References
- Townsend A RM, Rothbard J, Gotch F M, Bahadur G, Wraith D, McMichael A J. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 1986; 44: 959–968
- Braciale T J, Morrison L A, Sweetser M T, Sambrook J, Bething M J, Braciale V L. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol. Rev. 1987; 98: 95–114
- Dialynas D P, Wilde D B, Marrack P, Pierres A, Wall K A, Harran W, Otten G, Loken M R, Pierres M, Kappler J, Fitch F W. 1983. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: Expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol. Rev. 1983; 74: 29–56
- Swain S L. T cell subsets and the recognition of MHC class. Immunol. Rev. 1983; 74: 129–142
- Bevan M J, Fink P J. The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells. Immunol. Rev. 1978; 42: 3–19
- Sprent J. Restricted helper function of Fl-parent bone marrow chimeras controlled by K-end of H-2 complex. J. Exp. Med. 1978; 147: 1838–1842
- Marrack P, Kushnir E, Born W, McDuffie M, Kappler J. The development of helper T cell precursors in mouse thymus. J. Immunol. 1988; 140: 2508–2514
- Zuniga-Pfluccker J C, Longo D I, Kruisbeek A M. Positive selection of CD4-CD8+ T cells in the thymus of nominal mice. Nature 1989; 338: 76–78
- Sha W C, Nelson C A, Newberrry R D, Kranz D M, Russell J H, Loh D Y. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988; 336: 73–76
- Teh H S, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, von Boehmer H. Thymic major histocompatibility complex antigens and the aβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 1988; 335: 229–233
- Berg L J, Fazekas de StGroth B, Pullen A M, Davis M M. Phenotypic differences between aβ versus β T-cell receptor transgenic mice undergoing negative selection. Nature 1989; 340: 559–562
- Kaye J, Hsu M-L, Sauron M-E, Jameson S C, Gascoigne N RJ, Hedrick S M. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 1989; 341: 746–749
- Kappler J W, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273–280
- Kappler J W, Staerz U, White J, Marrack P. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 1988; 332: 35–40
- Kisielow P, Bluthmann H, Staerz U D, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 1988; 333: 742–746
- MacDonald H R, Schneider R, Lees R K, Howe R C, Acha-Orbea H, Festenstein H, Zinkernagel R M, Hengartner H. T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 1988; 332: 40–44
- Nikolic-Zugic J, Bevan M J. Role of self-peptides in positively selecting the T-cell repertoire. Nature 1990; 344: 65–67
- Sha W C, Nelson C A, Newberry R D, Pullen J K, Pease L R, Russel J H, Loh D Y. Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding. Proc. Natl. Acad. Sci. USA 1990; 87: 6186–6190
- Kaye J, Vasquez N J, Hedrick S M. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J. Immunol. 1992; 148: 3342–3353
- Murphy K M, Heimberger A B, Loh D Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+ TCR10 thymocytes in vivo. Science 1990; 250: 1720–1723
- Mamalaki C, Norton T, Tanaka Y, Townsend A R, Chandler P, Simpson E, Kioussis D. Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 1992; 89: 11342–11346
- Kyewski B A, Fathman C G, Kaplan H S. Intrathymic presentation of circulating non-major histocompatibility complex antigens. Nature 1984; 308: 196–199
- Rock K L, Gamble Rothstein S. Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science 1990; 249: 918–921
- Grant E P, Rock K L. MHC class 1-restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo. J. Immunol. 1992; 148: 13–18
- Rock K L, Rothstein L, Gamble S, Fleischacker C. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J. Immunol. 1993; 150: 438–446
- Morahan G, Allison J, Miller J FAP. Tolerance of class I histocompatibility antigens expressed extra-thymically. Nature 1989; 339: 622–624
- Miller J FAP, Morahan G, Allison J, Hoffmann M. A transgenic approach to the study of peripheral T-cell tolerance. Immunol. Rev. 1991; 122: 103–116
- Schonrich G, Kalinke U, Momburg F, Malissen M, Schmitt-Verhulst A M, Mallissen B, Hammerling G J, Arnold B. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extra thymic tolerance induction. Cell 1991; 65: 293–304
- Heath W R, Allison J, Hoffmann M W, Schonrich G, Hammerling G, Arnold B, Miller J FAP. (1992). Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 1992; 359: 547–549
- Miller J FAP, Heath W R. Self ignorance in the peripheral T cell pool. Immunol. Rev. 1993, in press
- Miller J FAP, Morahan G, Allison J. Extrathymic acquisition of tolerance by T lymphocytes. J. Cold Spring Harbor Symp. Quant. Biol. 1989; 54: 807–813
- MacKay C R. Immunological memory. Ann. Rev. Immunol. 1993, in press
- Schonrich G, Momburg F, Malissen M, Schmitt-Verhulst A-M, Malissen B, Hammerling G J, Arnold B. Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen. Inter. Immunol. 1992; 4: 581–590
- Allison J, Campbell I L, Morahan G, Mandel T E, Harrison L C, Miller J FAP. Diabetes in transgenic mice resulting form over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 1988; 333: 529–533
- Ohashi P S, Oehen S, Buerki K, Pircher H, Ohashi C T, Oder-Matt B, Malissen B, Zinkernagel R M, Hengartner H. Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991; 65: 305–317
- Oldstone M BA, Merenberg P S, Price J, Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 1991; 65: 319–331
- Heath W R, Hurd M, Carbone F, Sherman L A. Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes. Nature 1989; 341: 749–752
- Heath Sherman W R. Cell-type-specific recognition of allogeneic cells by alloreactive cytotoxic T cells: a consequence of peptide dependent allorecognition. Eur J Immunol 1991; 21: 153–159
- Heath W R, Kane K P, Mescher M F, Sherman L A. Alloreactive T cells discriminate among a diverse set of endogenous peptides. Proc. Natl. Acad. Sci. 1991; 88: 5101–5105
- Rotzschke O, Falk K, Faath S, Rammensee H-G. On the nature of peptides involved in T cell alloreactivity. J. Exp. Med. 1991; 174: 1059–1071
- Zinkernagel R M, Hengartner H. Virally induced immunosuppression. Current Opinion in Immunology 1992; 4: 408–412
- Dustin M L, Springer T A. Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Annu. Rev. Immunol. 1991; 9: 27–66
- Allison J, Malcolm L, Chosich N, Miller J FAP. Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet β cells. Eur. J. Immunol. 1992; 22: 1115–1121
- Lo D, Freedman J, Gesse S, Palmiter R D, Brinster R L, Sherman L A. Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur. J. Immunol. 1992; 22: 1013–1022
- Bretscher P A, Cohn M. A theory of self-nonself discrimination: paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 1970; 169: 1042–1049
- Lafferty K J, Woolnough J. The origin and mechanism of the allograft reaction. Immunol. Rev. 1977; 35: 231–262
- Lafferty K J, Prowse S J, Simeonovic C J. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann. Rev. Immunol. 1983; 1: 143–173
- Steinman R M, Gutchinov B, Witmer M D, Nussenzweig M C. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J. Exp. Med. 1983; 157: 613–627
- Sprent J, Webb S R. Function and specificity of T cell subsets in the mouse. Adv. Immunology 1987; 41: 39–133
- Steinman R M. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol. 1991; 9: 271–296