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Original Article

Nicotinamide Decreases Nitric Oxide Production and Partially Protects Human Pancreatic Islets Against the Suppressive Effects of Combinations of Cytokines

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Pages 193-198 | Received 21 Nov 1994, Published online: 07 Jul 2009

References

  • Rabinovitch A. Roles of cytokines in IDDM pathogenesis and islet β‐cell destruction. Diabetes Rev 1993; 1: 215–240
  • Mandrup‐Poulsen T., Helqvist S., Wogensen L. D., Mølvig J., Pociot F., Johannensen J., Nerup J. Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Current Top. Microbiol. Immunol 1990; 164: 169–193
  • Sandier S., Eizirik D. L., Svensson C., Strandell E., Welsh M., Welsh N. Biochemical and Molecular actions of interleukin‐1 on pancreatic β‐cells. Autoimmunity 1991; 10: 241–253
  • Corbett J. A., McDaniel M. I. Does nitric oxide mediate autoimmune destruction of β‐cells? Possible therapeutic interventions in IDDM. Diabetes 1992; 41: 897–903
  • Eizirik D. L., Welsh N., Hellerström C. Predominance of stimulatory effects of interleukin‐1 β on isolated human pancreatic islets. J. Clin. Endocrinol Metab 1993; 76: 399–403
  • Corbett J. A., Sweetland M. A., Wang J. L., Lancaster J. R., Jr, McDaniel M. L. Nitric oxide mediates cytokine‐induced inhibition of insulin secretion by human islets of Langer‐hans. Proc. Natl Acad. Sci. USA 1993; 90: 1731–1735
  • Eizirik D. L., Sandier S., Welsh N., Cetkovic‐Cvrlje M., Nieman A., Geller D. A., Pipeleers D. G., Bendtzen K., Hellerström C. Cytokines suppress human islet function irrespective of their effect on nitric oxide generation. J. Clin. Invest 1994; 93: 1968–1974
  • Pociot F., Reimers J. I., Andersen H. U. Nicotinamide—biological actions and therapeutic potential in diabetes pre‐vention IDIG workshop, Copenhagen, Denmark. Diabetologia 1993; 36: 574–576
  • Schein P. S., Cooney D. A., Vernon M. L. The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity. Cancer Res 1967; 27: 2324–2332
  • Yamada K., Novaka K., Hanafusa T., Miyazaki T., Toyoshima H., Tarui S. Preventive and therapeutic effects of large‐dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice. Diabetes 1982; 31: 749–753
  • Yonemura Y., Takashima T., Matsuda Y., Miwa K., Sugiyama K., Miyazaki I., Yamamoto M., Okamoto H. Induction of islet B‐cell regeneration in partially pancreatectomized rats by poly(ADP‐ribose) synthase inhibitors. In. J. Pancreatol 1988; 3: 73–82
  • Elliot R. B., Chase H. P. Prevention or delay of type 1 (insulin‐dependent) diabetes mellitus in children using nicotinamide. Diabetologia 1991; 34: 362–365
  • Manna R., Migliore A., Martin L. S., Ferrara E., Ponte E., Marietti G., Scuderi F., Cristiano G., Ghirlanda G., Gambassi G. Nicotinamide treatment in subjects at high risk of developing IDDM improves insulin secretion. Brit. J. Clin. Pract 1992; 46: 177–179
  • Kröncke K. D., Funda J., Berschick B., Kolb H., Kolb‐Bachofen V. Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta‐cell specific. Diabetologia 1991; 34: 232–238
  • Buscema M., Vinci C., Gatta C., Rabuazzo M. A., Vigneri R., Purrelo F. Nicotinamide partially reverses the interleukin‐1β inhibition of glucose‐induced insulin release in pancreatic islets. Metabolism 1992; 41: 296–300
  • Andersen H. U., Jørgensen K. H., Egeberg J., Mandrup‐Poulsen T., Nerup J. Nicotinamide reduces interleukin‐l‐induced nitric oxide production and inhibition of insulin release in rat islets of Langerhans. Diabetes 1994; 43: 770–777
  • Cetkovic‐Cvrlje M., Sandier S., Eizirik D. L. Nicotinamide and dexamethasone inhibit interleukin‐1‐induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase. Endocrinology 1993; 133: 1739–1743
  • Sandier S., Andersson A. Long‐term effects of exposure of pancreatic islets to nicotinamide in vitro on DNA synthesis, metabolism and B‐cell function. Diabetologia 1986; 29: 199–202
  • Sandier S., Hellerström C., Eizirik D. L. Effects of nicotinamide supplementation on human pancreatic islet function in tissue culture. J. Clin. Endocrinol. Metab 1993; 77: 1574–1576
  • Eizirik D. L., Korbutt G. S., Hellerström C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β‐cell function. J. Clin. Invest 1992; 90: 1263–1268
  • Strandell E., Eizirik D. L., Korsgren O., Sandier S. Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations. Mol. Cell. Endocrinol 1988; 59: 83–91
  • Wallenstein S., Zucker C. L., Fleiss J. Some statistical methods useful in circulation research. Circ. Res 1980; 47: 1–9
  • Eizirik D. L., Pipeleers D., Ling Z., Welsh N., Hellerström C., Andersson A. Major species differences between human and rodents in the susceptibility to pancreatic β‐cell injury. Proc. Natl Acad. Sci. USA 1994; 91: 9253–9256
  • Cetkovic‐Cvrlje M., Eizirik D. L. TNF‐α and IFN‐γ potentiate the deleterious effects of IL‐lβ on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 1994; 6: 399–406
  • Schmidt H. H. H. W., Warner T. D., Ischii K., Sheng H., Murad F. Insulin secretion from pancreatic β‐cells caused by L‐arginine‐derived nitric oxide. Science 1991; 255: 721–723
  • Hauschildt S., Scheipers P., Bessler W. G., Mülsch A. Induction of nitric oxide synthase in L929 cells by tumour‐necrosis factor α is prevented by inhibitors of poly(ADP‐ribose) polymerase. Biochem. J 1992; 288: 255–260
  • Kolb H., Kolb‐Bachofen V. Type 1(insulin‐dependent) diabetes mellitus and nitric oxide. Diabetologia 1992; 35: 767–796
  • Mandrup‐Poulsen T., Corbertt J. A., McDaniel M. L., Nerup J. What are the types and cellular sources of free radicals in the pathogenesis of type 1(insulin‐dependent) diabetes mellitus?. Diabetologia 1993; 36: 470–473
  • Okamoto H. Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin‐dependent diabetes mellitus. Mol. Cell. Biochem 1981; 37: 43–61
  • Wilson G. L., Patton N. J., McCord J. M., Mullins D. W., Mossman B. T. Mechanisms of streptozotocin‐and alloxan‐induced damage in rat. B cells. Diabetologia 1984; 27: 587–591
  • Levi V., Jacobson E. L., Jacobson M. K. Inhibition of poly(ADP‐ribose) polymerase by methylated xanthines and cytokinins. FEBS Lett 1978; 88: 144–146
  • Rabinovitch A., Suarez W. L., Thomas K., Strynadka K., Simpson I. Cytotoxic effects of cytokines on rat islets: evidence for involvements of free radicals and lipid peroxidation. Diabetologia 1992; 35: 409–413
  • Beckman J. S., Beckman T. W., Chen J., Marshall P. A., Freeman B. A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl Acad. Sci. USA 1990; 87: 1620–1624

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