler M. Measurement of insulin in human sera using a new RIA Kit 1. Insulin determination in the absence of insulin antibodies—conventional assay and micro modification. Exp. Clin. Endocrinol 1987; 90: 264–270
   PubMedGoogle Scholar
• Kohnert K D, Hahn H J, Gylfe E, Borg H, Hellman B. Calcium and pancreatic β-cell function. 6. Glucose and intracellular45Ca distribution. Molec and Cellular Endocrinol 1979; 16: 205–220
   PubMed Web of Science ®Google Scholar
• Ziegler B., Klöting I, Besch W., Ziegler M, Hahn H J. Cytotoxic activity of sera from diabetic BB rats against BB rats islets—a functional study. Diabetes Res 1987; 4: 67–72
   PubMedGoogle Scholar
• Schröder D, Wanka H, Hehmke B, Klöting I, Köhler E, Knospe S, Schmidt S. Beta cell destruction of pancreatic islets transplanted into diabetic BB/OK rats may be reflected by increased antibody-mediated anti-islet cyto toxicity. Diabetes Res 1990; 15: 27–32
   PubMedGoogle Scholar
• Markholst H., Lemmark Å. Reduced pancreatic insulin is associated with retarded growth of the pancreas in young prediabetic BB rats. Pancreas 1988; 3: 140–144
   PubMed Web of Science ®Google Scholar
• Vogt L., Klöting I. Model-based prediction of diabetes incidence in BB/OK rats. Diab et Metab 1992, in press
   Web of Science ®Google Scholar
• Schröder D, Hehmke B, Klöting I, Besch W, Hahn H J. Complement-dependent cyto toxicity to islet cells and lymphocytes in diabetes-prone BB/OK rats. Diabetologia 1987; 30: 579A, 496, abstract
   Web of Science ®Google Scholar
• Hahn H J, Klöting I, Kuttler B. The immune dysregulation is more pronounced in diabetic than in nondiabetic BB/OK rats: Evaluation by allogeneic skin transplantation. Diabetologia 1992; 35: A215, 832, abstract, Suppl 1
   Web of Science ®Google Scholar